DK151808C - Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater - Google Patents

Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Info

Publication number
DK151808C
DK151808C DK510282A DK510282A DK151808C DK 151808 C DK151808 C DK 151808C DK 510282 A DK510282 A DK 510282A DK 510282 A DK510282 A DK 510282A DK 151808 C DK151808 C DK 151808C
Authority
DK
Denmark
Prior art keywords
hydrogen
formula
image
oxadiazolylimidazo
preparation
Prior art date
Application number
DK510282A
Other languages
Danish (da)
English (en)
Other versions
DK151808B (da
DK510282A (da
Inventor
Claus Thyco Braestrup
Joergen Anders Christensen
Mogens Engelstoft
Frank Waetjen
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan As filed Critical Ferrosan As
Priority to DK510282A priority Critical patent/DK151808C/da
Priority to FI834137A priority patent/FI78095C/fi
Priority to EP83730110A priority patent/EP0109921B1/en
Priority to AT83730110T priority patent/ATE32721T1/de
Priority to DE8383730110T priority patent/DE3375785D1/de
Priority to IE2644/83A priority patent/IE56233B1/xx
Priority to JP58213456A priority patent/JPS59104385A/ja
Priority to US06/551,818 priority patent/US4507313A/en
Priority to ES83527295A priority patent/ES8504196A1/es
Priority to NO834187A priority patent/NO163820C/no
Priority to ES529150A priority patent/ES529150A0/es
Priority to ES529149A priority patent/ES8507143A1/es
Publication of DK510282A publication Critical patent/DK510282A/da
Priority to DK123685A priority patent/DK151809C/da
Publication of DK151808B publication Critical patent/DK151808B/da
Application granted granted Critical
Publication of DK151808C publication Critical patent/DK151808C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DK510282A 1982-11-15 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater DK151808C (da)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DK510282A DK151808C (da) 1982-11-16 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
FI834137A FI78095C (fi) 1982-11-16 1983-11-11 Foerfarande foer framstaellning av som psykofarmaceutiska medel anvaendbara oxadiazolyl-imidazo/1,4/ bensodiazepinderivat.
EP83730110A EP0109921B1 (en) 1982-11-16 1983-11-12 Benzodiazepine receptors and their preparation
AT83730110T ATE32721T1 (de) 1982-11-16 1983-11-12 Benzodiazepin-rezeptoren und ihre herstellung.
DE8383730110T DE3375785D1 (en) 1982-11-16 1983-11-12 Benzodiazepine receptors and their preparation
IE2644/83A IE56233B1 (en) 1982-11-16 1983-11-14 Benzodiazepine receptors and their preparation
JP58213456A JPS59104385A (ja) 1982-11-16 1983-11-15 オキサジアゾリル−イミダゾ−〔１，４〕ベンゾジアゼピン誘導体、その製法及びこれを含有する中枢神経系疾患治療剤
US06/551,818 US4507313A (en) 1982-11-15 1983-11-15 Oxadiazolyl-imidazo-[1,4]benzodiazepines and their use in treatment of diseases of the central nervous system
ES83527295A ES8504196A1 (es) 1982-11-16 1983-11-15 Metodo de preparar derivados de oxadiazolil-imidazo (1,4) benzodiazepina
NO834187A NO163820C (no) 1982-11-16 1983-11-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive oksadiazolylbenzodiazepinderivater.
ES529150A ES529150A0 (es) 1982-11-16 1984-01-25 Metodo de preparar derivados de oxadiazolil-imidazo (1, 4) benzodiazepina
ES529149A ES8507143A1 (es) 1982-11-16 1984-01-25 Metodo de preparar derivados de oxadiazolil-imidazo (1, 4) benzodiazepina
DK123685A DK151809C (da) 1982-11-16 1985-03-19 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK510282 1982-11-16
DK510282A DK151808C (da) 1982-11-16 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Publications (3)

Publication Number Publication Date
DK510282A DK510282A (da) 1984-05-17
DK151808B DK151808B (da) 1988-01-04
DK151808C true DK151808C (da) 1988-06-20

Family

ID=8139462

Family Applications (1)

Application Number Title Priority Date Filing Date
DK510282A DK151808C (da) 1982-11-15 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Country Status (10)

Country Link
US (1) US4507313A (enExample)
EP (1) EP0109921B1 (enExample)
JP (1) JPS59104385A (enExample)
AT (1) ATE32721T1 (enExample)
DE (1) DE3375785D1 (enExample)
DK (1) DK151808C (enExample)
ES (3) ES8504196A1 (enExample)
FI (1) FI78095C (enExample)
IE (1) IE56233B1 (enExample)
NO (1) NO163820C (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DE202441T1 (de) * 1985-05-17 1987-03-19 Aktieselskabet Ferrosan, Soeborg Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4622321A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
EP0226282B1 (en) * 1985-10-17 1989-07-05 A/S Ferrosan Heterocyclic compounds and their preparation and use
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A7 (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
GB8923008D0 (en) * 1989-10-12 1989-11-29 Roussel Lab Ltd Chemical compounds
GB8927928D0 (en) * 1989-12-11 1990-02-14 Roussel Lab Ltd Chemical compounds
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5317018A (en) * 1992-06-09 1994-05-31 Armin Walser Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
DK0730581T3 (da) * 1993-11-22 2001-11-26 Merck & Co Inc 3-acylaminobezazepiner
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5658901A (en) * 1994-08-18 1997-08-19 Merck & Co., Inc. 2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
ATE235472T1 (de) * 1995-06-07 2003-04-15 Merck & Co Inc N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepi - 3-yl)-3-amide
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
CN101827597B (zh) * 2007-08-20 2013-03-13 伊沃泰克国际有限责任公司 睡眠障碍的治疗
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
US10071427B2 (en) * 2014-09-05 2018-09-11 Mazak Corporation Vertical machine tool apparatus and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT361486B (de) * 1975-08-07 1981-03-10 Hoffmann La Roche Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines

Also Published As

Publication number Publication date
JPS635031B2 (enExample) 1988-02-01
ES527295A0 (es) 1985-04-16
ATE32721T1 (de) 1988-03-15
DK151808B (da) 1988-01-04
ES529149A0 (es) 1985-09-01
ES8507143A1 (es) 1985-09-01
ES8507144A1 (es) 1985-09-01
US4507313A (en) 1985-03-26
NO163820C (no) 1990-08-01
NO163820B (no) 1990-04-17
FI834137A0 (fi) 1983-11-11
NO834187L (no) 1984-05-18
JPS59104385A (ja) 1984-06-16
EP0109921A1 (en) 1984-05-30
IE832644L (en) 1984-05-15
ES529150A0 (es) 1985-09-01
ES8504196A1 (es) 1985-04-16
DK510282A (da) 1984-05-17
FI78095C (fi) 1989-06-12
IE56233B1 (en) 1991-05-22
FI834137A7 (fi) 1984-05-17
DE3375785D1 (en) 1988-04-07
FI78095B (fi) 1989-02-28
EP0109921B1 (en) 1988-03-02

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