US8212004B2
(en)
|
1999-03-02 |
2012-07-03 |
Human Genome Sciences, Inc. |
Neutrokine-alpha fusion proteins
|
US6812327B1
(en)
|
1996-10-25 |
2004-11-02 |
Human Genome Sciences, Inc. |
Neutrokine-alpha polypeptides
|
US7833529B1
(en)
|
1999-01-07 |
2010-11-16 |
Zymogenetics, Inc. |
Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
|
US20030095967A1
(en)
|
1999-01-25 |
2003-05-22 |
Mackay Fabienne |
BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
|
AU2048501A
(en)
*
|
2000-02-16 |
2001-08-27 |
Genentech Inc. |
Uses of agonists and antagonists to modulate activity of tnf-related molecules
|
US7879328B2
(en)
|
2000-06-16 |
2011-02-01 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to B lymphocyte stimulator
|
CA2407910C
(en)
*
|
2000-06-16 |
2013-03-12 |
Steven M. Ruben |
Antibodies that immunospecifically bind to blys
|
US20030091565A1
(en)
|
2000-08-18 |
2003-05-15 |
Beltzer James P. |
Binding polypeptides and methods based thereon
|
UA83458C2
(uk)
*
|
2000-09-18 |
2008-07-25 |
Байоджен Айдек Ма Інк. |
Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
|
ES2329012T3
(es)
*
|
2000-11-07 |
2009-11-20 |
Zymogenetics, Inc. |
Receptor del factor de necrosis tumoral humano.
|
WO2002072827A1
(fr)
*
|
2001-02-28 |
2002-09-19 |
Riken |
Recepteur specifique de cellule b se liant a traf3
|
US20030103986A1
(en)
|
2001-05-24 |
2003-06-05 |
Rixon Mark W. |
TACI-immunoglobulin fusion proteins
|
EP1401870A4
(en)
|
2001-05-24 |
2006-04-19 |
Human Genome Sciences |
ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL)
|
JP2005510208A
(ja)
*
|
2001-08-03 |
2005-04-21 |
ジェネンテック・インコーポレーテッド |
TACIs及びBR3ポリペプチドとその用途
|
US7112410B1
(en)
|
2001-08-29 |
2006-09-26 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor TR21 and methods based thereon
|
AU2002330074A1
(en)
*
|
2001-09-21 |
2003-04-01 |
Amgen Inc. |
Tall-1 receptor molecules and uses thereof
|
WO2003045422A1
(en)
*
|
2001-11-29 |
2003-06-05 |
Genset S.A. |
Agonists and antagonists of prolixin for the treatment of metabolic disorders
|
WO2003055509A1
(en)
*
|
2001-12-26 |
2003-07-10 |
Genset S.A. |
Agonists and antagonists of bromix for the treatment of metabolic disorders
|
EP1495055B1
(en)
*
|
2002-04-18 |
2013-08-14 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
BR0313033A
(pt)
*
|
2002-07-25 |
2007-07-10 |
Genentech Inc |
anticorpos, anticorpos monoclonais, linhagens de células de hibridoma, anticorpos receptores de anti-taci isolados, anticorpos anti -taci, métodos de modulação da atividade biológica
|
CA2520097C
(en)
|
2003-03-28 |
2014-10-07 |
Biogen Idec Ma Inc. |
Truncated baff receptors
|
US20050163775A1
(en)
*
|
2003-06-05 |
2005-07-28 |
Genentech, Inc. |
Combination therapy for B cell disorders
|
ES2537738T3
(es)
*
|
2003-06-05 |
2015-06-11 |
Genentech, Inc. |
Terapia de combinación para trastornos de células B
|
CN103394083B
(zh)
|
2003-11-06 |
2017-07-18 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
EP1586585A1
(de)
*
|
2004-04-14 |
2005-10-19 |
F. Hoffmann-La Roche Ag |
Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung
|
EP2286844A3
(en)
|
2004-06-01 |
2012-08-22 |
Genentech, Inc. |
Antibody-drug conjugates and methods
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
WO2007019575A2
(en)
|
2005-08-09 |
2007-02-15 |
Zymogenetics, Inc. |
Methods for treating b-cell malignancies using taci-ig fusion molecule
|
JP5118037B2
(ja)
|
2005-08-09 |
2013-01-16 |
ザイモジェネティクス, インコーポレイテッド |
Taci融合分子を用いた異常細胞増殖の処置及び予防のための方法
|
KR20140077946A
(ko)
*
|
2005-10-13 |
2014-06-24 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물
|
US9168286B2
(en)
|
2005-10-13 |
2015-10-27 |
Human Genome Sciences, Inc. |
Methods and compositions for use in treatment of patients with autoantibody positive disease
|
AU2006318539B2
(en)
*
|
2005-11-23 |
2012-09-13 |
Genentech, Inc. |
Methods and compositions related to B cell assays
|
AU2007225175A1
(en)
*
|
2006-03-10 |
2007-09-20 |
Mallinckrodt Inc. |
Photoactive compounds and compositions and uses thereof
|
US8211649B2
(en)
|
2006-03-31 |
2012-07-03 |
Human Genome Sciences, Inc. |
Methods of diagnosing and prognosing hodgkin's lymphoma
|
JP2009537563A
(ja)
*
|
2006-05-15 |
2009-10-29 |
アレス トレーディング ソシエテ アノニム |
Taci融合分子を使用する自己免疫疾患を治療するための方法
|
WO2008131242A1
(en)
|
2007-04-18 |
2008-10-30 |
Zymogenetics, Inc. |
Single chain fc, methods of making and methods of treatment
|
CA2701329C
(en)
|
2007-10-16 |
2017-08-22 |
Zymogenetics, Inc. |
Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease
|
US20110263484A1
(en)
*
|
2008-10-13 |
2011-10-27 |
Zymogenetics, Inc. |
Single chain fc type iii interferons and methods of using same
|
WO2010075249A2
(en)
|
2008-12-22 |
2010-07-01 |
Genentech, Inc. |
A method for treating rheumatoid arthritis with b-cell antagonists
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
EP3211094A3
(en)
|
2009-09-03 |
2017-11-01 |
F. Hoffmann-La Roche AG |
Methods for treating, diagnosing, and monitoring rheumatoid arthritis
|
JP2013504585A
(ja)
|
2009-09-09 |
2013-02-07 |
セントローズ, エルエルシー |
細胞外標的化薬物複合体
|
WO2011109280A1
(en)
|
2010-03-05 |
2011-09-09 |
Lerner Research Institute |
Methods and compositions to treat immune-mediated disorders
|
DK2528625T3
(da)
|
2010-04-15 |
2013-10-14 |
Spirogen Sarl |
Pyrrolobenzodiazepiner og konjugater deraf
|
CN103068406B
(zh)
|
2010-06-08 |
2017-06-30 |
基因泰克公司 |
半胱氨酸改造的抗体和偶联物
|
JP5889912B2
(ja)
|
2010-11-17 |
2016-03-22 |
ジェネンテック, インコーポレイテッド |
アラニニルメイタンシノール抗体コンジュゲート
|
US9540438B2
(en)
|
2011-01-14 |
2017-01-10 |
Redwood Bioscience, Inc. |
Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
|
CN103502472B
(zh)
|
2011-02-28 |
2017-06-06 |
弗·哈夫曼-拉罗切有限公司 |
生物标记物和用于预测对b‑细胞拮抗剂的响应的方法
|
EP3415528B1
(en)
*
|
2011-04-13 |
2021-05-26 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
MX2013013054A
(es)
|
2011-05-12 |
2014-02-20 |
Genentech Inc |
Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura.
|
EP2750713B1
(en)
|
2011-10-14 |
2015-09-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepines and conjugates thereof
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
PL2906298T3
(pl)
|
2012-10-12 |
2019-04-30 |
Adc Therapeutics Sa |
Koniugaty pirolobenzodiazepina - przeciwciało
|
PT2906251T
(pt)
|
2012-10-12 |
2017-12-04 |
Medimmune Ltd |
Conjugados de pirrolobenzodiazepina-anticorpo anti-cd22
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
JP6270859B2
(ja)
|
2012-10-12 |
2018-01-31 |
エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl |
ピロロベンゾジアゼピン−抗体結合体
|
SI2839860T1
(sl)
|
2012-10-12 |
2019-07-31 |
MedImmune Limited, |
Pirolobenzodiazepini in njihovi konjugati
|
WO2014057119A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
WO2014057120A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
EP2935268B2
(en)
|
2012-12-21 |
2021-02-17 |
MedImmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
EP2935273A1
(en)
|
2012-12-21 |
2015-10-28 |
MedImmune Limited |
Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
|
BR112015023333A8
(pt)
|
2013-03-13 |
2018-04-17 |
Medimmune Ltd |
pirrolbenzodiazepinas e conjugados dos mesmos
|
EP2968596B1
(en)
|
2013-03-13 |
2019-03-06 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
AU2014229529B2
(en)
|
2013-03-13 |
2018-02-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
SG11201601005XA
(en)
|
2013-08-12 |
2016-03-30 |
Genentech Inc |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
US9950078B2
(en)
|
2013-10-11 |
2018-04-24 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
EP3054986B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
WO2015095212A1
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
AU2014364927A1
(en)
|
2013-12-16 |
2016-07-07 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
MX371092B
(es)
|
2013-12-16 |
2020-01-16 |
Genentech Inc |
Compuestos peptidomimeticos y conjugados de anticuerpo-farmaco de los mismos.
|
JP6531166B2
(ja)
|
2014-09-10 |
2019-06-12 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン及びそのコンジュゲート
|
RU2017107502A
(ru)
|
2014-09-12 |
2018-10-12 |
Дженентек, Инк. |
Антитела и конъюгаты, сконструированные введением цистеина
|
WO2016040825A1
(en)
|
2014-09-12 |
2016-03-17 |
Genentech, Inc. |
Anthracycline disulfide intermediates, antibody-drug conjugates and methods
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
PE20170905A1
(es)
|
2014-09-17 |
2017-07-12 |
Genentech Inc |
Pirrolobenzodiazepinas y conjugados de anticuerpo-disulfuro de las mismas
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
JP6878287B2
(ja)
|
2014-11-25 |
2021-05-26 |
アーデーセー セラピューティクス ソシエテ アノニム |
ピロロベンゾジアゼピン−抗体コンジュゲート
|
AU2015358532C1
(en)
|
2014-12-03 |
2020-10-29 |
Genentech, Inc. |
Quaternary amine compounds and antibody-drug conjugates thereof
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
MA43345A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
MA45326A
(fr)
|
2015-10-20 |
2018-08-29 |
Genentech Inc |
Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
EP4273551A3
(en)
|
2016-03-25 |
2024-01-17 |
F. Hoffmann-La Roche AG |
Multiplexed total antibody and antibody-conjugated drug quantification assay
|
US11208632B2
(en)
|
2016-04-26 |
2021-12-28 |
R.P. Scherer Technologies, Llc |
Antibody conjugates and methods of making and using the same
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
EP3458101B1
(en)
|
2016-05-20 |
2020-12-30 |
H. Hoffnabb-La Roche Ag |
Protac antibody conjugates and methods of use
|
WO2017205741A1
(en)
|
2016-05-27 |
2017-11-30 |
Genentech, Inc. |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
US10639378B2
(en)
|
2016-06-06 |
2020-05-05 |
Genentech, Inc. |
Silvestrol antibody-drug conjugates and methods of use
|
JP7093767B2
(ja)
|
2016-08-11 |
2022-06-30 |
ジェネンテック, インコーポレイテッド |
ピロロベンゾジアゼピンプロドラッグ及びその抗体コンジュゲート
|
EP3522933B1
(en)
|
2016-10-05 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Methods for preparing antibody drug conjugates
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
WO2018146189A1
(en)
|
2017-02-08 |
2018-08-16 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
PL3612537T3
(pl)
|
2017-04-18 |
2022-11-07 |
Medimmune Limited |
Koniugaty pirolobenzodiazepin
|
CA3057748A1
(en)
|
2017-04-20 |
2018-10-25 |
Adc Therapeutics Sa |
Combination therapy with an anti-axl antibody-drug conjugate
|
WO2018206715A2
(en)
|
2017-05-09 |
2018-11-15 |
Cyano Biotech Gmbh |
Modified microcystins and nodularins
|
WO2018219619A1
(en)
|
2017-05-09 |
2018-12-06 |
Cyano Biotech Gmbh |
Method for modifying microcystins and nodularins
|
MX2019015042A
(es)
|
2017-06-14 |
2020-08-06 |
Adc Therapeutics Sa |
Regimen de dosificacion.
|
HRP20220311T1
(hr)
|
2017-08-18 |
2022-05-13 |
Medimmune Limited |
Konjugati pirolobenzodiazepina
|
CA3074688A1
(en)
|
2017-09-20 |
2019-03-28 |
Ph Pharma Co., Ltd. |
Thailanstatin analogs
|
PT3687287T
(pt)
*
|
2017-09-29 |
2023-11-03 |
Regeneron Pharma |
Roedores que expressam complexo c1q humanizado
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
TW202037381A
(zh)
|
2018-10-24 |
2020-10-16 |
瑞士商赫孚孟拉羅股份公司 |
綴合化學降解誘導劑及使用方法
|
CN113227119A
(zh)
|
2018-12-10 |
2021-08-06 |
基因泰克公司 |
用于与含Fc的蛋白质进行位点特异性缀合的光交联肽
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
WO2024138128A2
(en)
|
2022-12-23 |
2024-06-27 |
Genentech, Inc. |
Cereblon degrader conjugates, and uses thereof
|