DK1416917T3 - Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT) - Google Patents

Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT)

Info

Publication number
DK1416917T3
DK1416917T3 DK02745697T DK02745697T DK1416917T3 DK 1416917 T3 DK1416917 T3 DK 1416917T3 DK 02745697 T DK02745697 T DK 02745697T DK 02745697 T DK02745697 T DK 02745697T DK 1416917 T3 DK1416917 T3 DK 1416917T3
Authority
DK
Denmark
Prior art keywords
water
mct
excipient
active substance
aqueous dispersion
Prior art date
Application number
DK02745697T
Other languages
Danish (da)
English (en)
Inventor
Ulf Olsson
Tommy Urban Skantze
Per Lennart Lindfors
Corswant Lars Christian Von
Schantz Anna Elisa Zzackrisson
Pia Margaretha Cecilia Skantze
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0119081A external-priority patent/GB0119081D0/en
Priority claimed from GB0212463A external-priority patent/GB0212463D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1416917T3 publication Critical patent/DK1416917T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK02745697T 2001-08-06 2002-08-01 Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT) DK1416917T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0119081A GB0119081D0 (en) 2001-08-06 2001-08-06 Process
GB0212463A GB0212463D0 (en) 2002-05-30 2002-05-30 Process
PCT/GB2002/003583 WO2003013472A1 (fr) 2001-08-06 2002-08-01 Dispersion aqueuse comprenant des nanoparticules stables d'un triglyceride a chaine moyenne (mtc) insoluble dans l'eau actif et d'un triglyceride a chaine moyenne de type excipient

Publications (1)

Publication Number Publication Date
DK1416917T3 true DK1416917T3 (da) 2007-09-17

Family

ID=26246405

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02745697T DK1416917T3 (da) 2001-08-06 2002-08-01 Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT)

Country Status (20)

Country Link
US (1) US20050009908A1 (fr)
EP (1) EP1416917B1 (fr)
JP (1) JP4714412B2 (fr)
KR (1) KR100914113B1 (fr)
CN (1) CN1254233C (fr)
AT (1) ATE365537T1 (fr)
AU (1) AU2002317409B2 (fr)
BR (1) BR0211705A (fr)
CA (1) CA2456180C (fr)
CY (1) CY1107059T1 (fr)
DE (1) DE60220923T2 (fr)
DK (1) DK1416917T3 (fr)
ES (1) ES2287293T3 (fr)
HK (1) HK1064048A1 (fr)
IL (2) IL160103A0 (fr)
MX (1) MXPA04001071A (fr)
NO (1) NO20040484L (fr)
NZ (1) NZ530916A (fr)
PT (1) PT1416917E (fr)
WO (1) WO2003013472A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0230087D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
US20060135523A1 (en) * 2003-06-18 2006-06-22 Astrazeneca Ab 2-substituted 5,6-diaryl-pyrazine derivatives as cb1 modulator
GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314261D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
US20060159767A1 (en) * 2004-12-22 2006-07-20 Elan Pharma International Limited Nanoparticulate bicalutamide formulations
EP1915131A4 (fr) * 2005-08-12 2012-07-25 Astrazeneca Ab Processus
WO2008013785A2 (fr) 2006-07-24 2008-01-31 Singh-Broemer And Company, Inc. Formulation de nanoparticules solides de substances pharmaceutiques insolubles dans l'eau avec mûrissement d'ostwald réduit
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
JP2010517759A (ja) * 2007-02-09 2010-05-27 アストラゼネカ・アクチエボラーグ 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
JP2010533714A (ja) * 2007-07-16 2010-10-28 ポニアード ファーマシューティカルズ， インコーポレイテッド ピコプラチンのための経口製剤
CN102014624A (zh) * 2008-02-08 2011-04-13 帕纳德制药公司 治疗肺癌的吡铂和氨柔比星
BRPI1004808B1 (pt) * 2010-10-27 2020-09-29 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Composições baseadas em nanopartículas de própolis, processos de obtenção e uso
NZ629722A (en) 2012-02-29 2017-03-31 Pulmatrix Operating Co Inc Inhalable dry powders
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
PT106738B (pt) 2013-01-09 2015-06-08 Hovione Farmaciencia Sa Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
WO2014122077A1 (fr) * 2013-02-08 2014-08-14 Basf Se Fabrication de matériaux composites inorganiques-organiques par séchage réactif par pulvérisation
WO2019055525A1 (fr) * 2017-09-12 2019-03-21 Raj Selvaraj Formulation de nanoparticules solides de substances pharmaceutiques insolubles dans l'eau avec mûrissement d'ostwald réduit
JP2024530045A (ja) 2021-11-05 2024-08-14 シンクルス・ファーマ・ホールディング・アクチエボラグ リナプラザングルレート塩酸塩の多形

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2224133B2 (de) * 1972-05-17 1974-06-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von bestimmten Mikroorganismen-Stämmen zur Gewinnung von Cholesterinoxydase, welche Cholesterin mit O tief 2 zu Cholestenon + H tief 2 O tief 2 oxydiert
US4348385A (en) * 1980-11-17 1982-09-07 Mobay Chemical Corporation Flowable pesticides
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
US4799962A (en) * 1987-12-24 1989-01-24 Aqualon Company Water-soluble polymer dispersion
EP0379591B1 (fr) * 1988-06-28 1994-01-19 Matsushita Electric Industrial Co., Ltd. Epurateur de fumee d'echappement
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
CA2044706C (fr) * 1990-06-15 2003-02-25 Michael Midler Jr. Methode de cristallisation destinee a ameliorer la structure et la grosseur des cristaux
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
EP0615445B1 (fr) * 1991-12-05 1996-05-15 ALFATEC-PHARMA GmbH Nanosol utilisable en pharmacie et son procede de preparation
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5468604A (en) * 1992-11-18 1995-11-21 Eastman Kodak Company Photographic dispersion
GB9319129D0 (en) * 1993-09-15 1993-11-03 Dowelanco Ltd Storage and dilution of stable aqueous dispersions
SE9303281D0 (sv) * 1993-10-07 1993-10-07 Astra Ab New formulation
SE9403846D0 (sv) * 1994-11-09 1994-11-09 Univ Ohio State Res Found Small particle formation
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
DE69727244T2 (de) * 1996-10-03 2004-11-25 Hermes Biosciences Inc., San Francisco Hydrophile Mikroteilchen und Verfahren zu deren Herstellung
FR2789079B3 (fr) * 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US6267989B1 (en) * 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations

Also Published As

Publication number Publication date
CY1107059T1 (el) 2012-10-24
JP2005500362A (ja) 2005-01-06
DE60220923T2 (de) 2008-03-06
HK1064048A1 (en) 2005-01-21
KR100914113B1 (ko) 2009-08-27
PT1416917E (pt) 2007-08-16
CA2456180C (fr) 2011-10-11
ATE365537T1 (de) 2007-07-15
IL160103A0 (en) 2004-06-20
ES2287293T3 (es) 2007-12-16
CN1254233C (zh) 2006-05-03
NZ530916A (en) 2005-07-29
DE60220923D1 (de) 2007-08-09
US20050009908A1 (en) 2005-01-13
WO2003013472A1 (fr) 2003-02-20
BR0211705A (pt) 2004-09-28
MXPA04001071A (es) 2004-05-20
EP1416917B1 (fr) 2007-06-27
JP4714412B2 (ja) 2011-06-29
KR20040025739A (ko) 2004-03-25
NO20040484L (no) 2004-03-31
EP1416917A1 (fr) 2004-05-12
AU2002317409B2 (en) 2007-06-21
CN1564677A (zh) 2005-01-12
IL160103A (en) 2008-11-26
CA2456180A1 (fr) 2003-02-20

Similar Documents

Publication Publication Date Title
DK1416917T3 (da) Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT)
EP1829530A3 (fr) Stabilisation d'agents actifs pour une formulation sous forme de nanoparticules
EP2241308A3 (fr) Procédé de revêtement de particules fines avec un film de lipides
WO2006113808A3 (fr) Procedes de fabrication et de modification de dispositifs poreux destines a des applications biomedicales
ATE318078T1 (de) Lignin-mikropartikel für die gesteuerte freisetzung von aktivstoffen für die landwirtschaft
WO2000066679A3 (fr) Milieu electrochromique avec stabilite amelioree de la concentration, son procede de preparation et son utilisation dans des dispositifs electrochromiques
SE0004620D0 (sv) Processes to generate submicron particles of waterinsoluble componunds
NZ593214A (en) Compounds and Processes for preparing serine protease inhibitors
EP1769867A4 (fr) Procédé de fabrication de fine particule de métal, fine particule de métal produite ainsi, composition contenant ladite particule, matériau photo-absorbant, et application de celui-ci
NO20054908L (no) Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon
CY1111817T1 (el) Απομακρυνση του διαλυτη με μια διαδικασια προσθιας οσμωσης
WO2007142618A3 (fr) Compositions et mélanges aqueux à activité biocide et à concentration élevée
ATE399566T1 (de) Stabile dispersion fester teilchen mit einer wasserunlöslichen pyrazin-verbindung
ATE449643T1 (de) Verfahren zur stabilisierung von peroxycarbonsäuren in tensidhaltigen dispersionen
WO2001062088A3 (fr) Procede de traitement de plantes et d'amelioration de la croissance des plantes et de phytoprotection de fortes concentrations de photocatalyseurs pour l'utilisation de polyacylglycosides et/ou de polyalkylglycosides et formulations de mise en oeuvre
ATE440594T1 (de) Herstellung von kolloidale teilchen enthaltenden pulvern
ITSA20030013A1 (it) Manufatti microporosi e nanoporosi a base di
DK1775285T3 (da) Fremgangsmåde til krystallisation af bicalutamid
WO2005097058A3 (fr) Compositions pharmaceutiques de pyrimidine-2,4,6-triones
WO2005037446A3 (fr) Application de materiau d'impression sur des substrats a l'aide de champs electromagnetiques
FI20010164A0 (fi) Menetelmä parantuneen stabiliteetin omaavien natriumperkarbonaattirakeiden valmistamiseksi
JP2010126492A (ja) 還元型ＣｏＱ１０−ＣＤ包接体の製造方法
CO5530054A1 (es) Medio de cultivo para la deteccion de hongos y levaduras
RU2005105705A (ru) Способ ускоренного выращивания кристаллов с применением структурированного излучения