DK1621633T3 - Glycoproteiner produceret i planter med undertrykt ekspression af beta 1,2-xylosyltransferase - Google Patents

Glycoproteiner produceret i planter med undertrykt ekspression af beta 1,2-xylosyltransferase

Info

Publication number
DK1621633T3
DK1621633T3 DK05108014.1T DK05108014T DK1621633T3 DK 1621633 T3 DK1621633 T3 DK 1621633T3 DK 05108014 T DK05108014 T DK 05108014T DK 1621633 T3 DK1621633 T3 DK 1621633T3
Authority
DK
Denmark
Prior art keywords
plants
xylosyltransferase
beta
glycoproteins produced
suppressed expression
Prior art date
Application number
DK05108014.1T
Other languages
Danish (da)
English (en)
Inventor
Josef Glössl
Herta Steinkellner
Iain B Wilson
Lukas Mach
Jan Mucha
Richard Strasser
Friedrich Altmann
Original Assignee
Josef Glössl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3672559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1621633(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Josef Glössl filed Critical Josef Glössl
Application granted granted Critical
Publication of DK1621633T3 publication Critical patent/DK1621633T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02038—Glycoprotein 2-beta-D-xylosyltransferase (2.4.2.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01052—Beta-N-acetylhexosaminidase (3.2.1.52)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK05108014.1T 2000-03-03 2001-03-02 Glycoproteiner produceret i planter med undertrykt ekspression af beta 1,2-xylosyltransferase DK1621633T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0035500A AT409381B (de) 2000-03-03 2000-03-03 Xylosyltransferase-gen
EP01919367.1A EP1263968B2 (en) 2000-03-03 2001-03-02 Beta 1, 2-xylosyltransferase-gene from arabidopsis

Publications (1)

Publication Number Publication Date
DK1621633T3 true DK1621633T3 (da) 2014-05-19

Family

ID=3672559

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05108014.1T DK1621633T3 (da) 2000-03-03 2001-03-02 Glycoproteiner produceret i planter med undertrykt ekspression af beta 1,2-xylosyltransferase
DK01919367.1T DK1263968T4 (da) 2000-03-03 2001-03-02 Beta 1,2-xylosyltransferasegen fra arabidopsis

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01919367.1T DK1263968T4 (da) 2000-03-03 2001-03-02 Beta 1,2-xylosyltransferasegen fra arabidopsis

Country Status (12)

Country Link
US (3) US7205137B2 (https=)
EP (2) EP1621633B1 (https=)
JP (2) JP5279976B2 (https=)
KR (5) KR100861437B1 (https=)
AT (2) AT409381B (https=)
AU (1) AU781010B2 (https=)
CA (1) CA2402015C (https=)
DE (1) DE60115863T3 (https=)
DK (2) DK1621633T3 (https=)
ES (2) ES2252208T5 (https=)
PT (1) PT1621633E (https=)
WO (1) WO2001064901A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1137789T3 (da) 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
DE60044858D1 (de) 1999-10-26 2010-09-30 Stichting Dienst Landbouwkundi Säugetierartige Glykosylierung in Pflanzen
DK1356068T3 (en) 2001-01-19 2015-02-16 Phyton Holdings Llc PROCESS FOR THE PRODUCTION OF secretory glycoprotein with HUMAN TYPE SUGAR CHAIN ​​FOR USING A PLANT CELL
CN101613705A (zh) 2002-03-19 2009-12-30 国际植物研究所 在植物中优化聚糖生成
CN1665934B (zh) 2002-03-19 2010-05-26 国际植物研究所 GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
EP1510584B1 (en) 2003-08-11 2009-03-18 Greenovation Biotech GmbH Expression promoting sequences from mosses and their uses
JP2009526520A (ja) * 2006-01-17 2009-07-23 バイオレックス セラピュティックス インク 植物中でのｎ−グリカンのヒト化及び最適化のための組成物及び方法
US20090060921A1 (en) * 2006-01-17 2009-03-05 Biolex Therapeutics, Inc. Glycan-optimized anti-cd20 antibodies
CA2646583A1 (en) * 2006-03-23 2007-09-27 Bayer Bioscience N.V. Novel nucleotide sequences encoding nicotiana beta-1,2-xylosyltransferase
WO2008125972A2 (en) 2007-04-17 2008-10-23 Plant Research International B.V. Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
RU2485180C2 (ru) 2007-06-07 2013-06-20 Эгрикалча Энд Эгри-Фуд Кэнэда Способ трансфекции и трансдукции растительных клеток
EP2789686A1 (en) 2013-04-11 2014-10-15 Greenovation Biotech GmbH Expression of phosphorylated glycoproteins in plants
JP6934666B2 (ja) * 2018-01-18 2021-09-15 国立研究開発法人産業技術総合研究所 植物細胞においてキシロース修飾タンパク質を製造する方法、コアオリゴ糖修飾タンパク質を製造する方法、及びプロテオグリカンを製造する方法
EP3871687A1 (en) 2020-02-27 2021-09-01 eleva GmbH Enzyme replacement therapy for treating pompe disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69631540T2 (de) * 1995-11-23 2005-01-27 Cancer Research Technology Ltd. Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen
AU1808699A (en) * 1997-12-08 1999-06-28 Board Of Trustees Of The University Of Arkansas, The Purified beta1,2-xylosyltransferase and uses thereof
DE19754622A1 (de) † 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
WO1999032623A1 (en) * 1997-12-19 1999-07-01 Pharmacia & Upjohn Company Human sel-10 polypeptides and polynucleotides that encode them
US6207811B1 (en) * 1998-03-18 2001-03-27 Karl Tryggvason Nephrin gene and protein
EP1105479B1 (en) * 1998-08-11 2011-01-12 Darwin Discovery Limited Identification of the gene causing the mouse scurfy phenotype and its human ortholog
EP1033405A3 (en) * 1999-02-25 2001-08-01 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
BR0014945A (pt) * 1999-10-21 2004-08-31 Monsanto Co Modificação pós-traducional de proteìnas recombinantes produzidas em plantas

Also Published As

Publication number Publication date
CA2402015C (en) 2012-07-17
AU4649501A (en) 2001-09-12
US20120331578A1 (en) 2012-12-27
DE60115863T2 (de) 2006-08-10
DK1263968T4 (da) 2014-11-03
JP2013116113A (ja) 2013-06-13
AT409381B (de) 2002-07-25
US20040121325A1 (en) 2004-06-24
EP1621633A2 (en) 2006-02-01
KR20090101981A (ko) 2009-09-29
CA2402015A1 (en) 2001-09-07
ES2460672T3 (es) 2014-05-14
ATE312931T1 (de) 2005-12-15
DE60115863T3 (de) 2015-01-22
WO2001064901A1 (en) 2001-09-07
EP1263968B2 (en) 2014-09-10
KR20080077296A (ko) 2008-08-21
ES2252208T3 (es) 2006-05-16
KR100861437B1 (ko) 2008-10-02
AU781010B2 (en) 2005-04-28
KR20100119005A (ko) 2010-11-08
JP5279976B2 (ja) 2013-09-04
DK1263968T3 (da) 2006-05-01
JP2004500096A (ja) 2004-01-08
KR101185123B1 (ko) 2012-09-21
KR20030030987A (ko) 2003-04-18
EP1621633A3 (en) 2006-02-08
EP1263968B1 (en) 2005-12-14
US7205137B2 (en) 2007-04-17
PT1621633E (pt) 2014-07-18
KR100859919B1 (ko) 2008-09-23
ATA3552000A (de) 2001-12-15
ES2252208T5 (es) 2014-11-04
KR20070058018A (ko) 2007-06-07
EP1263968A1 (en) 2002-12-11
DE60115863D1 (de) 2006-01-19
EP1621633B1 (en) 2014-04-16
US20070186311A1 (en) 2007-08-09

Similar Documents

Publication Publication Date Title
DK1621633T3 (da) Glycoproteiner produceret i planter med undertrykt ekspression af beta 1,2-xylosyltransferase
EA200401467A1 (ru) Пептиды, полученные из казеина, и их применение в терапии
DK2251353T3 (da) Homogene fremstillinger af IL-29
DE69739035D1 (de) Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
DK1356052T3 (da) Produktion af hele antistoffer i prokaryotiske celler
DK0733103T3 (da) Fremstilling af höje titre af rekombinante AAV vektorer
PT703983E (pt) Regulacao do crescimento de plantas
DK0507933T3 (da) Nær-vaskulariserende implantationsmateriale
ATE254448T1 (de) Kosmetische oder dermatologische zusammensetzung, enthaltend zumindest ein natürliches oder rekombinantes seidenprotein von arachniden oder ein analoges protein
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
NO941186D0 (no) Hormonanaloger med multiple CTP-forlengelser
ATE286118T1 (de) Anwendungen für humane nicht autologe, mesenchymale stammzellen
ES2300276T3 (es) P40 de interleuquina-12 de mamifero e interleuquina b30. sus combinaciones. anticuerpos. usos en composiciones farmaceuticas.
ES2149167T3 (es) Factor transformante del crecimiento tipo beta.
EP1037523A4 (en) LENS OF WATER GENETICALLY FOCUSED
DE69939330D1 (de) Wachstumsfaktor-homologe zvegf-3
DK0614980T3 (da) Trans-dominante TAT-varianter fra humant immundeficiens-virus
DK1501936T3 (da) Familie af cytokin-proteiner
EP0592566A4 (en) CYSTEIN-FREE IL-6 MUTANTS.
LV11816A (lv) Implantejama zalu forma
DE69434968D1 (de) Tiermodell für hepatitis-virus infektion
FI952088A0 (fi) Transformoituja endoteelisoluja
BR0008187A (pt) Controle biológico de nematódeos
AR024430A1 (es) Proteinas insecticidas y combinaciones sinergicas de las mismas
ATE441713T1 (de) Tumorantigenprotein und dessen verwendung