DK1492874T3 - Multigene vektorplasmider og fremgangsmåder til forøgelse af ekspressionen af rekombinante polypeptider - Google Patents

Multigene vektorplasmider og fremgangsmåder til forøgelse af ekspressionen af rekombinante polypeptider

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Publication number
DK1492874T3
DK1492874T3 DK03808015.6T DK03808015T DK1492874T3 DK 1492874 T3 DK1492874 T3 DK 1492874T3 DK 03808015 T DK03808015 T DK 03808015T DK 1492874 T3 DK1492874 T3 DK 1492874T3
Authority
DK
Denmark
Prior art keywords
expression
methods
recombinant polypeptides
enhancing
vector plasmids
Prior art date
Application number
DK03808015.6T
Other languages
English (en)
Inventor
Arnold H Horwitz
Original Assignee
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd filed Critical Xoma Technology Ltd
Application granted granted Critical
Publication of DK1492874T3 publication Critical patent/DK1492874T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
DK03808015.6T 2002-03-29 2003-03-31 Multigene vektorplasmider og fremgangsmåder til forøgelse af ekspressionen af rekombinante polypeptider DK1492874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36853002P 2002-03-29 2002-03-29
PCT/US2003/010154 WO2004033693A1 (en) 2002-03-29 2003-03-31 Methods vectors plasmids and methods for increasing expression of recombinant polypeptides

Publications (1)

Publication Number Publication Date
DK1492874T3 true DK1492874T3 (da) 2011-03-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK03808015.6T DK1492874T3 (da) 2002-03-29 2003-03-31 Multigene vektorplasmider og fremgangsmåder til forøgelse af ekspressionen af rekombinante polypeptider

Country Status (9)

Country Link
US (4) US7192737B2 (da)
EP (2) EP2311962B1 (da)
JP (2) JP4554370B2 (da)
AT (1) ATE496134T1 (da)
AU (2) AU2003300588B2 (da)
CA (1) CA2492008C (da)
DE (1) DE60335794D1 (da)
DK (1) DK1492874T3 (da)
WO (1) WO2004033693A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100311954A1 (en) * 2002-03-01 2010-12-09 Xencor, Inc. Optimized Proteins that Target Ep-CAM
WO2004033693A1 (en) 2002-03-29 2004-04-22 Xoma Technology Ltd. Methods vectors plasmids and methods for increasing expression of recombinant polypeptides
US20050009097A1 (en) * 2003-03-31 2005-01-13 Better Marc D. Human engineered antibodies to Ep-CAM
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
CA2531698A1 (en) * 2003-07-09 2005-01-27 Sentigen Biosciences, Inc. Method for assaying protein-protein interaction
US20050202539A1 (en) * 2004-03-11 2005-09-15 Hydra Biosciences System for screening eukaryotic membrane proteins
WO2006060769A2 (en) * 2004-12-03 2006-06-08 Xoma Technology Ltd. Methods and materials for expression of a recombinant protein
US20060154336A1 (en) * 2004-12-14 2006-07-13 Millennium Pharmaceuticals, Inc. Nucleic acid molecules for optimized CAB-2 expression and their use
US20070072174A1 (en) * 2005-09-28 2007-03-29 Sayler Gary S Bioreporter for detection of microbes
EP1783228A1 (en) * 2005-11-08 2007-05-09 ETH Zürich Recombinant expression of multiprotein complexes using polygenes
EP2010569A4 (en) 2006-03-20 2009-09-09 Xoma Technology Ltd FOR GASTRIN SPECIFIC HUMAN ANTIBODIES, MATERIALS AND METHODS
GEP20125612B (en) 2006-08-18 2012-08-27 Novartis Ag Prlr-specific antibody and usage thereof
WO2008070780A1 (en) 2006-12-07 2008-06-12 Novartis Ag Antagonist antibodies against ephb3
AU2008233196B2 (en) * 2007-03-30 2011-10-13 Abbvie Inc. Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells
US8071332B2 (en) * 2007-08-10 2011-12-06 Toto Ltd. Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest
CN101918579A (zh) 2007-10-22 2010-12-15 先灵公司 完全人抗-vegf抗体和使用方法
WO2011009090A1 (en) * 2009-07-16 2011-01-20 Xoma Technology Ltd. Antibodies to high molecular weight melanoma associated antigen
CN102549160B (zh) * 2009-07-29 2014-04-02 希格马托制药工业公司 改善的人长五聚环蛋白3表达系统及其用途
WO2012011955A2 (en) * 2010-07-21 2012-01-26 Duke University Compositions and methods for production and screening of monoclonal antibodies
WO2012077128A1 (en) * 2010-12-07 2012-06-14 Intas Biopharmaceuticals Limited A novel cell line development process to produce recombinant proteins using twin vector expression system
CA2904125C (en) * 2013-03-12 2022-06-07 Cmc Icos Biologics, Inc. Improved recombinant protein expression using a hybrid chef1 promoter
US9388239B2 (en) 2014-05-01 2016-07-12 Consejo Nacional De Investigation Cientifica Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
AR102333A1 (es) 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas
WO2018047154A1 (en) 2016-09-07 2018-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-nkp46 antibodies and therapeutic use of same
US10318741B2 (en) 2016-11-21 2019-06-11 Bank Of America Corporation Data security and risk ranking tool
IL253984A0 (en) 2017-08-14 2017-09-28 Yeda Res & Dev Immunotherapy against aranviruses that bind through transferrin receptor 1 (tfr1
JP7278261B2 (ja) * 2017-08-23 2023-05-19 ノバルティス アーゲー マルチコピー遺伝子タンパク質発現系
CA3069238A1 (en) * 2017-11-02 2019-05-09 Systimmune, Inc. Bispecific antibodies and methods of making and using thereof
IL276627A (en) 2020-08-10 2022-03-01 Yeda Res & Dev Compositions for diagnosis and treatment of coronavirus infections

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612282A (en) 1981-12-15 1986-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Monoclonal antibodies reactive with human breast cancer
US4880741A (en) * 1983-10-06 1989-11-14 Pfizer Inc. Process for transformation of Yarrowia lipolytica
IN163393B (da) * 1983-10-06 1988-09-17 Pfizer
US5198541A (en) 1987-08-11 1993-03-30 New York University Dna encoding bactericidal/permeability-increasing proteins
US5576184A (en) 1988-09-06 1996-11-19 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
ES2202310T3 (es) 1991-12-13 2004-04-01 Xoma Corporation Metodos y materiales para la preparacion de dominios variables de anticuerpos modificados y sus usos terapeuticos.
WO1993023434A2 (en) 1992-05-19 1993-11-25 Xoma Corporation Bpi-immunoglobulin fusion proteins
WO1993023540A2 (en) 1992-05-19 1993-11-25 Xoma Corporation Improved methods for the preparation of endotoxin-binding proteins
US5420019A (en) 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
US5652332A (en) 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5733872A (en) 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
DK0690872T3 (da) 1993-03-12 1999-05-10 Xoma Corp Biologisk aktive peptider fra funktionelle domæner af baktericidt/permeabilitetsforøgende protein og anvendelser deraf
US5348942A (en) 1993-03-12 1994-09-20 Xoma Corporation Therapeutic uses of bactericidal/permeability increasing protein products
JPH08509703A (ja) 1993-03-12 1996-10-15 ゾーマ コーポレイション 殺菌／透過性増加タンパク質産物の治療用途
US5447913A (en) 1994-03-11 1995-09-05 Xoma Corporation Therapeutic uses of bactericidal/permeability-increasing protein dimer products
AU709738B2 (en) 1994-09-15 1999-09-02 Xoma Corporation Anti-fungal peptides
US5866402A (en) 1995-05-05 1999-02-02 Chiron Corporation Chimeric MCP and DAF proteins with cell surface localizing domain
CA2227292A1 (en) 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
US5851802A (en) 1996-03-22 1998-12-22 Xoma Corporation Methods for recombinant microbial production of fusion proteins and BPI-derived peptides
US5998174A (en) 1997-05-12 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Multigene vectors
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
EP1228237A1 (en) 1999-11-01 2002-08-07 Chiron Corporation Expression vectors, transfection systems, and method of use thereof
US6908751B2 (en) * 2000-04-26 2005-06-21 Zymogenetics, Inc. Methods for enhancing the expression of a protein of interest by recombinant host cells
WO2004033693A1 (en) * 2002-03-29 2004-04-22 Xoma Technology Ltd. Methods vectors plasmids and methods for increasing expression of recombinant polypeptides
US9320293B2 (en) 2008-06-06 2016-04-26 Gold Medal Products Company Popcorn kettle
US9402401B1 (en) 2008-11-03 2016-08-02 William P. Benzel Extruded three loop pretzel having a twist-knot appearance at its middle portion, apparatus and die for making said pretzel, and method of forming said pretzel
CA2816272C (en) 2009-10-28 2017-06-27 Advanced Businesslink Corporation Role-based modernization of legacy applications
CN103282977B (zh) 2010-12-28 2016-06-08 日立金属株式会社 铁氧体烧结磁体及其制造方法
WO2013172339A1 (ja) 2012-05-15 2013-11-21 大鵬薬品工業株式会社 腹圧性尿失禁予防剤及び／又は治療剤
US9410427B2 (en) 2012-06-05 2016-08-09 United Technologies Corporation Compressor power and torque transmitting hub
AU2013334776B2 (en) 2012-10-22 2017-08-31 ZS Pharma, Inc. Microporous zirconium silicate for treating hyperkalemia
JP6453542B2 (ja) 2013-02-14 2019-01-16 ソウル セミコンダクター カンパニー リミテッド 半導体装置及びこれの製造方法
KR20150087669A (ko) 2014-01-22 2015-07-30 삼성전기주식회사 컨커런트 다중밴드 고주파 증폭회로
US9503125B2 (en) 2014-05-08 2016-11-22 Sandisk Technologies Llc Modified trellis-based min-max decoder for non-binary low-density parity-check error-correcting codes
US9402465B1 (en) 2014-06-11 2016-08-02 Paul Edward LaForge Shaving brush with vented holder
US9218176B1 (en) 2014-06-13 2015-12-22 International Business Machines Corporation Software deployment in a distributed virtual machine environment

Also Published As

Publication number Publication date
US7993915B2 (en) 2011-08-09
US20120178126A1 (en) 2012-07-12
US8497096B2 (en) 2013-07-30
EP1492874A1 (en) 2005-01-05
AU2009200829A1 (en) 2009-03-19
US20030203447A1 (en) 2003-10-30
US20070281334A1 (en) 2007-12-06
CA2492008C (en) 2012-06-26
AU2003300588B2 (en) 2008-12-04
DE60335794D1 (de) 2011-03-03
JP2005528925A (ja) 2005-09-29
JP2006141415A (ja) 2006-06-08
CA2492008A1 (en) 2004-04-22
US20080145895A1 (en) 2008-06-19
WO2004033693A1 (en) 2004-04-22
EP2311962B1 (en) 2013-03-13
AU2003300588A1 (en) 2004-05-04
EP2311962A1 (en) 2011-04-20
JP4554370B2 (ja) 2010-09-29
ATE496134T1 (de) 2011-02-15
EP1492874B1 (en) 2011-01-19
US7192737B2 (en) 2007-03-20

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