DK119432B - Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocykliske forbindelser eller deres salte. - Google Patents

Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocykliske forbindelser eller deres salte.

Info

Publication number
DK119432B
DK119432B DK377564AA DK377564A DK119432B DK 119432 B DK119432 B DK 119432B DK 377564A A DK377564A A DK 377564AA DK 377564 A DK377564 A DK 377564A DK 119432 B DK119432 B DK 119432B
Authority
DK
Denmark
Prior art keywords
hydroxy
salts
preparation
substituted
heterocyclic compounds
Prior art date
Application number
DK377564AA
Other languages
English (en)
Inventor
R Howe
B Mcloughlin
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Priority to DK622865A priority Critical patent/DK119357B/da
Priority to DK622965A priority patent/DK111114C/da
Publication of DK119432B publication Critical patent/DK119432B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12—Eight-membered rings
DK377564AA 1963-07-30 1964-07-30 Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocykliske forbindelser eller deres salte. DK119432B (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK622865A DK119357B (da) 1963-07-30 1965-12-03 Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocycliske forbindelser eller deres salte.
DK622965A DK111114C (da) 1963-07-30 1965-12-03 Fremgangsmade til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocycliske forbindelser eller deres salte

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB30135/63A GB1058822A (en) 1963-07-30 1963-07-30 3-amino-2-hydroxypropoxy heterocyclic derivatives
GB199064 1964-01-16

Publications (1)

Publication Number Publication Date
DK119432B true DK119432B (da) 1971-01-04

Family

ID=26237125

Family Applications (2)

Application Number Title Priority Date Filing Date
DK377564AA DK119432B (da) 1963-07-30 1964-07-30 Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede heterocykliske forbindelser eller deres salte.
DK623065AA DK111267B (da) 1963-07-30 1965-12-03 Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede xanthener eller deres salte.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK623065AA DK111267B (da) 1963-07-30 1965-12-03 Fremgangsmåde til fremstilling af basisk substituerede propylethere af hydroxysubstituerede xanthener eller deres salte.

Country Status (10)

Country Link
US (1) US3340266A (da)
BE (1) BE651032A (da)
BR (1) BR6461288D0 (da)
CH (2) CH468372A (da)
DK (2) DK119432B (da)
ES (1) ES302622A1 (da)
FR (2) FR1583153A (da)
GB (1) GB1058822A (da)
NL (1) NL139234B (da)
SE (4) SE316781C (da)

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US3509170A (en) * 1967-06-12 1970-04-28 Du Pont Heterocyclic amino-oxazolines
GB1253709A (en) * 1968-05-22 1971-11-17 Frosst & Co Charles E Thiadiazole derivatives
US3655661A (en) * 1968-05-22 1972-04-11 Frosst & Co Charles E Benzothiadiazole compounds
US3668206A (en) * 1968-10-16 1972-06-06 Venkatachala Lakshmi Narayanan Heterocyclic amine derivatives of 5,8-dihydronaphthyloxy propanols
GB1308191A (en) * 1970-04-06 1973-02-21 Science Union & Cie Thiochroman derivatives and a process for preparing them
US3853923A (en) * 1971-05-13 1974-12-10 Kakenyaku Kako Kk 2-substituted-(2-hydroxy-3-lower alkaminopropoxy)-benzofurans
JPS517672B2 (da) * 1972-04-13 1976-03-10
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
US3856818A (en) * 1972-07-03 1974-12-24 Squibb & Sons Inc Tricyclic phenoxy aminopropanols
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (da) * 1972-12-14 1977-10-03
US4073909A (en) * 1973-10-08 1978-02-14 Sandoz Ltd. Isoquinoline compounds
GB1509527A (en) * 1974-06-05 1978-05-04 Ici Ltd 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them
US3894058A (en) * 1974-05-17 1975-07-08 Hoechst Co American Tetrahydrobenzofuranylphenoxypropylamines
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
GB1472959A (en) * 1974-09-26 1977-05-11 Roche Products Ltd Benzofuran derivatives and a process for the manufacture thereof
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
AR206061A1 (es) * 1974-11-15 1976-06-23 Knoll Ag Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1
GB1544952A (en) * 1975-03-26 1979-04-25 Sandoz Ltd Isoquinolines
FI760704A (da) * 1975-03-26 1976-09-27 Sandoz Ag
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
GB1504424A (en) * 1975-08-09 1978-03-22 Beecham Group Ltd Isoquinoline-derived aminoethers
CA1089866A (en) * 1975-10-20 1980-11-18 Kiyoshi Ito Benzofuran derivatives, preparation thereof and pharmaceutical compositions thereof
US4139537A (en) 1976-06-29 1979-02-13 Cooper Laboratories, Inc. 3-Aryloxy-1-(2- or 4-iminodihydro-1-pyridyl)-2-propanol antiarrhythmic compounds
DE2704793C2 (de) * 1977-02-05 1979-03-08 Basf Ag, 6700 Ludwigshafen 4-Hydroxy-l,2-benzisothiazole
DE2704794C3 (de) * 1977-02-05 1979-10-11 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate des 4-Hydroxy-l^-benzisothiazols
NZ187066A (en) * 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
US4235919A (en) * 1977-07-21 1980-11-25 Sandoz Ltd. 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof
DE2801980A1 (de) * 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
EP0003758A1 (de) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2901336A1 (de) 1979-01-15 1980-07-24 Boehringer Mannheim Gmbh Neue arylether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
FR2479825A1 (fr) * 1980-04-04 1981-10-09 Fabre Sa Pierre Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments
US4472427A (en) * 1980-12-23 1984-09-18 Merck & Co., Inc. (Aralkylamino-2-OR-propoxy)heterocyclic compounds
CA1188311A (en) * 1981-05-01 1985-06-04 Edwin S. Wu Antihypertensive agents
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
US4471128A (en) * 1981-09-08 1984-09-11 Ciba-Geigy Corporation 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
FR2588260B1 (fr) * 1985-10-04 1987-11-20 Adir Nouveau derive du thiochromanne, son procede de preparation et les compositions pharmaceutiques qui le contiennent
DK630987D0 (da) * 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
US5198448A (en) * 1988-08-10 1993-03-30 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
FR2746395B1 (fr) * 1996-03-22 1998-04-17 Adir Nouveaux derives d'arylethanolamine et d'aryloxypropanolamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
EA002984B1 (ru) * 1996-04-09 2002-12-26 Эн Пи Эс Фармасьютикалз, Инк. Кальцилитические соединения, фармацевтические композиции и способ скрининга кальцилитических соединений
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds

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US2807567A (en) * 1953-06-02 1957-09-24 Saul & Co Preparation for the treatment of allergic diseases
US2872374A (en) * 1955-02-02 1959-02-03 Nat Drug Co Muscle-relaxing tranquilizer compositions
US2984668A (en) * 1958-07-31 1961-05-16 Searle & Co 3-(2-hydroxyethyl)-4-methyl-5-phenyloxazolidine and certain esters
US3198806A (en) * 1963-08-07 1965-08-03 Dow Chemical Co 2-alkoxy-2-oxazolines

Also Published As

Publication number Publication date
DK111267B (da) 1968-07-15
DE1493853A1 (de) 1969-06-04
NL6408650A (da) 1965-02-01
US3340266A (en) 1967-09-05
CH472402A (de) 1969-05-15
CH468372A (de) 1969-02-15
SE316781B (sv) 1969-11-03
SE316487C (sv) 1972-11-02
NL139234B (nl) 1973-07-16
ES302622A1 (es) 1965-03-16
BR6461288D0 (pt) 1973-08-09
SE316486C (sv) 1972-11-02
SE316486B (sv) 1969-10-27
FR1583153A (da) 1969-10-24
GB1058822A (en) 1967-02-15
BE651032A (da) 1965-01-27
SE316488B (da) 1969-10-27
FR4161M (da) 1966-05-16
SE316487B (sv) 1969-10-27
SE316781C (sv) 1972-11-02

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