DK158789C - Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden

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Publication number
DK158789C
DK158789C DK489477A DK489477A DK158789C DK 158789 C DK158789 C DK 158789C DK 489477 A DK489477 A DK 489477A DK 489477 A DK489477 A DK 489477A DK 158789 C DK158789 C DK 158789C
Authority
DK
Denmark
Prior art keywords
pyrimido
isoquinolin
imino
analogy
exposure
Prior art date
Application number
DK489477A
Other languages
Danish (da)
English (en)
Other versions
DK158789B (da
DK489477A (da
Inventor
Bansi Lal
Horst Dornauer
Bani Kanta Bhattacharya
Alihussein Nomanbha Dohadwalla
Noel John De Souza
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK489477A publication Critical patent/DK489477A/da
Publication of DK158789B publication Critical patent/DK158789B/da
Application granted granted Critical
Publication of DK158789C publication Critical patent/DK158789C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK489477A 1977-05-05 1977-11-03 Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden DK158789C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (de) 1977-05-05 1977-05-05 Pyrimido(6,1-a)isochinolin-2-on- derivate
DE2720085 1977-05-05

Publications (3)

Publication Number Publication Date
DK489477A DK489477A (da) 1978-11-06
DK158789B DK158789B (da) 1990-07-16
DK158789C true DK158789C (da) 1990-11-26

Family

ID=6008073

Family Applications (2)

Application Number Title Priority Date Filing Date
DK489477A DK158789C (da) 1977-05-05 1977-11-03 Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden
DK267089A DK267089A (da) 1977-05-05 1989-06-01 Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK267089A DK267089A (da) 1977-05-05 1989-06-01 Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf

Country Status (18)

Country Link
US (2) US4482556A (no)
JP (2) JPS53137997A (no)
AT (1) AT372383B (no)
BE (1) BE862785A (no)
CH (2) CH640854A5 (no)
DK (2) DK158789C (no)
EG (1) EG12982A (no)
ES (3) ES464776A1 (no)
FI (1) FI64370C (no)
FR (1) FR2389623B1 (no)
GR (1) GR72114B (no)
IL (1) IL53336A (no)
IT (1) IT1192252B (no)
NL (1) NL185078C (no)
NO (2) NO148032C (no)
PT (1) PT67265B (no)
SE (2) SE436357B (no)
ZA (1) ZA776706B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ZW6284A1 (en) * 1983-05-05 1985-10-30 Hoffmann La Roche Novel pyrimidone derivatives
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
DE68902811D1 (de) * 1988-11-19 1992-10-15 Hoechst Ag Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung.
DE60005493T2 (de) * 1999-03-31 2004-07-01 Vernalis Ltd., Wokingham Pyrimido[6,1-a]isochinolinonderivate
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
AU2019302610B2 (en) 2018-07-13 2023-11-23 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor
JP2023512471A (ja) * 2020-01-15 2023-03-27 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｐｄｅ３／ｐｄｅ４二重阻害剤の結晶及びその使用
US20230060174A1 (en) * 2020-01-15 2023-03-02 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
CA3211820A1 (en) * 2021-04-29 2022-11-03 Zhiya LI Isoquinolone compound and use thereof
WO2024088402A1 (zh) * 2022-10-28 2024-05-02 江苏恒瑞医药股份有限公司 一种异喹啉酮类化合物的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Also Published As

Publication number Publication date
IT7822619A0 (it) 1978-04-21
BE862785A (fr) 1978-07-10
NL185078B (nl) 1989-08-16
ES475027A1 (es) 1979-05-16
CH640854A5 (de) 1984-01-31
SE8206619D0 (sv) 1982-11-19
DK267089D0 (da) 1989-06-01
FI64370C (fi) 1983-11-10
FR2389623A1 (no) 1978-12-01
IL53336A0 (en) 1978-01-31
JPS6041677A (ja) 1985-03-05
JPS6312871B2 (no) 1988-03-23
US4482556A (en) 1984-11-13
PT67265A (de) 1977-12-01
NO821266L (no) 1978-11-07
EG12982A (en) 1982-03-31
IT1192252B (it) 1988-03-31
SE436357B (sv) 1984-12-03
ATA784477A (de) 1983-02-15
JPS53137997A (en) 1978-12-01
ES472606A1 (es) 1979-02-16
NO774131L (no) 1978-11-07
DK158789B (da) 1990-07-16
JPS6225150B2 (no) 1987-06-01
CH642949A5 (de) 1984-05-15
IL53336A (en) 1984-02-29
AT372383B (de) 1983-09-26
SE8206619L (sv) 1982-11-19
DK267089A (da) 1989-06-01
DK489477A (da) 1978-11-06
ZA776706B (en) 1978-08-30
ES464776A1 (es) 1979-01-01
NL7800149A (nl) 1978-11-07
FI773286A (fi) 1978-11-06
US4598148A (en) 1986-07-01
FI64370B (fi) 1983-07-29
FR2389623B1 (no) 1980-10-31
SE7712513L (sv) 1978-11-06
NL185078C (nl) 1990-01-16
PT67265B (de) 1981-01-05
NO148032B (no) 1983-04-18
GR72114B (no) 1983-09-15
SE439307B (sv) 1985-06-10
NO148032C (no) 1983-07-27

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