ATE469231T1 - Von rna-virus abgeleitetes pflanzenexpressionssystem - Google Patents
Von rna-virus abgeleitetes pflanzenexpressionssystemInfo
- Publication number
- ATE469231T1 ATE469231T1 AT04797791T AT04797791T ATE469231T1 AT E469231 T1 ATE469231 T1 AT E469231T1 AT 04797791 T AT04797791 T AT 04797791T AT 04797791 T AT04797791 T AT 04797791T AT E469231 T1 ATE469231 T1 AT E469231T1
- Authority
- AT
- Austria
- Prior art keywords
- plant
- agrobacteria
- replicon
- sequence
- expression system
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8205—Agrobacterium mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2003/012530 WO2006012906A1 (en) | 2003-11-10 | 2003-11-10 | Rna virus-derived plant expression system |
| EP04016012 | 2004-07-07 | ||
| PCT/EP2004/012743 WO2005049839A2 (en) | 2003-11-10 | 2004-11-10 | Rna virus-derived plant expression system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469231T1 true ATE469231T1 (de) | 2010-06-15 |
Family
ID=34621451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04797791T ATE469231T1 (de) | 2003-11-10 | 2004-11-10 | Von rna-virus abgeleitetes pflanzenexpressionssystem |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10287602B2 (de) |
| EP (2) | EP2184363B1 (de) |
| JP (2) | JP5096743B2 (de) |
| AT (1) | ATE469231T1 (de) |
| CA (1) | CA2541294C (de) |
| DE (1) | DE602004027403D1 (de) |
| DK (1) | DK1682667T3 (de) |
| ES (1) | ES2346224T4 (de) |
| IL (1) | IL173859A (de) |
| WO (1) | WO2005049839A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2192172B1 (de) | 2003-02-03 | 2014-12-03 | iBio, Inc. | System zur Expression von Genen in Pflanzen |
| ES2427641T3 (es) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana |
| EP1564295A1 (de) * | 2004-01-23 | 2005-08-17 | Icon Genetics AG | Von RNA Viren abgeleitetes Expressionssystem |
| EP1616959A1 (de) | 2004-07-07 | 2006-01-18 | Icon Genetics AG | Biologisch sichere transiente Proteinexpression in Pflanzen |
| CA2616859C (en) | 2005-08-03 | 2015-04-14 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
| EP1764414A1 (de) | 2005-09-17 | 2007-03-21 | Icon Genetics AG | Partikeln eines Pflanzenvirus, die eine Vielzahl von Fusionsproteinen bestehend aus einem Hüllprotein eines Pflanzenvirus, einem Peptidlinker und einem rekombinanten Protein umfassen, sowie deren Verwendung zur Proteinaufreinigung. |
| CA2642056A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
| AU2007215066A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Production of foreign nucleic acids and polypeptides in plant systems |
| JP2009535306A (ja) | 2006-04-21 | 2009-10-01 | ダウ・アグロサイエンス・エル・エル・シー | 鳥インフルエンザに対するワクチンおよび使用方法 |
| ES2382179T3 (es) * | 2006-05-29 | 2012-06-06 | Icon Genetics Gmbh | Sistema de expresión inducible basado en virus de plantas |
| US8624080B2 (en) | 2006-05-29 | 2014-01-07 | Icon Genetics Gmbh | Plant virus-based inducible expression system |
| US8936937B2 (en) | 2007-01-29 | 2015-01-20 | The Ohio State University Research Foundation | System for expression of genes in plants from a virus-based expression vector |
| CA2689535C (en) | 2007-04-27 | 2015-05-19 | Japan Science And Technology Agency | Viral vector and use thereof |
| CA2692933C (en) | 2007-07-11 | 2016-10-18 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| CA2776144C (en) | 2009-09-29 | 2020-10-27 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| EP2418283A1 (de) | 2010-08-07 | 2012-02-15 | Nomad Bioscience GmbH | Verfahren zum Transfizieren von Pflanzen |
| EP2584042A1 (de) | 2011-10-17 | 2013-04-24 | Nomad Bioscience GmbH | Herstellung, Lagerung und Verwendung von zellwandabbauenden Enzymen |
| EP2647715A1 (de) | 2012-04-03 | 2013-10-09 | Nomad Bioscience GmbH | Agrobakterie zur transienten Transfektion ganzer Pflanzen |
| WO2013154233A1 (ko) * | 2012-04-12 | 2013-10-17 | 한국생명공학연구원 | Ｓｙｃｍｖ 유래의 재조합 바이러스 벡터 및 이의 용도 |
| WO2014129560A1 (ja) | 2013-02-20 | 2014-08-28 | 独立行政法人産業技術総合研究所 | 植物において外来遺伝子を発現させるための核酸分子及び方法 |
| EP2777711A1 (de) | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | HER2/neu-Krebsimpfstoff |
| US20160097056A1 (en) | 2013-05-23 | 2016-04-07 | Nomad Bioscience Gmbh | Process of Providing Plants with Abiotic Stress Resistance |
| EP3097783B1 (de) | 2015-05-26 | 2019-11-13 | Nomad Bioscience GmbH | Colicin m zur kontrolle von ehec |
| EP3178313A1 (de) | 2015-12-09 | 2017-06-14 | Leibniz-Institut für Pflanzenbiochemie | Gen und protein zur synthese von oxidierten zingiberenderivaten |
| EP3372091A1 (de) | 2017-03-07 | 2018-09-12 | Nomad Bioscience GmbH | Verfahren zur verringerung der verschmutzung eines objekts mit clostridium |
| EP3378485A1 (de) | 2017-03-24 | 2018-09-26 | Nomad Bioscience GmbH | Bakteriocine zur kontrolle von salmonella enterica |
| EP3456829A1 (de) | 2017-09-18 | 2019-03-20 | Nomad Bioscience GmbH | Verfahren zur verbesserung der potexviralen vektorstabilität |
| US11633467B2 (en) | 2018-02-15 | 2023-04-25 | Icon Genetics Gmbh | Immunogenic composition and vaccine for generating an immune response to norovirus |
| KR20220021451A (ko) | 2019-03-12 | 2022-02-22 | 아이콘 제네틱스 지엠비에이치 | 안정성이 향상된 노로바이러스 유사 입자 |
| EP3980442A1 (de) | 2019-06-06 | 2022-04-13 | Nomad Bioscience GmbH | Klebicine zur kontrolle von klebsiella |
| CN111349649B (zh) * | 2020-03-16 | 2020-11-17 | 三峡大学 | 一种用于双孢蘑菇的基因编辑的方法及应用 |
| BR112022027078A2 (pt) | 2020-07-16 | 2023-01-31 | Nomad Bioscience Gmbh | Produtos para consumo oral com teor reduzido de açúcar |
| AU2022331129A1 (en) | 2021-08-20 | 2024-02-29 | Nomad Bioscience Gmbh | Sweetener blend comprising thaumatin and brazzein |
| MX2024005239A (es) * | 2021-11-01 | 2024-07-22 | Flagship Pioneering Innovations Vii Llc | Polinucleotidos para modificar organismos. |
| WO2023141540A2 (en) * | 2022-01-20 | 2023-07-27 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
| EP4248987A1 (de) | 2022-03-21 | 2023-09-27 | Nomad Bioscience GmbH | Chimäre bacteriocine und verfahren zur bekämpfung von pseudomonas |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CH14313A (de) | 1897-03-13 | 1897-11-15 | Arthur Petzenbuerger | Stromzuführungsvorrichtung für elektrische Bahnen |
| CH15499A (de) | 1897-11-24 | 1898-06-15 | Friedrich Scharpf | An Tischen, Stühlen etc. befestigbarer Schirm- oder Stockhalter aus Draht |
| CH16888A (de) | 1898-04-22 | 1899-02-28 | M Bissinger Friedricih | Vorrichtung zur Förderung der Pökellake beim Einpökeln von Fleisch |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| CA1280081C (en) | 1984-09-24 | 1991-02-12 | Calgene, Inc. | Plant cell microinjection technique |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US4795855A (en) | 1985-11-14 | 1989-01-03 | Joanne Fillatti | Transformation and foreign gene expression with woody species |
| WO1987006614A1 (en) | 1986-04-30 | 1987-11-05 | Boyce Thompson Institute For Plant Research, Inc. | Electric field mediated dna transformation of plant cells and organelles |
| ATE92530T1 (de) | 1986-05-29 | 1993-08-15 | Calgene Inc | Transformation und expression eines fremden gens in -i(brassica) spezies. |
| AU7335187A (en) | 1986-06-10 | 1987-12-17 | Calgene, Inc. | Agrobacterium transformation of plant tissue |
| NZ224470A (en) | 1987-05-05 | 1991-06-25 | Sandoz Ltd | Method of transforming plant cell material; plant cell material and plants |
| US5840557A (en) * | 1987-07-21 | 1998-11-24 | Mogen International Nv | Method for producing seeds and plants thereof involving an in vitro step |
| EP0317511A3 (de) | 1987-11-18 | 1991-10-16 | Ciba-Geigy Ag | Insektizide Baumwollpflanzenzellen |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5977438A (en) | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| US5955330A (en) | 1989-05-18 | 1999-09-21 | Research Corporation Technologies | Means for enhancing gene expression |
| US6093554A (en) | 1989-10-03 | 2000-07-25 | Aveve N.V. | Genetics manipulations with recombinant DNA virus comprising sequences derived from RNA virus |
| EP0434616B1 (de) | 1989-12-19 | 1995-11-15 | Ciba-Geigy Ag | Verfahren und Vorrichtung zur genetischen Transformation von Zellen |
| CA2036935A1 (en) | 1990-02-26 | 1991-08-27 | Paul Christou | Plant transformation process with early identification of germ line transformation events |
| DK0558676T3 (da) | 1990-11-23 | 2000-09-25 | Aventis Cropscience Nv | Fremgangsmåde til transformering af enkimbladede planter |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| US5187287A (en) | 1992-02-20 | 1993-02-16 | Arco Chemical Technology, L.P. | Lower alkylene oxide purification |
| DE69331055T2 (de) | 1992-04-13 | 2002-06-20 | Syngenta Ltd., Haselmere | Dna-konstruktionen und diese enthaltende pflanzen |
| AU4539593A (en) | 1992-06-23 | 1994-01-24 | South Dakota State University | Transformation of plants by direct injection of dna |
| ATE398679T1 (de) | 1992-07-07 | 2008-07-15 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| ES2194865T3 (es) | 1992-12-30 | 2003-12-01 | Biosource Genetics Corp | Amplificacion viral de arn mensajero recombinante en plantas transgenicas. |
| US5981236A (en) | 1993-02-26 | 1999-11-09 | Calgene Inc | Geminivirus-based gene expression system |
| GB9311593D0 (en) | 1993-06-04 | 1993-07-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5491076A (en) | 1993-11-01 | 1996-02-13 | The Texas A&M University System | Expression of foreign genes using a replicating polyprotein producing virus vector |
| HUP9800353A3 (en) * | 1995-03-03 | 2001-01-29 | Syngenta Participations Ag | Control of gene expression in plants by receptor mediated transactivation in the presence of a chemical ligand |
| CA2146712C (en) | 1995-04-10 | 2002-06-25 | Jas Singh | Cold induced promoter from winter brassica napus |
| US5693512A (en) * | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
| FI972293A (fi) | 1997-05-30 | 1998-12-01 | Joseph Atabekov | Useamman kuin yhden geenin yhteisekspressiomenetelmät |
| CA2298882A1 (en) * | 1997-07-31 | 1999-02-11 | Sanford Scientific, Inc. | Transgenic plants using the tdc gene for crop improvement |
| US6632980B1 (en) * | 1997-10-24 | 2003-10-14 | E. I. Du Pont De Nemours And Company | Binary viral expression system in plants |
| EP1025234A1 (de) | 1997-10-24 | 2000-08-09 | E.I. Du Pont De Nemours And Company | Binäre virale expressionssysteme in pflanzen |
| WO1999025855A1 (en) * | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Mobilization of viral genomes from t-dna using site-specific recombination systems |
| US6063985A (en) | 1998-01-28 | 2000-05-16 | The Rockefeller University | Chemical inducible promotor used to obtain transgenic plants with a silent marker |
| CA2372306A1 (en) * | 1999-03-09 | 2000-09-14 | Large Scale Biology Corp. | Multiple component rna vector system for expression of foreign sequences |
| DE10121283B4 (de) | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
| NZ514547A (en) * | 2001-09-28 | 2004-10-29 | Duncan Stanley | Plastid alph-amylase protein and nucleic acids encoding same and methods for altering the starch content of a plant |
| AU2002314021B2 (en) | 2002-04-30 | 2008-04-10 | Icon Genetics Gmbh | Amplification vectors based on trans-splicing |
| MXPA06003715A (es) | 2003-11-10 | 2006-06-23 | Icon Genetics Ag | Sistema de expresion de planta derivado de virus de arn. |
-
2004
- 2004-11-10 WO PCT/EP2004/012743 patent/WO2005049839A2/en active Application Filing
- 2004-11-10 DE DE602004027403T patent/DE602004027403D1/de active Active
- 2004-11-10 JP JP2006538788A patent/JP5096743B2/ja active Active
- 2004-11-10 DK DK04797791.3T patent/DK1682667T3/da active
- 2004-11-10 EP EP10000553.7A patent/EP2184363B1/de active Active
- 2004-11-10 EP EP04797791A patent/EP1682667B1/de active Active
- 2004-11-10 CA CA2541294A patent/CA2541294C/en active Active
- 2004-11-10 AT AT04797791T patent/ATE469231T1/de active
- 2004-11-10 ES ES04797791T patent/ES2346224T4/es active Active
-
2006
- 2006-02-21 IL IL173859A patent/IL173859A/en active IP Right Grant
-
2010
- 2010-09-21 JP JP2010211319A patent/JP2011024591A/ja active Pending
-
2016
- 2016-01-05 US US14/988,092 patent/US10287602B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP5096743B2 (ja) | 2012-12-12 |
| US10287602B2 (en) | 2019-05-14 |
| ES2346224T4 (es) | 2011-06-01 |
| IL173859A0 (en) | 2006-07-05 |
| JP2007510423A (ja) | 2007-04-26 |
| WO2005049839A2 (en) | 2005-06-02 |
| EP2184363A1 (de) | 2010-05-12 |
| CA2541294C (en) | 2013-06-25 |
| US20160208276A1 (en) | 2016-07-21 |
| EP1682667B1 (de) | 2010-05-26 |
| DK1682667T3 (da) | 2010-08-23 |
| JP2011024591A (ja) | 2011-02-10 |
| EP1682667A2 (de) | 2006-07-26 |
| DE602004027403D1 (de) | 2010-07-08 |
| CA2541294A1 (en) | 2005-06-02 |
| IL173859A (en) | 2012-06-28 |
| ES2346224T3 (es) | 2010-10-13 |
| EP2184363B1 (de) | 2013-08-28 |
| WO2005049839A3 (en) | 2005-11-03 |
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