DK1622610T3 - 1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer - Google Patents
1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationerInfo
- Publication number
- DK1622610T3 DK1622610T3 DK04751319T DK04751319T DK1622610T3 DK 1622610 T3 DK1622610 T3 DK 1622610T3 DK 04751319 T DK04751319 T DK 04751319T DK 04751319 T DK04751319 T DK 04751319T DK 1622610 T3 DK1622610 T3 DK 1622610T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- kinase
- treatment
- penyl
- pyrazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46828503P | 2003-05-06 | 2003-05-06 | |
PCT/US2004/013875 WO2004100946A1 (fr) | 2003-05-06 | 2004-05-05 | Derives de 1-(2h-pyrazol-3-yl)-3-{4-`1-(benzoyl)-piperidin-4-ylmethyl!-phenyl}-uree et composes associes utilises comme inhibiteurs de la kinase p38 et/ou comme inhibiteurs du facteur de necrose tumorale (tnf) dans le traitement des inflammations |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1622610T3 true DK1622610T3 (da) | 2007-04-23 |
Family
ID=28792177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04751319T DK1622610T3 (da) | 2003-05-06 | 2004-05-05 | 1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer |
Country Status (26)
Country | Link |
---|---|
US (1) | US7541368B2 (fr) |
EP (1) | EP1622610B1 (fr) |
JP (1) | JP4714150B2 (fr) |
AT (1) | ATE348610T1 (fr) |
AU (2) | AU2004238241A1 (fr) |
BR (1) | BRPI0409991A (fr) |
CA (1) | CA2524043C (fr) |
CL (1) | CL2004000965A1 (fr) |
CY (1) | CY1107433T1 (fr) |
DE (1) | DE602004003806T2 (fr) |
DK (1) | DK1622610T3 (fr) |
ES (1) | ES2277271T3 (fr) |
GB (1) | GB0320244D0 (fr) |
HN (1) | HN2004000150A (fr) |
HR (1) | HRP20070020T3 (fr) |
JO (1) | JO2473B1 (fr) |
MX (1) | MXPA05011400A (fr) |
MY (1) | MY140830A (fr) |
PA (1) | PA8601901A1 (fr) |
PE (1) | PE20050523A1 (fr) |
PL (1) | PL1622610T3 (fr) |
PT (1) | PT1622610E (fr) |
SI (1) | SI1622610T1 (fr) |
TW (1) | TWI335223B (fr) |
UY (1) | UY28310A1 (fr) |
WO (1) | WO2004100946A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
US7767674B2 (en) | 2004-06-23 | 2010-08-03 | Eli Lilly And Company | Kinase inhibitors |
DK1778686T3 (da) | 2004-08-12 | 2009-01-12 | Pfizer | Triazolopyridinylsulfanylderivater som P38 MAP kinase-inhibitorer |
DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
MY151835A (en) | 2006-01-31 | 2014-07-14 | Array Biopharma Inc | Kinase inhibitors and methods of use thereof |
JP2009526039A (ja) * | 2006-02-10 | 2009-07-16 | ファイザー・プロダクツ・インク | ピリジノンピラゾール尿素およびピリミジノンピラゾール尿素誘導体 |
WO2007113005A2 (fr) * | 2006-04-03 | 2007-10-11 | European Molecular Biology Laboratory (Embl) | Inhibiteurs de la kinase aurora |
AU2007275301A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
EP2086970B1 (fr) | 2006-08-24 | 2014-02-26 | Novartis AG | Dérivés de 2-(pyrazin-2-yl)-thiazole et de 2-(1h pyrazol-3-yl)-thiazole et composés similaires en tant qu' inhibiteurs de stearoyl-coa desaturase (scd) pour le traitement de maladies metaboliques, cardiovasculaires et d'autres maladies |
JP5351025B2 (ja) | 2006-09-22 | 2013-11-27 | ノバルティス アーゲー | ヘテロ環式有機化合物 |
BRPI0720452A2 (pt) | 2006-12-20 | 2014-01-14 | Novartis Ag | Compostos orgânicos |
DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
WO2010038086A2 (fr) * | 2008-10-02 | 2010-04-08 | Respivert Limited | Nouveaux composés |
AU2009326148B2 (en) | 2008-12-11 | 2014-05-08 | Respivert Limited | p38 MAP kinase inhibitors |
EP2236505A1 (fr) | 2009-04-03 | 2010-10-06 | Bayer CropScience AG | Aminopyridines et pyridazines acylés en tant qu'insecticides |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
WO2011021645A1 (fr) * | 2009-08-19 | 2011-02-24 | 大日本住友製薬株式会社 | Dérivé d'urée bicyclique ou sel pharmaceutiquement acceptable correspondant |
WO2011066137A1 (fr) | 2009-11-24 | 2011-06-03 | Schering Corporation | Dérivés de biaryle substitué et leurs procédés d'utilisation |
EP2556068B1 (fr) | 2010-04-08 | 2019-01-23 | Respivert Limited | Inhibiteurs de la map kinase p38 |
KR101332830B1 (ko) | 2012-07-05 | 2013-11-27 | 한국화학연구원 | 페닐우레아 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 항암감작제 |
TWI648282B (zh) * | 2014-03-27 | 2019-01-21 | 印度商托仁特生技有限公司 | 新熔合咪唑苯并噻唑化合物 |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
US10125123B2 (en) * | 2016-03-03 | 2018-11-13 | Cornell University | Small molecule IRE1-α inhibitors |
PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
US11407771B2 (en) | 2018-05-30 | 2022-08-09 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
JP2022517901A (ja) * | 2018-11-20 | 2022-03-11 | シロナックス・リミテッド | 環状尿素 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001526222A (ja) * | 1997-12-22 | 2001-12-18 | バイエル コーポレイション | アリールおよびヘテロアリール置換複素環尿素を使用するp38キナーゼ活性の阻害 |
US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents |
-
2003
- 2003-08-29 GB GBGB0320244.7A patent/GB0320244D0/en not_active Ceased
-
2004
- 2004-04-25 JO JO200448A patent/JO2473B1/en active
- 2004-05-03 PE PE2004000447A patent/PE20050523A1/es not_active Application Discontinuation
- 2004-05-04 HN HN2004000150A patent/HN2004000150A/es unknown
- 2004-05-05 DE DE602004003806T patent/DE602004003806T2/de not_active Expired - Lifetime
- 2004-05-05 EP EP04751319A patent/EP1622610B1/fr not_active Expired - Lifetime
- 2004-05-05 CA CA002524043A patent/CA2524043C/fr not_active Expired - Fee Related
- 2004-05-05 JP JP2006532565A patent/JP4714150B2/ja not_active Expired - Fee Related
- 2004-05-05 MX MXPA05011400A patent/MXPA05011400A/es active IP Right Grant
- 2004-05-05 AU AU2004238241A patent/AU2004238241A1/en not_active Abandoned
- 2004-05-05 PT PT04751319T patent/PT1622610E/pt unknown
- 2004-05-05 AT AT04751319T patent/ATE348610T1/de active
- 2004-05-05 PL PL04751319T patent/PL1622610T3/pl unknown
- 2004-05-05 WO PCT/US2004/013875 patent/WO2004100946A1/fr active IP Right Grant
- 2004-05-05 SI SI200430166T patent/SI1622610T1/sl unknown
- 2004-05-05 ES ES04751319T patent/ES2277271T3/es not_active Expired - Lifetime
- 2004-05-05 DK DK04751319T patent/DK1622610T3/da active
- 2004-05-05 BR BRPI0409991-5A patent/BRPI0409991A/pt not_active IP Right Cessation
- 2004-05-05 CL CL200400965A patent/CL2004000965A1/es unknown
- 2004-05-06 PA PA20048601901A patent/PA8601901A1/es unknown
- 2004-05-06 UY UY28310A patent/UY28310A1/es not_active Application Discontinuation
- 2004-05-06 TW TW093112701A patent/TWI335223B/zh not_active IP Right Cessation
- 2004-05-06 MY MYPI20041681A patent/MY140830A/en unknown
-
2005
- 2005-11-01 US US11/264,063 patent/US7541368B2/en not_active Expired - Fee Related
-
2007
- 2007-01-19 HR HR20070020T patent/HRP20070020T3/xx unknown
- 2007-03-15 CY CY20071100359T patent/CY1107433T1/el unknown
-
2010
- 2010-10-26 AU AU2010236021A patent/AU2010236021A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JO2473B1 (en) | 2009-01-20 |
PL1622610T3 (pl) | 2007-05-31 |
DE602004003806D1 (de) | 2007-02-01 |
EP1622610A1 (fr) | 2006-02-08 |
TWI335223B (en) | 2011-01-01 |
SI1622610T1 (sl) | 2007-04-30 |
MXPA05011400A (es) | 2005-12-12 |
ES2277271T3 (es) | 2007-07-01 |
US20060063796A1 (en) | 2006-03-23 |
AU2010236021A1 (en) | 2010-11-18 |
HRP20070020T3 (en) | 2007-04-30 |
CY1107433T1 (el) | 2012-12-19 |
CA2524043C (fr) | 2009-12-29 |
CL2004000965A1 (es) | 2005-04-22 |
ATE348610T1 (de) | 2007-01-15 |
PA8601901A1 (es) | 2004-11-26 |
AU2004238241A1 (en) | 2004-11-25 |
GB0320244D0 (en) | 2003-10-01 |
US7541368B2 (en) | 2009-06-02 |
JP4714150B2 (ja) | 2011-06-29 |
HN2004000150A (es) | 2008-03-03 |
PE20050523A1 (es) | 2005-07-07 |
DE602004003806T2 (de) | 2007-11-22 |
MY140830A (en) | 2010-01-29 |
BRPI0409991A (pt) | 2006-05-09 |
TW200509912A (en) | 2005-03-16 |
JP2007502324A (ja) | 2007-02-08 |
PT1622610E (pt) | 2007-02-28 |
EP1622610B1 (fr) | 2006-12-20 |
WO2004100946A1 (fr) | 2004-11-25 |
UY28310A1 (es) | 2004-11-30 |
CA2524043A1 (fr) | 2004-11-25 |
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