HRP20031066B1 - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents

Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Info

Publication number
HRP20031066B1
HRP20031066B1 HR20031066A HRP20031066A HRP20031066B1 HR P20031066 B1 HRP20031066 B1 HR P20031066B1 HR 20031066 A HR20031066 A HR 20031066A HR P20031066 A HRP20031066 A HR P20031066A HR P20031066 B1 HRP20031066 B1 HR P20031066B1
Authority
HR
Croatia
Prior art keywords
production
drug
crystalline
anticholinergic
crystalline anticholinergic
Prior art date
Application number
HR20031066A
Other languages
English (en)
Croatian (hr)
Inventor
Sieger Peter
Werthmann Ulrike
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Publication of HRP20031066A2 publication Critical patent/HRP20031066A2/xx
Publication of HRP20031066B1 publication Critical patent/HRP20031066B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
HR20031066A 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug HRP20031066B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
PCT/EP2002/006291 WO2003000265A1 (de) 2001-06-22 2002-06-08 Kristallines anticholinergikum, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number Publication Date
HRP20031066A2 HRP20031066A2 (en) 2004-04-30
HRP20031066B1 true HRP20031066B1 (en) 2011-10-31

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20031066A HRP20031066B1 (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Country Status (37)

Country Link
EP (1) EP1401445B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005504015A (cg-RX-API-DMAC7.html)
KR (2) KR101011353B1 (cg-RX-API-DMAC7.html)
CN (1) CN100586948C (cg-RX-API-DMAC7.html)
AR (1) AR037491A1 (cg-RX-API-DMAC7.html)
AT (1) ATE337006T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002345016B2 (cg-RX-API-DMAC7.html)
BG (1) BG66303B1 (cg-RX-API-DMAC7.html)
BR (1) BR0210537A (cg-RX-API-DMAC7.html)
CA (1) CA2450961C (cg-RX-API-DMAC7.html)
CO (1) CO5550423A2 (cg-RX-API-DMAC7.html)
CY (1) CY1105223T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ302786B6 (cg-RX-API-DMAC7.html)
DE (1) DE50207943D1 (cg-RX-API-DMAC7.html)
DK (1) DK1401445T3 (cg-RX-API-DMAC7.html)
EA (1) EA005813B1 (cg-RX-API-DMAC7.html)
EE (1) EE05316B1 (cg-RX-API-DMAC7.html)
EG (1) EG24851A (cg-RX-API-DMAC7.html)
ES (1) ES2271280T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20031066B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0400333A3 (cg-RX-API-DMAC7.html)
IL (2) IL159238A0 (cg-RX-API-DMAC7.html)
ME (1) ME00412B (cg-RX-API-DMAC7.html)
MX (1) MXPA03011718A (cg-RX-API-DMAC7.html)
MY (1) MY122779A (cg-RX-API-DMAC7.html)
NO (1) NO334301B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ530690A (cg-RX-API-DMAC7.html)
PE (2) PE20081305A1 (cg-RX-API-DMAC7.html)
PL (1) PL208137B1 (cg-RX-API-DMAC7.html)
PT (1) PT1401445E (cg-RX-API-DMAC7.html)
RS (1) RS50441B (cg-RX-API-DMAC7.html)
SA (1) SA02230255B1 (cg-RX-API-DMAC7.html)
SI (1) SI1401445T1 (cg-RX-API-DMAC7.html)
SK (1) SK287262B6 (cg-RX-API-DMAC7.html)
TW (2) TWI261589B (cg-RX-API-DMAC7.html)
UY (1) UY27342A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003000265A1 (cg-RX-API-DMAC7.html)

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DE602004020337D1 (de) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
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EA013239B1 (ru) 2005-04-28 2010-04-30 Бёрингер Ингельхайм Интернациональ Гмбх Новые соединения для лечения воспалительных заболеваний
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US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
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EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
DE502007006951D1 (de) 2006-08-07 2011-05-26 Boehringer Ingelheim Pharma Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
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GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PT2215092E (pt) 2007-10-19 2012-04-10 Boehringer Ingelheim Int Piperidino-di-hidrotienopirimidinas substituídas
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
PE20120061A1 (es) 2008-12-19 2012-02-19 Boehringer Ingelheim Int Derivados de pirimidina como antagonistas del receptor ccr2
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２の新規アンタゴニスト及びこれらの使用
WO2011073154A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists and uses thereof
KR20120125267A (ko) 2010-01-29 2012-11-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 나프티리딘 및 ｓｙｋ 키나제 억제제로서의 이의 용도
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
WO2012101013A1 (en) 2011-01-28 2012-08-02 Boehringer Ingelheim International Gmbh Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
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WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
PT2782914T (pt) 2011-11-25 2018-11-16 Adverio Pharma Gmbh Processo para a preparação de 5-flúor-1h-pirazolopiridinas substituídas
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
HRP20191364T1 (hr) 2014-03-19 2019-11-01 Boehringer Ingelheim Int Sik-inhibitori tipa heteroarila
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Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0418716A1 (de) * 1989-09-16 1991-03-27 Boehringer Ingelheim Kg Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
WO2002051840A1 (de) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung des anticholinergikums tiotropiumbromid

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US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0418716A1 (de) * 1989-09-16 1991-03-27 Boehringer Ingelheim Kg Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
WO2002051840A1 (de) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Also Published As

Publication number Publication date
CN100586948C (zh) 2010-02-03
AR037491A1 (es) 2004-11-17
BG66303B1 (bg) 2013-03-29
SK522004A3 (en) 2004-06-08
EA200301293A1 (ru) 2004-08-26
EA005813B1 (ru) 2005-06-30
IL159238A (en) 2010-04-15
PE20081305A1 (es) 2008-10-01
TWI261589B (en) 2006-09-11
AU2002345016B2 (en) 2008-04-17
HUP0400333A3 (en) 2012-10-29
HK1068540A1 (zh) 2005-04-29
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
EE200400029A (et) 2004-04-15
MEP62008A (en) 2011-05-10
DE50207943D1 (de) 2006-10-05
HUP0400333A2 (hu) 2004-12-28
JP2005504015A (ja) 2005-02-10
TW200617007A (en) 2006-06-01
CZ2004120A3 (cs) 2004-05-12
KR100971616B1 (ko) 2010-07-22
KR20040018285A (ko) 2004-03-02
ATE337006T1 (de) 2006-09-15
ES2271280T3 (es) 2007-04-16
DK1401445T3 (da) 2006-11-27
UY27342A1 (es) 2003-02-28
BG108440A (bg) 2004-08-31
CO5550423A2 (es) 2005-08-31
EP1401445A1 (de) 2004-03-31
SK287262B6 (sk) 2010-04-07
KR101011353B1 (ko) 2011-01-28
CN1520294A (zh) 2004-08-11
KR20090031638A (ko) 2009-03-26
EP1401445B1 (de) 2006-08-23
WO2003000265A1 (de) 2003-01-03
BR0210537A (pt) 2004-06-22
RS50441B (sr) 2010-03-02
PL364489A1 (en) 2004-12-13
EE05316B1 (et) 2010-08-16
SA02230255B1 (ar) 2006-10-31
SI1401445T1 (sl) 2007-02-28
MXPA03011718A (es) 2004-12-06
HRP20031066A2 (en) 2004-04-30
IL159238A0 (en) 2004-06-01
MY122779A (en) 2006-05-31
CA2450961A1 (en) 2003-01-03
NO334301B1 (no) 2014-02-03
NZ530690A (en) 2005-05-27
PT1401445E (pt) 2006-10-31
EG24851A (en) 2010-10-27
PE20030130A1 (es) 2003-04-02
NO20035696D0 (no) 2003-12-19
CZ302786B6 (cs) 2011-11-09
ME00412B (me) 2011-10-10
CA2450961C (en) 2010-03-30
YU99703A (sh) 2006-05-25

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