DK1058544T3 - Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer - Google Patents

Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer

Info

Publication number
DK1058544T3
DK1058544T3 DK99961268T DK99961268T DK1058544T3 DK 1058544 T3 DK1058544 T3 DK 1058544T3 DK 99961268 T DK99961268 T DK 99961268T DK 99961268 T DK99961268 T DK 99961268T DK 1058544 T3 DK1058544 T3 DK 1058544T3
Authority
DK
Denmark
Prior art keywords
heparin
tnf
inhibition
preparations
soluble
Prior art date
Application number
DK99961268T
Other languages
English (en)
Inventor
Dan Aderka
Englender Talma Eshed
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of DK1058544T3 publication Critical patent/DK1058544T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
DK99961268T 1998-12-30 1999-12-30 Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer DK1058544T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12785198A IL127851A0 (en) 1998-12-30 1998-12-30 Inhibition of TNF activity
PCT/IL1999/000709 WO2000040225A2 (en) 1998-12-30 1999-12-30 Inhibition of tnf activity

Publications (1)

Publication Number Publication Date
DK1058544T3 true DK1058544T3 (da) 2005-03-14

Family

ID=11072323

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99961268T DK1058544T3 (da) 1998-12-30 1999-12-30 Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer

Country Status (12)

Country Link
US (1) US6608044B1 (da)
EP (1) EP1058544B1 (da)
JP (1) JP2002534375A (da)
AT (1) ATE289506T1 (da)
AU (1) AU780203B2 (da)
CA (1) CA2322229C (da)
DE (1) DE69923832T2 (da)
DK (1) DK1058544T3 (da)
ES (1) ES2237959T3 (da)
IL (2) IL127851A0 (da)
PT (1) PT1058544E (da)
WO (1) WO2000040225A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074420A1 (fr) * 2000-04-05 2001-10-11 Toray Industries, Inc. Adsorbants pour proteines de la famille hmg et colonne de purification de liquide organique
CA2431709A1 (en) * 2000-12-16 2002-06-20 Aventis Pharma Deutschland Gmbh Use of low molecular heparin for treating osteoarthritis
US20050214276A9 (en) 2002-05-03 2005-09-29 Myette James R Delta 4, 5 glycuronidase and uses thereof
US7307361B1 (en) 2006-11-13 2007-12-11 Drs Power & Control Technologies, Inc. Medium voltage power converter formed using low voltage drives
US7576604B2 (en) * 2006-12-15 2009-08-18 Bin Xu All-digital class-D audio amplifier
WO2009141821A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
EP2310409A2 (en) * 2008-06-17 2011-04-20 Apogenix GmbH Multimeric tnf receptors
WO2010013231A2 (en) * 2008-07-29 2010-02-04 Yeda Research And Development Co. Ltd. Modulation of coagulation factors and effectors of same for control of transplant organ size

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98078A0 (en) * 1991-05-07 1992-06-21 Yeda Res & Dev Pharmaceutical compositions comprising an anticytokyne
KR100235782B1 (ko) * 1991-05-02 1999-12-15 파울리나 벤-아미 병리학적 과정의 예방 또는 치료를 위한 성분물
EP0620739A4 (en) * 1992-09-15 1997-01-15 Immunex Corp Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists.
EP0710121B1 (en) * 1993-07-30 2000-10-11 Kennedy Institute Of Rheumatology Method for treating multiple sclerosis
DE4435612A1 (de) * 1994-10-05 1996-04-11 Braun Melsungen Ag Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit
AUPN673995A0 (en) * 1995-11-22 1995-12-14 Down Hole Technologies Pty Ltd A sleeve for orientating a tool
US6623472B1 (en) * 1997-08-16 2003-09-23 Orthogen Gentechnologic. Gmbh Method for inducing therapeutically-effective proteins

Also Published As

Publication number Publication date
JP2002534375A (ja) 2002-10-15
WO2000040225A3 (en) 2000-09-21
ATE289506T1 (de) 2005-03-15
DE69923832T2 (de) 2005-12-29
IL138024A (en) 2006-09-05
EP1058544B1 (en) 2005-02-23
DE69923832D1 (de) 2005-03-31
EP1058544A1 (en) 2000-12-13
AU1796100A (en) 2000-07-24
ES2237959T3 (es) 2005-08-01
CA2322229A1 (en) 2000-07-13
CA2322229C (en) 2008-05-06
US6608044B1 (en) 2003-08-19
PT1058544E (pt) 2005-04-29
IL127851A0 (en) 1999-10-28
AU780203B2 (en) 2005-03-10
WO2000040225A2 (en) 2000-07-13

Similar Documents

Publication Publication Date Title
NL300136I1 (nl) Farmacologisch actieve catecholderivaten en samenstellingen ervan.
UY26082A1 (es) Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
ITRM910922A1 (it) Composizione farmaceutica anticefalalgica per somministrazione endonasale, procedimento per prepararla e suo impiego terapeutico
SE8804629D0 (sv) New therapeutically active compounds
KR930003912A (ko) 울혈성 심장 마비 치료법
ES2160949T3 (es) Derivados de fenilen-sulfonamida sustituidos en meta.
NO981436D0 (no) Farmasöytiske angiostatiske dipeptidsammensetninger og anvendelse derav
DK0902789T3 (da) Androstenderivater
DK1058544T3 (da) Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer
DK1187611T3 (da) Oftalmiske histaminholdige sammensætninger og anvendelse deraf
IL126175A0 (en) Method or treating heart failure with endothelin antagonists and pharmaceutical compositions containing the same
IT9020020A0 (it) "n,n'-ditrimetossibenzoilpiperazine 2-sostituite, procedimento per la loro preparazione e composizioni terapeutiche che le contengono
ITRM950589A0 (it) Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire malattie causate dalla sovrapproduzione di dette citochine naturali, e composizioni farmaceutiche cosi' ottenibili
LV10917A (lv) Bambuterina pielietojums lipidu saturu pazeminosu farmaceitisku kompoziciju pagatavosanai
ITMI911445A1 (it) Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
IT8622783A0 (it) Derivati imidazolici adattivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT9022371A0 (it) Derivati dell'1-arilsolfonil 2-pirrolidone, loro procedimento di preparazione e i nuovi intermedi cosi' ottenuti, il loro impiego come farmaci e le composizioni farmaceutiche che li contengono.
IT9048605A0 (it) Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono.
ITMI911653A0 (it) Derivati dell'eseridina ad attivita' amticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI922832A1 (it) DERIVATI DELL'ESEROLINA AD ATTIVITAy ANTICOLINESTERASICA, PROCEDIMENTO PER LA LORO PREPARAZIONE E COMPOSIZIONI FARMACEUTICHE CHE LI CONTENGONO.
IT8321740A0 (it) Derivati dell'isoindolina e composizioni terapeutiche che li comprendono come principio attivo.
IT9047769A0 (it) Derivati 8-azaxantinici, loro sali fisiologicamente accettabili e loro composizioni farmaceutiche ad attivita' antibroncospastica.
IT8025473A0 (it) Derivati piridossinici ad attivita' terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
ITRM910829A0 (it) Derivati dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono