JP2004502640A5 - - Google Patents
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- Publication number
- JP2004502640A5 JP2004502640A5 JP2001557366A JP2001557366A JP2004502640A5 JP 2004502640 A5 JP2004502640 A5 JP 2004502640A5 JP 2001557366 A JP2001557366 A JP 2001557366A JP 2001557366 A JP2001557366 A JP 2001557366A JP 2004502640 A5 JP2004502640 A5 JP 2004502640A5
- Authority
- JP
- Japan
- Prior art keywords
- adenosine
- fibrosis
- administering
- subject
- need
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010016654 Fibrosis Diseases 0.000 claims 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 6
- 208000004930 Fatty Liver Diseases 0.000 claims 4
- 206010019708 Hepatic steatosis Diseases 0.000 claims 4
- 230000007882 cirrhosis Effects 0.000 claims 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims 4
- 208000010706 fatty liver disease Diseases 0.000 claims 4
- 230000004761 fibrosis Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 3
- 229960005305 adenosine Drugs 0.000 claims 3
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18154600P | 2000-02-10 | 2000-02-10 | |
| PCT/US2001/004341 WO2001058241A2 (en) | 2000-02-10 | 2001-02-12 | Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502640A JP2004502640A (ja) | 2004-01-29 |
| JP2004502640A5 true JP2004502640A5 (enExample) | 2005-02-03 |
Family
ID=22664744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557366A Pending JP2004502640A (ja) | 2000-02-10 | 2001-02-12 | 肝繊維症、硬変症および脂肪肝を治療および予防するアデノシンａ２ａ受容体拮抗薬 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6555545B2 (enExample) |
| EP (1) | EP1272897B1 (enExample) |
| JP (1) | JP2004502640A (enExample) |
| AT (1) | ATE394104T1 (enExample) |
| AU (2) | AU3812401A (enExample) |
| CA (1) | CA2398908C (enExample) |
| DE (1) | DE60133887D1 (enExample) |
| DK (1) | DK1272897T3 (enExample) |
| ES (1) | ES2307593T3 (enExample) |
| PT (1) | PT1272897E (enExample) |
| WO (1) | WO2001058241A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6196459B1 (en) * | 1998-05-11 | 2001-03-06 | Ubiq Incorporated | Smart card personalization in a multistation environment |
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| ITRM20070088A1 (it) * | 2007-02-19 | 2008-08-20 | Francesco Fringuelli | Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico. |
| EA201000201A1 (ru) * | 2007-08-10 | 2010-12-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Азотсодержащие бициклические химические вещества для лечения вирусных инфекций |
| WO2009055021A1 (en) * | 2007-10-26 | 2009-04-30 | New York University School Of Medicine | Methods and compositions for treating hepatic diseases |
| JP5302900B2 (ja) * | 2008-01-31 | 2013-10-02 | アステラス製薬株式会社 | 脂肪性肝疾患の治療用医薬組成物 |
| WO2010040003A2 (en) * | 2008-10-01 | 2010-04-08 | The Scripps Research Institute | Human a2a adenosine receptor crystals and uses thereof |
| US20100204265A1 (en) * | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
| BRPI1009398A2 (pt) | 2009-03-13 | 2016-03-08 | Advinus Therapeutics Private Ltd | compostos de pirimidina fundida substituída |
| SI2408775T1 (sl) * | 2009-03-20 | 2015-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Oksidirani derivati triazolilpurinov, ki so uprabni kot ligandi receptorja adenozina A2A, in njihova uporaba kot zdravila |
| WO2011055391A1 (en) | 2009-11-09 | 2011-05-12 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| US8809525B2 (en) | 2010-02-05 | 2014-08-19 | Heptares Therapeutics Limited | 1,2,4-triazine-4-amine derivatives |
| WO2012066330A1 (en) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Compounds useful as a2a receptor inhibitors |
| JP2020525472A (ja) | 2017-06-30 | 2020-08-27 | ライブ・セラピューティクス・スプウカ・アクツィーナＲｙｖｕ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓ．Ａ． | アデノシンａ２ａ受容体のイミダゾ［１，２−ａ］ピラジン調節剤 |
| US20200316077A1 (en) | 2017-12-19 | 2020-10-08 | Impetis Biosciences Ltd. | Pharmaceutical composition for the treatment of cancer |
| JP7361697B2 (ja) | 2018-01-04 | 2023-10-16 | インペティス・バイオサイエンシーズ・リミテッド | 三環性化合物、組成物及びその医薬品用途 |
| WO2020128036A1 (en) | 2018-12-21 | 2020-06-25 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a receptor |
| WO2025018901A1 (en) | 2023-07-17 | 2025-01-23 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a and a2b receptor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705658A (en) | 1986-04-07 | 1987-11-10 | Capsule Technology International, Ltd. | Method for drying gelatin in the manufacture of hard shell gelatin capsules |
| US5063233A (en) | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US5036381A (en) | 1990-06-15 | 1991-07-30 | Motorola, Inc. | Multiple electronic devices within a single carrier structure |
| GB2264948B (en) | 1992-03-13 | 1996-10-16 | Merck & Co Inc | Human adenosine receptors |
| US5426101A (en) | 1992-09-30 | 1995-06-20 | Merrell Dow Pharmaceuticals Inc. | 2-substituted adenosines with A-2 receptor affinity |
| WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5877180A (en) * | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| US5859019A (en) | 1997-03-07 | 1999-01-12 | Trustees Of The University Of Pennsylvania | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists |
| WO1998050047A1 (en) | 1997-05-09 | 1998-11-12 | Trustees Of The University Of Pennsylvania | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| AU7449598A (en) * | 1997-05-23 | 1998-12-11 | Nippon Shinyaku Co. Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| US6303619B1 (en) * | 1998-03-12 | 2001-10-16 | University Of Virginia | Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
-
2001
- 2001-02-12 WO PCT/US2001/004341 patent/WO2001058241A2/en not_active Ceased
- 2001-02-12 PT PT01910529T patent/PT1272897E/pt unknown
- 2001-02-12 CA CA002398908A patent/CA2398908C/en not_active Expired - Fee Related
- 2001-02-12 ES ES01910529T patent/ES2307593T3/es not_active Expired - Lifetime
- 2001-02-12 JP JP2001557366A patent/JP2004502640A/ja active Pending
- 2001-02-12 AT AT01910529T patent/ATE394104T1/de not_active IP Right Cessation
- 2001-02-12 DE DE60133887T patent/DE60133887D1/de not_active Expired - Lifetime
- 2001-02-12 DK DK01910529T patent/DK1272897T3/da active
- 2001-02-12 AU AU3812401A patent/AU3812401A/xx active Pending
- 2001-02-12 US US09/780,365 patent/US6555545B2/en not_active Expired - Lifetime
- 2001-02-12 AU AU2001238124A patent/AU2001238124B2/en not_active Ceased
- 2001-02-12 EP EP01910529A patent/EP1272897B1/en not_active Expired - Lifetime
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