DK145001C - Fremgangsmaade til fremstilling af derivater af vinca-alkaloider - Google Patents

Fremgangsmaade til fremstilling af derivater af vinca-alkaloider

Info

Publication number
DK145001C
DK145001C DK541077A DK541077A DK145001C DK 145001 C DK145001 C DK 145001C DK 541077 A DK541077 A DK 541077A DK 541077 A DK541077 A DK 541077A DK 145001 C DK145001 C DK 145001C
Authority
DK
Denmark
Prior art keywords
procedure
vinca alkaloid
alkaloid derivatives
preparing
preparing vinca
Prior art date
Application number
DK541077A
Other languages
Danish (da)
English (en)
Other versions
DK541077A (da
DK145001B (da
Inventor
J C Miller
G E Gutowski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK541077A publication Critical patent/DK541077A/da
Publication of DK145001B publication Critical patent/DK145001B/da
Application granted granted Critical
Publication of DK145001C publication Critical patent/DK145001C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
DK541077A 1976-12-06 1977-12-05 Fremgangsmaade til fremstilling af derivater af vinca-alkaloider DK145001C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/747,575 US4096148A (en) 1976-12-06 1976-12-06 Oxazolidinedione derivatives of Vinca alkaloids
US74757576 1976-12-06

Publications (3)

Publication Number Publication Date
DK541077A DK541077A (da) 1978-06-07
DK145001B DK145001B (da) 1982-07-26
DK145001C true DK145001C (da) 1982-12-27

Family

ID=25005690

Family Applications (2)

Application Number Title Priority Date Filing Date
DK541077A DK145001C (da) 1976-12-06 1977-12-05 Fremgangsmaade til fremstilling af derivater af vinca-alkaloider
DK541177A DK144916C (da) 1976-12-06 1977-12-05 Fremgangsmaade til fremstilling af vlb-3-spiro-5"-oxazolidin-2",4"-dion eller ikke-toxiske syreadditionssalte heraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK541177A DK144916C (da) 1976-12-06 1977-12-05 Fremgangsmaade til fremstilling af vlb-3-spiro-5"-oxazolidin-2",4"-dion eller ikke-toxiske syreadditionssalte heraf

Country Status (31)

Country Link
US (1) US4096148A (nl)
JP (1) JPS5371100A (nl)
AR (1) AR218467A1 (nl)
AT (2) AT353987B (nl)
AU (1) AU513936B2 (nl)
BE (1) BE861417A (nl)
BG (2) BG33437A3 (nl)
CA (2) CA1082180A (nl)
CH (2) CH632516A5 (nl)
CS (2) CS195344B2 (nl)
DD (2) DD134228A5 (nl)
DE (1) DE2753791A1 (nl)
DK (2) DK145001C (nl)
ES (2) ES464765A1 (nl)
FR (1) FR2372839A1 (nl)
GB (1) GB1590649A (nl)
GR (2) GR67244B (nl)
HK (1) HK57281A (nl)
HU (2) HU180724B (nl)
IE (1) IE46105B1 (nl)
IL (1) IL53506A (nl)
MX (1) MX4326E (nl)
MY (1) MY8200176A (nl)
NL (1) NL7713336A (nl)
NZ (1) NZ185818A (nl)
PL (2) PL110671B1 (nl)
PT (2) PT67342B (nl)
RO (2) RO75391A (nl)
SE (2) SE436036B (nl)
SU (2) SU865127A3 (nl)
ZA (1) ZA777237B (nl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4357334A (en) * 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
GR81790B (nl) * 1983-04-29 1984-12-12 Omnichem Sa
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT649883A (nl) * 1960-05-24
HU165986B (nl) * 1973-02-16 1974-12-28
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid

Also Published As

Publication number Publication date
GR67243B (nl) 1981-06-25
SU843753A3 (ru) 1981-06-30
BE861417A (fr) 1978-06-02
ATA868877A (de) 1979-05-15
CH634076A5 (de) 1983-01-14
ES464765A1 (es) 1979-01-01
MX4326E (es) 1982-03-24
DK541177A (da) 1978-06-07
IL53506A (en) 1981-09-13
SU865127A3 (ru) 1981-09-15
NL7713336A (nl) 1978-06-08
AU513936B2 (en) 1981-01-15
RO75391A (ro) 1980-11-30
BG33436A3 (en) 1983-02-15
PL110671B1 (en) 1980-07-31
CA1082180A (en) 1980-07-22
HK57281A (en) 1981-11-27
SE7713586L (sv) 1978-06-07
GR67244B (nl) 1981-06-25
AU3123077A (en) 1979-06-14
HU180725B (en) 1983-04-29
IE46105B1 (en) 1983-02-23
PL106522B1 (pl) 1979-12-31
IL53506A0 (en) 1978-03-10
DD134228A5 (de) 1979-02-14
SE436036B (sv) 1984-11-05
DK541077A (da) 1978-06-07
DK144916B (da) 1982-07-05
ZA777237B (en) 1979-07-25
PL202660A1 (pl) 1978-08-28
RO74137A (ro) 1981-08-30
PL202659A1 (pl) 1978-12-04
IE46105L (en) 1978-06-06
GB1590649A (en) 1981-06-03
PT67343A (en) 1977-12-01
DE2753791A1 (de) 1978-06-08
DK145001B (da) 1982-07-26
PT67342B (en) 1979-04-26
SE435930B (sv) 1984-10-29
NZ185818A (en) 1979-12-11
JPS625160B2 (nl) 1987-02-03
SE7713587L (sv) 1978-06-07
US4096148A (en) 1978-06-20
HU180724B (en) 1983-04-29
PT67342A (en) 1977-12-01
JPS5371100A (en) 1978-06-24
BG33437A3 (bg) 1983-02-15
CS195344B2 (en) 1980-01-31
ES464764A1 (es) 1979-01-01
FR2372839A1 (fr) 1978-06-30
DD134227A5 (de) 1979-02-14
CA1103664A (en) 1981-06-23
DK144916C (da) 1982-12-06
FR2372839B1 (nl) 1981-11-06
PT67343B (en) 1979-04-26
ATA868777A (de) 1980-08-15
DE2753791C2 (nl) 1990-08-02
AR218467A1 (es) 1980-06-13
AT353987B (de) 1979-12-10
CS195343B2 (en) 1980-01-31
AT361638B (de) 1981-03-25
MY8200176A (en) 1982-12-31
CH632516A5 (de) 1982-10-15

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PBP Patent lapsed