DK142194A - Fremgangsmåde til affinitetsseparering - Google Patents

Fremgangsmåde til affinitetsseparering

Info

Publication number
DK142194A
DK142194A DK142194A DK142194A DK142194A DK 142194 A DK142194 A DK 142194A DK 142194 A DK142194 A DK 142194A DK 142194 A DK142194 A DK 142194A DK 142194 A DK142194 A DK 142194A
Authority
DK
Denmark
Prior art keywords
affinity separation
affinity
separation
Prior art date
Application number
DK142194A
Other languages
Danish (da)
English (en)
Inventor
Peter J Degen
Tony Alex
Richard Frank Salinaro
Original Assignee
Pall Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pall Corp filed Critical Pall Corp
Publication of DK142194A publication Critical patent/DK142194A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/76—Handling the filter cake in the filter for purposes other than for regenerating
    • B01D29/78—Handling the filter cake in the filter for purposes other than for regenerating for washing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/76—Handling the filter cake in the filter for purposes other than for regenerating
    • B01D29/86—Retarding cake deposition on the filter during the filtration period, e.g. using stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/88—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices
    • B01D29/94—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices for discharging the filter cake, e.g. chutes
    • B01D29/945—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices for discharging the filter cake, e.g. chutes for continuously discharging concentrated liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
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    • B01J20/28016—Particle form
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    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
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    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3092—Packing of a container, e.g. packing a cartridge or column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
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    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
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    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
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    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
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    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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    • B01J2220/4825—Polysaccharides or cellulose materials, e.g. starch, chitin, sawdust, wood, straw, cotton
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK142194A 1993-12-23 1994-12-12 Fremgangsmåde til affinitetsseparering DK142194A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17247593A 1993-12-23 1993-12-23

Publications (1)

Publication Number Publication Date
DK142194A true DK142194A (da) 1995-06-24

Family

ID=22627841

Family Applications (1)

Application Number Title Priority Date Filing Date
DK142194A DK142194A (da) 1993-12-23 1994-12-12 Fremgangsmåde til affinitetsseparering

Country Status (10)

Country Link
US (1) US5567615A (fr)
JP (1) JPH07265606A (fr)
CN (1) CN1107748A (fr)
CA (1) CA2127605A1 (fr)
DE (1) DE4445517A1 (fr)
DK (1) DK142194A (fr)
FR (1) FR2714299B1 (fr)
GB (1) GB2287662B (fr)
NL (1) NL9402136A (fr)
SE (1) SE9404250L (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2160282A1 (fr) * 1995-02-14 1996-08-15 Michael R. Gildersleeve Ensemble a membrane supportee
DE29611336U1 (de) * 1996-06-28 1996-09-19 Gesellschaft für Biotechnologische Forschung mbH (GBF), 38124 Braunschweig Filtrationsvorrichtung
US6478969B2 (en) * 1996-09-06 2002-11-12 Pall Corporation Shear separation method and system
US5789333A (en) * 1997-03-05 1998-08-04 Iowa State University Research Foundation, Inc. Catalyst system comprising a first catalyst system tethered to a supported catalyst
US6022477A (en) * 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
US20020104801A1 (en) * 1998-04-06 2002-08-08 Nicolas Voute Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles
US6315900B1 (en) * 1998-06-03 2001-11-13 Accurate Polymers Static separation method using non-porous cellulose beads
US7071005B1 (en) * 1998-08-24 2006-07-04 Centrus International, Inc. Method and device for concentrating selected groups of microorganisms
AU5384999A (en) * 1998-08-24 2000-03-14 Nst Neurosurvival Technologies Ltd. Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids
IL125908A (en) 1998-08-24 2005-05-17 Nst Neurosurvival Technologies Peptides and pharmaceutical compositions comprising same
IL131266A0 (en) 1999-08-05 2001-01-28 N S T Neurosurvival Technologi Peptides and pharmaceutical compositions comprising same
US6214221B1 (en) 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
AU756832B2 (en) * 1999-02-22 2003-01-23 Ncsrt, Inc. Purification of biological substances
US6436722B1 (en) * 2000-04-18 2002-08-20 Idexx Laboratories, Inc. Device and method for integrated diagnostics with multiple independent flow paths
WO2003010512A2 (fr) * 2001-07-23 2003-02-06 Accurate Polymers, Inc. Separation solide-liquide a grande vitesse
SE0201257D0 (sv) * 2002-04-25 2002-04-25 Medical Invest In Sweden Ab Improved Separation
US6986847B2 (en) * 2002-05-10 2006-01-17 New Jersey Institute Of Technology Method and apparatus for isolation and purification of biomolecules
DE10236664B4 (de) * 2002-08-09 2016-05-12 Sartorius Stedim Biotech Gmbh Verfahren und Vorrichtung zur adsorptiven Stofftrennung
US20050037331A1 (en) * 2003-08-13 2005-02-17 William Galbraith Apparatuses and methods for reducing albumin in samples
US20060105349A1 (en) * 2004-11-12 2006-05-18 Promega Corporation Device and method for purification of biological materials
US20060105391A1 (en) * 2004-11-12 2006-05-18 Promega Corporation Device and method for separating molecules
US9375499B2 (en) 2006-07-14 2016-06-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
US8070965B2 (en) * 2007-04-18 2011-12-06 Tarves Robert J Jun Dual walled dynamic phase separator
US20090078657A1 (en) * 2007-09-26 2009-03-26 Honeywell International Inc. Device for separation of particulates from a biological sample
CN102906027A (zh) * 2010-03-22 2013-01-30 索法塔斯有限责任公司 用于水处理的浸渍碳
GB2496122A (en) * 2011-10-31 2013-05-08 Ge Healthcare Bio Sciences Ab Biological sample preservation on paper
JP6237031B2 (ja) * 2013-09-18 2017-11-29 凸版印刷株式会社 成分分離方法、成分分析方法及び成分分離装置
CN103933780B (zh) * 2014-04-01 2015-08-05 西安交通大学 一种纤维过滤实时动态观察系统
FR3035794B1 (fr) * 2015-05-06 2017-05-05 Elicityl Procede pour la purification du sang total ou d'un produit issu du sang
FR3035799B1 (fr) * 2015-05-06 2017-05-05 Elicityl Support pour la purification de liquides biologiques
FI4035762T3 (fi) 2015-09-09 2023-12-04 Drawbridge Health Inc Laitteita näytteiden keräämistä, stabilointia ja säilytystä varten
CN108136338B (zh) 2015-10-23 2021-09-03 3M创新有限公司 用于生物材料纯化的过滤介质序列
CN111916656A (zh) * 2020-07-21 2020-11-10 合肥通用机械研究院有限公司 一种用于三元材料的集成式生产系统
DE102020216579B4 (de) 2020-12-28 2022-08-18 Cellcopedia GmbH Vorrichtung und Verfahren zur Separation von Partikeln in einer Flüssigkeit, Kit enthaltend die Vorrichtung und Verwendungen der Vorrichtung

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3088875A (en) * 1959-10-27 1963-05-07 Hyland Lab Immunological diagnostics utilizing polystyrene latex particles of 0.15 to 0.25 micron
US3519130A (en) * 1966-09-21 1970-07-07 Waclaw Jachna Apparatus for classifying of finegrained solids in wet condition
US3796634A (en) * 1970-03-19 1974-03-12 Us Health Education & Welfare Insolubilized biologically active enzymes
DE2054968C3 (de) * 1970-11-09 1980-05-29 Hans-Joachim 6148 Heppenheim Titus Ro tationsfilter
US3956065A (en) * 1973-02-02 1976-05-11 Cpc International Inc. Inert, non-porous granules for flow control in a plug flow reactor
US3896217A (en) * 1973-03-19 1975-07-22 Summa Corp Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent
US3997447A (en) * 1974-06-07 1976-12-14 Composite Sciences, Inc. Fluid processing apparatus
JPS5247355B2 (fr) * 1974-10-15 1977-12-01
CH602160A5 (fr) * 1975-12-11 1978-07-31 Escher Wyss Ag
CH602161A5 (fr) * 1975-12-11 1978-07-31 Escher Wyss Ag
US4335017A (en) * 1975-12-15 1982-06-15 United Kingdom Atomic Energy Authority Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography
US4143203A (en) * 1976-03-19 1979-03-06 Amicon Corporation Particulate support material
US4070286A (en) * 1976-06-15 1978-01-24 E. I. Du Pont De Nemours And Company Macroporous microspheroids and a process for their manufacture
US4092114A (en) * 1976-10-20 1978-05-30 Fisher Scientific Company Indirect latex test for determination of immunoglobulins
US4210722A (en) * 1977-11-14 1980-07-01 Minnesota Mining And Manufacturing Company Protein immobilizer
US4278651A (en) * 1978-09-27 1981-07-14 Becton Dickinson & Company Supported receptor and use thereof in an assay
JPS56115727A (en) * 1980-02-19 1981-09-11 Kuraray Co Ltd Carrier for immobilizing physiologically active substance
ZA811104B (en) * 1980-02-26 1982-03-31 Tate & Lyle Ltd Immobilized enzymes, a process for their preparation and their use in converting substrates to products
JPS56141559A (en) * 1980-04-04 1981-11-05 Toray Ind Inc Reagent for immunological inspection
US4357142A (en) * 1980-07-18 1982-11-02 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
SE8006102L (sv) * 1980-09-02 1982-03-03 Gambro Ab Sett att utvinna en peptidinnehallande forening samt medel for genomforande av settet
US4357311A (en) * 1980-10-03 1982-11-02 Warner-Lambert Company Substrate for immunoassay and means of preparing same
DE3267499D1 (en) * 1981-03-18 1986-01-02 Fujirebio Kk Support material for use in serological testing and process for the production thereof
US4629690A (en) * 1981-09-18 1986-12-16 Syntex (U.S.A.) Inc. Homogeneous enzyme specific binding assay on non-porous surface
DE3145082A1 (de) * 1981-11-13 1983-05-19 Behringwerke Ag, 3550 Marburg "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung"
SE457797B (sv) * 1982-01-13 1989-01-30 Kureha Chemical Ind Co Ltd Foerfarande foer framstaellning av poroest substrat innefattande paerlor som har metylolgrupper av sampolymer paa basis av tvaerbunden styren och anvaendni ng av substratet vid vaetskekromatografi
DE3202064A1 (de) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Vorrichtung zur nassen siebanalyse
CH655018A5 (de) * 1982-02-09 1986-03-27 Escher Wyss Ag Verfahren zum regeln eines kontinuierlich arbeitenden druckfilters.
US4732851A (en) * 1982-03-16 1988-03-22 Purification Engineering, Inc. Immobilization of cells with a polyazetidine prepolymer
US4663278A (en) * 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
FR2534486B1 (fr) * 1982-10-15 1987-11-20 Commissariat Energie Atomique Support particulaire greffe en surface, son procede de preparation et adsorbants pour chromatographie d'affinite incorporant ce support, ainsi que leur utilisation, notamment en biologie
JPS59224565A (ja) * 1983-04-28 1984-12-17 Morinaga Milk Ind Co Ltd 抗原検出用試薬
SE451843B (sv) * 1983-05-09 1987-11-02 Gambro Lundia Ab Forfarande for utvinning av en forening
US4547466A (en) * 1983-06-01 1985-10-15 Allied Corporation Detecting rheumatoid factor with synthetic particles having immune complexes thereon
US4590169A (en) * 1983-11-18 1986-05-20 Beckman Instruments, Inc. Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations
US4536478A (en) * 1984-04-05 1985-08-20 Seragan Diagnostics, Inc. Method for reducing non-specific interferences in agglutination immunoassays
US5135653A (en) * 1984-04-05 1992-08-04 Daicel Chemical Industries, Ltd. Optical resolution with β-1,4-xylan dibenzoate
JPS60256057A (ja) * 1984-06-01 1985-12-17 Dai Ichi Pure Chem Co Ltd 免疫学的測定法
US5037562A (en) * 1984-08-22 1991-08-06 Tarves Robert J Jun Oil/liquid dynamic separation rotating disk filter system with barrier layer formation
US4720465A (en) * 1985-05-14 1988-01-19 Fisher Scientific Company Centrifugal kinetic agglutination assay
US4806488A (en) * 1985-09-06 1989-02-21 Syntex (U.S.A.) Inc. Ligand-receptor assays employing squarate dye compositions
GB8600582D0 (en) * 1986-01-10 1986-02-19 Ca Minister Nat Defence Purifying biological materials
SE459715B (sv) * 1986-09-08 1989-07-31 Karl J Allsing Foerfarande vid s.k.roterande filter samt filter
US5248611A (en) * 1987-05-28 1993-09-28 Scripps Clinic And Research Foundation Stereoisomer separation method using antibody combing site-containing molecules
CH673407A5 (fr) * 1987-06-24 1990-03-15 Sulzer Ag
US5077210A (en) * 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US4952317A (en) * 1989-03-10 1990-08-28 Bradley Culkin Device and method for filtering a colloidal suspension
US5124041A (en) * 1989-07-28 1992-06-23 Applied Biosystems, Inc. Biomolecule sample immobilization
US5167824A (en) * 1990-02-14 1992-12-01 Creative Biomolecules, Inc. Separation by carrier mediated transport
US5143630A (en) * 1991-05-30 1992-09-01 Membrex, Inc. Rotary disc filtration device
GB9223334D0 (en) * 1992-11-06 1992-12-23 Hybaid Ltd Magnetic solid phase supports
GB2275626B (en) * 1993-02-11 1996-10-23 Pall Corp An affinity separation device and its use for immunoglobulin separation

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US5567615A (en) 1996-10-22
DE4445517A1 (de) 1995-06-29
SE9404250L (sv) 1995-06-24
GB2287662A (en) 1995-09-27
CN1107748A (zh) 1995-09-06
JPH07265606A (ja) 1995-10-17
FR2714299A1 (fr) 1995-06-30
GB9422829D0 (en) 1995-01-04
SE9404250D0 (sv) 1994-12-07
NL9402136A (nl) 1995-07-17
GB2287662B (en) 1997-11-19
CA2127605A1 (fr) 1995-06-24
FR2714299B1 (fr) 1997-05-09

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