DK1272897T3 - Adenosin-A2A-receptorantagonister til behandling og forebyggelse af leverfibrose, cirrose og fedtlever - Google Patents
Adenosin-A2A-receptorantagonister til behandling og forebyggelse af leverfibrose, cirrose og fedtleverInfo
- Publication number
- DK1272897T3 DK1272897T3 DK01910529T DK01910529T DK1272897T3 DK 1272897 T3 DK1272897 T3 DK 1272897T3 DK 01910529 T DK01910529 T DK 01910529T DK 01910529 T DK01910529 T DK 01910529T DK 1272897 T3 DK1272897 T3 DK 1272897T3
- Authority
- DK
- Denmark
- Prior art keywords
- adenosine
- cirrhosis
- liver
- prevention
- treatment
- Prior art date
Links
- 208000019425 cirrhosis of liver Diseases 0.000 title abstract 3
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 title abstract 2
- 208000004930 Fatty Liver Diseases 0.000 title abstract 2
- 206010019708 Hepatic steatosis Diseases 0.000 title abstract 2
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 title abstract 2
- 208000010706 fatty liver disease Diseases 0.000 title abstract 2
- 231100000240 steatosis hepatitis Toxicity 0.000 title abstract 2
- 230000007882 cirrhosis Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- 206010019668 Hepatic fibrosis Diseases 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18154600P | 2000-02-10 | 2000-02-10 | |
| PCT/US2001/004341 WO2001058241A2 (en) | 2000-02-10 | 2001-02-12 | Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1272897T3 true DK1272897T3 (da) | 2008-09-15 |
Family
ID=22664744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01910529T DK1272897T3 (da) | 2000-02-10 | 2001-02-12 | Adenosin-A2A-receptorantagonister til behandling og forebyggelse af leverfibrose, cirrose og fedtlever |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6555545B2 (enExample) |
| EP (1) | EP1272897B1 (enExample) |
| JP (1) | JP2004502640A (enExample) |
| AT (1) | ATE394104T1 (enExample) |
| AU (2) | AU3812401A (enExample) |
| CA (1) | CA2398908C (enExample) |
| DE (1) | DE60133887D1 (enExample) |
| DK (1) | DK1272897T3 (enExample) |
| ES (1) | ES2307593T3 (enExample) |
| PT (1) | PT1272897E (enExample) |
| WO (1) | WO2001058241A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6196459B1 (en) * | 1998-05-11 | 2001-03-06 | Ubiq Incorporated | Smart card personalization in a multistation environment |
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| ITRM20070088A1 (it) * | 2007-02-19 | 2008-08-20 | Francesco Fringuelli | Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico. |
| CN101842098A (zh) * | 2007-08-10 | 2010-09-22 | 基因实验室技术有限公司 | 用于治疗病毒感染的含氮的二环化学实体 |
| WO2009055021A1 (en) * | 2007-10-26 | 2009-04-30 | New York University School Of Medicine | Methods and compositions for treating hepatic diseases |
| CA2711673A1 (en) * | 2008-01-31 | 2009-08-06 | Astellas Pharma Inc. | Pharmaceutical compositions for treating fatty liver disease |
| US8536306B2 (en) | 2008-10-01 | 2013-09-17 | The Scripps Research Institute | Human A2A adenosine receptor crystals and uses thereof |
| US20100204265A1 (en) * | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
| BRPI1009398A2 (pt) | 2009-03-13 | 2016-03-08 | Advinus Therapeutics Private Ltd | compostos de pirimidina fundida substituída |
| SI2408775T1 (sl) * | 2009-03-20 | 2015-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oksidirani derivati triazolilpurinov, ki so uprabni kot ligandi receptorja adenozina A2A, in njihova uporaba kot zdravila |
| EP2499142B1 (en) | 2009-11-09 | 2016-09-21 | Advinus Therapeutics Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| ES2579949T3 (es) | 2010-02-05 | 2016-08-17 | Heptares Therapeutics Limited | Derivados de 1,2,4-triazin-4-amina |
| WO2012066330A1 (en) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Compounds useful as a2a receptor inhibitors |
| AU2018294557A1 (en) | 2017-06-30 | 2020-01-02 | Ryvu Therapeutics S.A. | Imidazo(1,2-a)pyrazine modulators of the adenosine A2A receptor |
| AU2018389313B2 (en) | 2017-12-19 | 2021-08-19 | Impetis Biosciences Ltd. | Pharmaceutical composition for the treatment of cancer |
| AU2019205661B2 (en) | 2018-01-04 | 2022-06-30 | Impetis Biosciences Ltd. | Tricyclic compounds, compositions and medicinal applications thereof |
| WO2020128036A1 (en) | 2018-12-21 | 2020-06-25 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a receptor |
| AU2023454063A1 (en) | 2023-07-17 | 2026-01-15 | BioNTech SE | Modulators of the adenosine a2a and a2b receptor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705658A (en) | 1986-04-07 | 1987-11-10 | Capsule Technology International, Ltd. | Method for drying gelatin in the manufacture of hard shell gelatin capsules |
| US5063233A (en) | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US5036381A (en) | 1990-06-15 | 1991-07-30 | Motorola, Inc. | Multiple electronic devices within a single carrier structure |
| GB2264948B (en) | 1992-03-13 | 1996-10-16 | Merck & Co Inc | Human adenosine receptors |
| US5426101A (en) | 1992-09-30 | 1995-06-20 | Merrell Dow Pharmaceuticals Inc. | 2-substituted adenosines with A-2 receptor affinity |
| WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5877180A (en) * | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| US5859019A (en) | 1997-03-07 | 1999-01-12 | Trustees Of The University Of Pennsylvania | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists |
| WO1998050047A1 (en) | 1997-05-09 | 1998-11-12 | Trustees Of The University Of Pennsylvania | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| WO1998052611A1 (en) * | 1997-05-23 | 1998-11-26 | Nippon Shinyaku Co., Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| US6303619B1 (en) * | 1998-03-12 | 2001-10-16 | University Of Virginia | Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
-
2001
- 2001-02-12 AT AT01910529T patent/ATE394104T1/de not_active IP Right Cessation
- 2001-02-12 EP EP01910529A patent/EP1272897B1/en not_active Expired - Lifetime
- 2001-02-12 JP JP2001557366A patent/JP2004502640A/ja active Pending
- 2001-02-12 DK DK01910529T patent/DK1272897T3/da active
- 2001-02-12 DE DE60133887T patent/DE60133887D1/de not_active Expired - Lifetime
- 2001-02-12 AU AU3812401A patent/AU3812401A/xx active Pending
- 2001-02-12 ES ES01910529T patent/ES2307593T3/es not_active Expired - Lifetime
- 2001-02-12 WO PCT/US2001/004341 patent/WO2001058241A2/en not_active Ceased
- 2001-02-12 CA CA002398908A patent/CA2398908C/en not_active Expired - Fee Related
- 2001-02-12 US US09/780,365 patent/US6555545B2/en not_active Expired - Lifetime
- 2001-02-12 AU AU2001238124A patent/AU2001238124B2/en not_active Ceased
- 2001-02-12 PT PT01910529T patent/PT1272897E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2398908A1 (en) | 2001-08-16 |
| EP1272897A2 (en) | 2003-01-08 |
| JP2004502640A (ja) | 2004-01-29 |
| WO2001058241A9 (en) | 2002-10-17 |
| CA2398908C (en) | 2009-12-15 |
| EP1272897B1 (en) | 2008-05-07 |
| AU2001238124B2 (en) | 2006-05-25 |
| US20020002145A1 (en) | 2002-01-03 |
| AU3812401A (en) | 2001-08-20 |
| US6555545B2 (en) | 2003-04-29 |
| WO2001058241A2 (en) | 2001-08-16 |
| ATE394104T1 (de) | 2008-05-15 |
| DE60133887D1 (de) | 2008-06-19 |
| PT1272897E (pt) | 2008-08-18 |
| ES2307593T3 (es) | 2008-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60133887D1 (de) | Adenosin a2a rezeptor-antagonisten zur behandlung und vorbeugung von leberfibrose, zirrhose und fettleber | |
| WO2005027895A3 (en) | Thyroid hormone analogs and methods of use in angiogenesis | |
| DK1135153T3 (da) | Anvendelser af EPH-receptorantagonister og -agonister til behandling af vaskulære forstyrrelser | |
| SG155054A1 (en) | Human anti- neutralizing antibodies as selective pathway inhibitors | |
| MXPA02012443A (es) | Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos. | |
| CY1119536T1 (el) | Συνθεση μονομερων προστατευμενου 3'-αμινο νουκλεοζιδιου | |
| DK1173441T3 (da) | 6-alkenyl-, 6-alkynyl- og 6-epoxy-epothilon-derivater, fremgangsmåde til fremstilling af disse samt deres anvendelse i farmaceutiske sammensætninger | |
| DK1523489T3 (da) | Modificerede 2'- og 3'-nukleosidprodrugs til behandling af flaviridae-infektioner | |
| DK1268616T3 (da) | Fyldstofkoncentrater til anvendelse i termoplaster | |
| WO2006031922A3 (en) | Thyroid hormone analogs for promoting angiogenesis | |
| ATE364595T1 (de) | Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika | |
| ATE506959T1 (de) | Verwendung von il-18 inhibitoren | |
| MX2007003078A (es) | Compuestos de imidazoquinolina. | |
| WO2008043107A3 (en) | Use of tight junction antagonists to treat inflammatory bowel disease | |
| JP2004502640A5 (enExample) | ||
| PT1513836E (pt) | Derivados de piperazinilacilpiperidina, sua preparacao e sua aplicacao em terapeutica | |
| EP1334221A4 (en) | CATHODIC PROTECTION OF STEEL IN STEEL CONCRETE WITH ELECTROSMOTIC TREATMENT | |
| AP2001002285A0 (en) | Immunomodulatory steroids, in particular the hemihydrate of. 16 alpha.-bromoepiandrosterone. | |
| TW200624125A (en) | Compositions and methods for increasing HDL and HDL-2b levels | |
| DK1411970T3 (da) | Anvendelse af SARP-1 til behandling og/eller forebyggelse af sclerodermia | |
| DK1058544T3 (da) | Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer | |
| AR026901A1 (es) | Peptidos con n-alquilacion que tienen actividad antiangiogenica | |
| IT1307736B1 (it) | Ossopiperazinil derivati e composizioni fotostabilizzate. | |
| NO20051261L (no) | Morfin-6-glukuronidsalt | |
| BR0002640A (pt) | Uso de simeticona para tratar colite ulcerativa |