DK14688D0 - Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler - Google Patents

Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler

Info

Publication number
DK14688D0
DK14688D0 DK014688A DK14688A DK14688D0 DK 14688 D0 DK14688 D0 DK 14688D0 DK 014688 A DK014688 A DK 014688A DK 14688 A DK14688 A DK 14688A DK 14688 D0 DK14688 D0 DK 14688D0
Authority
DK
Denmark
Prior art keywords
groups
group
heteroatoms
hydroxyl
alkyl
Prior art date
Application number
DK014688A
Other languages
English (en)
Other versions
DK14688A (da
Inventor
Alfred Mertens
Wolfgang Von Der Saal
Erwin Boehm
Klaus Strein
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK14688D0 publication Critical patent/DK14688D0/da
Publication of DK14688A publication Critical patent/DK14688A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Amplifiers (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK014688A 1987-01-17 1988-01-13 Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler DK14688A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873701277 DE3701277A1 (de) 1987-01-17 1987-01-17 Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
DK14688D0 true DK14688D0 (da) 1988-01-13
DK14688A DK14688A (da) 1988-07-18

Family

ID=6319010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK014688A DK14688A (da) 1987-01-17 1988-01-13 Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler

Country Status (14)

Country Link
US (2) US4954498A (da)
EP (1) EP0275888B1 (da)
JP (1) JPS63192773A (da)
KR (1) KR880009019A (da)
AT (1) ATE103915T1 (da)
DD (1) DD272649A5 (da)
DE (2) DE3701277A1 (da)
DK (1) DK14688A (da)
FI (1) FI880182A (da)
HU (1) HU205354B (da)
IL (1) IL85069A0 (da)
MX (1) MX10126A (da)
PT (1) PT86561B (da)
ZA (1) ZA88263B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JPH07509215A (ja) * 1990-11-14 1995-10-12 カイロン　コーポレイション ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物
US5661147A (en) * 1993-09-03 1997-08-26 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
US5476851A (en) * 1994-09-08 1995-12-19 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase
WO1999007701A1 (en) * 1997-08-05 1999-02-18 Sugen, Inc. Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
US5932580A (en) * 1997-12-01 1999-08-03 Yissum Research And Development Company Of The Hebrew University Of Jerusalem PDGF receptor kinase inhibitory compounds their preparation and compositions
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
JP2002502844A (ja) * 1998-02-03 2002-01-29 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
CA2333643A1 (en) * 1998-06-30 2000-01-06 James D. Rodgers Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
US6358954B1 (en) * 1999-11-09 2002-03-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
US6423844B1 (en) 2001-06-06 2002-07-23 The United States Of America As Represented By The Secretary Of The Navy Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
TW200403223A (en) * 2002-02-15 2004-03-01 Glaxo Group Ltd Novel compounds
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
WO2006108489A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
CN101160312A (zh) * 2005-04-14 2008-04-09 霍夫曼-拉罗奇有限公司 三环吡咯衍生物、它们的制备和作为药剂的应用
JP2009519279A (ja) * 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用
US20090291968A1 (en) * 2006-03-23 2009-11-26 Guy Georges Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
US20140309257A1 (en) * 2011-11-11 2014-10-16 The Regents Of The University Of Colorado, A Body Corporate Topoisomerase inhibitors and methods of making and use as therapeutic agents
HUE036600T2 (hu) * 2013-10-03 2018-07-30 Kura Oncology Inc ERK inhibitorok és alkalmazási eljárások
CN111278816B (zh) 2017-09-04 2024-03-15 C4医药公司 二氢喹啉酮
CN112638881A (zh) * 2018-07-31 2021-04-09 普林斯顿大学托管委员会 用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物
AU2022262654A1 (en) * 2021-04-22 2023-10-19 Kayothera Inc. Heterocyclic compounds and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148930B (da) * 1977-09-19 1981-07-25 Hoffmann La Roche
US4352931A (en) * 1980-05-22 1982-10-05 Siegfried Aktiengesellschaft Lin-benzoaminopurinols
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3410168A1 (de) * 1984-03-20 1985-09-26 Boehringer Mannheim Gmbh, 6800 Mannheim Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

Also Published As

Publication number Publication date
AU605822B2 (en) 1991-01-24
DE3888854D1 (de) 1994-05-11
EP0275888A3 (en) 1989-09-27
US5116843A (en) 1992-05-26
HUT46915A (en) 1988-12-28
FI880182A0 (fi) 1988-01-15
HU205354B (en) 1992-04-28
JPS63192773A (ja) 1988-08-10
PT86561B (pt) 1991-12-31
US4954498A (en) 1990-09-04
ATE103915T1 (de) 1994-04-15
KR880009019A (ko) 1988-09-13
PT86561A (de) 1988-02-01
EP0275888A2 (de) 1988-07-27
EP0275888B1 (de) 1994-04-06
FI880182A (fi) 1988-07-18
MX10126A (es) 1993-11-01
DK14688A (da) 1988-07-18
ZA88263B (en) 1988-06-29
DD272649A5 (de) 1989-10-18
AU1031688A (en) 1988-07-21
DE3701277A1 (de) 1988-07-28
IL85069A0 (en) 1988-06-30

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