DK123526B - Fremgangsmåde til fremstilling af 6-chlor-2,3,4,5-tetrahydro-1H-3-benzazepin eller syreadditionssalte deraf. - Google Patents

Fremgangsmåde til fremstilling af 6-chlor-2,3,4,5-tetrahydro-1H-3-benzazepin eller syreadditionssalte deraf.

Info

Publication number
DK123526B
DK123526B DK383268AA DK383268A DK123526B DK 123526 B DK123526 B DK 123526B DK 383268A A DK383268A A DK 383268AA DK 383268 A DK383268 A DK 383268A DK 123526 B DK123526 B DK 123526B
Authority
DK
Denmark
Prior art keywords
benzazepine
tetrahydro
chloro
preparation
acid addition
Prior art date
Application number
DK383268AA
Other languages
Danish (da)
English (en)
Inventor
E Habicht
K Hoegerle
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK123526B publication Critical patent/DK123526B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK383268AA 1968-02-09 1968-08-08 Fremgangsmåde til fremstilling af 6-chlor-2,3,4,5-tetrahydro-1H-3-benzazepin eller syreadditionssalte deraf. DK123526B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH197668A CH498122A (de) 1968-02-09 1968-02-09 Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates

Publications (1)

Publication Number Publication Date
DK123526B true DK123526B (da) 1972-07-03

Family

ID=4223010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK383268AA DK123526B (da) 1968-02-09 1968-08-08 Fremgangsmåde til fremstilling af 6-chlor-2,3,4,5-tetrahydro-1H-3-benzazepin eller syreadditionssalte deraf.

Country Status (10)

Country Link
AT (1) AT277257B (xx)
BE (1) BE719631A (xx)
CH (1) CH498122A (xx)
DE (1) DE1795132A1 (xx)
DK (1) DK123526B (xx)
ES (1) ES357247A1 (xx)
FR (1) FR1598948A (xx)
GB (1) GB1225053A (xx)
IL (1) IL30458A (xx)
NL (1) NL6811311A (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc
US4160765A (en) * 1976-11-17 1979-07-10 Smithkline Corporation Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
CN101274911B (zh) 2003-06-17 2011-01-26 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
TW200510324A (en) * 2003-08-11 2005-03-16 Lilly Co Eli 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist
JP5270167B2 (ja) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形
KR20130087622A (ko) 2004-12-23 2013-08-06 아레나 파마슈티칼스, 인크. 5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법
CN101466684B (zh) 2006-04-03 2012-06-20 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
WO2008070111A2 (en) 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
NZ630494A (en) 2010-09-01 2016-05-27 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
KR20150070249A (ko) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. 체중 관리 방법

Also Published As

Publication number Publication date
GB1225053A (en) 1971-03-17
IL30458A (en) 1972-03-28
FR1598948A (xx) 1970-07-15
NL6811311A (xx) 1969-08-12
ES357247A1 (es) 1970-03-01
CH498122A (de) 1970-10-31
AT277257B (de) 1969-12-29
BE719631A (xx) 1969-02-17
IL30458A0 (en) 1968-09-26
DE1795132A1 (de) 1972-01-05

Similar Documents

Publication Publication Date Title
DK124884B (da) Analogifremgangsmåde til fremstilling af 2-brom-α-ergokryptin eller syreadditionssalte deraf.
DK115473B (da) Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.
DK123526B (da) Fremgangsmåde til fremstilling af 6-chlor-2,3,4,5-tetrahydro-1H-3-benzazepin eller syreadditionssalte deraf.
DK131721B (da) Analogifremgangsmåde til fremstilling af adamantanylaminer eller 3,5,7-trimethylhomologe eller syreadditionssalte deraf.
DK137382B (da) Analogifremgangsmåde til fremstilling af 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piperidin)butyramider eller syreadditionssalte deraf.
DK127644B (da) Analogifremgangsmåde til fremstilling af ergopeptiner eller syreadditionssalte deraf.
DK126202B (da) Analogifremgangsmåde til fremstilling af azepinderivater eller syreadditionssalte deraf.
DK120548B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf.
DK129994B (da) Analogifremgangsmåde til fremstilling af 1-trimethoxybenzyl-6,7-dialkanoyl-1,2,3,4-tetrahydroisoquinoliner eller syreadditionssalte deraf.
DK120155B (da) Analogifremgangsmåde til fremstilling af aminopropiofenoner eller syreadditionssalte deraf.
DK135231B (da) Analogifremgangsmåde til fremstilling af basisk substituerede 2,3-cis, trans-diphenylcyclopropanderivater eller syreadditionssalte deraf.
DK126327B (da) Analogifremgangsmåde til fremstilling af derivater af p-aminoalkylbenzensulfonamid eller syreadditionssalte deraf.
DK127424B (da) Analogifremgangsmåde til fremstilling af 4-aryl-1-(4,4-diarylbutyl)-4-hydroxypiperidiner eller syreadditionssalte deraf.
DK137044B (da) Analogifremgangsmåde til fremstilling af 4,4-diphenylhexahydroazepinderivater eller syreadditionssalte deraf.
DK138740B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller syreadditionssalte deraf.
DK122323B (da) Fremgangsmåde til fremstilling af 1-alkyl-(eller alkenyl)-2-aminomethylpyrrolidiner eller syreadditionssalte heraf.
DK130114B (da) Analogifremgangsmåde til fremstilling af 5,6-dihydrofenantridinderivater eller syreadditionssalte eller kvaternære ammoniumsalte deraf.
DK121125B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller syreadditionssalte deraf.
DK121955B (da) Analogifremgangsmåde til fremstilling af 1,4-substituerede phenylpiperaziner eller syreadditionssalte deraf.
DK122725B (da) Analogifremgangsmåde til fremstilling af 10,11-dihydro-5H-dibenz(b,f)azepineddikesyrederivater eller salte deraf.
DK135765B (da) Fremgangsmåde til fremstilling af 1-substituerede 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoliner eller syreadditionssalte deraf.
DK124028B (da) Analogifremgangsmåde til fremstilling af quinolylformiminoethere eller syreadditionssalte deraf.
DK113431B (da) Fremgangsmåde til fremstilling af dibenz (b,f) azepinderivater eller syreadditionssalte deraf.
DK122764B (da) Analogifremgangsmåde til fremstilling af 10, 11-dihydro-5H-dibenz [b,f] azepinderivater eller syreadditionssalte deraf.
DK120294B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller syreadditionssalte deraf.