IL77218A - Pharmaceutical compositions containing certain n-acyl-histidyl-prolin-amide derivatives or salts thereof for the treatment of posttraumatic nervous injuries and their manufacture - Google Patents

Pharmaceutical compositions containing certain n-acyl-histidyl-prolin-amide derivatives or salts thereof for the treatment of posttraumatic nervous injuries and their manufacture

Info

Publication number
IL77218A
IL77218A IL77218A IL7721885A IL77218A IL 77218 A IL77218 A IL 77218A IL 77218 A IL77218 A IL 77218A IL 7721885 A IL7721885 A IL 7721885A IL 77218 A IL77218 A IL 77218A
Authority
IL
Israel
Prior art keywords
treatment
salts
stands
prolin
posttraumatic
Prior art date
Application number
IL77218A
Other languages
English (en)
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of IL77218A publication Critical patent/IL77218A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL77218A 1985-01-23 1985-12-03 Pharmaceutical compositions containing certain n-acyl-histidyl-prolin-amide derivatives or salts thereof for the treatment of posttraumatic nervous injuries and their manufacture IL77218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853502041 DE3502041A1 (de) 1985-01-23 1985-01-23 Verwendung von dipeptidderivaten zur behandlung posttraumatischer nervenschaeden

Publications (1)

Publication Number Publication Date
IL77218A true IL77218A (en) 1990-11-05

Family

ID=6260477

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77218A IL77218A (en) 1985-01-23 1985-12-03 Pharmaceutical compositions containing certain n-acyl-histidyl-prolin-amide derivatives or salts thereof for the treatment of posttraumatic nervous injuries and their manufacture

Country Status (11)

Country Link
US (1) US4906614A (da)
EP (1) EP0188810B1 (da)
JP (1) JPS61172828A (da)
AT (1) ATE57834T1 (da)
AU (1) AU578999B2 (da)
DE (2) DE3502041A1 (da)
DK (1) DK165733C (da)
IE (1) IE58805B1 (da)
IL (1) IL77218A (da)
SG (1) SG83791G (da)
ZA (1) ZA859187B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382842B1 (en) * 1987-04-08 1993-09-22 Grünenthal GmbH Nootropic
US5686420A (en) * 1987-06-05 1997-11-11 Georgetown University Thyrotropin-releasing hormone analogs and method of use
JPS63316724A (ja) * 1987-06-19 1988-12-26 Nippon Shinyaku Co Ltd 抗けいれん剤
US5049553A (en) * 1990-01-04 1991-09-17 E. R. Squibb & Sons, Inc. Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor
US6812208B2 (en) 1993-12-23 2004-11-02 Neuronz Ltd. Methods to improve neural outcome
EP0735894A4 (en) 1993-12-23 1999-08-18 Auckland Uniservices Ltd COMPOSITION AND METHODS FOR IMPROVING THE OUTCOME OF NERVOUS SYSTEM CONDITIONS
US5897858A (en) 1994-02-03 1999-04-27 Schering-Plough Healthcare Products, Inc. Nasal spray compositions exhibiting increased retention in the nasal cavity
US6187906B1 (en) * 1997-08-11 2001-02-13 Aukland Uniservices Limited Methods to improve neural outcome
US6475989B1 (en) 1997-10-09 2002-11-05 Albert Sattin Use of pyroglutamyl-glutamyl-prolyl amide (EEP) for neurological and neurobehavioral disorders
US20050233973A1 (en) * 1997-10-09 2005-10-20 Albert Sattin Tri-peptides for antidepressant applications
US20020151502A1 (en) * 1997-10-09 2002-10-17 Albert Sattin Tri-peptides for neurological and neurobehavior applications
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
WO2001028578A2 (en) * 1999-10-22 2001-04-26 Wrair A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME
IE20000240A1 (en) * 2000-02-17 2003-03-05 Trinity College Dublin TRH-like peptide derivatives
US7112570B2 (en) * 2000-08-24 2006-09-26 Neuren Pharmaceuticals, Ltd. GPE analogs
AU2001289160A1 (en) * 2000-08-24 2002-03-04 Neuronz Ltd. Gpe analogs
US20070004641A1 (en) * 2001-05-24 2007-01-04 Neuren Pharmaceuticals Limited Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate
US7605177B2 (en) * 2001-05-24 2009-10-20 Neuren Pharmaceuticals Limited Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
US7714020B2 (en) * 2001-05-24 2010-05-11 Neuren Pharmaceuticals Limited Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
ATE435852T1 (de) 2001-05-24 2009-07-15 Neuren Pharmaceuticals Ltd Gpe-analoga und peptidomimetika
US8791117B2 (en) 2003-09-03 2014-07-29 Neuren Pharmaceuticals Limited Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals
US7462595B2 (en) * 2004-09-17 2008-12-09 Prange Jr Arthur Jergen Methods for treating cancer-related fatigue
WO2006038206A2 (en) * 2004-10-01 2006-04-13 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Compounds that modulate trh actions and inhibit the trh-degrading enzyme
WO2015013397A2 (en) 2013-07-25 2015-01-29 Neuren Pharmaceuticals Limited Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449167C2 (de) 1974-10-16 1984-05-24 Grünenthal GmbH, 5190 Stolberg N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE2615455C2 (de) 1976-04-09 1985-06-20 Grünenthal GmbH, 5190 Stolberg N-Acyl-L-histidyl-L-prolin (N-substituierte)-amide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US4608365A (en) * 1984-03-30 1986-08-26 University Of Southern California Treatment of neurologic functions

Also Published As

Publication number Publication date
JPS61172828A (ja) 1986-08-04
DK165733B (da) 1993-01-11
JPH0584286B2 (da) 1993-12-01
IE852905L (en) 1986-07-23
DK32786D0 (da) 1986-01-22
DE3502041A1 (de) 1986-07-24
EP0188810B1 (de) 1990-10-31
US4906614A (en) 1990-03-06
EP0188810A2 (de) 1986-07-30
ATE57834T1 (de) 1990-11-15
DK165733C (da) 1993-06-07
DK32786A (da) 1986-07-24
IE58805B1 (en) 1993-11-17
AU5260186A (en) 1986-07-31
AU578999B2 (en) 1988-11-10
SG83791G (en) 1991-11-22
DE3580351D1 (de) 1990-12-06
EP0188810A3 (en) 1988-09-07
ZA859187B (en) 1986-08-27

Similar Documents

Publication Publication Date Title
IL77218A (en) Pharmaceutical compositions containing certain n-acyl-histidyl-prolin-amide derivatives or salts thereof for the treatment of posttraumatic nervous injuries and their manufacture
IL88507A (en) 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
HUT45038A (en) Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
IL60715A (en) 4-phenoxypiperidines,process for their preparation and pharmaceutical compositions containing them
EP0263506A3 (en) Anticonvulsant composition containing amino acid derivative and use of said amino acid derivative
HK1000284A1 (en) N-(5,6,7,8-tetrahydropyrido(2,3D)pyrimidin-6-Yl-alkanoyl)-glutamic acid derivatives
DE3665309D1 (en) Novel peptides, compositions containing them and processes for their production
ZA868873B (en) Peptide immunostimulants
ZA892258B (en) Use of isoxazolinones as cerebro-active drugs
ES2027492A6 (es) Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables.
EP0220654A3 (en) Gonadoliberine analogues, process for preparing them, pharmaceutical composition and use
IL69525A0 (en) Spiro(2h-1,4-benzodioxepin-3(5h)4'piperidine and 3'-pyrrolidino)compounds,a process for preparing the same and their use as medicaments
KR900009638A (ko) 신규 화합물들
ES2058315T3 (es) Compuestos eficaces contra insuficiencia cerebral.
ES8704477A1 (es) Procedimiento para preparar piridin-1-oxidos varias veces substituidos
LTIP1787A (en) Novel acrylic amide derivatives, aprocess for their preparation, pharmaceutical compositions containing the same and their use in medicine
ES477164A1 (es) Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina.
TH919A (th) การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน
TH1819B (th) การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน

Legal Events

Date Code Title Description
RH Patent void