DK1303269T3 - 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer - Google Patents

3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer

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Publication number
DK1303269T3
DK1303269T3 DK01940246T DK01940246T DK1303269T3 DK 1303269 T3 DK1303269 T3 DK 1303269T3 DK 01940246 T DK01940246 T DK 01940246T DK 01940246 T DK01940246 T DK 01940246T DK 1303269 T3 DK1303269 T3 DK 1303269T3
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Prior art keywords
potassium channel
channel modulators
oxindole derivatives
kcnq potassium
substituted oxindole
Prior art date
Application number
DK01940246T
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Danish (da)
English (en)
Inventor
Rikke L Schroeder
Dorte Stroebaek
Soeren Peter Olesen
Bo Skaaning Jensen
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Neurosearch As
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Publication date
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Publication of DK1303269T3 publication Critical patent/DK1303269T3/da

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
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  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
DK01940246T 2000-06-29 2001-06-14 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer DK1303269T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001022 2000-06-29
DKPA200100394 2001-03-08
PCT/DK2001/000412 WO2002000217A1 (en) 2000-06-29 2001-06-14 Use of 3-substituted oxindole derivatives as kcnq potassium channel modulators

Publications (1)

Publication Number Publication Date
DK1303269T3 true DK1303269T3 (da) 2006-03-20

Family

ID=26068847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01940246T DK1303269T3 (da) 2000-06-29 2001-06-14 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer

Country Status (12)

Country Link
US (1) US20030181507A1 (xx)
EP (2) EP1303269B1 (xx)
JP (1) JP2004501192A (xx)
CN (1) CN1222288C (xx)
AT (1) ATE311879T1 (xx)
AU (2) AU7388701A (xx)
CA (1) CA2412208C (xx)
DE (1) DE60115656T2 (xx)
DK (1) DK1303269T3 (xx)
MX (1) MXPA03000032A (xx)
NZ (1) NZ522794A (xx)
WO (1) WO2002000217A1 (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072088A2 (en) * 2001-02-20 2002-09-19 Bristol-Myers Squibb Company Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases
AU2002338333A1 (en) * 2001-04-04 2002-10-21 Wyeth Methods for treating hyperactive gastric motility
WO2005035498A1 (ja) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. 含窒素二環性化合物の摂食調節剤としての用途
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
UA92340C2 (xx) * 2005-03-03 2010-10-25 Х. Луннбек А/С Похідні заміщених піридинів$производные замещенных пиридинов
WO2007009462A2 (en) * 2005-07-15 2007-01-25 Region Hovedstaden V/Glostrup Hospital Treatment of migraine and headaches
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
WO2010105189A1 (en) * 2009-03-12 2010-09-16 The Johns Hopkins University Method for identifying compounds that attenuate the function or reduce abundance of a voltage-gated potassium channel and are associated with maintenance of cognitive function in old age
DK2437744T3 (en) * 2009-06-03 2015-07-27 Univ Marquette The modulation of the KCNQ potassium channel activity for the treatment of psychiatric disorders and symptoms thereof
AU2011317855B2 (en) * 2010-10-20 2015-04-30 Grunenthal Gmbh Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
BR112016026596A2 (pt) * 2014-06-26 2017-08-15 Hoffmann La Roche Derivados de indolin-2-ona ou pirrolo-piridin-2-ona, seu uso, composição farmacêutica e combinação
GB201502412D0 (en) * 2015-02-13 2015-04-01 Canbex Therapeutics Ltd Therapeutic use
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
JP6839184B2 (ja) 2015-11-06 2021-03-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ インドリン−２−オン誘導体
MY197370A (en) 2015-11-06 2023-06-14 Hoffmann La Roche Indolin-2-one derivatives
CN108349942B (zh) 2015-11-06 2021-03-30 豪夫迈·罗氏有限公司 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物
CA3026149A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
US20180207138A1 (en) * 2017-01-23 2018-07-26 Cadent Therapeutics, Inc. Methods for the treatment of tremors by positive modulation of sk channels
EP3571193B1 (en) 2017-01-23 2021-12-01 Cadent Therapeutics, Inc. Potassium channel modulators
AU2018225758A1 (en) * 2017-02-24 2019-09-05 Ovid Therapeutics Inc. Methods of treating seizure disorders
MA53978A (fr) 2018-10-22 2021-09-01 Cadent Therapeutics Inc Formes cristallines de modulateurs des canaux potassiques
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW457233B (en) * 1996-10-11 2001-10-01 Bristol Myers Squibb Co Preparation of 3-fluoro oxindole derivatives
EP1147134B1 (en) * 1999-01-26 2006-10-11 Neurosearch A/S Novel potassium channels and genes encoding these potassium channels
JP2003506388A (ja) * 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド 疼痛および不安症を処置または予防するための方法

Also Published As

Publication number Publication date
MXPA03000032A (es) 2003-08-19
WO2002000217A1 (en) 2002-01-03
EP1303269B1 (en) 2005-12-07
JP2004501192A (ja) 2004-01-15
ATE311879T1 (de) 2005-12-15
NZ522794A (en) 2005-04-29
DE60115656T2 (de) 2006-06-14
CN1438885A (zh) 2003-08-27
EP1634594A1 (en) 2006-03-15
AU7388701A (en) 2002-01-08
CN1222288C (zh) 2005-10-12
CA2412208C (en) 2009-08-18
DE60115656D1 (de) 2006-01-12
AU2001273887B2 (en) 2005-12-15
CA2412208A1 (en) 2002-01-03
US20030181507A1 (en) 2003-09-25
EP1303269A1 (en) 2003-04-23
AU2001273887B9 (en) 2006-02-02

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