DK159425C - 5-acyl-3-cyano-2-(1h)-pyridinoner eller syreadditionssalte deraf - Google Patents
5-acyl-3-cyano-2-(1h)-pyridinoner eller syreadditionssalte derafInfo
- Publication number
- DK159425C DK159425C DK213584A DK213584A DK159425C DK 159425 C DK159425 C DK 159425C DK 213584 A DK213584 A DK 213584A DK 213584 A DK213584 A DK 213584A DK 159425 C DK159425 C DK 159425C
- Authority
- DK
- Denmark
- Prior art keywords
- pyridinones
- acyl
- cyano
- acid addition
- addition salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49008183 | 1983-04-29 | ||
US06/490,081 US4568751A (en) | 1983-04-29 | 1983-04-29 | 5-Acyl-2-(1H)-pyridinones |
Publications (4)
Publication Number | Publication Date |
---|---|
DK213584D0 DK213584D0 (da) | 1984-04-27 |
DK213584A DK213584A (da) | 1984-10-30 |
DK159425B DK159425B (da) | 1990-10-15 |
DK159425C true DK159425C (da) | 1991-03-18 |
Family
ID=23946554
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK213584A DK159425C (da) | 1983-04-29 | 1984-04-27 | 5-acyl-3-cyano-2-(1h)-pyridinoner eller syreadditionssalte deraf |
DK213284A DK159424C (da) | 1983-04-29 | 1984-04-27 | 5-acyl-2-(1h)-pyridinoner eller syreadditionssalte deraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK213284A DK159424C (da) | 1983-04-29 | 1984-04-27 | 5-acyl-2-(1h)-pyridinoner eller syreadditionssalte deraf |
Country Status (22)
Country | Link |
---|---|
US (1) | US4568751A (es) |
EP (2) | EP0124090B1 (es) |
JP (2) | JPS59206356A (es) |
KR (2) | KR900005011B1 (es) |
AR (1) | AR240313A1 (es) |
AT (2) | ATE26262T1 (es) |
AU (2) | AU571219B2 (es) |
CA (2) | CA1256880A (es) |
DD (1) | DD223444A5 (es) |
DE (2) | DE3462503D1 (es) |
DK (2) | DK159425C (es) |
ES (2) | ES531910A0 (es) |
GR (2) | GR81967B (es) |
HU (2) | HU191928B (es) |
IE (2) | IE57273B1 (es) |
IL (2) | IL71649A (es) |
NO (2) | NO164416C (es) |
NZ (2) | NZ207961A (es) |
PH (1) | PH20256A (es) |
PT (2) | PT78493B (es) |
SU (1) | SU1299505A3 (es) |
ZA (2) | ZA843034B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118696A (en) * | 1983-04-29 | 1992-06-02 | Merrell Dow Pharmaceuticals Inc. | 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure |
US4731371A (en) * | 1984-03-29 | 1988-03-15 | Merrell Dow Pharmaceuticals Inc. | Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents |
US5428045A (en) * | 1983-04-29 | 1995-06-27 | Merrell Dow Pharmaceuticals Inc. | 5-acyl-2-(1H)-pyridinoes |
US4992452A (en) * | 1983-04-29 | 1991-02-12 | Merrell Dow Pharmaceuticals Inc. | Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure |
US4853395A (en) * | 1983-04-29 | 1989-08-01 | Merrell Dow Pharmaceuticals Inc. | Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties |
US4568751A (en) * | 1983-04-29 | 1986-02-04 | Merrell Dow Pharmaceuticals Inc. | 5-Acyl-2-(1H)-pyridinones |
US5212314A (en) * | 1983-11-03 | 1993-05-18 | Merrell Dow Pharmaceuticals Inc. | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
US4732982A (en) * | 1983-11-03 | 1988-03-22 | Merrell Dow Pharmaceuticals Inc. | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
US4657919A (en) * | 1984-08-03 | 1987-04-14 | E. I. Du Pont De Nemours & Co. | Pyridone esters as inotropic agents |
US4650806A (en) * | 1985-01-14 | 1987-03-17 | Sterling Drug Inc. | Cardiotonic 5-(heterylcarbonyl)-pyridones |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2531035A1 (de) * | 1975-07-11 | 1977-01-27 | Basf Ag | Verfahren zur herstellung von 5-cyanpyridonen-(6) |
US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
GB1596887A (en) * | 1977-07-15 | 1981-09-03 | Rohm & Haas | 2-pyridone derivatives and their use as plant growth regulators |
DE3005069A1 (de) * | 1980-02-11 | 1981-08-20 | Cassella Ag, 6000 Frankfurt | Pyridonderivate, ihre herstellung und ihre verwendung |
DE3106460A1 (de) * | 1980-03-03 | 1982-01-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen |
US4524149A (en) * | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
US4412077A (en) * | 1982-03-15 | 1983-10-25 | Sterling Drug Inc. | Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone |
US4568751A (en) * | 1983-04-29 | 1986-02-04 | Merrell Dow Pharmaceuticals Inc. | 5-Acyl-2-(1H)-pyridinones |
DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
-
1983
- 1983-04-29 US US06/490,081 patent/US4568751A/en not_active Expired - Lifetime
-
1984
- 1984-04-19 AU AU27141/84A patent/AU571219B2/en not_active Ceased
- 1984-04-19 AU AU27131/84A patent/AU557543B2/en not_active Ceased
- 1984-04-24 ZA ZA843034A patent/ZA843034B/xx unknown
- 1984-04-24 AR AR296404A patent/AR240313A1/es active
- 1984-04-24 ZA ZA843033A patent/ZA843033B/xx unknown
- 1984-04-25 ES ES531910A patent/ES531910A0/es active Granted
- 1984-04-25 ES ES531911A patent/ES8505956A1/es not_active Expired
- 1984-04-26 PT PT78493A patent/PT78493B/pt not_active IP Right Cessation
- 1984-04-26 EP EP84104704A patent/EP0124090B1/en not_active Expired
- 1984-04-26 HU HU841618A patent/HU191928B/hu not_active IP Right Cessation
- 1984-04-26 HU HU841619A patent/HU191753B/hu not_active IP Right Cessation
- 1984-04-26 NZ NZ207961A patent/NZ207961A/en unknown
- 1984-04-26 DE DE8484104703T patent/DE3462503D1/de not_active Expired
- 1984-04-26 IL IL71649A patent/IL71649A/xx unknown
- 1984-04-26 NZ NZ207960A patent/NZ207960A/en unknown
- 1984-04-26 AT AT84104704T patent/ATE26262T1/de not_active IP Right Cessation
- 1984-04-26 IL IL71648A patent/IL71648A/xx unknown
- 1984-04-26 PH PH30602A patent/PH20256A/en unknown
- 1984-04-26 DE DE8484104704T patent/DE3462889D1/de not_active Expired
- 1984-04-26 CA CA000452889A patent/CA1256880A/en not_active Expired
- 1984-04-26 EP EP84104703A patent/EP0124089B1/en not_active Expired
- 1984-04-26 AT AT84104703T patent/ATE25678T1/de active
- 1984-04-26 PT PT78491A patent/PT78491B/pt not_active IP Right Cessation
- 1984-04-26 CA CA000452888A patent/CA1242443A/en not_active Expired
- 1984-04-27 NO NO841690A patent/NO164416C/no unknown
- 1984-04-27 IE IE1046/84A patent/IE57273B1/en not_active IP Right Cessation
- 1984-04-27 IE IE1047/84A patent/IE57285B1/en not_active IP Right Cessation
- 1984-04-27 GR GR74536A patent/GR81967B/el unknown
- 1984-04-27 NO NO841691A patent/NO164415C/no unknown
- 1984-04-27 DD DD84262415A patent/DD223444A5/de not_active IP Right Cessation
- 1984-04-27 JP JP59084235A patent/JPS59206356A/ja active Granted
- 1984-04-27 GR GR74535A patent/GR81990B/el unknown
- 1984-04-27 DK DK213584A patent/DK159425C/da not_active IP Right Cessation
- 1984-04-27 JP JP59084234A patent/JPS59206355A/ja active Granted
- 1984-04-27 DK DK213284A patent/DK159424C/da not_active IP Right Cessation
- 1984-04-28 KR KR1019840002298A patent/KR900005011B1/ko not_active IP Right Cessation
- 1984-04-28 KR KR1019840002297A patent/KR900005010B1/ko not_active IP Right Cessation
- 1984-04-28 SU SU843732701A patent/SU1299505A3/ru active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |