DK1248768T3 - Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse - Google Patents
Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disseInfo
- Publication number
- DK1248768T3 DK1248768T3 DK00958461T DK00958461T DK1248768T3 DK 1248768 T3 DK1248768 T3 DK 1248768T3 DK 00958461 T DK00958461 T DK 00958461T DK 00958461 T DK00958461 T DK 00958461T DK 1248768 T3 DK1248768 T3 DK 1248768T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- diagnostics
- drugs
- processes
- medicaments containing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19941764A DE19941764A1 (de) | 1999-09-02 | 1999-09-02 | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1248768T3 true DK1248768T3 (da) | 2006-03-27 |
Family
ID=7920512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00958461T DK1248768T3 (da) | 1999-09-02 | 2000-08-17 | Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6451781B1 (enExample) |
| EP (1) | EP1248768B1 (enExample) |
| JP (1) | JP4768941B2 (enExample) |
| AT (1) | ATE309981T1 (enExample) |
| AU (1) | AU774083B2 (enExample) |
| CA (1) | CA2383729A1 (enExample) |
| DE (2) | DE19941764A1 (enExample) |
| DK (1) | DK1248768T3 (enExample) |
| ES (1) | ES2251403T3 (enExample) |
| IL (1) | IL148250A0 (enExample) |
| WO (1) | WO2001017954A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003048108A2 (en) * | 2001-11-29 | 2003-06-12 | Theracos, Inc | Compounds for treatment of inflammation, diabetes and related disorders |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス，インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるｎｈｅ媒介性アンチポートを阻害するための組成物および方法 |
| WO2018129556A1 (en) * | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014029984A1 (en) * | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR102287207B1 (ko) | 2013-04-12 | 2021-08-09 | 알데릭스, 인코포레이티드 | Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법 |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
| CA3049679A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| EP3890745B1 (en) | 2018-12-04 | 2025-11-19 | President and Fellows of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0667846B2 (ja) * | 1989-04-28 | 1994-08-31 | 一 滝川 | 利胆剤 |
| TW289021B (enExample) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| IT1274000B (it) * | 1994-04-06 | 1997-07-14 | Alfa Wassermann Spa | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
| JPH09315979A (ja) * | 1996-05-24 | 1997-12-09 | Tokyo Tanabe Co Ltd | 利胆剤 |
| DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1999
- 1999-09-02 DE DE19941764A patent/DE19941764A1/de not_active Withdrawn
-
2000
- 2000-08-17 WO PCT/EP2000/008025 patent/WO2001017954A1/de not_active Ceased
- 2000-08-17 AT AT00958461T patent/ATE309981T1/de not_active IP Right Cessation
- 2000-08-17 EP EP00958461A patent/EP1248768B1/de not_active Expired - Lifetime
- 2000-08-17 IL IL14825000A patent/IL148250A0/xx unknown
- 2000-08-17 AU AU69965/00A patent/AU774083B2/en not_active Ceased
- 2000-08-17 DE DE50011660T patent/DE50011660D1/de not_active Expired - Lifetime
- 2000-08-17 DK DK00958461T patent/DK1248768T3/da active
- 2000-08-17 JP JP2001521701A patent/JP4768941B2/ja not_active Expired - Fee Related
- 2000-08-17 CA CA002383729A patent/CA2383729A1/en not_active Abandoned
- 2000-08-17 ES ES00958461T patent/ES2251403T3/es not_active Expired - Lifetime
- 2000-09-05 US US09/655,725 patent/US6451781B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE309981T1 (de) | 2005-12-15 |
| EP1248768B1 (de) | 2005-11-16 |
| WO2001017954A1 (de) | 2001-03-15 |
| IL148250A0 (en) | 2002-09-12 |
| DE19941764A1 (de) | 2001-03-15 |
| EP1248768A1 (de) | 2002-10-16 |
| DE50011660D1 (de) | 2005-12-22 |
| AU774083B2 (en) | 2004-06-17 |
| AU6996500A (en) | 2001-04-10 |
| CA2383729A1 (en) | 2001-03-15 |
| ES2251403T3 (es) | 2006-05-01 |
| JP4768941B2 (ja) | 2011-09-07 |
| JP2003508513A (ja) | 2003-03-04 |
| US6451781B1 (en) | 2002-09-17 |
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