TWI261589B - Crystalline anticholinergic and processes for preparing it - Google Patents

Crystalline anticholinergic and processes for preparing it Download PDF

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Publication number
TWI261589B
TWI261589B TW091113373A TW91113373A TWI261589B TW I261589 B TWI261589 B TW I261589B TW 091113373 A TW091113373 A TW 091113373A TW 91113373 A TW91113373 A TW 91113373A TW I261589 B TWI261589 B TW I261589B
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TW
Taiwan
Prior art keywords
crystalline
bromide
monohydrate
anhydrous
patent application
Prior art date
Application number
TW091113373A
Other languages
English (en)
Chinese (zh)
Inventor
Peter Sieger
Ulrike Werthmann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of TWI261589B publication Critical patent/TWI261589B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
TW091113373A 2001-06-22 2002-06-19 Crystalline anticholinergic and processes for preparing it TWI261589B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08

Publications (1)

Publication Number Publication Date
TWI261589B true TWI261589B (en) 2006-09-11

Family

ID=26009556

Family Applications (2)

Application Number Title Priority Date Filing Date
TW091113373A TWI261589B (en) 2001-06-22 2002-06-19 Crystalline anticholinergic and processes for preparing it
TW095100968A TW200617007A (en) 2001-06-22 2002-06-19 Crystalline anticholinergic and its use for preparing a pharmaceutical composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW095100968A TW200617007A (en) 2001-06-22 2002-06-19 Crystalline anticholinergic and its use for preparing a pharmaceutical composition

Country Status (37)

Country Link
EP (1) EP1401445B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005504015A (cg-RX-API-DMAC7.html)
KR (2) KR101011353B1 (cg-RX-API-DMAC7.html)
CN (1) CN100586948C (cg-RX-API-DMAC7.html)
AR (1) AR037491A1 (cg-RX-API-DMAC7.html)
AT (1) ATE337006T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002345016B2 (cg-RX-API-DMAC7.html)
BG (1) BG66303B1 (cg-RX-API-DMAC7.html)
BR (1) BR0210537A (cg-RX-API-DMAC7.html)
CA (1) CA2450961C (cg-RX-API-DMAC7.html)
CO (1) CO5550423A2 (cg-RX-API-DMAC7.html)
CY (1) CY1105223T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ302786B6 (cg-RX-API-DMAC7.html)
DE (1) DE50207943D1 (cg-RX-API-DMAC7.html)
DK (1) DK1401445T3 (cg-RX-API-DMAC7.html)
EA (1) EA005813B1 (cg-RX-API-DMAC7.html)
EE (1) EE05316B1 (cg-RX-API-DMAC7.html)
EG (1) EG24851A (cg-RX-API-DMAC7.html)
ES (1) ES2271280T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20031066B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0400333A3 (cg-RX-API-DMAC7.html)
IL (2) IL159238A0 (cg-RX-API-DMAC7.html)
ME (1) ME00412B (cg-RX-API-DMAC7.html)
MX (1) MXPA03011718A (cg-RX-API-DMAC7.html)
MY (1) MY122779A (cg-RX-API-DMAC7.html)
NO (1) NO334301B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ530690A (cg-RX-API-DMAC7.html)
PE (2) PE20081305A1 (cg-RX-API-DMAC7.html)
PL (1) PL208137B1 (cg-RX-API-DMAC7.html)
PT (1) PT1401445E (cg-RX-API-DMAC7.html)
RS (1) RS50441B (cg-RX-API-DMAC7.html)
SA (1) SA02230255B1 (cg-RX-API-DMAC7.html)
SI (1) SI1401445T1 (cg-RX-API-DMAC7.html)
SK (1) SK287262B6 (cg-RX-API-DMAC7.html)
TW (2) TWI261589B (cg-RX-API-DMAC7.html)
UY (1) UY27342A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003000265A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
CN100586948C (zh) 2010-02-03
AR037491A1 (es) 2004-11-17
BG66303B1 (bg) 2013-03-29
SK522004A3 (en) 2004-06-08
EA200301293A1 (ru) 2004-08-26
EA005813B1 (ru) 2005-06-30
IL159238A (en) 2010-04-15
PE20081305A1 (es) 2008-10-01
AU2002345016B2 (en) 2008-04-17
HUP0400333A3 (en) 2012-10-29
HK1068540A1 (zh) 2005-04-29
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
EE200400029A (et) 2004-04-15
MEP62008A (en) 2011-05-10
DE50207943D1 (de) 2006-10-05
HUP0400333A2 (hu) 2004-12-28
JP2005504015A (ja) 2005-02-10
TW200617007A (en) 2006-06-01
CZ2004120A3 (cs) 2004-05-12
KR100971616B1 (ko) 2010-07-22
KR20040018285A (ko) 2004-03-02
ATE337006T1 (de) 2006-09-15
ES2271280T3 (es) 2007-04-16
DK1401445T3 (da) 2006-11-27
UY27342A1 (es) 2003-02-28
BG108440A (bg) 2004-08-31
CO5550423A2 (es) 2005-08-31
EP1401445A1 (de) 2004-03-31
SK287262B6 (sk) 2010-04-07
KR101011353B1 (ko) 2011-01-28
CN1520294A (zh) 2004-08-11
KR20090031638A (ko) 2009-03-26
EP1401445B1 (de) 2006-08-23
WO2003000265A1 (de) 2003-01-03
HRP20031066B1 (en) 2011-10-31
BR0210537A (pt) 2004-06-22
RS50441B (sr) 2010-03-02
PL364489A1 (en) 2004-12-13
EE05316B1 (et) 2010-08-16
SA02230255B1 (ar) 2006-10-31
SI1401445T1 (sl) 2007-02-28
MXPA03011718A (es) 2004-12-06
HRP20031066A2 (en) 2004-04-30
IL159238A0 (en) 2004-06-01
MY122779A (en) 2006-05-31
CA2450961A1 (en) 2003-01-03
NO334301B1 (no) 2014-02-03
NZ530690A (en) 2005-05-27
PT1401445E (pt) 2006-10-31
EG24851A (en) 2010-10-27
PE20030130A1 (es) 2003-04-02
NO20035696D0 (no) 2003-12-19
CZ302786B6 (cs) 2011-11-09
ME00412B (me) 2011-10-10
CA2450961C (en) 2010-03-30
YU99703A (sh) 2006-05-25

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