DK1366187T3 - Oligonukleotider til mærkning af oligonukleotidprober og proteiner - Google Patents
Oligonukleotider til mærkning af oligonukleotidprober og proteinerInfo
- Publication number
- DK1366187T3 DK1366187T3 DK01975189T DK01975189T DK1366187T3 DK 1366187 T3 DK1366187 T3 DK 1366187T3 DK 01975189 T DK01975189 T DK 01975189T DK 01975189 T DK01975189 T DK 01975189T DK 1366187 T3 DK1366187 T3 DK 1366187T3
- Authority
- DK
- Denmark
- Prior art keywords
- oligonucleotide probes
- collections
- oligonucleotides
- proteins
- provides
- Prior art date
Links
- 108020005187 Oligonucleotide Probes Proteins 0.000 title abstract 5
- 239000002751 oligonucleotide probe Substances 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000002372 labelling Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000007901 in situ hybridization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23317700P | 2000-09-15 | 2000-09-15 | |
| PCT/US2001/028014 WO2002022874A2 (en) | 2000-09-15 | 2001-09-06 | Oligonucleotides for labeling oligonucleotide probes and proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1366187T3 true DK1366187T3 (da) | 2009-02-16 |
Family
ID=22876207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01975189T DK1366187T3 (da) | 2000-09-15 | 2001-09-06 | Oligonukleotider til mærkning af oligonukleotidprober og proteiner |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7838655B2 (enExample) |
| EP (1) | EP1366187B1 (enExample) |
| JP (2) | JP4986367B2 (enExample) |
| AT (1) | ATE415491T1 (enExample) |
| AU (2) | AU9454201A (enExample) |
| CA (2) | CA2703141C (enExample) |
| DE (1) | DE60136746D1 (enExample) |
| DK (1) | DK1366187T3 (enExample) |
| ES (1) | ES2317939T3 (enExample) |
| WO (1) | WO2002022874A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4986367B2 (ja) | 2000-09-15 | 2012-07-25 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | イン・サイチュー解析のためのオリゴヌクレオチドプローブおよびタンパク質を標識するためのオリゴヌクレオチド配列式 |
| WO2002099135A1 (en) * | 2001-06-06 | 2002-12-12 | Canag Diagnostics Ab | Method to measure gene expression ratio of key genes |
| US8574836B2 (en) * | 2005-01-12 | 2013-11-05 | Ramesh Vallabhaneni | Method and apparatus for chromosome profiling |
| JP5588970B2 (ja) | 2008-05-27 | 2014-09-10 | ダコ・デンマーク・エー／エス | ハイブリダイゼーション組成物及び方法 |
| EP3133170B1 (en) * | 2008-09-10 | 2020-03-18 | Rutgers, the State University of New Jersey | Imaging individual mrna molecules using multiple singly labeled probes |
| US9303287B2 (en) | 2009-02-26 | 2016-04-05 | Dako Denmark A/S | Compositions and methods for RNA hybridization applications |
| US9550985B2 (en) | 2009-06-15 | 2017-01-24 | Netbio, Inc. | Methods for forensic DNA quantitation |
| ES2753274T5 (es) | 2015-08-21 | 2023-05-26 | 42 Life Sciences Gmbh & Co Kg | Composición y procedimiento de hibridación |
| EP3794548B1 (en) | 2018-05-15 | 2024-06-26 | Ventana Medical Systems, Inc. | Quantitation of signal in stain aggregates |
| CA3176620A1 (en) | 2020-03-31 | 2021-10-07 | Personal Genome Diagnostics Inc. | Compositions and methods for nucleic acid quality determination |
| CN115948608A (zh) * | 2022-08-05 | 2023-04-11 | 北京中杉金桥生物技术有限公司 | 一种用于eber检测的探针组及试剂盒 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3948922A (en) * | 1973-01-02 | 1976-04-06 | Lowe Orville G | Oxidation of thiols and disulfides to sulfonic acids |
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5489507A (en) * | 1988-11-30 | 1996-02-06 | Perkin-Elmer Corporation | DNA detection by color complementation |
| US5324829A (en) * | 1988-12-16 | 1994-06-28 | Ortho Diagnostic Systems, Inc. | High specific activity nucleic acid probes having target recognition and signal generating moieties |
| US5789161A (en) * | 1990-09-20 | 1998-08-04 | Amoco Corporation | Methods for genome identification using direct label probe composition |
| US5843660A (en) * | 1994-09-30 | 1998-12-01 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| US5684142A (en) * | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
| US5871917A (en) * | 1996-05-31 | 1999-02-16 | North Shore University Hospital Research Corp. | Identification of differentially methylated and mutated nucleic acids |
| US7504493B2 (en) * | 1997-01-23 | 2009-03-17 | The John Hopkins University | Characterization of the yeast transcriptome |
| JP4986367B2 (ja) * | 2000-09-15 | 2012-07-25 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | イン・サイチュー解析のためのオリゴヌクレオチドプローブおよびタンパク質を標識するためのオリゴヌクレオチド配列式 |
| US7399339B2 (en) * | 2005-06-15 | 2008-07-15 | Gas Technology Institute | Polyoxometalate material for gaseous stream purification at high temperature |
-
2001
- 2001-09-06 JP JP2002527314A patent/JP4986367B2/ja not_active Expired - Lifetime
- 2001-09-06 WO PCT/US2001/028014 patent/WO2002022874A2/en not_active Ceased
- 2001-09-06 EP EP01975189A patent/EP1366187B1/en not_active Expired - Lifetime
- 2001-09-06 CA CA2703141A patent/CA2703141C/en not_active Expired - Lifetime
- 2001-09-06 AU AU9454201A patent/AU9454201A/xx active Pending
- 2001-09-06 DE DE60136746T patent/DE60136746D1/de not_active Expired - Lifetime
- 2001-09-06 ES ES01975189T patent/ES2317939T3/es not_active Expired - Lifetime
- 2001-09-06 AU AU2001294542A patent/AU2001294542B8/en not_active Expired
- 2001-09-06 DK DK01975189T patent/DK1366187T3/da active
- 2001-09-06 US US10/380,584 patent/US7838655B2/en not_active Expired - Lifetime
- 2001-09-06 AT AT01975189T patent/ATE415491T1/de active
- 2001-09-06 CA CA2422440A patent/CA2422440C/en not_active Expired - Lifetime
-
2010
- 2010-10-22 US US12/910,454 patent/US8236502B2/en not_active Expired - Fee Related
-
2011
- 2011-10-24 JP JP2011233295A patent/JP5272063B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-28 US US13/536,021 patent/US8524877B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60136746D1 (de) | 2009-01-08 |
| WO2002022874A3 (en) | 2003-09-25 |
| JP2012065660A (ja) | 2012-04-05 |
| US8524877B2 (en) | 2013-09-03 |
| US20110034682A1 (en) | 2011-02-10 |
| CA2422440A1 (en) | 2002-03-21 |
| ES2317939T3 (es) | 2009-05-01 |
| AU2001294542B2 (en) | 2008-04-03 |
| CA2703141A1 (en) | 2002-03-21 |
| JP5272063B2 (ja) | 2013-08-28 |
| US8236502B2 (en) | 2012-08-07 |
| WO2002022874A2 (en) | 2002-03-21 |
| US20040014088A1 (en) | 2004-01-22 |
| AU9454201A (en) | 2002-03-26 |
| CA2422440C (en) | 2010-07-27 |
| CA2703141C (en) | 2014-10-21 |
| US7838655B2 (en) | 2010-11-23 |
| US20120309951A1 (en) | 2012-12-06 |
| WO2002022874A8 (en) | 2003-07-10 |
| JP2005503753A (ja) | 2005-02-10 |
| AU2001294542B8 (en) | 2008-07-03 |
| WO2002022874A9 (en) | 2003-04-03 |
| EP1366187A2 (en) | 2003-12-03 |
| JP4986367B2 (ja) | 2012-07-25 |
| EP1366187B1 (en) | 2008-11-26 |
| ATE415491T1 (de) | 2008-12-15 |
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