DK32786A - Anvendelse af dipeptidderivater til fremstilling af laegemidler til behandling af posttraumatiske nerveskader - Google Patents
Anvendelse af dipeptidderivater til fremstilling af laegemidler til behandling af posttraumatiske nerveskader Download PDFInfo
- Publication number
- DK32786A DK32786A DK32786A DK32786A DK32786A DK 32786 A DK32786 A DK 32786A DK 32786 A DK32786 A DK 32786A DK 32786 A DK32786 A DK 32786A DK 32786 A DK32786 A DK 32786A
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- stands
- hydrogen atom
- dipeptide derivatives
- posttraumatic
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853502041 DE3502041A1 (de) | 1985-01-23 | 1985-01-23 | Verwendung von dipeptidderivaten zur behandlung posttraumatischer nervenschaeden |
| DE3502041 | 1985-01-23 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK32786D0 DK32786D0 (da) | 1986-01-22 |
| DK32786A true DK32786A (da) | 1986-07-24 |
| DK165733B DK165733B (da) | 1993-01-11 |
| DK165733C DK165733C (da) | 1993-06-07 |
Family
ID=6260477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK032786A DK165733C (da) | 1985-01-23 | 1986-01-22 | Anvendelse af dipeptiderivater til fremstilling a f laegemidler til forhindring eller behandling af posttraumatiske nerveskader efter ved uheld fremkaldte rygmarvs- og/eller hjernetraumer. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4906614A (da) |
| EP (1) | EP0188810B1 (da) |
| JP (1) | JPS61172828A (da) |
| AT (1) | ATE57834T1 (da) |
| AU (1) | AU578999B2 (da) |
| DE (2) | DE3502041A1 (da) |
| DK (1) | DK165733C (da) |
| IE (1) | IE58805B1 (da) |
| IL (1) | IL77218A (da) |
| SG (1) | SG83791G (da) |
| ZA (1) | ZA859187B (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007867A1 (fr) * | 1987-04-08 | 1988-10-20 | Nippon Shinyaku Co., Ltd. | Nootropique |
| US5686420A (en) * | 1987-06-05 | 1997-11-11 | Georgetown University | Thyrotropin-releasing hormone analogs and method of use |
| JPS63316724A (ja) * | 1987-06-19 | 1988-12-26 | Nippon Shinyaku Co Ltd | 抗けいれん剤 |
| US5049553A (en) * | 1990-01-04 | 1991-09-17 | E. R. Squibb & Sons, Inc. | Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor |
| JPH09509404A (ja) | 1993-12-23 | 1997-09-22 | オークランド ユニサービシズ リミテッド | 神経アウトカムを改良するための組成物及び方法 |
| US6812208B2 (en) | 1993-12-23 | 2004-11-02 | Neuronz Ltd. | Methods to improve neural outcome |
| US5897858A (en) | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
| US6187906B1 (en) * | 1997-08-11 | 2001-02-13 | Aukland Uniservices Limited | Methods to improve neural outcome |
| US6475989B1 (en) | 1997-10-09 | 2002-11-05 | Albert Sattin | Use of pyroglutamyl-glutamyl-prolyl amide (EEP) for neurological and neurobehavioral disorders |
| US20020151502A1 (en) * | 1997-10-09 | 2002-10-17 | Albert Sattin | Tri-peptides for neurological and neurobehavior applications |
| US20050233973A1 (en) * | 1997-10-09 | 2005-10-20 | Albert Sattin | Tri-peptides for antidepressant applications |
| AU1574701A (en) * | 1999-10-22 | 2001-04-30 | Wrair Walter Reed Army Institute Of Research | A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
| US6815425B1 (en) | 1999-10-22 | 2004-11-09 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
| IE20000240A1 (en) * | 2000-02-17 | 2003-03-05 | Trinity College Dublin | TRH-like peptide derivatives |
| AU2001289160A1 (en) * | 2000-08-24 | 2002-03-04 | Neuronz Ltd. | Gpe analogs |
| US7112570B2 (en) * | 2000-08-24 | 2006-09-26 | Neuren Pharmaceuticals, Ltd. | GPE analogs |
| US7714020B2 (en) * | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
| AU2002303856A1 (en) | 2001-05-24 | 2002-12-03 | Neuronz Limited | Gpe analogs and peptidomimetics |
| US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US7605177B2 (en) * | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
| US8791117B2 (en) | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| US7462595B2 (en) * | 2004-09-17 | 2008-12-09 | Prange Jr Arthur Jergen | Methods for treating cancer-related fatigue |
| US7713935B2 (en) * | 2004-10-01 | 2010-05-11 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Compounds that modulate TRH actions |
| EP3024463B1 (en) | 2013-07-25 | 2020-03-25 | Neuren Pharmaceuticals Limited | Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2449167C2 (de) | 1974-10-16 | 1984-05-24 | Grünenthal GmbH, 5190 Stolberg | N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| DE2615455C2 (de) * | 1976-04-09 | 1985-06-20 | Grünenthal GmbH, 5190 Stolberg | N-Acyl-L-histidyl-L-prolin (N-substituierte)-amide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| US4608365A (en) * | 1984-03-30 | 1986-08-26 | University Of Southern California | Treatment of neurologic functions |
-
1985
- 1985-01-23 DE DE19853502041 patent/DE3502041A1/de not_active Withdrawn
- 1985-11-19 IE IE290585A patent/IE58805B1/en not_active IP Right Cessation
- 1985-11-29 ZA ZA859187A patent/ZA859187B/xx unknown
- 1985-12-03 IL IL77218A patent/IL77218A/xx not_active IP Right Cessation
- 1985-12-23 AT AT85116530T patent/ATE57834T1/de not_active IP Right Cessation
- 1985-12-23 EP EP85116530A patent/EP0188810B1/de not_active Expired - Lifetime
- 1985-12-23 DE DE8585116530T patent/DE3580351D1/de not_active Expired - Lifetime
-
1986
- 1986-01-22 DK DK032786A patent/DK165733C/da not_active IP Right Cessation
- 1986-01-22 AU AU52601/86A patent/AU578999B2/en not_active Ceased
- 1986-01-23 JP JP61011187A patent/JPS61172828A/ja active Granted
-
1988
- 1988-06-14 US US07/207,115 patent/US4906614A/en not_active Expired - Lifetime
-
1991
- 1991-10-11 SG SG837/91A patent/SG83791G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK165733B (da) | 1993-01-11 |
| IE852905L (en) | 1986-07-23 |
| EP0188810A2 (de) | 1986-07-30 |
| DK32786D0 (da) | 1986-01-22 |
| ZA859187B (en) | 1986-08-27 |
| ATE57834T1 (de) | 1990-11-15 |
| SG83791G (en) | 1991-11-22 |
| EP0188810B1 (de) | 1990-10-31 |
| IE58805B1 (en) | 1993-11-17 |
| DE3580351D1 (de) | 1990-12-06 |
| US4906614A (en) | 1990-03-06 |
| AU578999B2 (en) | 1988-11-10 |
| DK165733C (da) | 1993-06-07 |
| DE3502041A1 (de) | 1986-07-24 |
| IL77218A (en) | 1990-11-05 |
| JPS61172828A (ja) | 1986-08-04 |
| EP0188810A3 (en) | 1988-09-07 |
| JPH0584286B2 (da) | 1993-12-01 |
| AU5260186A (en) | 1986-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |