DK1622610T3 - 1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer - Google Patents

1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer

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Publication number
DK1622610T3
DK1622610T3 DK04751319T DK04751319T DK1622610T3 DK 1622610 T3 DK1622610 T3 DK 1622610T3 DK 04751319 T DK04751319 T DK 04751319T DK 04751319 T DK04751319 T DK 04751319T DK 1622610 T3 DK1622610 T3 DK 1622610T3
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Denmark
Prior art keywords
inhibitors
kinase
treatment
penyl
pyrazol
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DK04751319T
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Danish (da)
English (en)
Inventor
David R Borcherding
Alexandre Gross
Patrick Wai-Kwok Shum
Nicole Willard
Brian S Freed
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Aventis Pharma Inc
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Publication of DK1622610T3 publication Critical patent/DK1622610T3/da

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04751319T 2003-05-06 2004-05-05 1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer DK1622610T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46828503P 2003-05-06 2003-05-06
PCT/US2004/013875 WO2004100946A1 (fr) 2003-05-06 2004-05-05 Derives de 1-(2h-pyrazol-3-yl)-3-{4-`1-(benzoyl)-piperidin-4-ylmethyl!-phenyl}-uree et composes associes utilises comme inhibiteurs de la kinase p38 et/ou comme inhibiteurs du facteur de necrose tumorale (tnf) dans le traitement des inflammations

Publications (1)

Publication Number Publication Date
DK1622610T3 true DK1622610T3 (da) 2007-04-23

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DK04751319T DK1622610T3 (da) 2003-05-06 2004-05-05 1-(2H-pyrazol-3-yl)-3-{4-[1-[benzoyl)-piperidin-4-ylmethyl]-penyl}-urinstofderivater og beslægtede forbindelser som inhibitorer af p38-kinase og/eller TNF-inhibitorer til behandlingen af inflammationer

Country Status (26)

Country Link
US (1) US7541368B2 (fr)
EP (1) EP1622610B1 (fr)
JP (1) JP4714150B2 (fr)
AT (1) ATE348610T1 (fr)
AU (2) AU2004238241A1 (fr)
BR (1) BRPI0409991A (fr)
CA (1) CA2524043C (fr)
CL (1) CL2004000965A1 (fr)
CY (1) CY1107433T1 (fr)
DE (1) DE602004003806T2 (fr)
DK (1) DK1622610T3 (fr)
ES (1) ES2277271T3 (fr)
GB (1) GB0320244D0 (fr)
HN (1) HN2004000150A (fr)
HR (1) HRP20070020T3 (fr)
JO (1) JO2473B1 (fr)
MX (1) MXPA05011400A (fr)
MY (1) MY140830A (fr)
PA (1) PA8601901A1 (fr)
PE (1) PE20050523A1 (fr)
PL (1) PL1622610T3 (fr)
PT (1) PT1622610E (fr)
SI (1) SI1622610T1 (fr)
TW (1) TWI335223B (fr)
UY (1) UY28310A1 (fr)
WO (1) WO2004100946A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7767674B2 (en) 2004-06-23 2010-08-03 Eli Lilly And Company Kinase inhibitors
DK1778686T3 (da) 2004-08-12 2009-01-12 Pfizer Triazolopyridinylsulfanylderivater som P38 MAP kinase-inhibitorer
DE102004039789A1 (de) * 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
MY151835A (en) 2006-01-31 2014-07-14 Array Biopharma Inc Kinase inhibitors and methods of use thereof
JP2009526039A (ja) * 2006-02-10 2009-07-16 ファイザー・プロダクツ・インク ピリジノンピラゾール尿素およびピリミジノンピラゾール尿素誘導体
WO2007113005A2 (fr) * 2006-04-03 2007-10-11 European Molecular Biology Laboratory (Embl) Inhibiteurs de la kinase aurora
AU2007275301A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
EP2086970B1 (fr) 2006-08-24 2014-02-26 Novartis AG Dérivés de 2-(pyrazin-2-yl)-thiazole et de 2-(1h pyrazol-3-yl)-thiazole et composés similaires en tant qu' inhibiteurs de stearoyl-coa desaturase (scd) pour le traitement de maladies metaboliques, cardiovasculaires et d'autres maladies
JP5351025B2 (ja) 2006-09-22 2013-11-27 ノバルティス アーゲー ヘテロ環式有機化合物
BRPI0720452A2 (pt) 2006-12-20 2014-01-14 Novartis Ag Compostos orgânicos
DE102007047737A1 (de) * 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
WO2010038086A2 (fr) * 2008-10-02 2010-04-08 Respivert Limited Nouveaux composés
AU2009326148B2 (en) 2008-12-11 2014-05-08 Respivert Limited p38 MAP kinase inhibitors
EP2236505A1 (fr) 2009-04-03 2010-10-06 Bayer CropScience AG Aminopyridines et pyridazines acylés en tant qu'insecticides
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
WO2011021645A1 (fr) * 2009-08-19 2011-02-24 大日本住友製薬株式会社 Dérivé d'urée bicyclique ou sel pharmaceutiquement acceptable correspondant
WO2011066137A1 (fr) 2009-11-24 2011-06-03 Schering Corporation Dérivés de biaryle substitué et leurs procédés d'utilisation
EP2556068B1 (fr) 2010-04-08 2019-01-23 Respivert Limited Inhibiteurs de la map kinase p38
KR101332830B1 (ko) 2012-07-05 2013-11-27 한국화학연구원 페닐우레아 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 항암감작제
TWI648282B (zh) * 2014-03-27 2019-01-21 印度商托仁特生技有限公司 新熔合咪唑苯并噻唑化合物
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10125123B2 (en) * 2016-03-03 2018-11-13 Cornell University Small molecule IRE1-α inhibitors
PT3691620T (pt) 2017-10-05 2022-10-06 Fulcrum Therapeutics Inc Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US11407771B2 (en) 2018-05-30 2022-08-09 Washington University Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
JP2022517901A (ja) * 2018-11-20 2022-03-11 シロナックス・リミテッド 環状尿素

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JP2001526222A (ja) * 1997-12-22 2001-12-18 バイエル コーポレイション アリールおよびヘテロアリール置換複素環尿素を使用するp38キナーゼ活性の阻害
US6316466B1 (en) * 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
UA73492C2 (en) * 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents

Also Published As

Publication number Publication date
JO2473B1 (en) 2009-01-20
PL1622610T3 (pl) 2007-05-31
DE602004003806D1 (de) 2007-02-01
EP1622610A1 (fr) 2006-02-08
TWI335223B (en) 2011-01-01
SI1622610T1 (sl) 2007-04-30
MXPA05011400A (es) 2005-12-12
ES2277271T3 (es) 2007-07-01
US20060063796A1 (en) 2006-03-23
AU2010236021A1 (en) 2010-11-18
HRP20070020T3 (en) 2007-04-30
CY1107433T1 (el) 2012-12-19
CA2524043C (fr) 2009-12-29
CL2004000965A1 (es) 2005-04-22
ATE348610T1 (de) 2007-01-15
PA8601901A1 (es) 2004-11-26
AU2004238241A1 (en) 2004-11-25
GB0320244D0 (en) 2003-10-01
US7541368B2 (en) 2009-06-02
JP4714150B2 (ja) 2011-06-29
HN2004000150A (es) 2008-03-03
PE20050523A1 (es) 2005-07-07
DE602004003806T2 (de) 2007-11-22
MY140830A (en) 2010-01-29
BRPI0409991A (pt) 2006-05-09
TW200509912A (en) 2005-03-16
JP2007502324A (ja) 2007-02-08
PT1622610E (pt) 2007-02-28
EP1622610B1 (fr) 2006-12-20
WO2004100946A1 (fr) 2004-11-25
UY28310A1 (es) 2004-11-30
CA2524043A1 (fr) 2004-11-25

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