DK165733C - Anvendelse af dipeptiderivater til fremstilling a f laegemidler til forhindring eller behandling af posttraumatiske nerveskader efter ved uheld fremkaldte rygmarvs- og/eller hjernetraumer. - Google Patents
Anvendelse af dipeptiderivater til fremstilling a f laegemidler til forhindring eller behandling af posttraumatiske nerveskader efter ved uheld fremkaldte rygmarvs- og/eller hjernetraumer.Info
- Publication number
- DK165733C DK165733C DK032786A DK32786A DK165733C DK 165733 C DK165733 C DK 165733C DK 032786 A DK032786 A DK 032786A DK 32786 A DK32786 A DK 32786A DK 165733 C DK165733 C DK 165733C
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- stands
- hydrogen atom
- posttraumatic
- preparation
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 2
- 208000030886 Traumatic Brain injury Diseases 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853502041 DE3502041A1 (de) | 1985-01-23 | 1985-01-23 | Verwendung von dipeptidderivaten zur behandlung posttraumatischer nervenschaeden |
| DE3502041 | 1985-01-23 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK32786D0 DK32786D0 (da) | 1986-01-22 |
| DK32786A DK32786A (da) | 1986-07-24 |
| DK165733B DK165733B (da) | 1993-01-11 |
| DK165733C true DK165733C (da) | 1993-06-07 |
Family
ID=6260477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK032786A DK165733C (da) | 1985-01-23 | 1986-01-22 | Anvendelse af dipeptiderivater til fremstilling a f laegemidler til forhindring eller behandling af posttraumatiske nerveskader efter ved uheld fremkaldte rygmarvs- og/eller hjernetraumer. |
Country Status (11)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0382842B1 (en) * | 1987-04-08 | 1993-09-22 | Grünenthal GmbH | Nootropic |
| US5686420A (en) * | 1987-06-05 | 1997-11-11 | Georgetown University | Thyrotropin-releasing hormone analogs and method of use |
| JPS63316724A (ja) * | 1987-06-19 | 1988-12-26 | Nippon Shinyaku Co Ltd | 抗けいれん剤 |
| US5049553A (en) * | 1990-01-04 | 1991-09-17 | E. R. Squibb & Sons, Inc. | Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor |
| US6812208B2 (en) | 1993-12-23 | 2004-11-02 | Neuronz Ltd. | Methods to improve neural outcome |
| JPH09509404A (ja) | 1993-12-23 | 1997-09-22 | オークランド ユニサービシズ リミテッド | 神経アウトカムを改良するための組成物及び方法 |
| US5897858A (en) | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
| US6187906B1 (en) * | 1997-08-11 | 2001-02-13 | Aukland Uniservices Limited | Methods to improve neural outcome |
| US20020151502A1 (en) * | 1997-10-09 | 2002-10-17 | Albert Sattin | Tri-peptides for neurological and neurobehavior applications |
| US20050233973A1 (en) * | 1997-10-09 | 2005-10-20 | Albert Sattin | Tri-peptides for antidepressant applications |
| US6475989B1 (en) | 1997-10-09 | 2002-11-05 | Albert Sattin | Use of pyroglutamyl-glutamyl-prolyl amide (EEP) for neurological and neurobehavioral disorders |
| WO2001028578A2 (en) * | 1999-10-22 | 2001-04-26 | Wrair | A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME |
| US6815425B1 (en) | 1999-10-22 | 2004-11-09 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
| IE20000240A1 (en) * | 2000-02-17 | 2003-03-05 | Trinity College Dublin | TRH-like peptide derivatives |
| AU2001289160A1 (en) * | 2000-08-24 | 2002-03-04 | Neuronz Ltd. | Gpe analogs |
| US7112570B2 (en) * | 2000-08-24 | 2006-09-26 | Neuren Pharmaceuticals, Ltd. | GPE analogs |
| US7605177B2 (en) * | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
| EP1401808B1 (en) | 2001-05-24 | 2009-07-08 | Neuren Pharmaceuticals Limited | Gpe analogs and peptidomimetics |
| US7714020B2 (en) * | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
| US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US8791117B2 (en) | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| US7462595B2 (en) * | 2004-09-17 | 2008-12-09 | Prange Jr Arthur Jergen | Methods for treating cancer-related fatigue |
| DK1794182T3 (en) * | 2004-10-01 | 2015-08-24 | Trinity College Dublin | RELATIONS modulates TRH-EFFECTS AND INHIBITS TRH DECOMPOSITION ENZYME |
| SI3024463T1 (sl) | 2013-07-25 | 2020-08-31 | Neuren Pharmaceuticals Limited | Nevroprotektivne biciklične spojine in postopki za njihovo uporabo pri zdravljenju motenj avtističnega spektra in nevrorazvojnih motenj |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2449167C2 (de) | 1974-10-16 | 1984-05-24 | Grünenthal GmbH, 5190 Stolberg | N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| DE2615455C2 (de) * | 1976-04-09 | 1985-06-20 | Grünenthal GmbH, 5190 Stolberg | N-Acyl-L-histidyl-L-prolin (N-substituierte)-amide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| US4608365A (en) * | 1984-03-30 | 1986-08-26 | University Of Southern California | Treatment of neurologic functions |
-
1985
- 1985-01-23 DE DE19853502041 patent/DE3502041A1/de not_active Withdrawn
- 1985-11-19 IE IE290585A patent/IE58805B1/en not_active IP Right Cessation
- 1985-11-29 ZA ZA859187A patent/ZA859187B/xx unknown
- 1985-12-03 IL IL77218A patent/IL77218A/xx not_active IP Right Cessation
- 1985-12-23 EP EP85116530A patent/EP0188810B1/de not_active Expired - Lifetime
- 1985-12-23 DE DE8585116530T patent/DE3580351D1/de not_active Expired - Lifetime
- 1985-12-23 AT AT85116530T patent/ATE57834T1/de not_active IP Right Cessation
-
1986
- 1986-01-22 AU AU52601/86A patent/AU578999B2/en not_active Ceased
- 1986-01-22 DK DK032786A patent/DK165733C/da not_active IP Right Cessation
- 1986-01-23 JP JP61011187A patent/JPS61172828A/ja active Granted
-
1988
- 1988-06-14 US US07/207,115 patent/US4906614A/en not_active Expired - Lifetime
-
1991
- 1991-10-11 SG SG837/91A patent/SG83791G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA859187B (en) | 1986-08-27 |
| JPS61172828A (ja) | 1986-08-04 |
| IE852905L (en) | 1986-07-23 |
| AU5260186A (en) | 1986-07-31 |
| DE3502041A1 (de) | 1986-07-24 |
| SG83791G (en) | 1991-11-22 |
| IL77218A (en) | 1990-11-05 |
| DK165733B (da) | 1993-01-11 |
| DK32786A (da) | 1986-07-24 |
| EP0188810A2 (de) | 1986-07-30 |
| DK32786D0 (da) | 1986-01-22 |
| IE58805B1 (en) | 1993-11-17 |
| EP0188810B1 (de) | 1990-10-31 |
| ATE57834T1 (de) | 1990-11-15 |
| EP0188810A3 (en) | 1988-09-07 |
| DE3580351D1 (de) | 1990-12-06 |
| AU578999B2 (en) | 1988-11-10 |
| US4906614A (en) | 1990-03-06 |
| JPH0584286B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK165733C (da) | Anvendelse af dipeptiderivater til fremstilling a f laegemidler til forhindring eller behandling af posttraumatiske nerveskader efter ved uheld fremkaldte rygmarvs- og/eller hjernetraumer. | |
| DE3067618D1 (en) | 4-benzyl- and 4-benzoylimidazole derivatives, processes for their preparation and pharmaceutical compositions comprising the same | |
| DE3164764D1 (en) | 1,1,2-triphenyl-but-1-ene derivatives, process for their manufacture and their use as pharmaceutical agents | |
| SE8004002L (sv) | Terapeutiskt anvendbara tetralinderivat | |
| HUT72742A (en) | Novel 3,3-diphenylpropylamines, pharmaceutical compositions containing them and preparation | |
| ATE8874T1 (de) | Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate. | |
| AU8169287A (en) | New diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | |
| ES2058596T3 (es) | Empleo de derivados de l-carnitina en el tratamiento terapeutico de alteraciones degenerativas del sistema nervioso. | |
| ATE2670T1 (de) | 4-phenoxypiperidine, verfahren zu ihrer herstellung, ihre anwendung und sie enthaltende arzneimittel. | |
| TW355705B (en) | Substituted benzyloxycarbonylguanidines, process for their preparation, their medical use and pharmaceutical composition containing them | |
| CY2055B1 (en) | N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives | |
| DK69991A (da) | Heterocycliske acetyleniske aminer og deres anvendelse til fremstilling af laegemidler med indvirkning paa centralnervesystemet | |
| ES2109216T3 (es) | Un procedimiento para la preparacion de una composicion farmaceutica con actividad relajante muscular de accion central. | |
| DK517689A (da) | Laegemiddel, der indeholder nitroxyalkylamin med amidfunktion samt fremgangsmaade til fremstilling af saadanne forbindelser | |
| GB1195200A (en) | Pharmaceutical Compositions. | |
| EP0334674A3 (en) | Use of isoxazolinones as cerebro-active drugs | |
| ES552193A0 (es) | Un procedimiento para la preparacion de nuevos peptidos. | |
| ES2027492A6 (es) | Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables. | |
| ATE81127T1 (de) | 4-morpholinyl 1h-indol-derivate, ihre salze, verfahren und zwischenprodukte zur herstellung, verwendung als arzneimittel, sie enthaltende zusammensetzungen. | |
| EP0408106A3 (en) | Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine | |
| ES2052945T3 (es) | Derivados de la 20,21-dinoreburnamenina sustituidos en 15 con un grupo aminado y sus sales, su procedimiento de preparacion y los productos intermedios asi obtenidos, su aplicacion como medicamentos, y las composiciones farmaceuticas que los contienen. | |
| ES2071955T3 (es) | Nuevos derivados de aminoalquilcetona, su procedimiento de preparacion y sus aplicaciones en terapeutica. | |
| ATE48425T1 (de) | Einen stickstoffhaltigen heterocyclischen ring in position 1 enthaltende 3-amino-2-oxoazetidinderivate, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |