DK164596C - 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer, disse forbindelser til anvendelse til bekaempelse af sygdomme og deres anvendelse til fremstilling af et laegemiddel indeholdende dem - Google Patents

7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer, disse forbindelser til anvendelse til bekaempelse af sygdomme og deres anvendelse til fremstilling af et laegemiddel indeholdende dem

Info

Publication number
DK164596C
DK164596C DK249885A DK249885A DK164596C DK 164596 C DK164596 C DK 164596C DK 249885 A DK249885 A DK 249885A DK 249885 A DK249885 A DK 249885A DK 164596 C DK164596 C DK 164596C
Authority
DK
Denmark
Prior art keywords
dihalogen
cyclopropyl
dihydro
oxo
relationships
Prior art date
Application number
DK249885A
Other languages
Danish (da)
English (en)
Other versions
DK249885A (da
DK249885D0 (da
DK164596B (da
Inventor
Uwe Petersen
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK249885D0 publication Critical patent/DK249885D0/da
Publication of DK249885A publication Critical patent/DK249885A/da
Publication of DK164596B publication Critical patent/DK164596B/da
Application granted granted Critical
Publication of DK164596C publication Critical patent/DK164596C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK249885A 1984-06-04 1985-06-03 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer, disse forbindelser til anvendelse til bekaempelse af sygdomme og deres anvendelse til fremstilling af et laegemiddel indeholdende dem DK164596C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843420743 DE3420743A1 (de) 1984-06-04 1984-06-04 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420743 1984-06-04

Publications (4)

Publication Number Publication Date
DK249885D0 DK249885D0 (da) 1985-06-03
DK249885A DK249885A (da) 1985-12-05
DK164596B DK164596B (da) 1992-07-20
DK164596C true DK164596C (da) 1992-12-07

Family

ID=6237565

Family Applications (2)

Application Number Title Priority Date Filing Date
DK249885A DK164596C (da) 1984-06-04 1985-06-03 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer, disse forbindelser til anvendelse til bekaempelse af sygdomme og deres anvendelse til fremstilling af et laegemiddel indeholdende dem
DK159391A DK166276C (da) 1984-06-04 1991-09-12 7-fluor-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK159391A DK166276C (da) 1984-06-04 1991-09-12 7-fluor-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer

Country Status (22)

Country Link
US (2) US5571812A (es)
EP (1) EP0167763B1 (es)
JP (1) JPS611667A (es)
KR (1) KR920005112B1 (es)
AR (1) AR243510A1 (es)
AT (1) ATE36155T1 (es)
AU (1) AU575651B2 (es)
DD (1) DD240012A5 (es)
DE (2) DE3420743A1 (es)
DK (2) DK164596C (es)
ES (3) ES8607277A1 (es)
FI (1) FI852203L (es)
GR (1) GR851316B (es)
HK (1) HK7291A (es)
HU (1) HU208821B (es)
IE (1) IE57815B1 (es)
IL (1) IL75369A (es)
NO (1) NO173546C (es)
NZ (1) NZ212272A (es)
PH (2) PH23577A (es)
PT (1) PT80578B (es)
ZA (1) ZA854167B (es)

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DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
IN162769B (es) * 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
JPS62246541A (ja) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd ベンゾイル酢酸エステル誘導体とその製造方法
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DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
CN1019114B (zh) * 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3635218A1 (de) * 1986-10-16 1988-04-21 Bayer Ag 7-amino-1-cyclopropyl-8-chlor-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
EP0339406A1 (en) * 1988-04-19 1989-11-02 Hokuriku Pharmaceutical Co.,Ltd Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
EP0596395B1 (de) * 1992-11-04 2000-06-28 Clariant GmbH Verfahren zur Herstellung fluorierter Benzile
CA2114981A1 (en) * 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4342186A1 (de) 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
IL151451A0 (en) * 2000-02-25 2003-04-10 Daiichi Seiyaku Co Process for producing quinolonecarboxylic acids and intermediates thereof
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
WO2003064412A1 (en) * 2002-01-31 2003-08-07 Micro Science Tech Co., Ltd. Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof
US6878871B2 (en) * 2002-09-05 2005-04-12 Nanosys, Inc. Nanostructure and nanocomposite based compositions and photovoltaic devices
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
EP2816033A1 (en) * 2004-07-30 2014-12-24 Abbvie Inc. Preparation of pyridonecarboxylic acid antibacterials
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
DK1868581T3 (da) * 2005-04-11 2012-07-09 Abbott Lab Farmaceutiske sammensætninger med forbedrede opløsningsprofiler til dårligt opløselige lægemidler
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ

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Also Published As

Publication number Publication date
AR243510A1 (es) 1993-08-31
ES543836A0 (es) 1986-06-16
DK249885A (da) 1985-12-05
GR851316B (es) 1985-11-25
ZA854167B (en) 1986-01-29
JPH0369343B2 (es) 1991-10-31
DK249885D0 (da) 1985-06-03
PT80578B (pt) 1987-11-11
IL75369A (en) 1988-10-31
PH23577A (en) 1989-09-11
NO173546C (no) 1993-12-29
KR920005112B1 (ko) 1992-06-26
EP0167763B1 (de) 1988-08-03
DK164596B (da) 1992-07-20
AU575651B2 (en) 1988-08-04
ES553083A0 (es) 1987-01-16
KR860000281A (ko) 1986-01-27
IL75369A0 (en) 1985-09-29
DD240012A5 (de) 1986-10-15
NO852025L (no) 1985-12-05
DK159391D0 (da) 1991-09-12
NZ212272A (en) 1988-05-30
ES8702907A1 (es) 1987-01-16
US5969141A (en) 1999-10-19
FI852203A0 (fi) 1985-05-31
US5571812A (en) 1996-11-05
AU4329385A (en) 1985-12-12
PT80578A (en) 1985-07-01
HUT38336A (en) 1986-05-28
HK7291A (en) 1991-02-01
JPS611667A (ja) 1986-01-07
DK166276B (da) 1993-03-29
FI852203L (fi) 1985-12-05
ES8702400A1 (es) 1987-01-01
NO173546B (no) 1993-09-20
EP0167763A1 (de) 1986-01-15
IE57815B1 (en) 1993-04-21
PH24947A (en) 1990-12-26
DK166276C (da) 1993-08-23
HU910254D0 (en) 1991-08-28
DE3420743A1 (de) 1985-12-05
ES553084A0 (es) 1987-01-01
IE851365L (en) 1985-12-04
HU208821B (en) 1994-01-28
ES8607277A1 (es) 1986-06-16
DE3564108D1 (en) 1988-09-08
DK159391A (da) 1991-09-12
ATE36155T1 (de) 1988-08-15

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