DK1409101T3 - Dannelse af små krystaller - Google Patents

Dannelse af små krystaller

Info

Publication number
DK1409101T3
DK1409101T3 DK02769152T DK02769152T DK1409101T3 DK 1409101 T3 DK1409101 T3 DK 1409101T3 DK 02769152 T DK02769152 T DK 02769152T DK 02769152 T DK02769152 T DK 02769152T DK 1409101 T3 DK1409101 T3 DK 1409101T3
Authority
DK
Denmark
Prior art keywords
small crystals
mixer
formation
solution
ultrasound
Prior art date
Application number
DK02769152T
Other languages
Danish (da)
English (en)
Inventor
Michael Joseph Bowe
John William Firdale Stairmand
Linda Jane Mccausland
Original Assignee
Accentus Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0111083A external-priority patent/GB0111083D0/en
Priority claimed from GB0127380A external-priority patent/GB0127380D0/en
Application filed by Accentus Plc filed Critical Accentus Plc
Application granted granted Critical
Publication of DK1409101T3 publication Critical patent/DK1409101T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/86—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with vibration of the receptacle or part of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Metallurgy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Electrically Operated Instructional Devices (AREA)
DK02769152T 2001-05-05 2002-05-02 Dannelse af små krystaller DK1409101T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0111083A GB0111083D0 (en) 2001-05-05 2001-05-05 Formation of small crystals
GB0127380A GB0127380D0 (en) 2001-11-15 2001-11-15 Formation of small crystals

Publications (1)

Publication Number Publication Date
DK1409101T3 true DK1409101T3 (da) 2006-07-31

Family

ID=26246040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02769152T DK1409101T3 (da) 2001-05-05 2002-05-02 Dannelse af små krystaller

Country Status (17)

Country Link
US (1) US6960256B2 (cs)
EP (1) EP1409101B1 (cs)
JP (1) JP2004530545A (cs)
CN (1) CN1250312C (cs)
AT (1) ATE322936T1 (cs)
AU (1) AU2002307907B2 (cs)
BR (1) BR0209433A (cs)
CA (1) CA2445146A1 (cs)
CZ (1) CZ20032996A3 (cs)
DE (1) DE60210622T2 (cs)
DK (1) DK1409101T3 (cs)
ES (1) ES2261730T3 (cs)
NO (1) NO20034848L (cs)
NZ (1) NZ529258A (cs)
PL (1) PL364626A1 (cs)
PT (1) PT1409101E (cs)
WO (1) WO2002089942A1 (cs)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40407E1 (en) 1999-05-24 2008-07-01 Vortex Flow, Inc. Method and apparatus for mixing fluids
US8096700B2 (en) * 1999-11-24 2012-01-17 Impulse Devices Inc. Heat exchange system for a cavitation chamber
BR0309625A (pt) * 2002-04-29 2005-03-08 Bristol Myers Squibb Co Sistema de cristalização que utiliza atomização
GB0219815D0 (en) 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
US7244307B2 (en) * 2002-05-31 2007-07-17 Accentus Plc Production of crystalline materials by using high intensity ultrasound
BR0311332A (pt) 2002-05-31 2005-03-15 Accentus Plc Método para produção de material cristalino
ATE551993T1 (de) * 2002-10-17 2012-04-15 Boehringer Ingelheim Pharma Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente
US20040197275A1 (en) 2002-10-17 2004-10-07 Ecole Polytechnique Federale De Lausanne Process for the manufacture of powders of inhalable medicaments
EP1593417A4 (en) * 2003-01-31 2007-02-28 Ebara Corp METHOD AND APPARATUS FOR REMOVING IONS IN A FLUID BY CRYSTALLIZATION
DK1610878T3 (da) 2003-02-21 2014-12-01 Univ Bath Fremgangsmåde til fremstilling af partikler
CA2517727C (en) * 2003-03-04 2012-09-04 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
SE0302029D0 (sv) * 2003-07-07 2003-07-07 Astrazeneca Ab Novel process
CN1878602A (zh) * 2003-11-28 2006-12-13 三菱化学株式会社 有机化合物微粒的制造方法
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
GB0405108D0 (en) * 2004-03-06 2004-04-07 Accentus Plc Removal of sodium oxalate from a bayer liquor
US7314516B2 (en) * 2004-12-29 2008-01-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
WO2006113309A1 (en) 2005-04-15 2006-10-26 Dr. Reddy's Laboratories Ltd. Lacidipine particles
WO2008109577A1 (en) * 2007-03-05 2008-09-12 Transform Pharmaceuticals, Inc. Polymorphs of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid s,s dioxide and methods of making and using the same
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
CN101356958B (zh) * 2007-07-30 2012-12-19 广西工学院 一种强化硫熏中和反应的制糖澄清工艺方法
CA2729644C (en) 2008-07-18 2018-05-29 Prosonix Limited Process for improving crystallinity
GB0914240D0 (en) 2009-08-14 2009-09-30 Breath Ltd Steroid solvates
GB0914231D0 (en) 2009-08-14 2009-09-30 Breath Ltd Dry powder inhaler formulations
GB0918431D0 (en) * 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
AU2011350062B2 (en) 2010-12-30 2015-09-03 Yava Technologies Inc. Transition metal compound particles and methods of production
EP2500072A1 (en) 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. A novel process of residual solvent removal
US8821616B2 (en) 2011-04-04 2014-09-02 Georgia Tech Research Corporation Zeolite DDR nanoparticles
WO2012138418A1 (en) 2011-04-04 2012-10-11 Georgia Tech Research Corporation Zeolite ddr nanocrystals
WO2012138419A1 (en) * 2011-04-04 2012-10-11 Georgia Tech Research Corporation Mof nanocrystals
US20130026669A1 (en) * 2011-07-14 2013-01-31 Covaris, INC Systems and methods for preparing nanocrystalline compositions using focused acoustics
RU2497580C1 (ru) * 2012-03-05 2013-11-10 Долгополов Юрий Яковлевич Ультразвуковой диспергатор долгополова
US9375678B2 (en) 2012-05-25 2016-06-28 Georgia Tech Research Corporation Metal-organic framework supported on porous polymer
ES2714505T3 (es) * 2013-03-28 2019-05-28 Instillo Gmbh Dispositivo y procedimiento para producir dispersiones y sólidos
US9687791B2 (en) 2013-05-07 2017-06-27 Georgia Tech Research Corporation Flow processing and characterization of metal-organic framework (MOF) membranes in hollow fiber and tubular modules
US9994501B2 (en) 2013-05-07 2018-06-12 Georgia Tech Research Corporation High efficiency, high performance metal-organic framework (MOF) membranes in hollow fibers and tubular modules
US9789455B2 (en) * 2013-09-30 2017-10-17 Bedoukian Research, Inc. Vortex mixing apparatus and method of use thereof
CN107551920B (zh) * 2016-07-01 2024-04-26 中国科学院声学研究所 一种多尺度掺混器以及掺混方法
CN113646069B (zh) * 2019-04-10 2023-09-22 米其林集团总公司 用于生产基于弹性体的复合物的强力混合工具
JP2022546336A (ja) * 2019-08-22 2022-11-04 ビーエーエスエフ コーティングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 流体中で粒子を分散及び粉砕する方法
CN113521791A (zh) * 2021-06-23 2021-10-22 福建江夏学院 一种光电半导体薄膜的超声波振荡制备装置
CN113577806B (zh) * 2021-08-11 2022-08-02 中北大学 一种制备含能材料的喷雾干燥床及其制备含能材料的方法
CN115253367B (zh) * 2022-08-31 2024-07-09 浙江新和成股份有限公司 一种布洛芬微晶的生产装置及结晶方法和产品
CN115624892B (zh) * 2022-09-05 2024-05-07 安徽工业大学 一种用于模拟锅炉烟气气溶胶的生成装置和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979269A (en) * 1975-02-25 1976-09-07 DSO "Pharmachim Method for obtaining tetracyclinehydrochloride
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
GB9007027D0 (en) * 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
SE9501384D0 (sv) 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB2341120B (en) * 1998-09-04 2002-04-17 Aea Technology Plc Controlling uniformity of crystalline precipitates
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
EP1173265B1 (en) 1999-01-29 2005-12-21 Bristol-Myers Squibb Company Sonic impinging jet crystallization apparatus and process

Also Published As

Publication number Publication date
JP2004530545A (ja) 2004-10-07
CN1507365A (zh) 2004-06-23
ES2261730T3 (es) 2006-11-16
NZ529258A (en) 2004-07-30
DE60210622D1 (de) 2006-05-24
WO2002089942A1 (en) 2002-11-14
US20040139908A1 (en) 2004-07-22
PT1409101E (pt) 2006-07-31
US6960256B2 (en) 2005-11-01
DE60210622T2 (de) 2007-04-05
CZ20032996A3 (cs) 2004-04-14
NO20034848D0 (no) 2003-10-30
NO20034848L (no) 2004-01-05
PL364626A1 (en) 2004-12-13
EP1409101A1 (en) 2004-04-21
EP1409101B1 (en) 2006-04-12
CN1250312C (zh) 2006-04-12
CA2445146A1 (en) 2002-11-14
ATE322936T1 (de) 2006-04-15
BR0209433A (pt) 2004-08-03
AU2002307907B2 (en) 2007-03-01

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