BRPI0409991A - derivados de 1-(2h-pirazol-3-il)-3-{4-'1-(benzoil)-piperidin-4-ilmetil-fe nil}-uréia e compostos afins como inibidores da cinase p38 e/ou como inibidores de tnf para o tratamento de inflamações - Google Patents

derivados de 1-(2h-pirazol-3-il)-3-{4-'1-(benzoil)-piperidin-4-ilmetil-fe nil}-uréia e compostos afins como inibidores da cinase p38 e/ou como inibidores de tnf para o tratamento de inflamações

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Publication number
BRPI0409991A
BRPI0409991A BRPI0409991-5A BRPI0409991A BRPI0409991A BR PI0409991 A BRPI0409991 A BR PI0409991A BR PI0409991 A BRPI0409991 A BR PI0409991A BR PI0409991 A BRPI0409991 A BR PI0409991A
Authority
BR
Brazil
Prior art keywords
inhibitors
treatment
inflammations
pyrazol
piperidin
Prior art date
Application number
BRPI0409991-5A
Other languages
English (en)
Inventor
David R Borcherding
Alexandre Gross
Patrick Waikwok Shum
Nicole Willard
Brian S Freed
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0409991A publication Critical patent/BRPI0409991A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE 1-(2H-PIRAZOL-3-IL)-3-(4-<39>1-(BENZOIL)-PIPERIDIN-4-ILMETI L-FENIL)-URéIA E COMPOSTOS AFINS COMO INIBIDORES DA CINASE P38 E/OU COMO INIBIDORES DE TNF PARA O TRATAMENTO DE INFLAMAçõES". A presente invenção refere-se a compostos de fórmula (I) onde onde é uma ponte de etileno opcional; R¬ 1¬ é alquila, cicloalquila, arila ou arila substituída com um ou mais substituintes selecionados de alquila, alcóxi e amina, ou R¬ 1¬ é piridila ou piridila substituída com um ou mais substituintes selecionados de alquila, alcóxi e amino; R¬ 2¬ é alquila opcionalmente substituída, alcoxialquila, cicloalquilalquila opcionalmente substituída, arilalquila, ou R¬ 2¬ é arilalquila substituída com um ou mais substituintes selecionados de alquila, alcóxi; X é -C(O)-, -C(O)-CH~ 2~-, -S(O)~ 2~- ou -NH-C(O)-; e A é alquila opcionalmente substituída ou outros substituintes definidos na reivindicação 1. Composições farmacêuticas compreendendo esses compostos, sua preparação, e seu uso farmacêutico no tratamento de doenças que podem ser moduladas pela inibição de cinase p38 e/ou do fator de necrose tumoral (TNF), tal como asma ou inflamação das articulações.
BRPI0409991-5A 2003-05-06 2004-05-05 derivados de 1-(2h-pirazol-3-il)-3-{4-'1-(benzoil)-piperidin-4-ilmetil-fe nil}-uréia e compostos afins como inibidores da cinase p38 e/ou como inibidores de tnf para o tratamento de inflamações BRPI0409991A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46828503P 2003-05-06 2003-05-06
PCT/US2004/013875 WO2004100946A1 (en) 2003-05-06 2004-05-05 1- (2h-pyrazol -3-yl) -3yl) {4-`1- (benzoyl) -piperidin-4-ylmethyl!-phenyl}-urea derivatives and related compounds as inhbitors of p38 kinase and/or tnf inhibitors for the treatment of imflammations

Publications (1)

Publication Number Publication Date
BRPI0409991A true BRPI0409991A (pt) 2006-05-09

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ID=28792177

Family Applications (1)

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BRPI0409991-5A BRPI0409991A (pt) 2003-05-06 2004-05-05 derivados de 1-(2h-pirazol-3-il)-3-{4-'1-(benzoil)-piperidin-4-ilmetil-fe nil}-uréia e compostos afins como inibidores da cinase p38 e/ou como inibidores de tnf para o tratamento de inflamações

Country Status (26)

Country Link
US (1) US7541368B2 (pt)
EP (1) EP1622610B1 (pt)
JP (1) JP4714150B2 (pt)
AT (1) ATE348610T1 (pt)
AU (2) AU2004238241A1 (pt)
BR (1) BRPI0409991A (pt)
CA (1) CA2524043C (pt)
CL (1) CL2004000965A1 (pt)
CY (1) CY1107433T1 (pt)
DE (1) DE602004003806T2 (pt)
DK (1) DK1622610T3 (pt)
ES (1) ES2277271T3 (pt)
GB (1) GB0320244D0 (pt)
HN (1) HN2004000150A (pt)
HR (1) HRP20070020T3 (pt)
JO (1) JO2473B1 (pt)
MX (1) MXPA05011400A (pt)
MY (1) MY140830A (pt)
PA (1) PA8601901A1 (pt)
PE (1) PE20050523A1 (pt)
PL (1) PL1622610T3 (pt)
PT (1) PT1622610E (pt)
SI (1) SI1622610T1 (pt)
TW (1) TWI335223B (pt)
UY (1) UY28310A1 (pt)
WO (1) WO2004100946A1 (pt)

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CA2576297C (en) 2004-08-12 2011-01-25 Pfizer Inc. Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
DE102004039789A1 (de) 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2635813C (en) 2006-01-31 2014-01-07 Array Biopharma, Inc. Urea derivatives as kinase inhibitors and methods of use thereof
EP1987022A1 (en) * 2006-02-10 2008-11-05 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives
WO2007113005A2 (en) * 2006-04-03 2007-10-11 European Molecular Biology Laboratory (Embl) 2-substituted 3-aminosulfonyl-thiophene derivatives as aurora kinase inhibitors
CA2659155A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1
JP2010501567A (ja) 2006-08-24 2010-01-21 ノバルティス アクチエンゲゼルシャフト 代謝系、心血管系および他の障害の処置のためのステアロイル−ＣｏＡ不飽和化酵素（ＳＣＤ）阻害剤としての２−（ピラジン−２−イル）−チアゾールおよび２−（１Ｈ−ピラゾール−３−イル）チアゾール誘導体ならびに関連化合物
BRPI0718509A2 (pt) 2006-09-22 2015-09-29 Novartis Ag compostos orgânicos heterocíclicos
JP2010513403A (ja) 2006-12-20 2010-04-30 ノバルティス アーゲー Ｓｃｄ阻害剤としての２−置換５員ヘテロ環
DE102007047737A1 (de) * 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
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EP2236505A1 (de) 2009-04-03 2010-10-06 Bayer CropScience AG Acylierte Aminopyridine und - pyridazine als Insektizide
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
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TWI648282B (zh) * 2014-03-27 2019-01-21 印度商托仁特生技有限公司 新熔合咪唑苯并噻唑化合物
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
CA3016196A1 (en) 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
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HRP20221196T1 (hr) 2017-10-05 2022-12-09 Fulcrum Therapeutics, Inc. Inhibitori p38 kinaze smanjuju ekspresiju dux4 i nizvodnih gena u cilju liječenja fshd
US11407771B2 (en) 2018-05-30 2022-08-09 Washington University Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
BR112021009610A2 (pt) * 2018-11-20 2021-08-10 Sironax Ltd composto, composição farmacêutica, uso de um composto ou composição, e, método de inibir necrose, ferroptose, rip1 humana ou indicações relacionadas

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Also Published As

Publication number Publication date
AU2010236021A1 (en) 2010-11-18
HRP20070020T3 (en) 2007-04-30
PE20050523A1 (es) 2005-07-07
PT1622610E (pt) 2007-02-28
AU2004238241A1 (en) 2004-11-25
JP2007502324A (ja) 2007-02-08
GB0320244D0 (en) 2003-10-01
HN2004000150A (es) 2008-03-03
EP1622610B1 (en) 2006-12-20
US7541368B2 (en) 2009-06-02
PL1622610T3 (pl) 2007-05-31
CY1107433T1 (el) 2012-12-19
CL2004000965A1 (es) 2005-04-22
CA2524043A1 (en) 2004-11-25
JP4714150B2 (ja) 2011-06-29
TWI335223B (en) 2011-01-01
TW200509912A (en) 2005-03-16
ES2277271T3 (es) 2007-07-01
MY140830A (en) 2010-01-29
PA8601901A1 (es) 2004-11-26
US20060063796A1 (en) 2006-03-23
SI1622610T1 (sl) 2007-04-30
DE602004003806D1 (de) 2007-02-01
DK1622610T3 (da) 2007-04-23
WO2004100946A1 (en) 2004-11-25
EP1622610A1 (en) 2006-02-08
UY28310A1 (es) 2004-11-30
JO2473B1 (en) 2009-01-20
ATE348610T1 (de) 2007-01-15
CA2524043C (en) 2009-12-29
DE602004003806T2 (de) 2007-11-22
MXPA05011400A (es) 2005-12-12

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