DK167172B1 - Anvendelse af dopaminagonister til fremstilling af laegemidler til behandling af afhaengighed af psykostimulerende stoffer - Google Patents
Anvendelse af dopaminagonister til fremstilling af laegemidler til behandling af afhaengighed af psykostimulerende stoffer Download PDFInfo
- Publication number
- DK167172B1 DK167172B1 DK207086A DK207086A DK167172B1 DK 167172 B1 DK167172 B1 DK 167172B1 DK 207086 A DK207086 A DK 207086A DK 207086 A DK207086 A DK 207086A DK 167172 B1 DK167172 B1 DK 167172B1
- Authority
- DK
- Denmark
- Prior art keywords
- dopamine
- cocaine
- treatment
- use according
- psychostimulants
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 4
- 239000000126 substance Substances 0.000 title description 3
- 230000002582 psychostimulating effect Effects 0.000 title 1
- 239000003368 psychostimulant agent Substances 0.000 claims abstract description 22
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims abstract description 15
- 206010012335 Dependence Diseases 0.000 claims abstract description 8
- 229940052760 dopamine agonists Drugs 0.000 claims abstract description 6
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 42
- 229960003920 cocaine Drugs 0.000 claims description 21
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical group C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 229940025084 amphetamine Drugs 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 229960002802 bromocriptine Drugs 0.000 claims description 4
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 4
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 3
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- 229960004502 levodopa Drugs 0.000 claims description 3
- 229960004851 pergolide Drugs 0.000 claims description 3
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims description 2
- 229960001058 bupropion Drugs 0.000 claims description 2
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 2
- 229960000632 dexamfetamine Drugs 0.000 claims description 2
- 229960003587 lisuride Drugs 0.000 claims description 2
- 229960001252 methamphetamine Drugs 0.000 claims description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims description 2
- 229960000761 pemoline Drugs 0.000 claims description 2
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 claims description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940057948 magnesium stearate Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 16
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 9
- 229960003638 dopamine Drugs 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 201000009032 substance abuse Diseases 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000019788 craving Nutrition 0.000 description 2
- 230000003291 dopaminomimetic effect Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- AICMYQIGFPHNCY-UHFFFAOYSA-J methanesulfonate;tin(4+) Chemical compound [Sn+4].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O AICMYQIGFPHNCY-UHFFFAOYSA-J 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- SODPIMGUZLOIPE-UHFFFAOYSA-N (4-chlorophenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1 SODPIMGUZLOIPE-UHFFFAOYSA-N 0.000 description 1
- OQDPVLVUJFGPGQ-UHFFFAOYSA-N 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine Chemical compound C=1C=C2OCOC2=CC=1CN(CC1)CCN1C1=NC=CC=N1 OQDPVLVUJFGPGQ-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 208000027559 Appetite disease Diseases 0.000 description 1
- 208000022497 Cocaine-Related disease Diseases 0.000 description 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
- 206010013496 Disturbance in attention Diseases 0.000 description 1
- 229940121891 Dopamine receptor antagonist Drugs 0.000 description 1
- 206010015535 Euphoric mood Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 206010019075 Hallucination, visual Diseases 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010037213 Psychomotor retardation Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 1
- 206010048010 Withdrawal syndrome Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- -1 bromeriptin Chemical compound 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000001272 cocaine abuse Diseases 0.000 description 1
- 239000012059 conventional drug carrier Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000002825 dopamine reuptake Effects 0.000 description 1
- 210000005064 dopaminergic neuron Anatomy 0.000 description 1
- 230000002743 euphoric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 206010020765 hypersomnia Diseases 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000001009 nucleus accumben Anatomy 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- YVUQSNJEYSNKRX-UHFFFAOYSA-N pimozide Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 YVUQSNJEYSNKRX-UHFFFAOYSA-N 0.000 description 1
- 229960003634 pimozide Drugs 0.000 description 1
- 229960004310 piribedil Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73110285A | 1985-05-06 | 1985-05-06 | |
| US73110285 | 1985-05-06 | ||
| US79118885A | 1985-10-25 | 1985-10-25 | |
| US79118885 | 1985-10-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK207086D0 DK207086D0 (da) | 1986-05-05 |
| DK207086A DK207086A (da) | 1986-11-07 |
| DK167172B1 true DK167172B1 (da) | 1993-09-13 |
Family
ID=27112170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK207086A DK167172B1 (da) | 1985-05-06 | 1986-05-05 | Anvendelse af dopaminagonister til fremstilling af laegemidler til behandling af afhaengighed af psykostimulerende stoffer |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0204954B1 (enExample) |
| JP (1) | JPS61293929A (enExample) |
| AT (1) | ATE78395T1 (enExample) |
| AU (1) | AU591120B2 (enExample) |
| CA (1) | CA1277914C (enExample) |
| DE (2) | DE3615190A1 (enExample) |
| DK (1) | DK167172B1 (enExample) |
| FR (1) | FR2587213B1 (enExample) |
| GR (1) | GR861128B (enExample) |
| HU (1) | HU197512B (enExample) |
| IE (1) | IE58884B1 (enExample) |
| IL (1) | IL78689A (enExample) |
| IT (1) | IT1203782B (enExample) |
| NZ (1) | NZ216050A (enExample) |
| PT (1) | PT82515B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3814521A1 (de) * | 1987-05-07 | 1988-11-17 | Sandoz Ag | Neue anwendung von dopaminrezeptor-agonisten |
| DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| WO1991001732A1 (en) * | 1989-08-03 | 1991-02-21 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Slowly dissociating (tight binding) dopamine, serotonin or norepinephrine reuptake inhibitors as cocaine, amphetamine and phencyclidine antagonists |
| US6623752B1 (en) | 1996-07-02 | 2003-09-23 | Hexal Ag | Patch for transdermal application for pergolid |
| DE19626621A1 (de) * | 1996-07-02 | 1998-01-08 | Hexal Ag | Pflaster zur transdermalen Anwendung von Pergolid |
| WO1999015161A2 (en) * | 1997-09-24 | 1999-04-01 | The General Hospital Corporation | Inhibition of psychostimulant-induced and nicotine-induced craving |
| WO2019091870A1 (en) * | 2017-11-08 | 2019-05-16 | 4P-Pharma | Stimulant abuse-deterrent compositions |
| EP4316482A1 (en) * | 2022-08-01 | 2024-02-07 | 4P-Pharma | Levodopa for preventing addiction |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995058A (en) * | 1973-12-12 | 1976-11-30 | Miles Laboratories, Inc. | Treatment of ethanol withdrawal symptoms with levodopa |
-
1986
- 1986-04-29 GR GR861128A patent/GR861128B/el unknown
- 1986-05-02 JP JP61101222A patent/JPS61293929A/ja active Granted
- 1986-05-05 PT PT82515A patent/PT82515B/pt not_active IP Right Cessation
- 1986-05-05 IL IL78689A patent/IL78689A/xx not_active IP Right Cessation
- 1986-05-05 AT AT86106140T patent/ATE78395T1/de active
- 1986-05-05 FR FR868606448A patent/FR2587213B1/fr not_active Expired - Lifetime
- 1986-05-05 HU HU861855A patent/HU197512B/hu not_active IP Right Cessation
- 1986-05-05 AU AU57109/86A patent/AU591120B2/en not_active Ceased
- 1986-05-05 DE DE19863615190 patent/DE3615190A1/de not_active Ceased
- 1986-05-05 DK DK207086A patent/DK167172B1/da not_active IP Right Cessation
- 1986-05-05 DE DE8686106140T patent/DE3686097T2/de not_active Expired - Fee Related
- 1986-05-05 IE IE118986A patent/IE58884B1/en not_active IP Right Cessation
- 1986-05-05 NZ NZ216050A patent/NZ216050A/xx unknown
- 1986-05-05 IT IT47977/86A patent/IT1203782B/it active
- 1986-05-05 CA CA000508393A patent/CA1277914C/en not_active Expired - Lifetime
- 1986-05-05 EP EP86106140A patent/EP0204954B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3615190A1 (de) | 1987-05-21 |
| DE3686097D1 (de) | 1992-08-27 |
| DK207086D0 (da) | 1986-05-05 |
| IT8647977A0 (it) | 1986-05-05 |
| JPH0569093B2 (enExample) | 1993-09-30 |
| IE58884B1 (en) | 1993-12-01 |
| EP0204954A2 (en) | 1986-12-17 |
| IT1203782B (it) | 1989-02-23 |
| AU5710986A (en) | 1986-11-13 |
| CA1277914C (en) | 1990-12-18 |
| EP0204954B1 (en) | 1992-07-22 |
| HU197512B (en) | 1989-04-28 |
| DK207086A (da) | 1986-11-07 |
| JPS61293929A (ja) | 1986-12-24 |
| GR861128B (en) | 1986-08-26 |
| FR2587213B1 (fr) | 1990-06-08 |
| DE3686097T2 (de) | 1993-01-07 |
| IE861189L (en) | 1986-11-06 |
| EP0204954A3 (en) | 1989-11-08 |
| ATE78395T1 (de) | 1992-08-15 |
| HUT40915A (en) | 1987-03-30 |
| PT82515A (en) | 1986-06-01 |
| IL78689A0 (en) | 1986-08-31 |
| AU591120B2 (en) | 1989-11-30 |
| NZ216050A (en) | 1989-08-29 |
| PT82515B (pt) | 1988-10-14 |
| IL78689A (en) | 1990-09-17 |
| FR2587213A1 (fr) | 1987-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hanotin et al. | Efficacy and tolerability of sibutramine in obese patients: a dose-ranging study | |
| Findley et al. | Primidone in essential tremor of the hands and head: a double blind controlled clinical study. | |
| Post et al. | Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response | |
| Coccaro et al. | Second generation antidepressants: a comparative review | |
| Parkes et al. | Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa. | |
| Kahn et al. | Double-blind study of lofexidine and clonidine in the detoxification of opiate addicts in hospital | |
| Mawdsley | Treatment of Parkinsonism with Laevo-dopa | |
| JP2021098743A (ja) | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 | |
| AU703242B2 (en) | Film coated tablet of paracetamol and domperidone | |
| WO2001078704A2 (en) | Gaba substrate and the use thereof for treating cognitive and emotional disorders | |
| DK167172B1 (da) | Anvendelse af dopaminagonister til fremstilling af laegemidler til behandling af afhaengighed af psykostimulerende stoffer | |
| Pabis et al. | Pharmacotherapy of aggressive behavior | |
| EP1173167A1 (en) | Treatment of female arousal disorder | |
| Bever et al. | Dexfenfluramine hydrochloride: an anorexigenic agent | |
| WO2000010554A2 (en) | Methods and compositions employing optically pure s(+) vigabatrin | |
| CA2471338C (en) | Use of deoxypeganine for treating clinical depression | |
| KR100692235B1 (ko) | 안지오텐신 ⅱ 길항물질의 신규한 용도 | |
| JP2008519810A (ja) | 顔面紅潮の治療のためのｓミルタザピン | |
| Miller | Amphetamines: pharmacology, abuse and addiction | |
| Carpenter et al. | Drug treatment of obesity in type 2 diabetes mellitus | |
| Lesar et al. | Trazodone overdose | |
| Brogden et al. | Terbutaline: a preliminary report of its pharmacological properties and therapeutic efficacy in asthma | |
| MXPA01013403A (es) | Nueva asociacion farmaceutica con accion analgesica que contiene paracetamol y buspirona. | |
| JPH06509073A (ja) | 光学的に純粋なｓ（−）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物 | |
| US6281248B1 (en) | Composition for treating asthma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |