DK168444B1 - 7beta-methyl- eller 7beta-ethyl-11-aminophenylsteroidforbindelser, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse - Google Patents

7beta-methyl- eller 7beta-ethyl-11-aminophenylsteroidforbindelser, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse Download PDF

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Publication number
DK168444B1
DK168444B1 DK688088A DK688088A DK168444B1 DK 168444 B1 DK168444 B1 DK 168444B1 DK 688088 A DK688088 A DK 688088A DK 688088 A DK688088 A DK 688088A DK 168444 B1 DK168444 B1 DK 168444B1
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DK
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Prior art keywords
group
compounds
hydroxyl
methyl
hydroxy
Prior art date
Application number
DK688088A
Other languages
Danish (da)
English (en)
Other versions
DK688088A (da
DK688088D0 (da
Inventor
Hendrik Paul De Jongh
Nicolaas Pieter Van Vliet
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of DK688088D0 publication Critical patent/DK688088D0/da
Publication of DK688088A publication Critical patent/DK688088A/da
Application granted granted Critical
Publication of DK168444B1 publication Critical patent/DK168444B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Gyroscopes (AREA)
  • Fats And Perfumes (AREA)
DK688088A 1987-12-12 1988-12-09 7beta-methyl- eller 7beta-ethyl-11-aminophenylsteroidforbindelser, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse DK168444B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8703008 1987-12-12
NL8703008 1987-12-12

Publications (3)

Publication Number Publication Date
DK688088D0 DK688088D0 (da) 1988-12-09
DK688088A DK688088A (da) 1989-06-13
DK168444B1 true DK168444B1 (da) 1994-03-28

Family

ID=19851082

Family Applications (1)

Application Number Title Priority Date Filing Date
DK688088A DK168444B1 (da) 1987-12-12 1988-12-09 7beta-methyl- eller 7beta-ethyl-11-aminophenylsteroidforbindelser, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse

Country Status (16)

Country Link
US (1) US4921845A (xx)
EP (1) EP0321010B1 (xx)
JP (1) JP2768707B2 (xx)
KR (1) KR970009592B1 (xx)
CN (1) CN1019807B (xx)
AT (1) ATE85342T1 (xx)
AU (1) AU613433B2 (xx)
CA (1) CA1301162C (xx)
DE (1) DE3878198T2 (xx)
DK (1) DK168444B1 (xx)
ES (1) ES2053714T3 (xx)
FI (1) FI89056C (xx)
IE (1) IE61848B1 (xx)
NZ (1) NZ227269A (xx)
PT (1) PT89185B (xx)
ZA (1) ZA888996B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0411733T3 (da) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-oner
FR2650748B1 (fr) * 1989-08-08 1991-11-08 Roussel Uclaf Nouveaux esters d'acides organiques avec des alcools derives de 19-nor steroides et leurs sels, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions les renfermant
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
CA2149496C (en) * 1994-05-19 2006-12-19 Ronald Gebhard 11,21-bisphenyl-19-norpregnane derivatives
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
IL115659A (en) * 1994-10-27 2000-06-01 Akzo Nobel Nv Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
HU230492B1 (hu) * 1996-05-01 2016-08-29 The Government Of The United States Of America Új progesztációt gátló szerként használható 21-helyzetben szubsztituált progeszteron-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique
AU2001249661B2 (en) * 2000-03-31 2005-02-17 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha, 11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
EP1613640A4 (en) * 2003-02-28 2010-05-19 Us Gov Health & Human Serv PROCESS FOR PREPARING 17 ALPHA-ACETOXY-11 BETA- (4-N, N-DIMETHYLAMINOPHENYL) -19-NORPREGNA-4,9-DIENE-3,20-DION, INTERMEDIATE PRODUCTS AND METHOD OF MANUFACTURING THESE INTERMEDIATE PRODUCTS
CA2673128C (en) 2006-10-24 2018-07-03 Repros Therapeutics Inc. Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
UA110030C2 (uk) 2010-03-22 2015-11-10 Спосіб лікування ендометріозу або міоми матки і лікарська форма для щоденного введення на слизову піхви жінки

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids

Also Published As

Publication number Publication date
CN1034731A (zh) 1989-08-16
AU2646988A (en) 1989-06-15
CN1019807B (zh) 1992-12-30
JPH01211597A (ja) 1989-08-24
EP0321010A1 (en) 1989-06-21
ES2053714T3 (es) 1994-08-01
CA1301162C (en) 1992-05-19
KR890009968A (ko) 1989-08-05
KR970009592B1 (en) 1997-06-14
FI89056B (fi) 1993-04-30
JP2768707B2 (ja) 1998-06-25
PT89185A (pt) 1989-12-29
FI885717A (fi) 1989-06-13
ZA888996B (en) 1989-08-30
PT89185B (pt) 1993-06-30
FI89056C (fi) 1993-08-10
DK688088A (da) 1989-06-13
IE61848B1 (en) 1994-11-30
DE3878198D1 (de) 1993-03-18
NZ227269A (en) 1990-06-26
DE3878198T2 (de) 1993-06-24
FI885717A0 (fi) 1988-12-09
ATE85342T1 (de) 1993-02-15
IE883565L (en) 1989-06-12
EP0321010B1 (en) 1993-02-03
US4921845A (en) 1990-05-01
AU613433B2 (en) 1991-08-01
DK688088D0 (da) 1988-12-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed