DK120548B - Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf. - Google Patents

Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf.

Info

Publication number
DK120548B
DK120548B DK547766AA DK547766A DK120548B DK 120548 B DK120548 B DK 120548B DK 547766A A DK547766A A DK 547766AA DK 547766 A DK547766 A DK 547766A DK 120548 B DK120548 B DK 120548B
Authority
DK
Denmark
Prior art keywords
oxides
preparation
acid addition
addition salts
benzodiazepine derivatives
Prior art date
Application number
DK547766AA
Other languages
English (en)
Inventor
G Field
L Sternbach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK120548B publication Critical patent/DK120548B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/28—Ethers with hydroxy compounds containing oxirane rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DK547766AA 1965-10-22 1966-10-21 Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf. DK120548B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50238365A 1965-10-22 1965-10-22

Publications (1)

Publication Number Publication Date
DK120548B true DK120548B (da) 1971-06-14

Family

ID=33300144

Family Applications (2)

Application Number Title Priority Date Filing Date
DK547766AA DK120548B (da) 1965-10-22 1966-10-21 Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf.
DK547866AA DK111489B (da) 1965-10-22 1966-10-21 Fremgangsmåde til fremstilling af benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK547866AA DK111489B (da) 1965-10-22 1966-10-21 Fremgangsmåde til fremstilling af benzodiazepinderivater eller 4-oxider eller syreadditionssalte deraf.

Country Status (13)

Country Link
US (1) US3481921A (da)
BE (2) BE688357A (da)
BR (2) BR6683863D0 (da)
CH (2) CH497436A (da)
DE (2) DE1695161A1 (da)
DK (2) DK120548B (da)
ES (2) ES332579A1 (da)
FR (4) FR5905M (da)
GB (2) GB1135336A (da)
IL (2) IL26724A (da)
NL (2) NL6614924A (da)
NO (2) NO118918B (da)
SE (2) SE329856B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2024239B1 (da) * 1968-11-26 1973-01-12 Scherico Ltd
US3925358A (en) * 1973-07-27 1975-12-09 Hoffmann La Roche 1-Lower alkyl-2-substituted-1,4-benzodiazepines
US3932399A (en) * 1973-07-27 1976-01-13 Hoffmann-La Roche Inc. 2,5-Epithio-1,4-benzodiazepines
US3873525A (en) * 1973-08-29 1975-03-25 Hoffmann La Roche Preparation of 1-alkyl-1,4-benzodiazepin-2-ones
US4094870A (en) * 1974-03-20 1978-06-13 Fujisawa Pharmaceutical Co., Ltd. 2-Substituted thio-1,4-benzodiazepine derivatives
US3869447A (en) * 1974-05-13 1975-03-04 Squibb & Sons Inc 2,3,4,5-Tetrahydro-4-phenyl-1H-1,4-benzodiazepine-1-carboximidamide and related compounds
US4208327A (en) * 1979-04-03 1980-06-17 G. D. Searle & Co. 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds
US4545935A (en) * 1983-09-12 1985-10-08 Iowa State University Research Foundation, Inc. Amidoalkylation reactions of anilines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893922A (en) * 1954-12-09 1959-07-07 Union Carbide Corp Continuous automatic coker
US3051701A (en) * 1959-12-10 1962-12-28 Benzodiazepine compounds

Also Published As

Publication number Publication date
NO118918B (da) 1970-03-02
SE334620B (da) 1971-05-03
FR1502968A (fr) 1967-11-24
CH497436A (de) 1970-10-15
IL26725A (en) 1970-09-17
FR5905M (fr) 1968-03-25
FR7192M (da) 1969-08-18
BE688358A (fr) 1967-04-17
ES332580A1 (es) 1967-11-16
DE1695162A1 (de) 1970-12-10
CH473133A (de) 1969-05-31
ES332579A1 (es) 1967-10-01
GB1124157A (en) 1968-08-21
NL6614924A (da) 1967-04-24
GB1135336A (en) 1968-12-04
FR1499512A (fr) 1967-10-27
US3481921A (en) 1969-12-02
BR6683863D0 (pt) 1973-12-26
SE329856B (da) 1970-10-26
NO118326B (da) 1969-12-15
BE688357A (fr) 1967-04-17
BR6683862D0 (pt) 1973-12-26
DE1695161A1 (de) 1970-12-10
NL6614923A (da) 1967-04-24
DK111489B (da) 1968-09-02
IL26724A (en) 1970-11-30

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