DK1412317T3 - Retinoidderivater med antiangiogenetisk-, antitumor og pro-apoptotisk virkning - Google Patents
Retinoidderivater med antiangiogenetisk-, antitumor og pro-apoptotisk virkningInfo
- Publication number
- DK1412317T3 DK1412317T3 DK02760553.4T DK02760553T DK1412317T3 DK 1412317 T3 DK1412317 T3 DK 1412317T3 DK 02760553 T DK02760553 T DK 02760553T DK 1412317 T3 DK1412317 T3 DK 1412317T3
- Authority
- DK
- Denmark
- Prior art keywords
- antiangiogenetic
- tumor
- pro
- apoptotic effect
- retinoid derivatives
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 230000000861 pro-apoptotic effect Effects 0.000 title 1
- 150000004492 retinoid derivatives Chemical class 0.000 title 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000464A ITRM20010464A1 (it) | 2001-07-31 | 2001-07-31 | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
PCT/IT2002/000474 WO2003011808A1 (en) | 2001-07-31 | 2002-07-18 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1412317T3 true DK1412317T3 (da) | 2011-03-28 |
Family
ID=11455702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02760553.4T DK1412317T3 (da) | 2001-07-31 | 2002-07-18 | Retinoidderivater med antiangiogenetisk-, antitumor og pro-apoptotisk virkning |
Country Status (20)
Country | Link |
---|---|
US (2) | US8101793B2 (da) |
EP (1) | EP1412317B1 (da) |
JP (1) | JP4463550B2 (da) |
KR (1) | KR100888466B1 (da) |
CN (1) | CN1279014C (da) |
AT (1) | ATE492526T1 (da) |
AU (1) | AU2002326144B2 (da) |
BR (1) | BR0211521A (da) |
CA (1) | CA2454532C (da) |
CY (1) | CY1114535T1 (da) |
DE (1) | DE60238683D1 (da) |
DK (1) | DK1412317T3 (da) |
ES (1) | ES2358097T3 (da) |
HK (1) | HK1068868A1 (da) |
HU (1) | HU229308B1 (da) |
IT (1) | ITRM20010464A1 (da) |
MX (1) | MXPA04000877A (da) |
PL (1) | PL207530B1 (da) |
PT (1) | PT1412317E (da) |
WO (1) | WO2003011808A1 (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US7361341B2 (en) * | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
ITRM20010464A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
AU2002346620A1 (en) | 2001-11-30 | 2003-06-17 | Department Of Veteran Affairs | Induction of apoptosis in cancer cells |
JP2005516958A (ja) * | 2001-12-20 | 2005-06-09 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Trailレセプターに免疫特異的に結合する抗体 |
EP1856063B1 (en) | 2005-02-22 | 2012-01-25 | Ranbaxy Laboratories Limited | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases |
PL1868980T3 (pl) | 2005-04-08 | 2011-01-31 | Galderma Res & Dev | Nowy sposób wytwarzania kwasu 6-[3-(1-adamantylo)-4-metoksyfenylo]-2-naftoesowego |
FR2884248B1 (fr) * | 2005-04-08 | 2007-05-18 | Galderma Res & Dev | Nouveau procede de preparation de l'acide 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoique |
ITRM20050248A1 (it) | 2005-05-20 | 2006-11-21 | Sigma Tau Ind Farmaceuti | Uso acido adamantil metossidifenil propenoico per il trattamento di patologie cutanee. |
CA2607207C (en) * | 2005-06-28 | 2015-01-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Biphenyl and naphthyl-phenyl hydroxamic acid derivatives |
US20090281184A1 (en) * | 2005-09-27 | 2009-11-12 | Sapporo Medical University | Pharmaceutical for prevention and treatment of ophthalmic disease induced by in-crease in vasopermeability |
WO2007071605A1 (en) * | 2005-12-19 | 2007-06-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | The use of st1898 for the treatment of restenosis |
JP5054006B2 (ja) * | 2006-06-23 | 2012-10-24 | ロート製薬株式会社 | ヒアルロン酸産生促進能を有する組成物 |
WO2008077772A2 (en) * | 2006-12-22 | 2008-07-03 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Combination of a retinoid and a platinum anticancer agent |
WO2010000784A1 (en) * | 2008-07-03 | 2010-01-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Treatment of restenosis |
TW201031402A (en) * | 2008-12-24 | 2010-09-01 | Sigma Tau Ind Farmaceuti | New retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties |
WO2010091052A2 (en) | 2009-02-03 | 2010-08-12 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
US9056085B2 (en) | 2009-02-03 | 2015-06-16 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
WO2010106135A1 (en) | 2009-03-20 | 2010-09-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combined use for the treatment of ovarian carcinoma |
US9096544B2 (en) | 2009-12-23 | 2015-08-04 | Wayne State University | Therapeutic compounds |
EP2758371B1 (en) * | 2011-09-19 | 2016-06-15 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments |
JP5757602B2 (ja) * | 2012-05-11 | 2015-07-29 | 国立大学法人金沢大学 | 不斉選択性の切り替えが可能なクロマトグラフィー用充填剤 |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
US11707442B2 (en) | 2015-09-25 | 2023-07-25 | The General Hospital Corporation | Antibacterial and antifungal compounds |
EP3301085A1 (en) | 2016-09-29 | 2018-04-04 | Biogem S.Ca.R.L. | Retinoid derivatives with antitumor activity |
EP3615015B1 (en) | 2017-04-27 | 2024-03-13 | Vanderbilt University | Gamma-ketoaldehyde scavengers for treating atherosclerosis |
WO2018213609A1 (en) | 2017-05-17 | 2018-11-22 | Ausubel Frederick M | Antibiotic compounds |
WO2019018185A1 (en) | 2017-07-15 | 2019-01-24 | Arisan Therapeutics Inc. | ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS |
IT201900003343A1 (it) * | 2019-03-07 | 2020-09-07 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
CN111956806B (zh) * | 2020-09-03 | 2023-04-07 | 四川大学 | 一种药物载体、胶束、药剂及其制备方法和应用 |
IT202000029906A1 (it) * | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi. |
IT202000029882A1 (it) * | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
WO2022229017A1 (en) | 2021-04-27 | 2022-11-03 | Biogem S.C.A R.L. | Adamantyl retinoid derivative with anticancer activity |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2676052B1 (fr) * | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
BR9710255A (pt) * | 1996-07-08 | 1999-08-10 | Galderma Res & Dev | Método para o tratamento de cáncer composto de retinóide de adamantila composição farmacéutica ou cosmética de matéria método de tratamento ou de prevenção e método para controlar |
ITRM20010464A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
AU2002346620A1 (en) * | 2001-11-30 | 2003-06-17 | Department Of Veteran Affairs | Induction of apoptosis in cancer cells |
-
2001
- 2001-07-31 IT IT2001RM000464A patent/ITRM20010464A1/it unknown
-
2002
- 2002-07-18 JP JP2003517002A patent/JP4463550B2/ja not_active Expired - Fee Related
- 2002-07-18 WO PCT/IT2002/000474 patent/WO2003011808A1/en active Application Filing
- 2002-07-18 MX MXPA04000877A patent/MXPA04000877A/es active IP Right Grant
- 2002-07-18 DE DE60238683T patent/DE60238683D1/de not_active Expired - Lifetime
- 2002-07-18 HU HU0401604A patent/HU229308B1/hu not_active IP Right Cessation
- 2002-07-18 CA CA2454532A patent/CA2454532C/en not_active Expired - Fee Related
- 2002-07-18 PT PT02760553T patent/PT1412317E/pt unknown
- 2002-07-18 KR KR1020047001546A patent/KR100888466B1/ko not_active IP Right Cessation
- 2002-07-18 US US10/485,530 patent/US8101793B2/en not_active Expired - Fee Related
- 2002-07-18 ES ES02760553T patent/ES2358097T3/es not_active Expired - Lifetime
- 2002-07-18 EP EP02760553A patent/EP1412317B1/en not_active Expired - Lifetime
- 2002-07-18 BR BR0211521-2A patent/BR0211521A/pt not_active IP Right Cessation
- 2002-07-18 DK DK02760553.4T patent/DK1412317T3/da active
- 2002-07-18 AT AT02760553T patent/ATE492526T1/de active
- 2002-07-18 AU AU2002326144A patent/AU2002326144B2/en not_active Ceased
- 2002-07-18 CN CNB028150082A patent/CN1279014C/zh not_active Expired - Fee Related
- 2002-07-18 PL PL368412A patent/PL207530B1/pl not_active IP Right Cessation
-
2005
- 2005-02-16 HK HK05101240A patent/HK1068868A1/xx not_active IP Right Cessation
-
2007
- 2007-06-20 US US11/765,737 patent/US7449495B2/en not_active Expired - Fee Related
-
2011
- 2011-03-16 CY CY20111100294T patent/CY1114535T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20040235757A1 (en) | 2004-11-25 |
JP4463550B2 (ja) | 2010-05-19 |
US7449495B2 (en) | 2008-11-11 |
CA2454532C (en) | 2011-01-25 |
EP1412317A1 (en) | 2004-04-28 |
HU229308B1 (en) | 2013-10-28 |
CN1279014C (zh) | 2006-10-11 |
ES2358097T3 (es) | 2011-05-05 |
DE60238683D1 (de) | 2011-02-03 |
PL368412A1 (en) | 2005-03-21 |
ATE492526T1 (de) | 2011-01-15 |
US8101793B2 (en) | 2012-01-24 |
ITRM20010464A1 (it) | 2003-01-31 |
ITRM20010464A0 (it) | 2001-07-31 |
HK1068868A1 (en) | 2005-05-06 |
CN1537094A (zh) | 2004-10-13 |
HUP0401604A2 (hu) | 2004-12-28 |
CY1114535T1 (el) | 2016-10-05 |
CA2454532A1 (en) | 2003-02-13 |
JP2004536879A (ja) | 2004-12-09 |
US20080021088A1 (en) | 2008-01-24 |
PT1412317E (pt) | 2011-03-21 |
EP1412317B1 (en) | 2010-12-22 |
KR20040028968A (ko) | 2004-04-03 |
AU2002326144B2 (en) | 2008-04-10 |
MXPA04000877A (es) | 2004-06-03 |
HUP0401604A3 (en) | 2006-01-30 |
PL207530B1 (pl) | 2010-12-31 |
BR0211521A (pt) | 2004-09-14 |
WO2003011808A1 (en) | 2003-02-13 |
KR100888466B1 (ko) | 2009-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1412317T3 (da) | Retinoidderivater med antiangiogenetisk-, antitumor og pro-apoptotisk virkning | |
HRP20080664A2 (en) | Substituted pyridine herbicides | |
CY1110780T1 (el) | Τοπικα σκευασματα νεπαφενακης | |
CY1110064T1 (el) | Παραγωγα φαινυλ-πιπεραζινης ως αναστολεις επαναπροσληψης σεροτονινης | |
EA200701802A1 (ru) | Имидазо(1,2-а)пиридиновые соединения в качестве ингибиторов vegf-r2 | |
ECSP045245A (es) | N-aril-2-oxazolidinona-5-carboxamidas y sus derivados | |
EA200400582A1 (ru) | Тиофен- и тиазолсульфонамиды в качестве противоопухолевых средств | |
DK1414828T3 (da) | Antitumoranaloger | |
DK1847611T3 (da) | Rhamnose-inducerbart ekspressionssystem | |
CR8350A (es) | 4-anilino-3-quinolincarbonitrilos para el tratamiento de leucemia mielogenica cronica | |
DE602004024770D1 (de) | Substituierte 8-perfluoro-6,7,8,9-tetrahydropyrimido-(1,2a) pyrimidin-4-on derivate | |
EA200801365A1 (ru) | Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины | |
DE60224225D1 (de) | AZO Verbindung | |
NL1025932C2 (nl) | 3-Azabicycloó3.2.1!octaanderivaten. | |
ATE393776T1 (de) | Antitumorverbindungen basiert auf kahalalide f | |
BRPI0417205A (pt) | composições farmacêuticas | |
NO20044405L (no) | Neurotensinaktive 2,3-diaryl-pyrazolidin derivater | |
CY1115144T1 (el) | Παραγωγα του uk-2a | |
TW200640934A (en) | Eudistomin derivatives | |
UY3459Q (es) | Producto con piezas suspendidas | |
ITPD20030125A1 (it) | Struttura componibile per tavolo o simili. | |
ES1051306Y (es) | Panel expositor mejorado para piezas ceramicas. | |
ATE377744T1 (de) | Encoder | |
BR0109394A (pt) | Compostos de esponja antitumores | |
ES1041602Y (es) | Tarjeta para el calculo de conversiones matematicas mediante tablas de equivalencias. |