DK125174B - Analogifremgangsmåde til fremstilling af 17-estere af Δ<1,4>-6α-flour- eller 6α,9α-di-flour-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadiener eller 21-aldehyd-hydrater, -estere eller -acetaler deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 17-estere af Δ<1,4>-6α-flour- eller 6α,9α-di-flour-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadiener eller 21-aldehyd-hydrater, -estere eller -acetaler deraf.

Info

Publication number
DK125174B
DK125174B DK615167AA DK615167A DK125174B DK 125174 B DK125174 B DK 125174B DK 615167A A DK615167A A DK 615167AA DK 615167 A DK615167 A DK 615167A DK 125174 B DK125174 B DK 125174B
Authority
DK
Denmark
Prior art keywords
fluoro
esters
pregnadienes
trioxo
acetals
Prior art date
Application number
DK615167AA
Other languages
Danish (da)
English (en)
Inventor
Sa Ciba
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK125174B publication Critical patent/DK125174B/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK615167AA 1966-12-09 1967-12-08 Analogifremgangsmåde til fremstilling af 17-estere af Δ<1,4>-6α-flour- eller 6α,9α-di-flour-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadiener eller 21-aldehyd-hydrater, -estere eller -acetaler deraf. DK125174B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1763466A CH510654A (de) 1966-12-09 1966-12-09 Verfahren zur Herstellung von Aldehyden der Pregnanreihe und ihrer Derivate

Publications (1)

Publication Number Publication Date
DK125174B true DK125174B (da) 1973-01-08

Family

ID=4426902

Family Applications (2)

Application Number Title Priority Date Filing Date
DK615167AA DK125174B (da) 1966-12-09 1967-12-08 Analogifremgangsmåde til fremstilling af 17-estere af Δ<1,4>-6α-flour- eller 6α,9α-di-flour-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadiener eller 21-aldehyd-hydrater, -estere eller -acetaler deraf.
DK615067AA DK122762B (da) 1966-12-09 1967-12-08 Analogifremgangsmåde til fremstilling af Δ<1,4>-6α,9α-difluor-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadien eller 21-aldehydhydrater, -estere eller -acetaler deraf.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK615067AA DK122762B (da) 1966-12-09 1967-12-08 Analogifremgangsmåde til fremstilling af Δ<1,4>-6α,9α-difluor-11β,17α-dihydroxy-16α-methyl-3,20,21-trioxo-pregnadien eller 21-aldehydhydrater, -estere eller -acetaler deraf.

Country Status (11)

Country Link
US (2) US3519659A (xx)
JP (4) JPS4837030B1 (xx)
AT (11) AT301042B (xx)
BE (2) BE707760A (xx)
CH (11) CH502326A (xx)
DE (2) DE1643835B2 (xx)
DK (2) DK125174B (xx)
FR (5) FR1577251A (xx)
GB (2) GB1211220A (xx)
NL (2) NL160275C (xx)
SE (2) SE347964B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1961867A1 (de) * 1968-12-12 1970-07-02 Ciba Geigy Verfahren zur Herstellung von Aldehyden der Pregnanreihe und ihrer Derivate
NL189235C (nl) * 1974-02-28 1993-02-16 Akzo Nv Werkwijze voor de bereiding van een oraal toe te dienen farmaceutisch preparaat met androgene werking.
JPS5111606A (ja) * 1974-07-19 1976-01-29 Nitsutotekuno Guruupu Kk Suiheidoreenkoho
US4076737A (en) * 1975-02-20 1978-02-28 Ciba-Geigy Corporation Aldehydes of the pregnane series and derivatives thereof
NL7506407A (nl) * 1975-05-30 1976-12-02 Akzo Nv Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat.
US4011315A (en) * 1975-07-07 1977-03-08 Syntex (U.S.A.) Inc. 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
US3996358A (en) * 1975-07-07 1976-12-07 Syntex (U.S.A.) Inc. 21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation
JPS53156078U (xx) * 1977-05-13 1978-12-07
US4273770A (en) * 1978-04-05 1981-06-16 Syntex (U.S.A.) Inc. 4-Halo steroids
JPS54164057A (en) * 1978-06-16 1979-12-27 Ereko Kk Fluid mixer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2982774A (en) * 1954-08-06 1961-05-02 Merck & Co Inc 21-aldehydes of 9alpha-fluoro-steroids and derivatives thereof
US2841600A (en) * 1957-01-18 1958-07-01 Upjohn Co 6alpha-fluoro delta-cortisone and 6alpha-fluoro delta'-hydrocortisone and the 21-acylates thereof
US3068250A (en) * 1958-08-29 1962-12-11 Merek & Co Inc 16alpha-alkyl 21-aldehyde hydrate steroids and processes for preparing the same
US3020275A (en) * 1960-06-07 1962-02-06 American Cyanamid Co 21-nitrogen substituted steroids of the pregnane series and methods of preparing the same

Also Published As

Publication number Publication date
AT286510B (de) 1970-12-10
DK122762B (da) 1972-04-10
DE1643836A1 (de) 1971-06-03
AT293637B (de) 1971-10-25
NL159110B (nl) 1979-01-15
NL6716725A (xx) 1968-06-10
DE1643835A1 (de) 1971-07-22
CH507922A (de) 1971-05-31
AT292930B (de) 1971-09-10
FR7549M (xx) 1969-12-29
GB1211219A (en) 1970-11-04
NL160275C (nl) 1979-10-15
DE1643835B2 (de) 1977-06-16
NL160275B (nl) 1979-05-15
AT300211B (de) 1972-07-25
CH502328A (de) 1971-01-31
AT301044B (de) 1972-08-25
AT285066B (de) 1970-10-12
JPS4837030B1 (xx) 1973-11-08
CH510654A (de) 1971-07-31
CH502324A (de) 1971-01-31
NL6716724A (xx) 1968-06-10
AT301042B (de) 1972-08-25
AT301043B (de) 1972-07-15
AT297947B (de) 1972-04-10
FR7548M (xx) 1969-12-29
CH502325A (de) 1971-01-31
BE707760A (xx) 1968-06-10
SE347964B (xx) 1972-08-21
FR7550M (xx) 1969-12-29
GB1211220A (en) 1970-11-04
CH499507A (de) 1970-11-30
CH499508A (de) 1970-11-30
FR1577251A (xx) 1969-08-08
DE1643836B2 (de) 1976-08-26
BE707759A (xx) 1968-06-10
JPS4819310B1 (xx) 1973-06-12
US3519659A (en) 1970-07-07
CH532029A (de) 1972-12-31
AT293636B (de) 1971-10-25
SE347965B (xx) 1972-08-21
AT287935B (de) 1971-02-10
FR1572183A (xx) 1969-06-27
US3519660A (en) 1970-07-07
JPS5011386B1 (xx) 1975-04-30
JPS5011385B1 (xx) 1975-04-30
CH499506A (de) 1970-11-30
CH502329A (de) 1971-01-31
CH502326A (de) 1971-01-31

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