CO5550423A2 - Agente anticolinergico cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento - Google Patents

Agente anticolinergico cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento

Info

Publication number
CO5550423A2
CO5550423A2 CO04003764A CO04003764A CO5550423A2 CO 5550423 A2 CO5550423 A2 CO 5550423A2 CO 04003764 A CO04003764 A CO 04003764A CO 04003764 A CO04003764 A CO 04003764A CO 5550423 A2 CO5550423 A2 CO 5550423A2
Authority
CO
Colombia
Prior art keywords
tiotropium bromide
crystalline
preparation
drying
procedure
Prior art date
Application number
CO04003764A
Other languages
English (en)
Spanish (es)
Inventor
Peter Sieger
Wertmann Ulrike
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5550423A2 publication Critical patent/CO5550423A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CO04003764A 2001-06-22 2004-01-20 Agente anticolinergico cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento CO5550423A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08

Publications (1)

Publication Number Publication Date
CO5550423A2 true CO5550423A2 (es) 2005-08-31

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04003764A CO5550423A2 (es) 2001-06-22 2004-01-20 Agente anticolinergico cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento

Country Status (37)

Country Link
EP (1) EP1401445B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005504015A (cg-RX-API-DMAC7.html)
KR (2) KR101011353B1 (cg-RX-API-DMAC7.html)
CN (1) CN100586948C (cg-RX-API-DMAC7.html)
AR (1) AR037491A1 (cg-RX-API-DMAC7.html)
AT (1) ATE337006T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002345016B2 (cg-RX-API-DMAC7.html)
BG (1) BG66303B1 (cg-RX-API-DMAC7.html)
BR (1) BR0210537A (cg-RX-API-DMAC7.html)
CA (1) CA2450961C (cg-RX-API-DMAC7.html)
CO (1) CO5550423A2 (cg-RX-API-DMAC7.html)
CY (1) CY1105223T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ302786B6 (cg-RX-API-DMAC7.html)
DE (1) DE50207943D1 (cg-RX-API-DMAC7.html)
DK (1) DK1401445T3 (cg-RX-API-DMAC7.html)
EA (1) EA005813B1 (cg-RX-API-DMAC7.html)
EE (1) EE05316B1 (cg-RX-API-DMAC7.html)
EG (1) EG24851A (cg-RX-API-DMAC7.html)
ES (1) ES2271280T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20031066B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0400333A3 (cg-RX-API-DMAC7.html)
IL (2) IL159238A0 (cg-RX-API-DMAC7.html)
ME (1) ME00412B (cg-RX-API-DMAC7.html)
MX (1) MXPA03011718A (cg-RX-API-DMAC7.html)
MY (1) MY122779A (cg-RX-API-DMAC7.html)
NO (1) NO334301B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ530690A (cg-RX-API-DMAC7.html)
PE (2) PE20081305A1 (cg-RX-API-DMAC7.html)
PL (1) PL208137B1 (cg-RX-API-DMAC7.html)
PT (1) PT1401445E (cg-RX-API-DMAC7.html)
RS (1) RS50441B (cg-RX-API-DMAC7.html)
SA (1) SA02230255B1 (cg-RX-API-DMAC7.html)
SI (1) SI1401445T1 (cg-RX-API-DMAC7.html)
SK (1) SK287262B6 (cg-RX-API-DMAC7.html)
TW (2) TWI261589B (cg-RX-API-DMAC7.html)
UY (1) UY27342A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003000265A1 (cg-RX-API-DMAC7.html)

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US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (de) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
WO2006111549A1 (de) 2005-04-21 2006-10-26 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
EA013239B1 (ru) 2005-04-28 2010-04-30 Бёрингер Ингельхайм Интернациональ Гмбх Новые соединения для лечения воспалительных заболеваний
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GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
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EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
PE20120061A1 (es) 2008-12-19 2012-02-19 Boehringer Ingelheim Int Derivados de pirimidina como antagonistas del receptor ccr2
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２の新規アンタゴニスト及びこれらの使用
WO2011073154A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists and uses thereof
KR20120125267A (ko) 2010-01-29 2012-11-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 나프티리딘 및 ｓｙｋ 키나제 억제제로서의 이의 용도
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JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
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TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
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WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
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CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
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Also Published As

Publication number Publication date
CN100586948C (zh) 2010-02-03
AR037491A1 (es) 2004-11-17
BG66303B1 (bg) 2013-03-29
SK522004A3 (en) 2004-06-08
EA200301293A1 (ru) 2004-08-26
EA005813B1 (ru) 2005-06-30
IL159238A (en) 2010-04-15
PE20081305A1 (es) 2008-10-01
TWI261589B (en) 2006-09-11
AU2002345016B2 (en) 2008-04-17
HUP0400333A3 (en) 2012-10-29
HK1068540A1 (zh) 2005-04-29
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
EE200400029A (et) 2004-04-15
MEP62008A (en) 2011-05-10
DE50207943D1 (de) 2006-10-05
HUP0400333A2 (hu) 2004-12-28
JP2005504015A (ja) 2005-02-10
TW200617007A (en) 2006-06-01
CZ2004120A3 (cs) 2004-05-12
KR100971616B1 (ko) 2010-07-22
KR20040018285A (ko) 2004-03-02
ATE337006T1 (de) 2006-09-15
ES2271280T3 (es) 2007-04-16
DK1401445T3 (da) 2006-11-27
UY27342A1 (es) 2003-02-28
BG108440A (bg) 2004-08-31
EP1401445A1 (de) 2004-03-31
SK287262B6 (sk) 2010-04-07
KR101011353B1 (ko) 2011-01-28
CN1520294A (zh) 2004-08-11
KR20090031638A (ko) 2009-03-26
EP1401445B1 (de) 2006-08-23
WO2003000265A1 (de) 2003-01-03
HRP20031066B1 (en) 2011-10-31
BR0210537A (pt) 2004-06-22
RS50441B (sr) 2010-03-02
PL364489A1 (en) 2004-12-13
EE05316B1 (et) 2010-08-16
SA02230255B1 (ar) 2006-10-31
SI1401445T1 (sl) 2007-02-28
MXPA03011718A (es) 2004-12-06
HRP20031066A2 (en) 2004-04-30
IL159238A0 (en) 2004-06-01
MY122779A (en) 2006-05-31
CA2450961A1 (en) 2003-01-03
NO334301B1 (no) 2014-02-03
NZ530690A (en) 2005-05-27
PT1401445E (pt) 2006-10-31
EG24851A (en) 2010-10-27
PE20030130A1 (es) 2003-04-02
NO20035696D0 (no) 2003-12-19
CZ302786B6 (cs) 2011-11-09
ME00412B (me) 2011-10-10
CA2450961C (en) 2010-03-30
YU99703A (sh) 2006-05-25

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