DK141729B - Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. - Google Patents
Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. Download PDFInfo
- Publication number
- DK141729B DK141729B DK272975A DK272975A DK141729B DK 141729 B DK141729 B DK 141729B DK 272975 A DK272975 A DK 272975A DK 272975 A DK272975 A DK 272975A DK 141729 B DK141729 B DK 141729B
- Authority
- DK
- Denmark
- Prior art keywords
- cephalexin
- complexing
- aqueous solution
- recovering
- solution containing
- Prior art date
Links
- 229940106164 cephalexin Drugs 0.000 title description 15
- 238000000034 method Methods 0.000 title description 7
- 239000007864 aqueous solution Substances 0.000 title description 5
- 230000000536 complexating effect Effects 0.000 title description 4
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title 2
- AVGYWQBCYZHHPN-CYJZLJNKSA-N cephalexin monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 AVGYWQBCYZHHPN-CYJZLJNKSA-N 0.000 description 14
- 229940047526 cephalexin monohydrate Drugs 0.000 description 13
- YGZIWEZFFBPCLN-UHFFFAOYSA-N n,3-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound OOC1CCOP(=O)(NCCCl)N1CCCl YGZIWEZFFBPCLN-UHFFFAOYSA-N 0.000 description 13
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 239000013078 crystal Substances 0.000 description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
Landscapes
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK272975A DK141729B (da) | 1975-06-17 | 1975-06-17 | Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. |
| BE168011A BE843055R (fr) | 1973-12-18 | 1976-06-17 | Procede de preparation d'un complexe peu soluble de cephalexine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK272975A DK141729B (da) | 1975-06-17 | 1975-06-17 | Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. |
| DK272975 | 1975-06-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK272975A DK272975A (enrdf_load_stackoverflow) | 1976-12-18 |
| DK141729B true DK141729B (da) | 1980-06-02 |
| DK141729C DK141729C (enrdf_load_stackoverflow) | 1980-10-20 |
Family
ID=8115141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK272975A DK141729B (da) | 1973-12-18 | 1975-06-17 | Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK141729B (enrdf_load_stackoverflow) |
-
1975
- 1975-06-17 DK DK272975A patent/DK141729B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK141729C (enrdf_load_stackoverflow) | 1980-10-20 |
| DK272975A (enrdf_load_stackoverflow) | 1976-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100917698B1 (ko) | 레트로졸의 제조를 위한 개선된 방법 | |
| RO107257B1 (ro) | Procedeu de obtinere a unui dihidrat de azitromicina, cristalin | |
| CZ301160B6 (cs) | Zpusob výroby 17beta-(N-t-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-onu v polymorfní forme I | |
| US2528267A (en) | Eobeet j | |
| EP0024181B1 (en) | Process for the isolation of a solid salt of p-hydroxymandelic acid; some salts of p-hydroxymandelic acid | |
| DK141729B (da) | Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. | |
| US3574740A (en) | Method of preparing methane sulfonamide and its derivatives | |
| EP0112629B1 (en) | Plant growth regulators | |
| US3049536A (en) | Method for producing inosine | |
| US5349074A (en) | Process for pharmaceutical grade high purity hyodeoxycholic acid preparation | |
| DK148961B (da) | Fremgangsmaade til fremstilling af vindesin | |
| CN113735792A (zh) | 氯苯唑酸葡胺及其中间体的制备方法 | |
| KR950010597B1 (ko) | 세팔로스포린 유도체의 신규한 제조방법 | |
| EP1768980B1 (en) | Improved process for the manufacture of mirtazapine | |
| AU776674B2 (en) | Method for preparing and isolating 9-deoxo-9(Z)-hydroxyiminoerythromycin | |
| KR860001900B1 (ko) | β-클로로 아라닌의 제조법 | |
| CN108863888B (zh) | 一种(s)-1-(叔丁氧羰基)-5-氧吡咯烷-2-羧酸乙酯的制备方法 | |
| KR100325558B1 (ko) | 7-클로로퀴놀린-8-카르복실산의정제방법 | |
| US2678312A (en) | Preparation of thiamin chloride | |
| SE437828B (sv) | Forfarande for framstellning av cis-isomeren av n,n-dimetyl-9-/3-(4-metyl-1-piperazinyl)-propyliden/-tioxanten-2-sulfonamid | |
| US4331607A (en) | Process for the purification of chenodeoxycholic acid | |
| US4186133A (en) | Process for the preparation of an indole-3-acetohydroxamic acid | |
| US3158626A (en) | 3-thiosteroids and method of preparation | |
| HUP0004932A2 (hu) | Eljárás egy édesítőszer elkülönítésére vagy tisztítására | |
| US20010034434A1 (en) | Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A |