DK168008B1 - Pyridin-2,4- og -2,5-dicarboxylsyrediamid-derivater, deres fremstilling og laegemidler indeholdende dem - Google Patents
Pyridin-2,4- og -2,5-dicarboxylsyrediamid-derivater, deres fremstilling og laegemidler indeholdende dem Download PDFInfo
- Publication number
- DK168008B1 DK168008B1 DK066188A DK66188A DK168008B1 DK 168008 B1 DK168008 B1 DK 168008B1 DK 066188 A DK066188 A DK 066188A DK 66188 A DK66188 A DK 66188A DK 168008 B1 DK168008 B1 DK 168008B1
- Authority
- DK
- Denmark
- Prior art keywords
- pyridine
- dicarboxylic acid
- alkyl
- formula
- acid diamide
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000002253 acid Substances 0.000 title description 6
- 150000001470 diamides Chemical class 0.000 title 1
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- 238000000034 method Methods 0.000 claims abstract description 11
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- 230000008569 process Effects 0.000 claims abstract description 6
- 150000002148 esters Chemical class 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 9
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- 108010043005 Prolyl Hydroxylases Proteins 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 230000005764 inhibitory process Effects 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
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- 150000008064 anhydrides Chemical class 0.000 claims description 4
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 4
- 125000006239 protecting group Chemical group 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Treatment And Processing Of Natural Fur Or Leather (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873703962 DE3703962A1 (de) | 1987-02-10 | 1987-02-10 | Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| DE3703962 | 1987-02-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK66188D0 DK66188D0 (da) | 1988-02-09 |
| DK66188A DK66188A (da) | 1988-08-11 |
| DK168008B1 true DK168008B1 (da) | 1994-01-17 |
Family
ID=6320592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK066188A DK168008B1 (da) | 1987-02-10 | 1988-02-09 | Pyridin-2,4- og -2,5-dicarboxylsyrediamid-derivater, deres fremstilling og laegemidler indeholdende dem |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4968670A (sv) |
| EP (1) | EP0278454B1 (sv) |
| JP (1) | JPS63216871A (sv) |
| KR (1) | KR960004861B1 (sv) |
| AT (1) | ATE85048T1 (sv) |
| AU (1) | AU604293B2 (sv) |
| CA (1) | CA1315471C (sv) |
| DE (2) | DE3703962A1 (sv) |
| DK (1) | DK168008B1 (sv) |
| ES (1) | ES2046218T3 (sv) |
| FI (1) | FI90767C (sv) |
| GR (1) | GR3007607T3 (sv) |
| HU (1) | HU199801B (sv) |
| IE (1) | IE62353B1 (sv) |
| IL (1) | IL85360A0 (sv) |
| NO (1) | NO174852C (sv) |
| NZ (1) | NZ223432A (sv) |
| PH (1) | PH24512A (sv) |
| PT (1) | PT86735B (sv) |
| ZA (1) | ZA88895B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3707429A1 (de) * | 1987-03-07 | 1988-09-15 | Hoechst Ag | Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| DE3924093A1 (de) * | 1989-07-20 | 1991-02-07 | Hoechst Ag | N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung |
| US5425289A (en) * | 1993-10-21 | 1995-06-20 | Snap-On Incorporated | Bung tool |
| DE3938805A1 (de) * | 1989-11-23 | 1991-05-29 | Hoechst Ag | Pyridin-2,4- und 2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung |
| DE4020570A1 (de) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| DE4031000A1 (de) * | 1990-10-01 | 1992-04-09 | Hoechst Ag | 4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| YU9492A (sh) * | 1991-02-05 | 1995-03-27 | Hoechst Ag. | 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje |
| CA2085954A1 (en) * | 1991-12-24 | 1993-06-25 | Klaus Weidmann | Substituted pyridine n-oxides, processes for their preparation, and their use |
| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
| DE4233124A1 (de) * | 1992-10-02 | 1994-04-07 | Hoechst Ag | Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP2003522093A (ja) * | 1997-10-24 | 2003-07-22 | ファイブロゲン インコーポレイテッド | フェナントロリン誘導体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3432094A1 (de) * | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase |
| DE58908519D1 (de) * | 1988-08-04 | 1994-11-24 | Hoechst Ag | Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden. |
-
1987
- 1987-02-10 DE DE19873703962 patent/DE3703962A1/de not_active Withdrawn
-
1988
- 1988-02-08 FI FI880555A patent/FI90767C/sv not_active IP Right Cessation
- 1988-02-08 DE DE8888101793T patent/DE3877778D1/de not_active Expired - Fee Related
- 1988-02-08 NZ NZ223432A patent/NZ223432A/en unknown
- 1988-02-08 EP EP88101793A patent/EP0278454B1/de not_active Expired - Lifetime
- 1988-02-08 AT AT88101793T patent/ATE85048T1/de not_active IP Right Cessation
- 1988-02-08 US US07/153,440 patent/US4968670A/en not_active Expired - Fee Related
- 1988-02-08 ES ES198888101793T patent/ES2046218T3/es not_active Expired - Lifetime
- 1988-02-08 IL IL85360A patent/IL85360A0/xx not_active IP Right Cessation
- 1988-02-08 PH PH36468A patent/PH24512A/en unknown
- 1988-02-09 PT PT86735A patent/PT86735B/pt not_active IP Right Cessation
- 1988-02-09 NO NO880557A patent/NO174852C/no unknown
- 1988-02-09 KR KR88001197A patent/KR960004861B1/ko active IP Right Grant
- 1988-02-09 DK DK066188A patent/DK168008B1/da not_active IP Right Cessation
- 1988-02-09 IE IE35188A patent/IE62353B1/en not_active IP Right Cessation
- 1988-02-09 CA CA000558495A patent/CA1315471C/en not_active Expired - Fee Related
- 1988-02-09 JP JP63026722A patent/JPS63216871A/ja active Pending
- 1988-02-09 ZA ZA880895A patent/ZA88895B/xx unknown
- 1988-02-09 AU AU11451/88A patent/AU604293B2/en not_active Ceased
- 1988-02-10 HU HU88611A patent/HU199801B/hu not_active IP Right Cessation
-
1993
- 1993-04-09 GR GR930400360T patent/GR3007607T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0278454A2 (de) | 1988-08-17 |
| NZ223432A (en) | 1990-04-26 |
| NO880557L (no) | 1988-08-11 |
| IE880351L (en) | 1988-08-10 |
| DK66188A (da) | 1988-08-11 |
| ES2046218T3 (es) | 1994-02-01 |
| ATE85048T1 (de) | 1993-02-15 |
| NO174852B (no) | 1994-04-11 |
| EP0278454A3 (en) | 1989-10-18 |
| DK66188D0 (da) | 1988-02-09 |
| NO174852C (no) | 1994-07-20 |
| HUT47251A (en) | 1989-02-28 |
| GR3007607T3 (sv) | 1993-08-31 |
| PT86735A (pt) | 1988-03-01 |
| EP0278454B1 (de) | 1993-01-27 |
| HU199801B (en) | 1990-03-28 |
| ZA88895B (en) | 1988-08-08 |
| FI90767C (sv) | 1994-03-25 |
| KR960004861B1 (en) | 1996-04-16 |
| AU604293B2 (en) | 1990-12-13 |
| DE3703962A1 (de) | 1988-08-18 |
| JPS63216871A (ja) | 1988-09-09 |
| FI880555A (sv) | 1988-08-11 |
| AU1145188A (en) | 1988-08-11 |
| PT86735B (pt) | 1992-05-29 |
| IE62353B1 (en) | 1995-01-25 |
| FI880555A0 (sv) | 1988-02-08 |
| FI90767B (sv) | 1993-12-15 |
| KR880009934A (ko) | 1988-10-05 |
| IL85360A0 (en) | 1988-07-31 |
| NO880557D0 (no) | 1988-02-09 |
| CA1315471C (en) | 1993-03-30 |
| US4968670A (en) | 1990-11-06 |
| DE3877778D1 (de) | 1993-03-11 |
| PH24512A (en) | 1990-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |