DK150203C - Fremgangsmaade til fremstilling af alfa-anomere af anthracyclinglycosider eller hydrochlorider deraf - Google Patents

Fremgangsmaade til fremstilling af alfa-anomere af anthracyclinglycosider eller hydrochlorider deraf

Info

Publication number
DK150203C
DK150203C DK189676A DK189676A DK150203C DK 150203 C DK150203 C DK 150203C DK 189676 A DK189676 A DK 189676A DK 189676 A DK189676 A DK 189676A DK 150203 C DK150203 C DK 150203C
Authority
DK
Denmark
Prior art keywords
anthracycling
lycosides
anomers
hydrochlorides
procedure
Prior art date
Application number
DK189676A
Other languages
Danish (da)
English (en)
Other versions
DK189676A (da
DK150203B (da
Inventor
Federico Arcamone
Alberto Bargiotti
Aurelio Di Marco
Sergio Penco
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of DK189676A publication Critical patent/DK189676A/da
Publication of DK150203B publication Critical patent/DK150203B/da
Application granted granted Critical
Publication of DK150203C publication Critical patent/DK150203C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • G—PHYSICS
    • G04—HOROLOGY
    • G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
    • G04B37/00—Cases
    • G04B37/0008—Cases for pocket watches and wrist watches
    • G04B37/0025—Cases for pocket watches and wrist watches with cover or bottom with a spring (savonette) bench watches opening or closing with spring action G04B37/0463
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK189676A 1975-04-30 1976-04-28 Fremgangsmaade til fremstilling af alfa-anomere af anthracyclinglycosider eller hydrochlorider deraf DK150203C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB18098/75A GB1506200A (en) 1975-04-30 1975-04-30 Glycosides
GB1809875 1975-04-30

Publications (3)

Publication Number Publication Date
DK189676A DK189676A (da) 1976-10-31
DK150203B DK150203B (da) 1987-01-05
DK150203C true DK150203C (da) 1987-11-02

Family

ID=10106621

Family Applications (1)

Application Number Title Priority Date Filing Date
DK189676A DK150203C (da) 1975-04-30 1976-04-28 Fremgangsmaade til fremstilling af alfa-anomere af anthracyclinglycosider eller hydrochlorider deraf

Country Status (16)

Country Link
US (1) US4112076A (fr)
JP (1) JPS51133262A (fr)
AT (1) AT345457B (fr)
AU (1) AU500439B2 (fr)
BE (1) BE841266A (fr)
CA (1) CA1061335A (fr)
CH (1) CH624125A (fr)
DE (1) DE2618822C3 (fr)
DK (1) DK150203C (fr)
ES (1) ES447433A1 (fr)
FR (1) FR2309234A1 (fr)
GB (1) GB1506200A (fr)
NL (1) NL179587C (fr)
SE (2) SE431875B (fr)
SU (1) SU728719A3 (fr)
ZA (1) ZA762562B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374333A1 (fr) * 1976-12-20 1978-07-13 Inst Int Pathologie Cellulaire Nouveaux derives du naphtacene, leur preparation et les compositions qui les contiennent
GB1550879A (en) * 1976-12-22 1979-08-22 Farmaceutici Italia Antitumour glycosides
GB1567392A (en) * 1977-02-22 1980-05-14 Farmaceutici Italia Daunorubicin derivatives
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IT1196402B (it) * 1978-11-21 1988-11-16 Erba Farmitalia Antibiotici antitumorali
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
JPS5673039A (en) * 1979-08-20 1981-06-17 Hoffmann La Roche Naphthacene derivative
DE3060472D1 (en) * 1979-09-01 1982-07-15 Erba Farmitalia Anthracycline glycosides, processes for their preparation and pharmaceutical composition containing them
US4345068A (en) * 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
US4298726A (en) * 1980-03-07 1981-11-03 Purdue University Synthesis of N-benzoyl-L-ristosamine and intermediates used in its preparation
US4301276A (en) * 1980-03-07 1981-11-17 Purdue University Synthesis of daunosamine hydrochloride and intermediates used in its preparation
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
YU204982A (en) * 1981-09-18 1985-03-20 Erba Farmitalia Process for obtaining 3'-deamino anlogs of glycoside anthracycline antibiotics
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
DE3641835A1 (de) * 1986-12-08 1988-06-16 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
EP1638509B1 (fr) * 2003-07-02 2015-12-30 Solux Corporation Hydrochlorure d'epirubicine cristalline thermiquement stable et procede de fabrication correspondant
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CN101331147B (zh) * 2005-12-13 2011-11-30 苏洛克股份有限公司 用于制备4-脱甲基柔红霉素的方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2636676A3 (fr) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Cristallisation dýépidaunorubicine x HCI
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CN103204888B (zh) * 2012-01-15 2016-08-17 山东新时代药业有限公司 一种盐酸表柔比星中间体的制备方法
KR102155411B1 (ko) 2015-03-30 2020-09-11 메이지 세이카 파루마 가부시키가이샤 에피루비신 제조방법 및 그의 신규한 제조 중간체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
GB1470860A (en) * 1974-10-29 1977-04-21 Farmaceutici Italia Anthracycline glycosides

Also Published As

Publication number Publication date
ES447433A1 (es) 1977-07-01
US4112076A (en) 1978-09-05
SE431875B (sv) 1984-03-05
NL7604049A (nl) 1976-11-02
DK189676A (da) 1976-10-31
JPS51133262A (en) 1976-11-18
FR2309234B1 (fr) 1978-08-25
AU500439B2 (en) 1979-05-24
BE841266A (fr) 1976-10-29
NL179587B (nl) 1986-05-01
CH541176A4 (fr) 1981-07-15
SE7604908L (sv) 1976-10-31
CA1061335A (fr) 1979-08-28
FR2309234A1 (fr) 1976-11-26
DK150203B (da) 1987-01-05
DE2618822B2 (de) 1982-09-16
ATA302676A (de) 1978-01-15
DE2618822A1 (de) 1976-11-11
SE8001615L (sv) 1980-02-29
ZA762562B (en) 1977-04-27
NL179587C (nl) 1986-10-01
SE436884B (sv) 1985-01-28
SU728719A3 (ru) 1980-04-15
CH624125A (fr) 1981-07-15
AT345457B (de) 1978-09-25
AU1339076A (en) 1977-11-03
DE2618822C3 (de) 1983-04-28
JPS5619878B2 (fr) 1981-05-09
GB1506200A (en) 1978-04-05

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