DK149749C - Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater - Google Patents

Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater

Info

Publication number
DK149749C
DK149749C DK269178A DK269178A DK149749C DK 149749 C DK149749 C DK 149749C DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A DK 149749 C DK149749 C DK 149749C
Authority
DK
Denmark
Prior art keywords
ingrediates
piperide
trihydroxy
hydroxy
alkyl
Prior art date
Application number
DK269178A
Other languages
Danish (da)
English (en)
Other versions
DK269178A (da
DK149749B (da
Inventor
Hiromu Murai
Hiroshi Enomoto
Yoshiaki Aoyagi
Yoshiaki Yoshikuni
Masahiro Yagi
Ichiro Shirahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK269178A publication Critical patent/DK269178A/da
Publication of DK149749B publication Critical patent/DK149749B/da
Application granted granted Critical
Publication of DK149749C publication Critical patent/DK149749C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK269178A 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater DK149749C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP52075936A JPS5943459B2 (ja) 1977-06-25 1977-06-25 Ｎ−アルキルピペリジン誘導体
JP7593677 1977-06-25

Publications (3)

Publication Number Publication Date
DK269178A DK269178A (da) 1978-12-26
DK149749B DK149749B (da) 1986-09-22
DK149749C true DK149749C (da) 1987-03-02

Family

ID=13590624

Family Applications (1)

Application Number Title Priority Date Filing Date
DK269178A DK149749C (da) 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater

Country Status (12)

Country Link
US (1) US4182767A (OSRAM)
JP (1) JPS5943459B2 (OSRAM)
AT (1) AT365576B (OSRAM)
BE (1) BE868329A (OSRAM)
CH (1) CH633264A5 (OSRAM)
DE (1) DE2824781C3 (OSRAM)
DK (1) DK149749C (OSRAM)
FR (1) FR2420529A1 (OSRAM)
GB (1) GB1555654A (OSRAM)
IT (1) IT1104743B (OSRAM)
NL (1) NL176071C (OSRAM)
SE (1) SE430333B (OSRAM)

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DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2835069A1 (de) * 1978-08-10 1980-02-21 Bayer Ag N-amino-3,4,5-trihydroxypiperidine, ihre herstellung und verwendung
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
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US5310745A (en) * 1988-11-03 1994-05-10 G. D. Searle & Co. Antiviral compounds
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US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4937357A (en) * 1988-11-03 1990-06-26 G. D. Searle & Co. Intermediates for antiviral compounds
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US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) * 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
EP0453692A1 (en) * 1990-04-27 1991-10-30 Merrell Dow Pharmaceuticals Inc. Novel nojirimycin derivatives
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US6291657B1 (en) * 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
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US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
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AU762125B2 (en) 1998-02-12 2003-06-19 G.D. Searle & Co. Use of (N)-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1165080A2 (en) * 1999-02-12 2002-01-02 G.D. SEARLE & CO. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
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US20050032841A1 (en) * 1999-04-20 2005-02-10 Steven Walkley Therapeutic compositions and methods of treating glycolipid storage related disorders
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BRPI0517701A8 (pt) * 2004-11-10 2018-01-23 Genzyme Corp métodos de tratamento de diabetes mellitus
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CL2007000667A1 (es) * 2006-03-14 2008-03-14 Ranbaxi Lab Ltd Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e
ES2546181T3 (es) * 2006-05-09 2015-09-21 Genzyme Corporation Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos
MX2009000439A (es) * 2006-07-14 2009-02-04 Ranbaxy Lab Ltd Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
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US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594563B1 (en) 2007-05-31 2018-07-18 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
CA2701649C (en) 2007-10-05 2016-05-24 Genzyme Corporation Method of treating polycystic kidney diseases with ceramide derivatives
CA2731685A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
CN102271678B (zh) * 2008-10-03 2017-06-30 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂
EP2398321B1 (en) * 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
US20100222384A1 (en) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
EP2440205B1 (en) * 2009-06-12 2014-08-27 United Therapeutics Corporation Iminosugars for use in the treatment of bunyaviral and togaviral diseases
CA2772875A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
JP5575246B2 (ja) * 2009-09-04 2014-08-20 ユナイテッド セラピューティクス コーポレイション ポックスウイルス感染の治療方法
KR20120081990A (ko) * 2009-09-04 2012-07-20 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당 및 필로바이러스 질환의 치료 방법
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EP4106752A4 (en) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS

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DE2656602C3 (de) * 1975-12-29 1981-11-26 Nippon Shinyaku Co., Ltd., Kyoto Verfahren zum Extrahieren von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin aus Maulbeerpflanzen
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels

Also Published As

Publication number Publication date
FR2420529A1 (fr) 1979-10-19
US4182767A (en) 1980-01-08
DK269178A (da) 1978-12-26
IT7849760A0 (it) 1978-06-07
NL7805253A (nl) 1978-12-28
DE2824781B2 (OSRAM) 1980-01-31
AT365576B (de) 1982-01-25
SE7805329L (sv) 1978-12-26
BE868329A (fr) 1978-10-16
DK149749B (da) 1986-09-22
CH633264A5 (de) 1982-11-30
SE430333B (sv) 1983-11-07
NL176071C (nl) 1985-02-18
DE2824781A1 (de) 1979-01-04
NL176071B (nl) 1984-09-17
GB1555654A (en) 1979-11-14
FR2420529B1 (OSRAM) 1984-10-12
DE2824781C3 (de) 1980-09-18
JPS5412381A (en) 1979-01-30
JPS5943459B2 (ja) 1984-10-22
IT1104743B (it) 1985-10-28
ATA451778A (de) 1981-06-15

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PBP Patent lapsed