DK1236728T3 - S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf - Google Patents

S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf

Info

Publication number
DK1236728T3
DK1236728T3 DK02006610T DK02006610T DK1236728T3 DK 1236728 T3 DK1236728 T3 DK 1236728T3 DK 02006610 T DK02006610 T DK 02006610T DK 02006610 T DK02006610 T DK 02006610T DK 1236728 T3 DK1236728 T3 DK 1236728T3
Authority
DK
Denmark
Prior art keywords
type
preparation
acid ester
ester compounds
substituted hydroxy
Prior art date
Application number
DK02006610T
Other languages
Danish (da)
English (en)
Inventor
Takayuki Kawaguchi
Kenji Tsujihara
Sumihiro Nomura
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of DK1236728T3 publication Critical patent/DK1236728T3/da

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/133—Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
    • G02F1/1333—Constructional arrangements; Manufacturing methods
    • G02F1/1345—Conductors connecting electrodes to cell terminals
    • G02F1/13452—Conductors connecting driver circuitry and terminals of panels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/1303—Apparatus specially adapted to the manufacture of LCDs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nonlinear Science (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mathematical Physics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK02006610T 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf DK1236728T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28807496 1996-10-30
EP97308549A EP0845464B1 (fr) 1996-10-30 1997-10-27 Composés d'ester de l'acide hydroxy-2-indolinybutyrique 2-substitué du type S comme intermédiaires de camptothecin

Publications (1)

Publication Number Publication Date
DK1236728T3 true DK1236728T3 (da) 2006-10-30

Family

ID=17725479

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02006610T DK1236728T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf
DK97308549T DK0845464T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK97308549T DK0845464T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater

Country Status (14)

Country Link
US (7) US5932732A (fr)
EP (3) EP0845464B1 (fr)
KR (5) KR100474496B1 (fr)
CN (3) CN100473654C (fr)
AT (2) ATE247120T1 (fr)
CA (2) CA2533685C (fr)
DE (2) DE69724081T2 (fr)
DK (2) DK1236728T3 (fr)
ES (2) ES2267879T3 (fr)
HK (2) HK1011538A1 (fr)
ID (1) ID18747A (fr)
PT (2) PT1236728E (fr)
SG (4) SG103322A1 (fr)
TW (1) TW464652B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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SG103322A1 (en) * 1996-10-30 2004-04-29 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
EA006741B1 (ru) 2000-11-09 2006-04-28 Неофарм, Инк. Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение
US20090137816A1 (en) * 2000-12-15 2009-05-28 Kurt Baum Process for the manufacture of diaminofurazan
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
CN101337900B (zh) * 2001-02-21 2013-12-18 株式会社雅库路特本社 喜树碱相关化合物的合成方法
AR035684A1 (es) * 2001-02-21 2004-06-23 Yakult Honsha Kk Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
WO2003030864A1 (fr) * 2001-05-29 2003-04-17 Neopharm, Inc. Formulation liposomale d'irinotecan
WO2003101406A1 (fr) * 2002-06-03 2003-12-11 California Pacific Medical Center Derives d'homocamptothecine
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
WO2004035032A2 (fr) * 2002-08-20 2004-04-29 Neopharm, Inc. Formulation de sn-38 a base de lipides pharmaceutiquement actifs
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
CN100390177C (zh) * 2004-11-25 2008-05-28 复旦大学 6-氰基-7-甲基-1,1-(2,2-二甲基-1,3-亚丙二氧基)-5-氧-1,2,3,5-四氢吲哚哩啶(i)的制备方法
ES2432553T3 (es) 2005-08-03 2013-12-04 Avra Laboratories Pvt. Ltd. Procedimiento de síntesis de intermedios clave para la producción de derivados de camptotecina
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN104341429B (zh) * 2013-07-29 2016-08-10 北大方正集团有限公司 (s)-喜树碱中间体的制备方法及(s)-喜树碱的制备方法
EA202092410A1 (ru) * 2018-04-06 2021-02-09 Сиэтл Дженетикс, Инк. Конъюгаты камптотецина с пептидом
CN113041841B (zh) * 2021-03-22 2022-07-12 万华化学集团股份有限公司 一种抗污染浓水隔网的制备方法及应用

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JPS5711607A (en) * 1980-06-25 1982-01-21 Tokyo Shibaura Electric Co Movable shelf control apparatus
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US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
EP0220601B1 (fr) * 1985-10-21 1991-12-11 Daiichi Seiyaku Co., Ltd. Dérivés de la pyranoindolizine et procédé de préparation
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
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KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
TW438775B (en) * 1995-04-07 2001-06-07 Pharmacia & Upjohn Co Llc Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
WO1996036611A1 (fr) * 1995-05-19 1996-11-21 Chiroscience Limited Phenylsulfamides 3,4-disubstitues et leur utilisation therapeutique
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
ATE213232T1 (de) * 1995-11-13 2002-02-15 Hoechst Ag Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren
AU7732996A (en) 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (fr) * 1995-12-28 2004-04-20 Kenji Tsujihara Derives de la camptothecine
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
SG103322A1 (en) * 1996-10-30 2004-04-29 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
DE19719817A1 (de) * 1997-05-13 1998-11-19 Hoechst Ag Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren

Also Published As

Publication number Publication date
PT1236728E (pt) 2006-10-31
TW464652B (en) 2001-11-21
ATE332303T1 (de) 2006-07-15
US7060832B2 (en) 2006-06-13
EP0845464B1 (fr) 2003-08-13
CA2533685A1 (fr) 1998-04-30
KR100567957B1 (ko) 2006-04-05
DE69724081T2 (de) 2004-06-09
HK1011538A1 (en) 1999-07-16
US20030135049A1 (en) 2003-07-17
EP1236728B1 (fr) 2006-07-05
DE69724081D1 (de) 2003-09-18
US5932732A (en) 1999-08-03
ES2205134T3 (es) 2004-05-01
SG104284A1 (en) 2004-06-21
US6015901A (en) 2000-01-18
ATE247120T1 (de) 2003-08-15
DK0845464T3 (da) 2003-12-01
CN1077109C (zh) 2002-01-02
EP1528062A3 (fr) 2007-02-07
HK1050356A1 (en) 2003-06-20
CN100473654C (zh) 2009-04-01
CN1915995A (zh) 2007-02-21
US6388078B1 (en) 2002-05-14
KR100474496B1 (ko) 2005-09-30
ES2267879T3 (es) 2007-03-16
CN1183414A (zh) 1998-06-03
ID18747A (id) 1998-05-07
DE69736308D1 (de) 2006-08-17
CA2219692A1 (fr) 1998-04-30
CA2533685C (fr) 2009-05-26
KR19980033318A (ko) 1998-07-25
SG103322A1 (en) 2004-04-29
KR20060086818A (ko) 2006-08-01
PT845464E (pt) 2003-12-31
HK1050356B (zh) 2007-01-19
EP1528062A2 (fr) 2005-05-04
CA2219692C (fr) 2007-05-22
SG116433A1 (en) 2005-11-28
EP1236728A2 (fr) 2002-09-04
CN1313286A (zh) 2001-09-19
US20020161231A1 (en) 2002-10-31
KR100653592B1 (ko) 2006-12-05
EP0845464A2 (fr) 1998-06-03
DE69736308T2 (de) 2007-06-14
KR100578779B1 (ko) 2006-05-12
MX9708343A (es) 1998-08-30
US6114529A (en) 2000-09-05
EP0845464A3 (fr) 1999-06-23
KR100525025B1 (ko) 2005-10-31
CN100528879C (zh) 2009-08-19
US6277992B1 (en) 2001-08-21
EP1236728A3 (fr) 2002-12-18
SG88737A1 (en) 2002-05-21
US6716983B2 (en) 2004-04-06

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