DK1585822T3 - Promotorvarianter til ekspression af gener i en fungal celle - Google Patents
Promotorvarianter til ekspression af gener i en fungal celleInfo
- Publication number
- DK1585822T3 DK1585822T3 DK03789880.6T DK03789880T DK1585822T3 DK 1585822 T3 DK1585822 T3 DK 1585822T3 DK 03789880 T DK03789880 T DK 03789880T DK 1585822 T3 DK1585822 T3 DK 1585822T3
- Authority
- DK
- Denmark
- Prior art keywords
- seq
- biological substance
- nucleic acid
- promoter variants
- fungal host
- Prior art date
Links
- 230000002538 fungal effect Effects 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 5
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01003—Nitrate reductase (NADPH) (1.7.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04002—CTP synthase (6.3.4.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42731402P | 2002-11-18 | 2002-11-18 | |
| PCT/US2003/037139 WO2004046373A2 (en) | 2002-11-18 | 2003-11-18 | Promoter variants for expressing genes in a fungal cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1585822T3 true DK1585822T3 (da) | 2012-05-14 |
Family
ID=32326518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03789880.6T DK1585822T3 (da) | 2002-11-18 | 2003-11-18 | Promotorvarianter til ekspression af gener i en fungal celle |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US7368262B2 (enExample) |
| EP (1) | EP1585822B1 (enExample) |
| JP (1) | JP4490284B2 (enExample) |
| CN (2) | CN101497908B (enExample) |
| AT (1) | ATE542913T1 (enExample) |
| AU (1) | AU2003294397A1 (enExample) |
| DK (1) | DK1585822T3 (enExample) |
| WO (1) | WO2004046373A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030228906A1 (en) | 2002-04-19 | 2003-12-11 | Walker Jay S. | Methods and apparatus for providing communications services at a gaming machine |
| JP4490284B2 (ja) | 2002-11-18 | 2010-06-23 | ノボザイムス，インコーポレイティド | 菌類細胞において遺伝子を発現するためのプロモーター変異体 |
| US7335106B2 (en) | 2003-10-20 | 2008-02-26 | Las Vegas Gaming, Inc. | Closed-loop system for displaying promotional events and granting awards for electronic video games |
| CA2734173C (en) * | 2007-10-18 | 2019-04-23 | Mayo Foundation For Medical Education And Research | Igm-mediated receptor clustering |
| US8282480B2 (en) | 2010-02-10 | 2012-10-09 | Leap Forward Gaming | Candle device for providing transaction verification on a gaming machine |
| US8968086B2 (en) | 2010-02-10 | 2015-03-03 | Leap Forward Gaming, Inc. | Video processing and signal routing apparatus for providing picture in a picture capabilities on an electronic gaming machine |
| US9245419B2 (en) | 2010-02-10 | 2016-01-26 | Leap Forward Gaming, Inc. | Lottery games on an electronic gaming machine |
| US8814706B2 (en) | 2010-02-10 | 2014-08-26 | Leap Forward Gaming, Inc. | Radio candle mount |
| US8460091B2 (en) * | 2010-02-10 | 2013-06-11 | Leap Forward Gaming | Remote power reset feature on a gaming machine |
| US9240100B2 (en) | 2010-02-10 | 2016-01-19 | Leap Forward Gaming | Virtual players card |
| US8814681B2 (en) | 2010-02-10 | 2014-08-26 | Leap Forward Gaming, Inc. | Candle device for generating display interfaces on the main display of a gaming machine |
| US8241119B2 (en) | 2010-02-10 | 2012-08-14 | Leap Forward Gaming | Candle devices for gaming machines |
| US9359630B2 (en) | 2010-11-30 | 2016-06-07 | Novozymes, Inc. | Promoters for expressing genes in a fungal cell |
| US9404101B2 (en) * | 2011-08-24 | 2016-08-02 | Novozymes, Inc. | Methods for obtaining positive transformants of a filamentous fungal host cell |
| JP5971661B2 (ja) * | 2012-09-19 | 2016-08-17 | 国立大学法人 東京大学 | 神経活動依存的プロモータ活性を有するｄｎａ、及びこれを含むベクター |
| CN106636088B (zh) * | 2016-09-22 | 2020-06-23 | 南京百斯杰生物工程有限公司 | 一种酵母上游激活元件在丝状真菌中的应用 |
| JP7540709B2 (ja) | 2020-11-30 | 2024-08-27 | 大関株式会社 | 糸状菌用プロモーターおよびその利用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| PL178652B1 (pl) * | 1993-11-24 | 2000-05-31 | Monsanto Co | Zrekombinowana cząsteczka dwuniciowego DNA, sposób wytwarzania genetycznie stransformowanych, odpornych na choroby roślin, oraz genetycznie stransformowana komórka roślinna ziemniaka lub pszenicy |
| CN1192108C (zh) | 1994-06-03 | 2005-03-09 | 诺沃奇梅兹生物技术有限公司 | 纯化的毁丝霉属漆酶及编码该酶的核酸 |
| WO1996000787A1 (en) | 1994-06-30 | 1996-01-11 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| CN1062017C (zh) * | 1995-09-01 | 2001-02-14 | 中国科学院遗传研究所 | 防御素基因的植物表达载体质粒 |
| EP0877801B1 (en) | 1996-01-19 | 2005-04-27 | Novozymes Biotech, Inc. | Morphological mutants of filamentous fungi |
| CN1190673A (zh) * | 1996-04-29 | 1998-08-19 | 中国科学院微生物研究所 | 丝状真菌中独立复制的表达载体及表达系统 |
| EP0966521A1 (en) | 1996-09-13 | 1999-12-29 | Novo Nordisk Biotech, Inc. | Cells having dna insertion mutations which produce altered amounts of a polypeptide |
| AU4195099A (en) | 1998-05-20 | 1999-12-06 | Novo Nordisk Biotech, Inc. | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells |
| CN1197965C (zh) | 1998-10-26 | 2005-04-20 | 诺维信公司 | 在丝状真菌细胞内构建和筛选目的dna文库 |
| US6902887B1 (en) | 1999-03-22 | 2005-06-07 | Novozymes Biotech, Inc. | Methods for monitoring multiple gene expression |
| AU4025700A (en) * | 1999-03-22 | 2000-10-09 | Novo Nordisk Biotech, Inc. | Promoters for expressing genes in a fungal cell |
| US6361973B1 (en) * | 1999-03-22 | 2002-03-26 | Novozymes Biotech, Inc. | Promoters for expressing genes in a fungal cell |
| AU1783901A (en) * | 1999-11-30 | 2001-06-12 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide using a consensus translational initiator sequence |
| JP4490284B2 (ja) * | 2002-11-18 | 2010-06-23 | ノボザイムス，インコーポレイティド | 菌類細胞において遺伝子を発現するためのプロモーター変異体 |
| DE102006003576B4 (de) * | 2006-01-25 | 2007-10-25 | Tridelta Überspannungsableiter Gmbh | Überspannungsableiter mit Käfig-Design |
-
2003
- 2003-11-18 JP JP2004553980A patent/JP4490284B2/ja not_active Expired - Lifetime
- 2003-11-18 CN CN200910007772.7A patent/CN101497908B/zh not_active Expired - Fee Related
- 2003-11-18 DK DK03789880.6T patent/DK1585822T3/da active
- 2003-11-18 EP EP03789880A patent/EP1585822B1/en not_active Expired - Lifetime
- 2003-11-18 WO PCT/US2003/037139 patent/WO2004046373A2/en not_active Ceased
- 2003-11-18 AT AT03789880T patent/ATE542913T1/de active
- 2003-11-18 US US10/716,793 patent/US7368262B2/en not_active Expired - Fee Related
- 2003-11-18 CN CNB2003801089385A patent/CN100480391C/zh not_active Expired - Fee Related
- 2003-11-18 AU AU2003294397A patent/AU2003294397A1/en not_active Abandoned
-
2008
- 2008-03-24 US US12/054,125 patent/US8138325B2/en not_active Expired - Fee Related
-
2012
- 2012-03-19 US US13/424,018 patent/US8604181B2/en not_active Expired - Fee Related
-
2013
- 2013-12-05 US US14/097,659 patent/US9150856B2/en not_active Expired - Fee Related
-
2015
- 2015-09-10 US US14/850,448 patent/US9695429B2/en not_active Expired - Fee Related
-
2017
- 2017-04-26 US US15/498,011 patent/US9873881B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20140099669A1 (en) | 2014-04-10 |
| US20170233751A1 (en) | 2017-08-17 |
| US9695429B2 (en) | 2017-07-04 |
| US8604181B2 (en) | 2013-12-10 |
| CN101497908A (zh) | 2009-08-05 |
| AU2003294397A1 (en) | 2004-06-15 |
| US20080274500A1 (en) | 2008-11-06 |
| WO2004046373A2 (en) | 2004-06-03 |
| US9150856B2 (en) | 2015-10-06 |
| JP4490284B2 (ja) | 2010-06-23 |
| US20040146975A1 (en) | 2004-07-29 |
| CN101497908B (zh) | 2014-05-21 |
| CN100480391C (zh) | 2009-04-22 |
| EP1585822A2 (en) | 2005-10-19 |
| ATE542913T1 (de) | 2012-02-15 |
| US20120190067A1 (en) | 2012-07-26 |
| CN1780917A (zh) | 2006-05-31 |
| AU2003294397A8 (en) | 2004-06-15 |
| WO2004046373A3 (en) | 2005-02-10 |
| EP1585822B1 (en) | 2012-01-25 |
| US9873881B2 (en) | 2018-01-23 |
| US8138325B2 (en) | 2012-03-20 |
| JP2006506095A (ja) | 2006-02-23 |
| EP1585822A4 (en) | 2005-12-28 |
| US7368262B2 (en) | 2008-05-06 |
| US20150376630A1 (en) | 2015-12-31 |
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