DK1406568T3 - Sekventielle lægemiddelafgivelsessystemer - Google Patents
Sekventielle lægemiddelafgivelsessystemerInfo
- Publication number
- DK1406568T3 DK1406568T3 DK02749899T DK02749899T DK1406568T3 DK 1406568 T3 DK1406568 T3 DK 1406568T3 DK 02749899 T DK02749899 T DK 02749899T DK 02749899 T DK02749899 T DK 02749899T DK 1406568 T3 DK1406568 T3 DK 1406568T3
- Authority
- DK
- Denmark
- Prior art keywords
- active ingredient
- drug delivery
- delivery systems
- absorption
- dissolution
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 5
- 238000010521 absorption reaction Methods 0.000 abstract 3
- 238000004090 dissolution Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/901,983 US20030068356A1 (en) | 2001-07-10 | 2001-07-10 | Sequential drug delivery systems |
| PCT/US2002/021796 WO2003005944A1 (en) | 2001-07-10 | 2002-07-10 | Sequential drug delivery systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1406568T3 true DK1406568T3 (da) | 2007-10-01 |
Family
ID=25415151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02749899T DK1406568T3 (da) | 2001-07-10 | 2002-07-10 | Sekventielle lægemiddelafgivelsessystemer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20030068356A1 (https=) |
| EP (2) | EP1818029B1 (https=) |
| JP (1) | JP4617081B2 (https=) |
| AT (1) | ATE363261T1 (https=) |
| AU (2) | AU2002320385B2 (https=) |
| CA (1) | CA2451106C (https=) |
| DE (1) | DE60220408T2 (https=) |
| DK (1) | DK1406568T3 (https=) |
| ES (2) | ES2604780T3 (https=) |
| WO (1) | WO2003005944A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6974590B2 (en) * | 1998-03-27 | 2005-12-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| US20080213363A1 (en) * | 2003-01-23 | 2008-09-04 | Singh Nikhilesh N | Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa |
| EP1449525A1 (en) * | 2003-02-20 | 2004-08-25 | Cross Chem Llc | chewing gum in the form of multi-layer tablets |
| EA015349B1 (ru) * | 2003-07-11 | 2011-06-30 | Ф. Хоффманн-Ля Рош Аг | Твёрдая разовая пероральная фармацевтическая дозированная форма саквинавирмезилата и способ её изготовления |
| UA81335C2 (uk) * | 2003-07-11 | 2007-12-25 | Ф.Хоффманн-Ля Рош Аг | Оральна дозована форма саквінавіру мезилату |
| ME00391B (me) | 2003-08-08 | 2011-10-10 | Biovail Laboratories Int Srl | Tableta bupropion hidrohlorida sa modifikovanim otpuštanjem |
| DE602004031462D1 (de) | 2003-12-31 | 2011-03-31 | Cima Labs Inc | Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung |
| US7858121B2 (en) | 2003-12-31 | 2010-12-28 | Cima Labs, Inc. | Effervescent oral fentanyl dosage form and methods of administering fentanyl |
| CA2549642C (en) * | 2003-12-31 | 2012-10-30 | Cima Labs Inc. | Effervescent oral opiate dosage forms and methods of administering opiates |
| JP5179757B2 (ja) * | 2004-02-17 | 2013-04-10 | トランセプト ファーマシューティカルズ, インコーポレイティド | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
| US7615028B2 (en) * | 2004-12-03 | 2009-11-10 | Chf Solutions Inc. | Extracorporeal blood treatment and system having reversible blood pumps |
| GB0509317D0 (en) * | 2005-05-06 | 2005-06-15 | Clarke Anthony | Pharmaceutical formulation of apomorphine |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| EP1883408A4 (en) * | 2005-05-25 | 2009-11-11 | Transcept Pharmaceuticals Inc | SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8252328B2 (en) | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| EP1980240A1 (en) * | 2007-04-11 | 2008-10-15 | Cephalon France | Lyophilized pharmaceutical compositions and methods of making and using same |
| WO2009081411A2 (en) * | 2007-12-26 | 2009-07-02 | Rainbow Medical | Nitric oxide generation to treat female sexual dysfunction |
| US20090198271A1 (en) * | 2008-01-31 | 2009-08-06 | Rainbow Medical Ltd. | Electrode based filter |
| BRPI0918492A2 (pt) | 2008-09-09 | 2015-12-01 | Astrazeneca Ab | uso de naproxen, ou sal farmaceuticamente aceitável do mesmo, e esomeprazol, ou sal farmaceuticamente aceitável do mesmo |
| US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| RU2589823C2 (ru) * | 2009-04-09 | 2016-07-10 | Алкермес Фарма Айэленд Лимитед | Композиция для доставки лекарственных средств |
| PT2952191T (pt) * | 2009-06-12 | 2018-11-30 | Sunovion Pharmaceuticals Inc | Apomorfina sublingual |
| EP2445499A4 (en) | 2009-06-25 | 2013-02-27 | Astrazeneca Ab | METHOD FOR TREATING A PATIENT WITH RISK OF DEVELOPING A NSAID-ASSOCIATED SPURGE |
| US20120141584A1 (en) * | 2009-08-26 | 2012-06-07 | Aptapharma, Inc. | Multilayer Minitablets |
| US20110202108A1 (en) * | 2010-02-18 | 2011-08-18 | Rainbow Medical Ltd. | Electrical menorrhagia treatment |
| US8529914B2 (en) * | 2010-06-28 | 2013-09-10 | Richard C. Fuisz | Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive |
| NZ612686A (en) * | 2010-12-16 | 2015-11-27 | Cynapsus Therapeutics Inc | Sublingual films |
| MX377589B (es) | 2010-12-16 | 2025-03-10 | Novo Nordisk As | Composiciones sólidas que comprenden agonista de glp-1 y sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico. |
| RU2602601C2 (ru) | 2011-04-12 | 2016-11-20 | Ново Нордиск А/С | Дважды ацилированные производные glp-1 |
| SMT202100546T1 (it) | 2011-09-19 | 2021-11-12 | Orexo Ab | Compresse per via sublinguale resistenti all'abuso comprendenti buprenorfina e naloxone |
| UA115139C2 (uk) | 2011-12-28 | 2017-09-25 | Поузен Інк. | Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту |
| CN104203266B (zh) | 2012-03-22 | 2017-12-26 | 诺和诺德股份有限公司 | Glp‑1肽组合物及其制备 |
| DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
| EP3542790B1 (en) | 2012-03-22 | 2023-09-13 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| JP6203816B2 (ja) | 2012-03-29 | 2017-09-27 | セラバイオーム,エルエルシー | 回腸及び虫垂に対して活性の胃腸部位特異的経口ワクチン接種製剤 |
| SMT201800585T1 (it) | 2012-05-02 | 2019-01-11 | Orexo Ab | Nuova composizione di alfentanil per il trattamento di dolore acuto |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー/エス | ペプチド及び送達剤を含む錠剤製剤 |
| AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| JP6672140B2 (ja) | 2013-05-02 | 2020-03-25 | ノヴォ ノルディスク アー/エス | Glp−1化合物の経口投薬 |
| BR112017013311B1 (pt) | 2014-12-23 | 2022-05-31 | Acelrx Pharmaceuticals, Inc | Aparelho para a dispensação de formas de dosagem via oral e transmucosal |
| JP7211706B2 (ja) | 2015-04-21 | 2023-01-24 | サノヴィオン ファーマシュティカルズ インコーポレーテッド | 口腔粘膜へのアポモルフィンの投与によるパーキンソン病の治療方法 |
| PL3746111T3 (pl) | 2018-02-02 | 2024-01-15 | Novo Nordisk A/S | Stałe kompozycje zawierające agonistę glp-1 i sól kwasu n-(8-(2- hydroksybenzoilo)amino kaprylowego i substancję poślizgową |
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|---|---|---|---|---|
| US3131123A (en) * | 1959-03-13 | 1964-04-28 | Lab Francais De Therapeutique | Enteric tablets and manufacture thereof |
| US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| US4756710A (en) * | 1985-04-05 | 1988-07-12 | Merck & Co., Inc. | pH-Mediated drug delivery system |
| US4764375A (en) | 1985-09-11 | 1988-08-16 | Kv Pharmaceutical Company | Sachet drug delivery system |
| GB8820327D0 (en) * | 1988-08-26 | 1988-09-28 | May & Baker Ltd | New compositions of matter |
| DE3838431A1 (de) * | 1988-11-12 | 1990-05-17 | Bayer Ag | Ibuprofen-brausezubereitungen |
| WO1991004757A1 (en) * | 1989-10-02 | 1991-04-18 | Cima Labs, Inc. | Effervescent dosage form and method of administering same |
| US5178878A (en) * | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| IT1246382B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
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| TW212139B (https=) * | 1991-04-15 | 1993-09-01 | Yamanouchi Pharma Co Ltd | |
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| IT1270831B (it) | 1993-09-17 | 1997-05-13 | Romano Deghenghi | Composizioni farmaceutiche orali effervescenti contenenti estrone |
| ATE246909T1 (de) * | 1994-03-07 | 2003-08-15 | Theratech Inc | Medikament enthaltende, adhesive, zusammenbaubare,transdermale abgabevorrichtung |
| ES2270426T3 (es) * | 1994-03-18 | 2007-04-01 | Supernus Pharmaceuticals, Inc. | Sistema de suministros de farmacos emulsionados. |
| JP3170139B2 (ja) | 1994-04-08 | 2001-05-28 | エスエス製薬株式会社 | 発泡性錠剤 |
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| AU697456B2 (en) | 1994-06-15 | 1998-10-08 | Dumex-Alpharma A/S | Pellets |
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| CA2160423A1 (en) * | 1994-11-02 | 1996-05-03 | Hemant N. Joshi | Salts of nefazodone having improved dissolution rates |
| FR2732217B1 (fr) | 1995-03-29 | 1997-06-06 | Hesnard Xavier | Forme d'administration solide a usage oral |
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| DK0866691T4 (da) * | 1995-11-06 | 2005-06-06 | Somerset Pharmaceuticals Inc | Medikamenter til sublingual og bukkal administration af selegilin |
| DE69910183T2 (de) | 1998-03-11 | 2004-06-03 | Grelan Pharmaceutical Co., Ltd., Hamura | Darmlösliche sprudelnde zusammensetzungen |
| US6200604B1 (en) * | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6974590B2 (en) * | 1998-03-27 | 2005-12-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US20030118645A1 (en) * | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
| US20030091629A1 (en) * | 1998-03-27 | 2003-05-15 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6350470B1 (en) * | 1998-04-29 | 2002-02-26 | Cima Labs Inc. | Effervescent drug delivery system for oral administration |
| DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
| US6312728B1 (en) * | 1998-07-07 | 2001-11-06 | Cascade Development, Inc. | Sustained release pharmaceutical preparation |
| EP2127642A3 (en) | 1998-08-13 | 2010-02-24 | Cima Labs, Inc. | Microemulsions as solid dosage forms for oral administration |
| WO2000035418A2 (en) * | 1998-12-18 | 2000-06-22 | Bayer Corporation | Chewable drug delivery system |
| US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
| US6326384B1 (en) * | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| US6264981B1 (en) * | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US20070036853A1 (en) * | 2003-12-31 | 2007-02-15 | Cima Labs Inc. | Generally linear effervescent oral fentanyl dosage form and methods of administering |
| US7858121B2 (en) * | 2003-12-31 | 2010-12-28 | Cima Labs, Inc. | Effervescent oral fentanyl dosage form and methods of administering fentanyl |
| DE602004031462D1 (de) * | 2003-12-31 | 2011-03-31 | Cima Labs Inc | Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung |
| CA2549642C (en) * | 2003-12-31 | 2012-10-30 | Cima Labs Inc. | Effervescent oral opiate dosage forms and methods of administering opiates |
-
2001
- 2001-07-10 US US09/901,983 patent/US20030068356A1/en not_active Abandoned
-
2002
- 2002-07-10 AU AU2002320385A patent/AU2002320385B2/en not_active Ceased
- 2002-07-10 ES ES07006505.7T patent/ES2604780T3/es not_active Expired - Lifetime
- 2002-07-10 WO PCT/US2002/021796 patent/WO2003005944A1/en not_active Ceased
- 2002-07-10 AT AT02749899T patent/ATE363261T1/de active
- 2002-07-10 EP EP07006505.7A patent/EP1818029B1/en not_active Expired - Lifetime
- 2002-07-10 ES ES02749899T patent/ES2286263T3/es not_active Expired - Lifetime
- 2002-07-10 DE DE60220408T patent/DE60220408T2/de not_active Expired - Lifetime
- 2002-07-10 JP JP2003511754A patent/JP4617081B2/ja not_active Expired - Fee Related
- 2002-07-10 CA CA002451106A patent/CA2451106C/en not_active Expired - Fee Related
- 2002-07-10 EP EP02749899A patent/EP1406568B1/en not_active Expired - Lifetime
- 2002-07-10 DK DK02749899T patent/DK1406568T3/da active
-
2003
- 2003-07-18 US US10/623,069 patent/US20030232080A1/en not_active Abandoned
-
2004
- 2004-09-08 US US10/936,185 patent/US7670617B2/en not_active Expired - Fee Related
-
2008
- 2008-08-01 AU AU2008203464A patent/AU2008203464B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1406568A1 (en) | 2004-04-14 |
| EP1406568B1 (en) | 2007-05-30 |
| EP1818029A2 (en) | 2007-08-15 |
| US20030232080A1 (en) | 2003-12-18 |
| JP4617081B2 (ja) | 2011-01-19 |
| JP2004534839A (ja) | 2004-11-18 |
| HK1106126A1 (en) | 2008-03-07 |
| AU2008203464A1 (en) | 2008-08-21 |
| WO2003005944A1 (en) | 2003-01-23 |
| ES2286263T3 (es) | 2007-12-01 |
| CA2451106A1 (en) | 2003-01-23 |
| EP1818029B1 (en) | 2016-09-07 |
| ATE363261T1 (de) | 2007-06-15 |
| DE60220408T2 (de) | 2008-01-31 |
| EP1818029A3 (en) | 2008-06-11 |
| DE60220408D1 (de) | 2007-07-12 |
| US20050031677A1 (en) | 2005-02-10 |
| US7670617B2 (en) | 2010-03-02 |
| AU2002320385B2 (en) | 2008-05-01 |
| AU2008203464B2 (en) | 2010-07-01 |
| ES2604780T3 (es) | 2017-03-09 |
| EP1406568A4 (en) | 2004-12-15 |
| CA2451106C (en) | 2009-12-22 |
| US20030068356A1 (en) | 2003-04-10 |
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