DK146245C - Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf

Info

Publication number
DK146245C
DK146245C DK407577A DK407577A DK146245C DK 146245 C DK146245 C DK 146245C DK 407577 A DK407577 A DK 407577A DK 407577 A DK407577 A DK 407577A DK 146245 C DK146245 C DK 146245C
Authority
DK
Denmark
Prior art keywords
analogue
acid addition
addition salts
optically active
preparing racemic
Prior art date
Application number
DK407577A
Other languages
Danish (da)
English (en)
Other versions
DK146245B (da
DK407577A (da
Inventor
William Joseph Fanshawe
Joseph William Epstein
Lantz Stephen Crawley
Corris Mabelle Hofmann
Sidney Robert Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK407577A publication Critical patent/DK407577A/da
Priority to DK438580A priority Critical patent/DK438580A/da
Priority to DK438480A priority patent/DK438480A/da
Publication of DK146245B publication Critical patent/DK146245B/da
Application granted granted Critical
Publication of DK146245C publication Critical patent/DK146245C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK407577A 1976-09-15 1977-09-14 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf DK146245C (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK438580A DK438580A (da) 1976-09-15 1980-10-16 Mellemprodukt til fremstilling af azabicycloforbindelser
DK438480A DK438480A (da) 1976-09-15 1980-10-16 Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US72340276 1976-09-15
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US80934177 1977-06-23
US80933977 1977-06-23
US80934077 1977-06-23
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones

Publications (3)

Publication Number Publication Date
DK407577A DK407577A (da) 1978-03-16
DK146245B DK146245B (da) 1983-08-08
DK146245C true DK146245C (da) 1984-01-16

Family

ID=27505564

Family Applications (3)

Application Number Title Priority Date Filing Date
DK407577A DK146245C (da) 1976-09-15 1977-09-14 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf
DK438480A DK438480A (da) 1976-09-15 1980-10-16 Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da) 1976-09-15 1980-10-16 Mellemprodukt til fremstilling af azabicycloforbindelser

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK438480A DK438480A (da) 1976-09-15 1980-10-16 Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da) 1976-09-15 1980-10-16 Mellemprodukt til fremstilling af azabicycloforbindelser

Country Status (16)

Country Link
JP (1) JPS5337656A (fr)
AR (2) AR220684A1 (fr)
AT (2) AT367036B (fr)
AU (1) AU519620B2 (fr)
BE (1) BE858683A (fr)
CH (2) CH637929A5 (fr)
DD (1) DD133943A5 (fr)
DE (1) DE2740562A1 (fr)
DK (3) DK146245C (fr)
FR (1) FR2375212A1 (fr)
GR (1) GR72713B (fr)
HU (1) HU177531B (fr)
NL (1) NL189041C (fr)
PL (1) PL115869B1 (fr)
SE (2) SE435384B (fr)
YU (2) YU39499B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (fr) * 1978-06-27 1982-01-26 Janet A. Day Derives du 3-azabicyclo(3.1.0)hexane et methode de preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (ja) * 1986-07-25 1988-02-10 東京電力株式会社 シ−ルド掘進機
JPH0658037B2 (ja) * 1989-09-01 1994-08-03 日本鋼管株式会社 シールド掘進装置
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
KR20070034126A (ko) * 2004-07-22 2007-03-27 와이어쓰 신경계 질환 및 장애의 치료 방법
AU2005266997A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
KR20170005888A (ko) * 2005-07-27 2017-01-16 뉴로반스, 인크. 신규 1-아릴-3-아자바이사이클로［3.1.0］헥산：제조 방법 및 신경 정신 질환 치료를 위한 용도
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
YU188582A (en) 1985-03-20
AR220684A1 (es) 1980-11-28
DK146245B (da) 1983-08-08
NL7709691A (nl) 1978-03-17
ATA288280A (de) 1981-10-15
AT367037B (de) 1982-05-25
HU177531B (en) 1981-11-28
CH637929A5 (en) 1983-08-31
DD133943A5 (de) 1979-01-31
AU2844177A (en) 1979-03-08
YU217477A (en) 1983-01-21
DE2740562C2 (fr) 1989-05-03
SE435384B (sv) 1984-09-24
SE452610B (sv) 1987-12-07
ATA661577A (de) 1981-10-15
AU519620B2 (en) 1981-12-17
SE7710367L (sv) 1978-03-16
FR2375212A1 (fr) 1978-07-21
PL115869B1 (en) 1981-05-30
PL200831A1 (fr) 1980-02-11
SE8203437L (sv) 1982-06-03
BE858683A (fr) 1978-03-14
DE2740562A1 (de) 1978-03-23
NL189041C (nl) 1992-12-16
GR72713B (fr) 1983-12-01
JPS5337656A (en) 1978-04-06
JPS6129341B2 (fr) 1986-07-05
DK438480A (da) 1980-10-16
YU39499B (en) 1984-12-31
FR2375212B1 (fr) 1981-07-31
DK438580A (da) 1980-10-16
NL189041B (nl) 1992-07-16
AT367036B (de) 1982-05-25
DK407577A (da) 1978-03-16
AR227507A1 (es) 1982-11-15
CH637931A5 (en) 1983-08-31
YU43523B (en) 1989-08-31

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