DK169276B1 - Vaccine indeholdende et immunogent virusprotein - Google Patents
Vaccine indeholdende et immunogent virusprotein Download PDFInfo
- Publication number
- DK169276B1 DK169276B1 DK446287A DK446287A DK169276B1 DK 169276 B1 DK169276 B1 DK 169276B1 DK 446287 A DK446287 A DK 446287A DK 446287 A DK446287 A DK 446287A DK 169276 B1 DK169276 B1 DK 169276B1
- Authority
- DK
- Denmark
- Prior art keywords
- inactivated
- protein
- picornavirus
- poliovirus
- vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 32
- 230000002163 immunogen Effects 0.000 title claims description 12
- 108010067390 Viral Proteins Proteins 0.000 title claims description 4
- 102100023321 Ceruloplasmin Human genes 0.000 claims abstract description 47
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 46
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 45
- 108090000565 Capsid Proteins Proteins 0.000 claims abstract description 42
- 241000991587 Enterovirus C Species 0.000 claims abstract description 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 25
- 241000709664 Picornaviridae Species 0.000 claims abstract description 17
- 230000001681 protective effect Effects 0.000 claims abstract description 10
- 230000001939 inductive effect Effects 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 241000709661 Enterovirus Species 0.000 claims description 19
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 7
- 108050000278 Picornavirus capsid Proteins 0.000 claims description 6
- 241000709701 Human poliovirus 1 Species 0.000 claims description 5
- 241000709687 Coxsackievirus Species 0.000 claims description 3
- 241001466953 Echovirus Species 0.000 claims description 3
- 241000709721 Hepatovirus A Species 0.000 claims description 3
- 241000709704 Human poliovirus 2 Species 0.000 claims description 3
- 241000709727 Human poliovirus 3 Species 0.000 claims description 3
- 230000037452 priming Effects 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 230000036039 immunity Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 13
- 230000003053 immunization Effects 0.000 abstract description 10
- 239000002671 adjuvant Substances 0.000 abstract description 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract description 3
- 241000700605 Viruses Species 0.000 description 23
- 239000000427 antigen Substances 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 230000003472 neutralizing effect Effects 0.000 description 13
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000002649 immunization Methods 0.000 description 9
- 230000000638 stimulation Effects 0.000 description 9
- 230000002708 enhancing effect Effects 0.000 description 8
- 229940029583 inactivated polio vaccine Drugs 0.000 description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
- 239000000725 suspension Substances 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 210000002443 helper t lymphocyte Anatomy 0.000 description 6
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
- 230000000240 adjuvant effect Effects 0.000 description 4
- 235000019253 formic acid Nutrition 0.000 description 4
- 208000005252 hepatitis A Diseases 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 210000000234 capsid Anatomy 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 101710132601 Capsid protein Proteins 0.000 description 2
- 101800000593 Capsid protein 2 Proteins 0.000 description 2
- 101710197658 Capsid protein VP1 Proteins 0.000 description 2
- 102000009016 Cholera Toxin Human genes 0.000 description 2
- 108010049048 Cholera Toxin Proteins 0.000 description 2
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 102000002067 Protein Subunits Human genes 0.000 description 2
- 108010001267 Protein Subunits Proteins 0.000 description 2
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 101710108545 Viral protein 1 Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229960001539 poliomyelitis vaccine Drugs 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 241000500386 Boone cardiovirus Species 0.000 description 1
- 101800000592 Capsid protein 3 Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000709675 Coxsackievirus B3 Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000274177 Juniperus sabina Species 0.000 description 1
- 239000012741 Laemmli sample buffer Substances 0.000 description 1
- 241000710185 Mengo virus Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 101710166307 Protein lines Proteins 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000914334 Sahlbergella singularis Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000002516 postimmunization Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940023143 protein vaccine Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90073986 | 1986-08-27 | ||
| US06/900,739 US4946676A (en) | 1986-08-27 | 1986-08-27 | Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK446287D0 DK446287D0 (da) | 1987-08-26 |
| DK446287A DK446287A (da) | 1988-02-28 |
| DK169276B1 true DK169276B1 (da) | 1994-10-03 |
Family
ID=25413018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK446287A DK169276B1 (da) | 1986-08-27 | 1987-08-26 | Vaccine indeholdende et immunogent virusprotein |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4946676A (no) |
| EP (1) | EP0257721B1 (no) |
| JP (1) | JPS63132844A (no) |
| AT (1) | ATE71534T1 (no) |
| CA (1) | CA1292690C (no) |
| DE (1) | DE3776034D1 (no) |
| DK (1) | DK169276B1 (no) |
| ES (1) | ES2032812T3 (no) |
| GR (1) | GR3003754T3 (no) |
| NO (1) | NO873593L (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797270B1 (en) * | 1989-03-16 | 2004-09-28 | Center For Blood Research, Inc. | Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
| CA2105629A1 (en) * | 1992-09-14 | 1994-03-15 | Robert S. Becker | Potentiation of immunogenic response |
| US20040002058A1 (en) * | 2001-06-21 | 2004-01-01 | Uab Research Foundation | Chimeric capsid proteins and uses thereof |
| CA2454882A1 (en) * | 2001-06-21 | 2003-01-03 | Uab Research Foundation | Chimeric capsid proteins and uses thereof |
| US20090142364A1 (en) * | 2007-08-30 | 2009-06-04 | Fedor Alexandrovich Brovko | Method for finding novel peptide immunostimulatory adjuvants, compositions and methods of use |
| KR20180086180A (ko) | 2015-06-15 | 2018-07-30 | 에모리 유니버시티 | 다가 엔테로바이러스 백신 조성물 및 이와 관련된 용도 |
| WO2017165320A1 (en) * | 2016-03-20 | 2017-09-28 | The Trustees Of The University Of Pennsylvania | Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants |
-
1986
- 1986-08-27 US US06/900,739 patent/US4946676A/en not_active Expired - Lifetime
-
1987
- 1987-08-26 DK DK446287A patent/DK169276B1/da active
- 1987-08-26 NO NO873593A patent/NO873593L/no unknown
- 1987-08-27 ES ES198787201620T patent/ES2032812T3/es not_active Expired - Lifetime
- 1987-08-27 DE DE8787201620T patent/DE3776034D1/de not_active Expired - Lifetime
- 1987-08-27 EP EP87201620A patent/EP0257721B1/en not_active Expired - Lifetime
- 1987-08-27 JP JP62214131A patent/JPS63132844A/ja active Pending
- 1987-08-27 AT AT87201620T patent/ATE71534T1/de not_active IP Right Cessation
- 1987-08-27 CA CA000545494A patent/CA1292690C/en not_active Expired - Lifetime
-
1992
- 1992-02-11 GR GR920400176T patent/GR3003754T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO873593L (no) | 1988-02-29 |
| NO873593D0 (no) | 1987-08-26 |
| DE3776034D1 (de) | 1992-02-27 |
| US4946676A (en) | 1990-08-07 |
| DK446287D0 (da) | 1987-08-26 |
| DK446287A (da) | 1988-02-28 |
| CA1292690C (en) | 1991-12-03 |
| ATE71534T1 (de) | 1992-02-15 |
| EP0257721A2 (en) | 1988-03-02 |
| ES2032812T3 (es) | 1993-03-01 |
| JPS63132844A (ja) | 1988-06-04 |
| EP0257721A3 (en) | 1988-06-08 |
| EP0257721B1 (en) | 1992-01-15 |
| GR3003754T3 (no) | 1993-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A0 | Application filed |