DK1453798T3 - (20S)-1alfa-hydroxy-2-methylen-19-nor-bishomopregnacalciferol og anvendelser deraf - Google Patents

(20S)-1alfa-hydroxy-2-methylen-19-nor-bishomopregnacalciferol og anvendelser deraf

Info

Publication number
DK1453798T3
DK1453798T3 DK02794233T DK02794233T DK1453798T3 DK 1453798 T3 DK1453798 T3 DK 1453798T3 DK 02794233 T DK02794233 T DK 02794233T DK 02794233 T DK02794233 T DK 02794233T DK 1453798 T3 DK1453798 T3 DK 1453798T3
Authority
DK
Denmark
Prior art keywords
skin
compound
bishomopregnacalciferol
methylene
hydroxy
Prior art date
Application number
DK02794233T
Other languages
Danish (da)
English (en)
Inventor
Lori A Plum
James B Thoden
Hazel M Holden
Pawel Grzywacz
Hector F Deluca
Margaret Clagett-Dame
Sumithra Gowlugari
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/078,204 external-priority patent/US6627622B2/en
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK1453798T3 publication Critical patent/DK1453798T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK02794233T 2001-12-13 2002-12-12 (20S)-1alfa-hydroxy-2-methylen-19-nor-bishomopregnacalciferol og anvendelser deraf DK1453798T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34113801P 2001-12-13 2001-12-13
US10/078,204 US6627622B2 (en) 2002-02-18 2002-02-18 (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
PCT/US2002/039715 WO2003051828A2 (en) 2001-12-13 2002-12-12 (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses

Publications (1)

Publication Number Publication Date
DK1453798T3 true DK1453798T3 (da) 2009-02-16

Family

ID=26760229

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02794233T DK1453798T3 (da) 2001-12-13 2002-12-12 (20S)-1alfa-hydroxy-2-methylen-19-nor-bishomopregnacalciferol og anvendelser deraf

Country Status (17)

Country Link
EP (1) EP1453798B1 (el)
JP (1) JP4149928B2 (el)
KR (1) KR100631457B1 (el)
CN (1) CN1308303C (el)
AT (1) ATE411283T1 (el)
AU (1) AU2002359680B2 (el)
CA (1) CA2468833C (el)
CY (1) CY1108686T1 (el)
DE (1) DE60229430D1 (el)
DK (1) DK1453798T3 (el)
ES (1) ES2315426T3 (el)
HK (1) HK1077804A1 (el)
MX (1) MXPA04005652A (el)
NZ (1) NZ533424A (el)
PT (1) PT1453798E (el)
SI (1) SI1453798T1 (el)
WO (1) WO2003051828A2 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7704980B2 (en) * 2003-10-08 2010-04-27 Wisconsin Alumni Research Foundation Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
DE602005021245D1 (de) * 2004-11-22 2010-06-24 Wisconsin Alumni Res Found 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen
EP1831161B1 (en) * 2004-11-22 2017-07-26 Wisconsin Alumni Research Foundation Medical and cosmetic uses of 2-methylene-19-nor-(20r)-1-alpha-hydroxy-bishomopregnacalciferol
US8604008B2 (en) 2004-11-22 2013-12-10 Wisconsin Alumni Research Foundation 2-methylene-19,21-dinor-1α-hydroxy-bishomopregnacalciferol
WO2006119309A2 (en) 2005-05-03 2006-11-09 Wisconsin Alumni Research Foundation 19,26,27-TRINOR-1α,25-DIHYDROXYVITAMIN D3 COMPOUNDS
JP2009532457A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１８，１９，２１−トリノルビタミンＤ３類縁体およびその使用
JP2009532458A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
WO2007118198A2 (en) * 2006-04-06 2007-10-18 Wisconsin Alumni Research Foundation 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF
WO2008089093A2 (en) * 2007-01-12 2008-07-24 Quatrx Pharmaceuticals Company Efficient processes for preparing steroids and vitamin d derivatives with the unnatural configuration at c20 (20 alpha-methyl) from pregnenolone
EP2262507A1 (en) * 2008-03-06 2010-12-22 Wisconsin Alumni Research Foundation Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound
CA2824870C (en) * 2011-06-14 2018-08-14 Wisconsin Alumni Research Foundation 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses
WO2013012644A1 (en) * 2011-07-18 2013-01-24 Wisconsin Alumni I Research Foundation 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs
JP6114292B2 (ja) * 2011-10-21 2017-04-12 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−ビタミンｄ類似体およびそれらの使用
AU2012326538B2 (en) * 2011-10-21 2016-12-08 Wisconsin Alumni Research Foundation 2-methylene-vitamin D analogs and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599912B2 (en) * 1985-04-23 1990-08-02 Wisconsin Alumni Research Foundation Seco-sterol compounds effective in inducing the differentiation of malignant cells
JPH05238937A (ja) * 1992-03-09 1993-09-17 Wisconsin Alumni Res Found 細胞分化誘発薬剤
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
AU2001275445B2 (en) * 2000-09-08 2006-07-27 Wisconsin Alumni Research Foundation 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications

Also Published As

Publication number Publication date
ES2315426T3 (es) 2009-04-01
CA2468833C (en) 2009-09-08
NZ533424A (en) 2006-08-31
ATE411283T1 (de) 2008-10-15
CN1620431A (zh) 2005-05-25
EP1453798B1 (en) 2008-10-15
CY1108686T1 (el) 2014-04-09
WO2003051828A3 (en) 2003-09-12
WO2003051828A2 (en) 2003-06-26
AU2002359680A1 (en) 2003-06-30
DE60229430D1 (de) 2008-11-27
JP4149928B2 (ja) 2008-09-17
CA2468833A1 (en) 2003-06-26
SI1453798T1 (sl) 2009-04-30
HK1077804A1 (en) 2006-02-24
CN1308303C (zh) 2007-04-04
MXPA04005652A (es) 2005-03-23
EP1453798A2 (en) 2004-09-08
AU2002359680B2 (en) 2007-10-18
PT1453798E (pt) 2009-01-23
KR20040063949A (ko) 2004-07-14
JP2005513066A (ja) 2005-05-12
KR100631457B1 (ko) 2006-10-11

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