DK1401445T3 - Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel - Google Patents

Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel

Info

Publication number
DK1401445T3
DK1401445T3 DK02743165T DK02743165T DK1401445T3 DK 1401445 T3 DK1401445 T3 DK 1401445T3 DK 02743165 T DK02743165 T DK 02743165T DK 02743165 T DK02743165 T DK 02743165T DK 1401445 T3 DK1401445 T3 DK 1401445T3
Authority
DK
Denmark
Prior art keywords
drug
prepare
preparing
anticholinergic
crystalline
Prior art date
Application number
DK02743165T
Other languages
Danish (da)
English (en)
Inventor
Ulrike Werthmann
Peter Sieger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1401445T3 publication Critical patent/DK1401445T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
DK02743165T 2001-06-22 2002-06-08 Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel DK1401445T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08

Publications (1)

Publication Number Publication Date
DK1401445T3 true DK1401445T3 (da) 2006-11-27

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02743165T DK1401445T3 (da) 2001-06-22 2002-06-08 Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel

Country Status (37)

Country Link
EP (1) EP1401445B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005504015A (cg-RX-API-DMAC7.html)
KR (2) KR101011353B1 (cg-RX-API-DMAC7.html)
CN (1) CN100586948C (cg-RX-API-DMAC7.html)
AR (1) AR037491A1 (cg-RX-API-DMAC7.html)
AT (1) ATE337006T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002345016B2 (cg-RX-API-DMAC7.html)
BG (1) BG66303B1 (cg-RX-API-DMAC7.html)
BR (1) BR0210537A (cg-RX-API-DMAC7.html)
CA (1) CA2450961C (cg-RX-API-DMAC7.html)
CO (1) CO5550423A2 (cg-RX-API-DMAC7.html)
CY (1) CY1105223T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ302786B6 (cg-RX-API-DMAC7.html)
DE (1) DE50207943D1 (cg-RX-API-DMAC7.html)
DK (1) DK1401445T3 (cg-RX-API-DMAC7.html)
EA (1) EA005813B1 (cg-RX-API-DMAC7.html)
EE (1) EE05316B1 (cg-RX-API-DMAC7.html)
EG (1) EG24851A (cg-RX-API-DMAC7.html)
ES (1) ES2271280T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20031066B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0400333A3 (cg-RX-API-DMAC7.html)
IL (2) IL159238A0 (cg-RX-API-DMAC7.html)
ME (1) ME00412B (cg-RX-API-DMAC7.html)
MX (1) MXPA03011718A (cg-RX-API-DMAC7.html)
MY (1) MY122779A (cg-RX-API-DMAC7.html)
NO (1) NO334301B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ530690A (cg-RX-API-DMAC7.html)
PE (2) PE20081305A1 (cg-RX-API-DMAC7.html)
PL (1) PL208137B1 (cg-RX-API-DMAC7.html)
PT (1) PT1401445E (cg-RX-API-DMAC7.html)
RS (1) RS50441B (cg-RX-API-DMAC7.html)
SA (1) SA02230255B1 (cg-RX-API-DMAC7.html)
SI (1) SI1401445T1 (cg-RX-API-DMAC7.html)
SK (1) SK287262B6 (cg-RX-API-DMAC7.html)
TW (2) TWI261589B (cg-RX-API-DMAC7.html)
UY (1) UY27342A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003000265A1 (cg-RX-API-DMAC7.html)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
WO2005042527A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Neues kristallines anhydrat mit anticholinerger wirksamkeit
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
PT1781298E (pt) 2004-04-22 2012-02-03 Boehringer Ingelheim Int Combinações farmacêuticas contendo benzoxazinas para o tratamento de doenças respiratórias
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (de) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
WO2006111549A1 (de) 2005-04-21 2006-10-26 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
EA013239B1 (ru) 2005-04-28 2010-04-30 Бёрингер Ингельхайм Интернациональ Гмбх Новые соединения для лечения воспалительных заболеваний
PL1881980T3 (pl) * 2005-05-02 2013-01-31 Boehringer Ingelheim Int Nowe krystaliczne formy bromku tiotropium
MX2007013691A (es) * 2005-05-02 2008-01-21 Boehringer Ingelheim Int Nuevas formas cristalinas de bromuro de tiotropio.
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
AU2006281449B2 (en) 2005-08-15 2013-01-31 Boehringer Ingelheim International Gmbh Method for producing betamimetics
TWI396541B (zh) 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
PT1869035E (pt) 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
DE502007006951D1 (de) 2006-08-07 2011-05-26 Boehringer Ingelheim Pharma Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PT2215092E (pt) 2007-10-19 2012-04-10 Boehringer Ingelheim Int Piperidino-di-hidrotienopirimidinas substituídas
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
PE20120061A1 (es) 2008-12-19 2012-02-19 Boehringer Ingelheim Int Derivados de pirimidina como antagonistas del receptor ccr2
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２の新規アンタゴニスト及びこれらの使用
WO2011073154A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists and uses thereof
KR20120125267A (ko) 2010-01-29 2012-11-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 나프티리딘 및 ｓｙｋ 키나제 억제제로서의 이의 용도
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
WO2012101013A1 (en) 2011-01-28 2012-08-02 Boehringer Ingelheim International Gmbh Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
EP2721025B1 (en) 2011-06-16 2015-11-25 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
PT2782914T (pt) 2011-11-25 2018-11-16 Adverio Pharma Gmbh Processo para a preparação de 5-flúor-1h-pirazolopiridinas substituídas
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
HRP20191364T1 (hr) 2014-03-19 2019-11-01 Boehringer Ingelheim Int Sik-inhibitori tipa heteroarila
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
HRP20201343T1 (hr) 2014-10-21 2020-11-27 Ariad Pharmaceuticals, Inc. Kristalni oblici 5-kloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina
WO2017138896A1 (en) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
AU2002214996B2 (en) * 2000-10-12 2007-03-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums

Also Published As

Publication number Publication date
CN100586948C (zh) 2010-02-03
AR037491A1 (es) 2004-11-17
BG66303B1 (bg) 2013-03-29
SK522004A3 (en) 2004-06-08
EA200301293A1 (ru) 2004-08-26
EA005813B1 (ru) 2005-06-30
IL159238A (en) 2010-04-15
PE20081305A1 (es) 2008-10-01
TWI261589B (en) 2006-09-11
AU2002345016B2 (en) 2008-04-17
HUP0400333A3 (en) 2012-10-29
HK1068540A1 (zh) 2005-04-29
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
EE200400029A (et) 2004-04-15
MEP62008A (en) 2011-05-10
DE50207943D1 (de) 2006-10-05
HUP0400333A2 (hu) 2004-12-28
JP2005504015A (ja) 2005-02-10
TW200617007A (en) 2006-06-01
CZ2004120A3 (cs) 2004-05-12
KR100971616B1 (ko) 2010-07-22
KR20040018285A (ko) 2004-03-02
ATE337006T1 (de) 2006-09-15
ES2271280T3 (es) 2007-04-16
UY27342A1 (es) 2003-02-28
BG108440A (bg) 2004-08-31
CO5550423A2 (es) 2005-08-31
EP1401445A1 (de) 2004-03-31
SK287262B6 (sk) 2010-04-07
KR101011353B1 (ko) 2011-01-28
CN1520294A (zh) 2004-08-11
KR20090031638A (ko) 2009-03-26
EP1401445B1 (de) 2006-08-23
WO2003000265A1 (de) 2003-01-03
HRP20031066B1 (en) 2011-10-31
BR0210537A (pt) 2004-06-22
RS50441B (sr) 2010-03-02
PL364489A1 (en) 2004-12-13
EE05316B1 (et) 2010-08-16
SA02230255B1 (ar) 2006-10-31
SI1401445T1 (sl) 2007-02-28
MXPA03011718A (es) 2004-12-06
HRP20031066A2 (en) 2004-04-30
IL159238A0 (en) 2004-06-01
MY122779A (en) 2006-05-31
CA2450961A1 (en) 2003-01-03
NO334301B1 (no) 2014-02-03
NZ530690A (en) 2005-05-27
PT1401445E (pt) 2006-10-31
EG24851A (en) 2010-10-27
PE20030130A1 (es) 2003-04-02
NO20035696D0 (no) 2003-12-19
CZ302786B6 (cs) 2011-11-09
ME00412B (me) 2011-10-10
CA2450961C (en) 2010-03-30
YU99703A (sh) 2006-05-25

Similar Documents

Publication Publication Date Title
DK1401445T3 (da) Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel
DK1326862T3 (da) Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel
DK1667986T3 (da) Acetonesolvat af dimethoxydocetaxel og fremgangsmåde til fremstilling heraf
DK1381605T3 (da) Mercaptoacetylamidderivater, en fremgangsmåde til deres fremstilling og deres anvendelse
DK2380568T3 (da) Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10
DK1599478T3 (da) Dihydropteridinoner, fremgangsmåde til fremstilling af disse og anvendelse af disse som lægemiddel
DK1309555T3 (da) Metode til fremstilling af amlodipinmaleat
DK1144386T3 (da) Polymorf form af telmisartan, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel
DK1419776T3 (da) Aripiprazol-lægemiddelsubstans med lav hygroskopi og fremgangsmåde til fremstilling af denne
NO20040680D0 (no) Nye dihydropterinonerfremgangsmate for fremstilling derav og deres anvendelse som legemiddel
NO20025879D0 (no) Acylfenylureaderivater, fremgangsmåte for fremstilling derav og deres anvendelse som et legemiddel
DK1293507T3 (da) Fremgangsmåde til fremstilling af krystaller
NO20054533D0 (no) Oral insulinsammensetning og metoder for a lage og bruke den
DK1253153T3 (da) Fremgangsmåde til fremstilling af 4&#34;-substituerede-9-deoxo-9a-aza-9a-homoerythromycin-A-derivater
DK1414816T3 (da) Stabil polymorf af flibanserin, teknisk fremgangsmåde til fremstilling deraf og anvendelse deraf til lægemiddelfremstilling
DK1537096T3 (da) Derivater af dioxan-2-alkylcarbamater, fremstilling og terapeutisk anvendelse heraf
DK1759702T3 (da) Fremgangsmåde til fremstilling af en latanoprost-öjenoplösning og en således fremstillet oplösning
DK1383482T3 (da) Fremgangsmåde til fremstilling af en farmaceutisk lavdoseringssammensætning
DK1147075T3 (da) Fremgangsmåde til fremstilling af L-phenylephrinhydrochlorid
DK1432683T3 (da) Hidtil ukendte krystallinske polymorfe former af lercanidipinhydrochlorid og fremgangsmåder til fremstilling heraf
DK2083007T3 (da) Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
DK1261318T3 (da) En koncentreret opløsning af kvaternære ammoniumforbindelser og fremgangsmåder til anvendelse
DK1575941T3 (da) Fremgangsmåde til fremstilling af (S)-pantoprazol
DK1362040T3 (da) Fremgangsmåde til fremstilling af mesylater af piperidinderivater
DK1326836T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin