DK163143C - Fremgangsmaade til fremstilling af propargylammoniumchlorider - Google Patents
Fremgangsmaade til fremstilling af propargylammoniumchloriderInfo
- Publication number
- DK163143C DK163143C DK323683A DK323683A DK163143C DK 163143 C DK163143 C DK 163143C DK 323683 A DK323683 A DK 323683A DK 323683 A DK323683 A DK 323683A DK 163143 C DK163143 C DK 163143C
- Authority
- DK
- Denmark
- Prior art keywords
- general formula
- amine
- water
- phase
- general
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 239000012071 phase Substances 0.000 abstract 3
- 239000003513 alkali Substances 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical group OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000012074 organic phase Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- IKXNIQJDNKPPCH-UHFFFAOYSA-N hydron;prop-2-yn-1-amine;chloride Chemical class [Cl-].[NH3+]CC#C IKXNIQJDNKPPCH-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU822278A HU187775B (en) | 1982-07-14 | 1982-07-14 | New process for producing propargile-amines of pharmaceutical activity |
| HU227882 | 1982-07-14 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK323683D0 DK323683D0 (da) | 1983-07-13 |
| DK323683A DK323683A (da) | 1984-01-15 |
| DK163143B DK163143B (da) | 1992-01-27 |
| DK163143C true DK163143C (da) | 1992-06-22 |
Family
ID=10958648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK323683A DK163143C (da) | 1982-07-14 | 1983-07-13 | Fremgangsmaade til fremstilling af propargylammoniumchlorider |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4564706A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0099302B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5967249A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE22552T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1215394A (cg-RX-API-DMAC10.html) |
| DE (1) | DE3366589D1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK163143C (cg-RX-API-DMAC10.html) |
| ES (1) | ES8501361A1 (cg-RX-API-DMAC10.html) |
| FI (1) | FI78457C (cg-RX-API-DMAC10.html) |
| GR (1) | GR79594B (cg-RX-API-DMAC10.html) |
| HK (1) | HK46691A (cg-RX-API-DMAC10.html) |
| HU (1) | HU187775B (cg-RX-API-DMAC10.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3528548A1 (de) * | 1985-08-08 | 1987-02-19 | Dow Chemical Gmbh | Herstellung eines allylamins und quaternaerer diallylammoniumverbindungen daraus |
| CS269271B1 (en) * | 1988-05-30 | 1990-04-11 | Hajicek Josef | Method of selegiline's hydrochloride production |
| CA2039194C (en) * | 1990-08-31 | 1997-01-28 | Norton W. Milgram | Uses of l-deprenyl and compositions for same |
| US5561163A (en) * | 1990-08-31 | 1996-10-01 | Deprenyl Animal Health, Inc. | Treating hearing loss with deprenyl |
| US5225446A (en) * | 1990-08-31 | 1993-07-06 | Deprenyl Animal Health, Inc. | Use of 1-deprenyl for retention of specific physiological functions |
| US5565495A (en) * | 1990-08-31 | 1996-10-15 | Deprenyl Animal Health, Inc. | Method for survival curve shifting in dogs |
| US5151449A (en) * | 1990-08-31 | 1992-09-29 | Deprenyl Animal Health, Inc. | Use of L-deprenyl for retention of specific physiological functions |
| US5192808A (en) * | 1990-08-31 | 1993-03-09 | Deprenyl Animal Health, Inc. | Therapeutic effect of L-deprenyl in the management of pituitary-dependent hyperadrenocorticism (cushing's disease) |
| HU209605B (en) * | 1991-04-15 | 1994-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of wather-free transdermal preparation |
| IES61604B2 (en) * | 1993-12-16 | 1994-11-16 | Russinsky Ltd | A process for producing pharmaceutical compounds |
| DE4410360A1 (de) * | 1994-03-25 | 1995-09-28 | Basf Ag | Verfahren zur Herstellung von Arylbenzylaminen |
| DE4432610C1 (de) * | 1994-09-13 | 1996-02-01 | Knoll Ag | Verfahren zur Herstellung von Selegilin-Hydrochlorid |
| HU218927B (hu) * | 1994-11-22 | 2000-12-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Eljárás propargil-ammónium-klorid-származékok előállítására |
| US6299901B1 (en) | 1995-01-13 | 2001-10-09 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| US6033682A (en) | 1995-01-13 | 2000-03-07 | Somerset Pharmaceuticals, Inc. | S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions |
| US6348208B1 (en) | 1995-01-13 | 2002-02-19 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| US6319954B1 (en) | 1995-01-13 | 2001-11-20 | Somerset Pharmaceuticals, Inc. | S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions |
| AU3759697A (en) * | 1996-10-01 | 1998-04-09 | Rohm And Haas Company | Process for amines |
| CN101262867A (zh) * | 2005-07-01 | 2008-09-10 | 叶林发现公司 | 用于治疗肥胖的mao-b抑制剂 |
| WO2009147430A1 (en) * | 2008-06-02 | 2009-12-10 | Generics [Uk] Limited | A process for the preparation of enantiomerically pure amines |
| IT201700008702A1 (it) | 2017-01-26 | 2018-07-26 | Dipharma Francis Srl | Metodo di sintesi di selegilina base |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1121857A (en) * | 1965-01-05 | 1968-07-31 | Science Union & Cie | New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives |
| US3397236A (en) * | 1965-12-29 | 1968-08-13 | Norwich Pharma Co | Nu-2, 3-butadienyl-nu-methylbenzylamine or the 2-chloro-derivative thereof |
| US3496195A (en) * | 1966-05-11 | 1970-02-17 | Chinoin Gyogyszer Es Vegyeszet | D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts |
| FR2371196A1 (fr) * | 1976-11-17 | 1978-06-16 | Roussel Uclaf | Nouveaux derives de l'aminomethyl benzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits |
| US4156017A (en) * | 1977-02-22 | 1979-05-22 | Schering Aktiengesellschaft | Pesticides |
-
1982
- 1982-07-14 HU HU822278A patent/HU187775B/hu unknown
-
1983
- 1983-07-11 EP EP83401429A patent/EP0099302B1/en not_active Expired
- 1983-07-11 DE DE8383401429T patent/DE3366589D1/de not_active Expired
- 1983-07-11 AT AT83401429T patent/ATE22552T1/de not_active IP Right Cessation
- 1983-07-12 FI FI832538A patent/FI78457C/fi not_active IP Right Cessation
- 1983-07-13 DK DK323683A patent/DK163143C/da not_active IP Right Cessation
- 1983-07-13 ES ES524076A patent/ES8501361A1/es not_active Expired
- 1983-07-13 GR GR71930A patent/GR79594B/el unknown
- 1983-07-13 CA CA000432358A patent/CA1215394A/en not_active Expired
- 1983-07-14 JP JP58128687A patent/JPS5967249A/ja active Granted
- 1983-07-14 US US06/514,149 patent/US4564706A/en not_active Expired - Lifetime
-
1991
- 1991-06-11 HK HK466/91A patent/HK46691A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU187775B (en) | 1986-02-28 |
| FI78457C (fi) | 1989-08-10 |
| DK163143B (da) | 1992-01-27 |
| FI832538L (fi) | 1984-01-15 |
| GR79594B (cg-RX-API-DMAC10.html) | 1984-10-31 |
| FI832538A0 (fi) | 1983-07-12 |
| DK323683D0 (da) | 1983-07-13 |
| HK46691A (en) | 1991-06-21 |
| EP0099302B1 (en) | 1986-10-01 |
| US4564706A (en) | 1986-01-14 |
| ES524076A0 (es) | 1984-12-01 |
| CA1215394A (en) | 1986-12-16 |
| ATE22552T1 (de) | 1986-10-15 |
| ES8501361A1 (es) | 1984-12-01 |
| JPS6121938B2 (cg-RX-API-DMAC10.html) | 1986-05-29 |
| FI78457B (fi) | 1989-04-28 |
| EP0099302A3 (en) | 1984-09-19 |
| EP0099302A2 (en) | 1984-01-25 |
| JPS5967249A (ja) | 1984-04-16 |
| DE3366589D1 (en) | 1986-11-06 |
| DK323683A (da) | 1984-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |