DK1276497T3 - Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller - Google Patents

Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller

Info

Publication number
DK1276497T3
DK1276497T3 DK01931582T DK01931582T DK1276497T3 DK 1276497 T3 DK1276497 T3 DK 1276497T3 DK 01931582 T DK01931582 T DK 01931582T DK 01931582 T DK01931582 T DK 01931582T DK 1276497 T3 DK1276497 T3 DK 1276497T3
Authority
DK
Denmark
Prior art keywords
defibrotide
csf
progenitor cells
mixture
hematopoietic progenitor
Prior art date
Application number
DK01931582T
Other languages
Danish (da)
English (en)
Inventor
Laura Ferro
Roberto Porta
Massimo Iacobelli
Alessandro Massimo Gianni
Carmelo Carlo Stella
Original Assignee
Gentium Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentium Spa filed Critical Gentium Spa
Application granted granted Critical
Publication of DK1276497T3 publication Critical patent/DK1276497T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK01931582T 2000-04-18 2001-04-10 Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller DK1276497T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00830293A EP1147777A1 (en) 2000-04-18 2000-04-18 Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors

Publications (1)

Publication Number Publication Date
DK1276497T3 true DK1276497T3 (da) 2006-03-27

Family

ID=8175292

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05108424.2T DK1621207T3 (da) 2000-04-18 2001-04-10 Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors
DK01931582T DK1276497T3 (da) 2000-04-18 2001-04-10 Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05108424.2T DK1621207T3 (da) 2000-04-18 2001-04-10 Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors

Country Status (31)

Country Link
US (1) US20040131588A1 (sl)
EP (3) EP1147777A1 (sl)
JP (1) JP5205668B2 (sl)
KR (1) KR100849491B1 (sl)
CN (1) CN1183962C (sl)
AT (2) ATE310532T1 (sl)
AU (2) AU2001258322B2 (sl)
BG (1) BG107203A (sl)
CA (1) CA2406179C (sl)
CY (1) CY1104971T1 (sl)
CZ (1) CZ20023426A3 (sl)
DE (2) DE60115222T2 (sl)
DK (2) DK1621207T3 (sl)
EE (1) EE200200596A (sl)
ES (2) ES2252227T3 (sl)
HR (1) HRP20020835A2 (sl)
HU (1) HUP0300560A3 (sl)
IL (1) IL152328A (sl)
IS (1) IS2171B (sl)
MX (1) MXPA02010346A (sl)
NO (1) NO20024988L (sl)
NZ (1) NZ522016A (sl)
PL (1) PL358100A1 (sl)
PT (1) PT1621207E (sl)
RO (1) RO121006B1 (sl)
RU (1) RU2248216C2 (sl)
SI (1) SI21079B (sl)
SK (1) SK14892002A3 (sl)
UA (1) UA73566C2 (sl)
WO (1) WO2001078761A2 (sl)
ZA (1) ZA200208413B (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8771663B2 (en) 2000-04-18 2014-07-08 Gentium Spa Formulation having mobilising activity
JP2007535479A (ja) 2003-08-13 2007-12-06 チルドレンズ ホスピタル メディカル センター ＧＴＰａｓｅを調節するためのキメラペプチド
WO2005017160A2 (en) * 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
RU2376985C1 (ru) * 2008-07-17 2009-12-27 Владислав Николаевич Ласкавый Средство для активации стволовых клеток
AU2010363814B2 (en) 2010-11-12 2016-05-19 Gentium S.R.L. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
KR20150044877A (ko) 2012-06-22 2015-04-27 젠티엄 에스피에이 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
CN106567694A (zh) * 2016-11-14 2017-04-19 北京国泰通源技术有限公司 智能控水短节
KR102179423B1 (ko) * 2018-01-12 2020-11-16 셀미그 바이오랩스 주식회사 사이토캡슐 및 사이토캡슐 튜브의 형성 방법
CN114730031B (zh) 2019-11-13 2024-04-12 富士胶片株式会社 装饰膜、成型物及电子器件

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899481A (en) 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
IT1206341B (it) 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4694134A (en) 1985-05-28 1987-09-15 Ajax Magnethermic Corporation Apparatus for overheating edges of skelp for the production of compression welded pipe
US5223609A (en) 1986-04-17 1993-06-29 Crinos Industria Farmacobiologica S.P.A. Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
IT1190313B (it) 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
IT1223322B (it) * 1987-10-23 1990-09-19 Crinos Industria Farmaco Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso
JP2907447B2 (ja) * 1988-08-24 1999-06-21 中外製薬株式会社 抗血栓剤
IT1231509B (it) * 1989-09-07 1991-12-07 Crinos Industria Farmaco Composizione farmceutica ad uso topico per la terapia della fragilita' capillare.
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5977083A (en) * 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
JP3021906B2 (ja) * 1992-01-28 2000-03-15 松下電器産業株式会社 電動調理機
JPH08127539A (ja) * 1994-10-31 1996-05-21 Ajinomoto Co Inc ヒトｉｌ−１１を含有する末梢血幹細胞増加剤
EP0801076A4 (en) * 1994-11-30 1999-12-15 Chugai Pharmaceutical Co Ltd THROMBOCYTOTIC FACTOR
CA2260014A1 (en) * 1996-07-10 1998-01-15 Meiji Milk Products Co., Ltd. Novel use of mk family as hematopoietic factor
WO1999026639A1 (en) * 1997-11-26 1999-06-03 Allegheny University Of The Health Sciences Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
US6573372B2 (en) * 1999-01-07 2003-06-03 Heska Corporation Feline immunoglobulin E molecules and compositions there of

Also Published As

Publication number Publication date
CA2406179A1 (en) 2001-10-25
NO20024988L (no) 2002-12-02
IL152328A (en) 2009-12-24
ES2335776T3 (es) 2010-04-05
CN1183962C (zh) 2005-01-12
PT1621207E (pt) 2009-12-28
HUP0300560A2 (hu) 2003-06-28
IL152328A0 (en) 2003-05-29
ZA200208413B (en) 2003-10-17
CZ20023426A3 (cs) 2003-05-14
EP1276497B1 (en) 2005-11-23
SI21079A (sl) 2003-06-30
CN1434719A (zh) 2003-08-06
JP2004500437A (ja) 2004-01-08
IS2171B (is) 2006-11-15
SI21079B (sl) 2006-08-31
UA73566C2 (en) 2005-08-15
MXPA02010346A (es) 2004-09-06
EP1621207B1 (en) 2009-09-23
PL358100A1 (en) 2004-08-09
RO121006B1 (ro) 2006-11-30
EP1621207A3 (en) 2006-11-22
DE60115222D1 (de) 2005-12-29
CY1104971T1 (el) 2010-03-03
SK14892002A3 (sk) 2003-06-03
CA2406179C (en) 2012-03-27
RU2248216C2 (ru) 2005-03-20
EP1147777A1 (en) 2001-10-24
RU2002130719A (ru) 2004-03-27
BG107203A (bg) 2003-05-30
ATE310532T1 (de) 2005-12-15
EP1621207A2 (en) 2006-02-01
DE60140015D1 (de) 2009-11-05
ATE443524T1 (de) 2009-10-15
HRP20020835A2 (en) 2005-10-31
WO2001078761A3 (en) 2002-01-24
NO20024988D0 (no) 2002-10-16
IS6581A (is) 2002-10-14
ES2252227T3 (es) 2006-05-16
NZ522016A (en) 2004-10-29
EE200200596A (et) 2004-04-15
KR20030010603A (ko) 2003-02-05
KR100849491B1 (ko) 2008-07-31
DE60115222T2 (de) 2006-08-10
WO2001078761A2 (en) 2001-10-25
AU5832201A (en) 2001-10-30
US20040131588A1 (en) 2004-07-08
EP1276497A2 (en) 2003-01-22
JP5205668B2 (ja) 2013-06-05
AU2001258322B2 (en) 2006-03-16
HUP0300560A3 (en) 2005-07-28
DK1621207T3 (da) 2010-02-01

Similar Documents

Publication Publication Date Title
DK1276497T3 (da) Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller
IL119462A0 (en) Pyrrolopyrimidines
AR027715A1 (es) Composiciones basadas en taxanos y metodos de uso de las mismas
DK0774005T3 (da) Overfladeudtrykkelse af enzymer i genorienteret prodrug-terapi
AU2001269688A1 (en) Combination containing an antifolate and methylmalonic acid lowering agent
ATE194494T1 (de) Kombinierte zelluläre und immunsuppressive therapien
IL158155A0 (en) Use of erythropoietin to ameliorate chemotherapy-induced toxicity in vivo
MC2222A1 (fr) Nouveaux retinoides
AU2002332488A8 (en) R-bambuterol, its preparation and therapeutic uses
ITMI920710A0 (it) Siringa di sicurezza con ago retrattile dopo l'uso in modo da evitare il riutilizzo della siringa e la diffusione di malattie contagiose per punture accidentali dell'ago.
ES2090167T3 (es) Uso topico de glicosaminoglicanos en la prevencion y el tratamiento de enfermedades que afectan al tracto vaginal cervical.
SE8902624D0 (sv) New pharmaceutical preparations
YU79802A (sh) Formulacija sa aktivnošću mobilizacije
SU644924A1 (ru) Армоопалубочный пакет
IT8423800A0 (it) Procedimento di trattamento di stati ipotrofici nel bambino mediante somministrazioni di aspartato di arginina.
ECSP003380A (es) Derivados de campotecina con actividad antitumoral
IT8423938V0 (it) Balaustrone con punta telescopica.
ITAL930008V0 (it) Modello anello tipo "riviera" con castoni (servono per incassare le pietre) scorrevoli in un binario apribile, formato dalla testa dell'a nello medesimo.
NO893271D0 (no) Videospill-monitor med innebygd kraftforsyning.
JPS53134376A (en) Injection type laser
IT8520654A0 (it) Derivato della piridina ad azione terapeutica, in particolare antiflogistica, analgesica e antipiretica; procedimento per prepararlo, uso farmaceutico e composizioni farmaceutiche che lo contengono.
JPS52131737A (en) Photoconnector
FI870553A0 (fi) Haolladdning med riktad spraengverkan.