DK1658047T3 - Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet - Google Patents

Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet

Info

Publication number
DK1658047T3
DK1658047T3 DK04764317T DK04764317T DK1658047T3 DK 1658047 T3 DK1658047 T3 DK 1658047T3 DK 04764317 T DK04764317 T DK 04764317T DK 04764317 T DK04764317 T DK 04764317T DK 1658047 T3 DK1658047 T3 DK 1658047T3
Authority
DK
Denmark
Prior art keywords
storage stability
residual moisture
excellent storage
amorphous powder
low residual
Prior art date
Application number
DK04764317T
Other languages
English (en)
Inventor
Karoline Bechtold-Peters
Wolfgang Friess
Stefanie Schuele
Stefan Bassarab
Patrick Garidel
Torsten Schultz-Fademrecht
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1658047T3 publication Critical patent/DK1658047T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK04764317T 2003-08-22 2004-08-20 Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet DK1658047T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10339197A DE10339197A1 (de) 2003-08-22 2003-08-22 Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität
PCT/EP2004/009333 WO2005020953A1 (de) 2003-08-22 2004-08-20 Sprühgetrocknete amorphe pulver mit geringer restfeuchte und guter lagerstabilität

Publications (1)

Publication Number Publication Date
DK1658047T3 true DK1658047T3 (da) 2008-06-16

Family

ID=34202048

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04764317T DK1658047T3 (da) 2003-08-22 2004-08-20 Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet

Country Status (11)

Country Link
US (1) US20070298116A1 (da)
EP (1) EP1658047B1 (da)
JP (1) JP2007503380A (da)
KR (1) KR20070054590A (da)
AT (1) ATE388688T1 (da)
CA (1) CA2536319A1 (da)
DE (2) DE10339197A1 (da)
DK (1) DK1658047T3 (da)
ES (1) ES2302021T3 (da)
TW (1) TW200517142A (da)
WO (1) WO2005020953A1 (da)

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WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
DE202013012827U1 (de) * 2012-06-14 2020-02-13 Glycom A/S Verbesserung der Stabilität und Reinheit sowie Erhöhung der Bioverfügbarkeit von menschlichen Milch-Oligosacchariden oder Vorläufern oder Mischungen davon
ITMI20130571A1 (it) 2013-04-10 2014-10-11 Zambon Spa Composizione farmaceutica contenente budesonide e formoterolo
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Also Published As

Publication number Publication date
DE502004006512D1 (de) 2008-04-24
US20070298116A1 (en) 2007-12-27
JP2007503380A (ja) 2007-02-22
CA2536319A1 (en) 2005-03-10
WO2005020953A1 (de) 2005-03-10
EP1658047A1 (de) 2006-05-24
KR20070054590A (ko) 2007-05-29
EP1658047B1 (de) 2008-03-12
TW200517142A (en) 2005-06-01
ATE388688T1 (de) 2008-03-15
DE10339197A1 (de) 2005-03-24
ES2302021T3 (es) 2008-07-01

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