DK115474B - Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin. - Google Patents

Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin.

Info

Publication number
DK115474B
DK115474B DK547566AA DK547566A DK115474B DK 115474 B DK115474 B DK 115474B DK 547566A A DK547566A A DK 547566AA DK 547566 A DK547566 A DK 547566A DK 115474 B DK115474 B DK 115474B
Authority
DK
Denmark
Prior art keywords
fluorocytosine
chlorobenzoyl
preparation
analogous process
analogous
Prior art date
Application number
DK547566AA
Other languages
Danish (da)
English (en)
Inventor
R Duschinsky
M Hoffer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK115474B publication Critical patent/DK115474B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK547566AA 1965-10-22 1966-10-21 Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin. DK115474B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US502586A US3309359A (en) 1965-10-22 1965-10-22 N-mono-acyl-5-fluorocytosine derivatives and process

Publications (1)

Publication Number Publication Date
DK115474B true DK115474B (da) 1969-10-13

Family

ID=23998481

Family Applications (1)

Application Number Title Priority Date Filing Date
DK547566AA DK115474B (da) 1965-10-22 1966-10-21 Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin.

Country Status (11)

Country Link
US (1) US3309359A (xx)
BE (1) BE688539A (xx)
BR (1) BR6683864D0 (xx)
CH (1) CH475258A (xx)
DE (1) DE1695160A1 (xx)
DK (1) DK115474B (xx)
FR (1) FR5908M (xx)
GB (1) GB1110357A (xx)
IL (1) IL26726A (xx)
NL (1) NL6614240A (xx)
SE (1) SE330176B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894000A (en) * 1971-01-27 1975-07-08 Upjohn Co Ara-cytidine derivatives and process of preparation
US3975367A (en) * 1971-06-08 1976-08-17 The Upjohn Company Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
US4022963A (en) * 1972-06-08 1977-05-10 Deutsch Daniel Harold Acetylation process for nucleoside compounds
US3991045A (en) * 1973-05-30 1976-11-09 Asahi Kasei Kogyo Kabushiki Kaisha N4 -acylarabinonucleosides
JPS5159880A (en) * 1974-11-22 1976-05-25 Asahi Chemical Ind N44 ashirunukureoshidojikarubonsanesuteruno seiho
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
JPS59167600A (ja) * 1983-03-14 1984-09-21 Microbial Chem Res Found ２′−デオキシオキザノシンおよびその製造法
BR0214944A (pt) * 2001-12-14 2005-06-07 Pharmasset Ltd Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais
BRPI0907435A8 (pt) * 2008-01-22 2019-01-29 Dow Agrosciences Llc derivados de 5-flúor pirimidina
WO2010047866A2 (en) 2008-08-01 2010-04-29 Dow Agrosciences Llc Use of 5-fluorocytosine as a fungicide
UA112284C2 (uk) * 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
DK2462134T3 (da) * 2009-08-07 2014-08-11 Dow Agrosciences Llc N1-sulfonyl-5-fluorpyrimidinonderivater
UA107671C2 (xx) 2009-08-07 2015-02-10 Dow Agrosciences Llc Похідні n1-заміщеного-5-фтор-2-оксопіримідинон-1(2h)-карбоксаміду
UA106889C2 (uk) * 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-ацил-5-фторпіримідинону
PT2521452E (pt) * 2010-01-07 2015-02-24 Dow Agrosciences Llc Tiazolo[5,4-d]pirimidinas e a sua utilização como agroquímicos
MX354021B (es) 2011-08-17 2018-02-08 Adama Makhteshim Ltd Derivados de 5-fluor-4-imino-3- (sustituido) -3,4-dihidropirimidin -2 (1h) ona.
UA117743C2 (uk) 2012-12-28 2018-09-25 Адама Махтешім Лтд. N-(заміщені)-5-фтор-4-іміно-3-метил-2-оксо-3,4-дигідропіримідин-1(2h)-карбоксамідні похідні
UA115462C2 (uk) 2012-12-28 2017-11-10 Адама Махтешім Лтд. Похідні n-(заміщеного)-5-фтор-4-іміно-3-метил-2-оксо-3,4-дигідропіримідин-1(2h)-карбоксилату
KR20150103095A (ko) 2012-12-28 2015-09-09 다우 아그로사이언시즈 엘엘씨 1-(치환된-벤조일)-5-플루오로-4-이미노-3-메틸-3,4-디히드로피리미딘-2(1h)-온 유도체
MX2015008565A (es) 2012-12-31 2015-09-07 Dow Agrosciences Llc Derivados de 3-alquil-5-fluoro-4-sustituido-imino-3,4-dihidropirim idin-2(1h)-ona como fungicidas.
JP6608366B2 (ja) 2013-12-31 2019-11-20 アダマ・マクテシム・リミテッド 真菌防除のための相乗的殺真菌性混合物および組成物
CN111217759A (zh) 2013-12-31 2020-06-02 阿达玛马克西姆股份有限公司 一种化合物及其制备方法
CN111094252B (zh) 2017-07-17 2024-05-24 阿达玛克西姆股份有限公司 5-氟-4-亚氨基-3-甲基-1-甲苯磺酰基-3,4-二氢嘧啶-2-酮的多晶型物
CN109651467A (zh) * 2019-01-15 2019-04-19 齐鲁天和惠世制药有限公司 一种卡培他滨杂质及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949451A (en) * 1959-04-21 1960-08-16 Hoffmann La Roche Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
NL299755A (xx) * 1959-06-03
US3208997A (en) * 1962-11-15 1965-09-28 Sankyo Co Process for preparing purine and pyrimidine nucleosides

Also Published As

Publication number Publication date
IL26726A (en) 1970-06-17
FR5908M (xx) 1968-03-25
GB1110357A (en) 1968-04-18
CH475258A (de) 1969-07-15
BE688539A (xx) 1967-04-20
BR6683864D0 (pt) 1973-12-26
US3309359A (en) 1967-03-14
SE330176B (xx) 1970-11-09
NL6614240A (xx) 1967-04-24
DE1695160A1 (de) 1970-12-17

Similar Documents

Publication Publication Date Title
DK133618B (da) Analogifremgangsmåde til fremstilling af 1-hydroxyaryl-2-aminoalkanoler.
DK118769B (da) Fremgangsmåde til fremstilling af O-methyl-S-methyl-phosphoroamidothioat.
DK115474B (da) Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin.
DK111892B (da) Fremgangsmåde til fremstilling af pyrazinimidoyl-guanidinforbindelser.
DK127415B (da) Fremgangsmåde til fremstilling af α-benzyl-β,β-dialkoxypropionitriler.
DK118505B (da) Fremgangsmåde til fremstilling af isoindolin-2-sulfonylurinstoffer.
DK118239B (da) Fremgangsmåde til fremstilling af substituerede 4-hydroxykinoliner.
DK135234B (da) Analogifremgangsmåde til fremstilling af piperazin-phenylethanolforbindelser.
DK120193B (da) Fremgangsmåde til fremstilling af 3-amino-isoxazolderivater.
DK117954B (da) Fremgangsmåde til fremstilling af 3-amino-2-cyanoacrylamid.
DK124886B (da) Fremgangsnmåde til fremstilling af 1-hydroxy-benzimidazol-N-oxider.
DK121759B (da) Analogifremgangsmåde til fremstilling af 3-oxo-7α-methylgona-4,9-diener.
DK115551B (da) Fremgangsmåde til fremstilling af 6-aminouracil-5-carbonamid-N-sulfonamider.
DK118670B (da) Fremgangsmåde til fremstilling af cyanphenoler.
DK118458B (da) Fremgangsmåde til fremstilling af 5-halogen-2-amino-benzophenoniminer.
DK118132B (da) Fremgangsmåde til fremstilling af derivater af 5-nitro-2-furyl-isoxazoler.
DK114063B (da) Fremgangsmåde til fremstilling af 1-methyl-2-isopropyl-5-nitro-imidazol.
DK120344B (da) Fremgangsmåde til fremstilling af 5-benzyl-pyrimidiner.
DK122527B (da) Fremgangsmåde til fremstilling af 3-nitro-2-oxo-tetrahydro-imidazoler.
DK119980B (da) Fremgangsmåde til fremstilling af 2-alkoxy-4-sulfanilamido-quinazolinderivater.
DK114204B (da) Fremgangsmåde til fremstilling af carboxamidoalkyl-1,3-benzoxaziner.
DK117956B (da) Fremgangsmåde til fremstilling af 3-oxogona-4,9-diener.
DK114626B (da) Fremgangsmåde til fremstilling af 2-substitueret-4-amino-5-acylamidometylpyrimidin.
DK126378B (da) Analogifremgangsmåde til fremstilling af 17α-acyloxy-9α-chlor-11β-hydroxy-progesteroner.
DK119830B (da) Analogifremgangsmåde til fremstilling af arylsulfonylsemicarbazider.