DK153944C - Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater - Google Patents

Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater

Info

Publication number
DK153944C
DK153944C DK526080A DK526080A DK153944C DK 153944 C DK153944 C DK 153944C DK 526080 A DK526080 A DK 526080A DK 526080 A DK526080 A DK 526080A DK 153944 C DK153944 C DK 153944C
Authority
DK
Denmark
Prior art keywords
substituted
aryl
alpha
group
hydrocarbon
Prior art date
Application number
DK526080A
Other languages
Danish (da)
English (en)
Other versions
DK526080A (da
DK153944B (da
Inventor
Werner Skuballa
Bernd Raduechel
Helmut Vorbrueggen
Walter Elger
Olaf Loge
Ekkehard Schillinger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK526080A publication Critical patent/DK526080A/da
Publication of DK153944B publication Critical patent/DK153944B/da
Application granted granted Critical
Publication of DK153944C publication Critical patent/DK153944C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
DK526080A 1979-12-10 1980-12-10 Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater DK153944C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792950027 DE2950027A1 (de) 1979-12-10 1979-12-10 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE2950027 1979-12-10

Publications (3)

Publication Number Publication Date
DK526080A DK526080A (da) 1981-06-11
DK153944B DK153944B (da) 1988-09-26
DK153944C true DK153944C (da) 1989-02-20

Family

ID=6088285

Family Applications (2)

Application Number Title Priority Date Filing Date
DK526080A DK153944C (da) 1979-12-10 1980-12-10 Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater
DK573687A DK573687A (da) 1979-12-10 1987-11-02 9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK573687A DK573687A (da) 1979-12-10 1987-11-02 9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem.

Country Status (14)

Country Link
US (2) US4444788A (en, 2012)
EP (1) EP0030377B1 (en, 2012)
JP (1) JPS5692860A (en, 2012)
AT (1) ATE6364T1 (en, 2012)
AU (1) AU543797B2 (en, 2012)
CA (1) CA1196327A (en, 2012)
CS (1) CS226419B2 (en, 2012)
DE (2) DE2950027A1 (en, 2012)
DK (2) DK153944C (en, 2012)
ES (1) ES497589A0 (en, 2012)
HU (1) HU183263B (en, 2012)
IE (1) IE51212B1 (en, 2012)
IL (1) IL61669A (en, 2012)
SU (1) SU1026652A3 (en, 2012)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2950027A1 (de) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US5204371A (en) * 1979-12-10 1993-04-20 Schering Aktiengesellschaft Pharmaceutically active 9-chloroprostaglandins
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3148743A1 (de) * 1981-12-04 1983-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-brom-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3325175A1 (de) * 1983-07-08 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen 11-halogen-prostanderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3337450A1 (de) * 1983-10-12 1985-04-25 Schering AG, 1000 Berlin und 4709 Bergkamen Prostaglandine und antigestagene fuer den schwangerschaftsabbruch
DE3347128A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3414509A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 9-halogen-prostaglandine
DE3504044A1 (de) * 1985-02-04 1986-08-07 Schering AG, Berlin und Bergkamen, 1000 Berlin 9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
EP0299914B2 (de) * 1987-07-17 2003-04-23 Schering Aktiengesellschaft 9-Halogen-(Z)-prostaglandinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU624078B2 (en) * 1987-07-17 1992-06-04 Schering Aktiengesellschaft Berlin Und Bergkamen 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
US5891910A (en) * 1987-07-17 1999-04-06 Schering Aktiengesellschaft 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
DE3724189A1 (de) * 1987-07-17 1989-01-26 Schering Ag 9-halogen-(z)-(delta)(pfeil hoch)4(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel
DE3724190A1 (de) * 1987-07-17 1989-01-26 Schering Ag 9-halogen-3-oxa-(z)-(delta)(pfeil hoch)5(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4036140A1 (de) * 1990-11-09 1992-05-14 Schering Ag 9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA2140853A1 (en) * 1992-07-24 1994-02-03 Takehiro Amano Prostaglandin derivatives
DE4229048A1 (de) * 1992-08-31 1994-03-03 Schering Ag Ester von 9-Chlor-Prostaglandinen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
ATE166642T1 (de) * 1992-08-31 1998-06-15 Schering Ag 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
DE4229050A1 (de) * 1992-08-31 1994-03-03 Schering Ag Neue 9-Chlor-Prostaglandin-Ester und -amide
US5972991A (en) * 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
IT1257479B (it) * 1992-12-01 1996-01-25 Derivati prostaglandinici aventi effetti radioprotettivi
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
US5721273A (en) 1993-12-15 1998-02-24 Alcon Laboratories, Inc. Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6235780B1 (en) 1998-07-21 2001-05-22 Ono Pharmaceutical Co., Ltd. ω-cycloalkyl-prostaglandin E1 derivatives
US7563924B2 (en) * 2005-11-21 2009-07-21 Schering Aktiengesellschaft 9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
ES2302122T3 (es) * 2005-11-21 2008-07-01 Bayer Schering Pharma Aktiengesellschaft Derivados de 9-cloro-15-desoxiprostaglandina, proceso para su preparacion y su uso como medicamento.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2517773A1 (de) * 1975-04-18 1976-10-28 Schering Ag Neue 11-oxo-prostaglandin-derivate und verfahren zu ihrer herstellung
US4163016A (en) * 1977-07-05 1979-07-31 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4192799A (en) * 1977-09-21 1980-03-11 The Upjohn Company Conjugates formed by reacting a prostaglandin mimic compound with a carrier molecule
DE2950027A1 (de) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
JPS5692860A (en) 1981-07-27
ES8200336A1 (es) 1981-11-16
DK526080A (da) 1981-06-11
DK573687D0 (da) 1987-11-02
DK573687A (da) 1987-11-02
EP0030377A1 (de) 1981-06-17
CS226419B2 (en) 1984-03-19
IE802572L (en) 1981-06-10
AU6519080A (en) 1981-06-18
DE3066726D1 (en) 1984-03-29
ATE6364T1 (de) 1984-03-15
DE2950027A1 (de) 1981-06-11
US4444788A (en) 1984-04-24
EP0030377B1 (de) 1984-02-22
US5079259A (en) 1992-01-07
ES497589A0 (es) 1981-11-16
IL61669A0 (en) 1981-01-30
SU1026652A3 (ru) 1983-06-30
IE51212B1 (en) 1986-11-12
JPS6224422B2 (en, 2012) 1987-05-28
AU543797B2 (en) 1985-05-02
HU183263B (en) 1984-04-28
IL61669A (en) 1986-08-31
DK153944B (da) 1988-09-26
CA1196327A (en) 1985-11-05

Similar Documents

Publication Publication Date Title
DK153944C (da) Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater
ES508124A0 (es) "procedimiento para la preparacion de derivados de carbaciclina".
NO159174C (no) Fluorerte kopolymerer, samt fremgangsmaate ved fremstilling derav.
DK123587A (da) Analogifremgangsmaade til fremstilling af 9-fluor-prostaglandinderivater
DK154022C (da) Fremgangsmaade til fremstilling af benzothiazepinderivater
DK292579A (da) Fremgangsmaade til fremstilling af 3,20-dioxo-4,9-dien-21-hydroxylsteroider
SE7705423L (sv) Forfarande for framstellning av prostaglandinderivat
MX9203752A (es) Novedosos derivados de acido p-oxibenzoico y procedimiento para la preparacion de los mismos y su uso como medicamentos.
GB2018750A (en) Methyltetrahalobenzylacrylates and methacrylates, and polymers and plastics compositions based thereon
SE7706245L (sv) Forfarande for framstellning av prostacyklinderivat
DK146246C (da) Fremgangsmaade til fremstilling af 17alfa-hydroxy-etiocarboxylsyrer eller 17aalfa-hydroxy-d-homo-etiocarboxylsyrer
KR830004243A (ko) 5,6-디하이드로 pgi₁동족체의 제조방법
PT74184B (fr) Procede de preparation de nouveaux derives steroides 3-ceto delta 4 ou delta 1, 4 substitues en position 7
CH609682A5 (en) Process for the preparation of compounds analogous to prostaglandins
ATE60785T1 (de) Verfahren zur herstellung von estran-derivaten.
KR880701272A (ko) r-1-시아노-1-R²-시스-4-R¹-시클로헥산 화합물
ES395036A2 (es) Procedimiento para producir un compuesto opticamente acti- vo.
JPS53132069A (en) Production of fluorine-containing membrane
GB1537199A (en) Intermediates in the preparation of sterols
ES451289A1 (es) Un procedimiento para la preparacion de hornoesterprocedimiento para la preparacion de derivados de oides. benzofura-no.
ES517915A0 (es) Procedimiento para la preparacion de derivados 9-bromo-prostanicos.

Legal Events

Date Code Title Description
PBP Patent lapsed